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File154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans2008-012009-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

DocumentFinal report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.01
Location: Arquivo PCA - Pasta 5/2006
Title:
Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Publication year: 2009
URL:
http://www.bial.com/imagem/Bolsa15406_21022014.pdf
Abstract/Results: RESULTS:
This study relied on nine epilepsy surgery candidates implanted with foramen ovale electrodes. 1.5-3Hz rhythmic slow activity (RSA) was a predominant activity pattern during REM sleep in most patients. This activity was also found to be highly synchronous both intra- and interhemispherically. Positive half-waves of the 1.5–3Hz RSA were identified by a semi-automatic algorithm during REM sleep. High-frequency activity was assessed as root mean square (RMS) for 11 consecutive 20 Hz–wide frequency bands between 20 and 240Hz. Calculating individual spectra revealed a broad but definite peak in the high-frequency band in seven cases (hemispheres). Statistical analysis revealed a clear phase-coupling of high-frequency activity in all patients and for most of the high-frequency bands studied. This phase relation was similar across the high frequency bands within the same patient and hemisphere. This allowed us to use individually defined fixed intervals of 0.1 s to statistically compare RMS values corresponding to the peak and the trough of the triggered RMS curve. Typically the preferred phase occurred before the RSA peak used as trigger. In most cases modulation statistics exhibited a U-shaped curve with highest significance levels in the middle frequency bands (60–80Hz and 80–100Hz). Compared to these bands modulation generally weakened across both decreasing and increasing frequency ranges. Such a phase-coupling between delta and gamma activity is similar to that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding delta rather than theta as the human analogue of RSA in animals.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Sleep / Epilepsy / Rhythmic slow activity

Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

DocumentPhase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.02
Location: Arquivo PCA - Pasta 5/2006
Title:
Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans
Publication year: 2009
URL:
http://www.sciencedirect.com/science/article/pii/S0306452209010690
Abstract/Results: ABSTRACT:
In the human sleep literature there is much controversy regarding the existence and the characteristics of hippocampal rhythmic slow activity (RSA). Generally the human RSA is believed to occur in short bursts of theta activity. An earlier study, however, reported mesiotemporal RSA during rapid-eye-movement (REM) sleep that instead of theta fell in the delta frequency band. We conjectured that if this RSA activity is indeed a human analogue of the animal hippocampal theta then characteristics associated with the animal theta should also be reflected in the human recordings. Here our aim was to examine possible phase coupling between mesiotemporal RSA and gamma activity during REM sleep. The study relied on nine epilepsy surgery candidates implanted with foramen ovale electrodes. Positive half-waves of the 1.5–3 Hz RSA were identified by an automatic algorithm during REM sleep. High-frequency activity was assessed for 11 consecutive 20 Hz–wide frequency bands between 20 and 240 Hz. Increase in high frequency activity was phase coupled with RSA in most frequency bands and patients. Such a phase coupling closely resembles that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding delta rather than theta as the human analogue of RSA in animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Weiss, B., Szucs, A., Eross, L., Rásonyi, G., Halász, P.
Document type:
Article
Reference:
Clemens, Z., Weiss, B., Szucs, A., Eross, L., Rásonyi, G., & Halász, P. (2009). Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans. Neuroscience, 163(1), 388-96. doi: 10.1016/j.neuroscience.2009.06.044
2-year Impact Factor: 3.292|2009
Times cited: 21|2020-03-10
Indexed document: Yes
Quartile: Q2
Keywords: Hippocampus / Rhythmic slow activity / Theta / Foramen ovale / Mesial temporal lobe

DocumentInterhemispheric propagation of seizures in mesial temporal lobe epilepsy2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.03
Location: Arquivo PCA - Pasta 5/2006
Title:
Interhemispheric propagation of seizures in mesial temporal lobe epilepsy
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pubmed/19835273
Abstract/Results: ABSTRACT:
OBJECTIVES:
To investigate interhemispheric propagation of mesial temporal lobe epilepsy seizures in patients undergoing long-term video-EEG monitoring with combined scalp and foramen ovale electrodes.
AIM OF THE STUDY:
To reveal possible interhemispheric propagation patterns in mesial temporal lobe epilepsy, to improve presurgical evaluation of temporal epileptic patients.
METHODS:
Sixty-five seizures from 20 patients were analyzed. We defined two contralateral seizure propagation patterns: Type I for those seizures that spread to the contralateral foramen ovale electrodes earlier than to the contralateral scalp electrodes, and type II for the opposite.
PARTICIPANTS:
Twenty drug resistant epileptic patients were investigated in frame of their presurgical evaluation.
RESULTS:
The majority of seizures (80%) were classified as type I. Inter-foramen ovale electrode propagation time was significantly shorter for type I compared to type II seizures. Ninety percent of patients had either type I or type II seizures only. Patients with type I seizures significantly more often had mesiotemporal structural alterations evident on magnetic resonance imaging scans, and became more often seizure-free after surgery compared to patients with type II seizures whose surgical outcome was less favorable or surgery could not be indicated because of independent bilateral ictal seizure-onset.
CONCLUSIONS:
The two types of contralateral propagation patterns we are describing seem to represent two subtypes of mesial temporal lobe epilepsy with different morphological and prognostic features. The predominance of type I over type II seizures together with shorter propagation times for type I seizures indicate a role of a more direct and dominant interhemispheric pathway in mesial temporal lobe epilepsy.
Accessibility: Document does not exist in file
Language:
eng
Author:
Eross, L.
Secondary author(s):
Entz, L., Fabó, D., Jakus, R., Szucs, A., Rásonyi, G., Halász, P.
Document type:
Article
Reference:
Eross, L., Entz, L., Fabó, D., Jakus, R., Szucs, A., Rásonyi, G., ... Halász, P. (2009). Interhemispheric propagation of seizures in mesial temporal lobe epilepsy. Ideggyogyaszati Szemle-Clinical Neuroscience, 62(9-10), 319-325.
2-year Impact Factor: 0.236|2010
Impact factor notes: Impact factor computed since 2010
Times cited: 5|2020-03-10
Indexed document: Yes
Quartile: Q4
Keywords: Hippocampus / Epilepsy / Temporal lobe / Hippocampal commissure / Epilepsy surgery

Interhemispheric propagation of seizures in mesial temporal lobe epilepsy

Interhemispheric propagation of seizures in mesial temporal lobe epilepsy

DocumentFine-tuned coupling between human parahippocampal ripples and sleep spindles2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.04
Location: Arquivo PCA - Pasta 5/2006
Title:
Fine-tuned coupling between human parahippocampal ripples and sleep spindles
Publication year: 2011
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2010.07505.x/pdf
Abstract/Results: ABSTRACT:
Sleep-associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led to the concept that ripples originating from hippocampus combine with spindles to provide a fine-tuned temporal frame for a persistent transfer of memory-related information to the neocortex. The present study focused on characterizing the temporal relationship between parahippocampal ripple activity (80-140 Hz) and spindles recorded from frontal, parietal and parahippocampal cortices in 12 epilepsy patients implanted with parahippocampal foramen ovale electrodes. Overall, parietal and parahippocampal spindles showed closer relationships to parahippocampal ripple activity than frontal spindles, with the latter following parietal and parahippocampal spindles at a variable delay of up to 0.5 s. On a timescale of seconds, ripple activity showed a continuous increase before the peak of parietal and parahippocampal spindles, and decreased thereafter. At a fine timescale of milliseconds, parahippocampal ripple activity was tightly phase-locked to the troughs of these spindles. The demonstration of spindle phase-locked ripple activity in humans is consistent with the idea of a temporally fine-tuned hippocampus-to-neocortex transfer of information taking place during SWS.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., Born, J.
Document type:
Article
Reference:
Clemens, Z., Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., & Born, J. (2011). Fine-tuned coupling between human parahippocampal ripples and sleep spindles. European Journal of Neuroscience, 33(3), 511-520. doi: 10.1111/j.1460-9568.2010.07505.x
2-year Impact Factor: 3.631|2011
Times cited: 101|2020-03-10
Indexed document: Yes
Quartile: Q2
Keywords: Epilepsy / Hippocampus / Ripples / Sleep / Spindles

Fine-tuned coupling between human parahippocampal ripples and sleep spindles

Fine-tuned coupling between human parahippocampal ripples and sleep spindles

DocumentHigh-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.05
Location: Arquivo PCA - Pasta 5/2006
Title:
High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
To examine possible phase-relation between high-frequency (gamma) and rhythmic slow activity (RSA) during REM sleep in human mesiotemporal EEG recordings. To seek for analogies between the animal hippocampal theta and the human mesiotemporal RSA during REM sleep.
METHODS:
The study relied on nine epilepsy surgery candidates implanted with bilateral semi-invasive foramen ovale electrodes placed beneath the mesiotemporal surface. Positive half-waves of the 1.5–3 Hz RSA were identified by a semi-automatic algorithm during REM sleep. High-frequency activity was assessed for 11 consecutive 20 Hz–wide frequency bands between 20 and 240 Hz. To investigate time relations between RSA
oscillation and high-frequency activity the root mean square of each high-frequency band was averaged for intervals of 0.5 s around all detected RSA oscillation peaks.
RESULTS:
RSA at 1-5-3 Hz was a striking feature of most foramen ovale recordings during REM sleep. Increase in high frequency activity was phase coupled with RSA in most frequency bands and patients. The phase of the highest gamma activity increase was similar across increasing high frequency bands and typically occurred shortly (~0.1 s) before the RSA peak used as trigger. Highest level of modulation was found for the middle high frequency bands (60-80 Hz and 80-100 Hz) which gradually weakened across both decreasing and increasing high-frequency bands.
CONCLUSIONS:
Such a phase coupling closely resembles that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding the 1.5-3 Hz delta rather than theta as the human analogue of RSA in animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Document type:
Conference abstract
Reference:
Halász, P., Clemens, Z., Borbély, C., & Fabó, D. (2010). High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundaçăo Bial (p. 236). Porto: Fundaçăo Bial.
Indexed document: No
Keywords: Hippocampus / Rhythmic slow activity / Theta / Mesial temporal lobe / Epilepsy

High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

DocumentIncreased mesiotemporal delta activity characterizes virtual navigation in humans2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.06
Location: Arquivo PCA - Pasta 5/2006
Title:
Increased mesiotemporal delta activity characterizes virtual navigation in humans
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0168010213000795
Abstract/Results: ABSTRACT:
Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal theta occurs in short and phasic bursts. On the contrary, our earlier studies provide evidence that REM-dependent mesiotemporal RSA is continuous like in animals but instead of the theta it falls in the delta frequency range. Here we used a virtual navigation task in 24 epilepsy patients implanted with foramen ovale electrodes. EEG was analyzed for 1-Hz wide frequency bins up to 10 Hz according to four conditions: resting, non-learning route-following, acquisition and recall. We found progressively increasing spectral power in frequency bins up the 4 Hz across these conditions. No spectral power increase relative to resting was revealed within the traditional theta band and above in any of the navigation conditions. Thus the affected frequency bins were below the theta band and were similar to those characterizing REM sleep in our previous studies providing further indication that it is delta rather than theta that should be regarded as a human analog of the animal RSA.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Borbély, C., Weiss, B., Eross, L., Szucs, A., Kelemen, A., Fabó, D., Rásonyi, G., Janszky, J., Halász, P.
Document type:
Article
Reference:
Clemens, Z., Borbély, C., Weiss, B., Eross, L., Szucs, A., Kelemen, A., Fabó, D., Rásonyi, G., Janszky, J., & Halász, P. (2013). Increased mesiotemporal delta activity characterizes virtual navigation in humans. Neuroscience Research, 76(1-2), 67-75. doi: 10.1016/j.neures.2013.03.004
2-year Impact Factor: 2.145|2013
Times cited: 11|2020-03-11
Indexed document: Yes
Quartile: Q3
Keywords: Rhythmic slow activity / Hippocampus / Learning / Memory