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File161 - The relation of mind to body. Psychophysiological studies of the placebo effect2007-012010-05

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

DocumentFinal report - The relation of mind to body. Psychophysiological studies of the placebo effect2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.01
Location: Arquivo PCA - Pasta 12/2006
Title:
Final report - The relation of mind to body. Psychophysiological studies of the placebo effect
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa14406_28012014.pdf
Abstract/Results: ABSTRACT:
Placebo analgesia is the reduction in pain after administration of a placebo with information that it will reduce pain. We have shown that placebo analgesia can be objectively recorded by physiological measures (electromyography, heart rate variability, and event-related potentials (ERP)). Reduced ERPs indicate that placebos activate descending pain inhibitory pathways. The placebo response, or more precisely, the expectation of drug effects, can add to the effect of the drug. There is some evidence that placebo effects are strongest when expectations are reinforced by administration of an active drug. Of special importance to the present project was the investigation of the role of stress and negative emotions in placebo analgesia. Our hypothesis was that the placebo reduced stress and nervousness, and thereby reduced pain. Fear of pain was positively related to stress both during pain and in the anticipation of pain, and negatively related to placebo analgesia. However, other factors also contribute to the placebo analgesia. The present findings suggest that decreased stress may strengthen the placebo response. This may have important clinical consequences, as stress reduction could aid in treatment of pain. Furthermore, male subjects responded with lower stress after placebo medication, and larger placebo responses. These findings suggest that males respond differently to verbal placebo information compared to females. It is not know whether this is due to more effective pain inhibitory mechanisms in males, or to cognitive factors. In sum, there is a contribution of reduced stress to placebo analgesia, and for reasons unknown this effect is larger in males.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Flaten, M.
Document type:
Final report
Indexed document:
No
Keywords: Placebo effect / Placebo analgesia / Pain / Event-related potential (ERP) / Emotion / Stress

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

DocumentThe roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.02
Location: Arquivo PCA - Pasta 12/2006
Title:
The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain
Publication year: 2008
URL:
http://www.ncbi.nlm.nih.gov/pubmed/18725424
Abstract/Results: ABSTRACT:
OBJECTIVE:
To examine whether reduction of negative emotions and associated autonomic activity could explain placebo analgesia, and to test the effect of experimenter gender on the placebo analgesic response.
METHODS:
Sixty-three (n = 32 females) students participated in a within-subjects design where subjects were tested on two separate days, one day for the experimental condition (placebo) and one day for the natural history condition. In the experimental condition, the participants received capsules containing lactose with information that the capsules were a high dose of a potent painkiller. In the natural history condition, the procedures were identical except that the placebo capsules were not administrated. The experimenters were blinded to the fact that all participants received placebo. Pain was induced by a thermode holding +46 degrees C with duration of 240 seconds to the forearm. Electrocardiogram was measured to obtain data for analysis of heart rate variability. Subjective measurements consisted of pain intensity, pain unpleasantness, stress, arousal, and mood.
RESULTS:
The results showed a placebo effect on pain intensity and a concomitant reduction in subjective stress and cardiac activity. Stepwise regressions revealed that reduced subjective stress was the only predictor for the placebo analgesic response. Contrary to our hypothesis, male subjects displayed increased placebo analgesia when a male acted as experimenter.
CONCLUSIONS:
The results indicate that reduced negative emotional activation could be a mechanism in placebo analgesia and that experimenter gender is probably not systematically related to placebo analgesia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Article
Reference:
Aslaksen, P., & Flaten, M. (2008). The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain. Psychosomatic Medicine, 70(7), 811-818. doi: 10.1097/PSY.0b013e31818105ed
2-year Impact Factor: 3.460|2008
Times cited: 53|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Gender / Negative emotions / Autonomic activation

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

DocumentDrug effects: agonistic and antagonistic processes2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.03
Location: Arquivo PCA - Pasta 12/2006
Title:
Drug effects: agonistic and antagonistic processes
Publication year: 2009
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1467-9450.2009.00776.x/pdf
Abstract/Results: ABSTRACT:
The research presented here has shown that tolerance to drugs can be accelerated by conditioning processes. Placebo effects may be considered the opposite of tolerance, and we have shown that placebo effects may be objectively recorded by physiological measures (electromyography, skin conductance responses, and event-related potentials), as well as by behavioral and subjective methods. The placebo response, or more precisely, the expectation of drug effects, can add to the effect of the drug. Drug antagonistic expectations can also reverse the effect of the drug. There is some evidence that placebo effects are strongest when expectations are reinforced by administration of an active drug. Expectations have graded effects and may affect symptoms to a smaller or larger degree. Although drug effects can be considered stimuli, the investigation of the role of classical conditioning in drug use and drug effects involves special issues that must be carefully considered.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Document type:
Article
Reference:
Flaten, M. A. (2009). Drug effects: agonistic and antagonistic processes. Scandinavian Journal of Psychology, 50(6), 652-659. doi: 10.1111/j.1467-9450.2009.00776.x
2-year Impact Factor: 1.148|2009
Times cited: 8|2020-03-10
Indexed document: Yes
Quartile: Q2
Keywords: Placebo response / Placebo effect / Placebo analgesia / Startle / Classical conditioning / Expectancy

Drug effects: agonistic and antagonistic processes

Drug effects: agonistic and antagonistic processes

DocumentIs fear of pain related to placebo analgesia?2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.04
Location: Arquivo PCA - Pasta 12/2006
Title:
Is fear of pain related to placebo analgesia?
Publication year: 2010
URL:
http://www.sciencedirect.com/science/article/pii/S0022399909004553
Abstract/Results: ABSTRACT:
OBJECTIVE:
Verbal information that a painkiller has been administered generates an expectation of pain relief which in turn decreases pain. This expectation-based pain reduction is termed placebo analgesia. We hypothesized that fear of pain would be related to higher stress and pain intensity and to reduced placebo analgesia.
METHODS:
Sixty-three students (30 females) participated in a Two-Condition (placebo, natural history)xFive-Test (one pretest, four post-tests) within-subjects design. Heat pain was induced by a 30x30-mm contact thermode to the medial volar forearm. Each pain test lasted for 4 min at a temperature of 46 degrees C. Stress, arousal, and pain intensity and pain unpleasantness were rated on 100-mm visual analogue scales.
RESULTS:
Fear of pain was related to higher anticipatory stress and to higher stress and pain intensity during pain. Fear of pain was also related to reduced placebo analgesic responding.
CONCLUSION:
Fear of pain was positively related to stress both during pain and in the anticipation of pain, and negatively related to placebo analgesia. Previous research has indicated a role for increased stress in the nocebo response, and the present findings suggest that decreased stress may strengthen the placebo response.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Aslaksen, P., Flaten, M.
Document type:
Article
Reference:
Lyby, P., Aslaksen, P., & Flaten, M. (2010). Is fear of pain related to placebo analgesia? Journal of Psychosomatic Research, 68(4), 369-377. doi: 10.1016/j.jpsychores.2009.10.009
2-year Impact Factor: 2.842|2010
Times cited: 39|2020-03-10
Indexed document: Yes
Quartile: Q2
Keywords: Placebo analgesia / Expectancy / Fear of pain / Stress

Is fear of pain related to placebo analgesia?

Is fear of pain related to placebo analgesia?

DocumentGender differences in placebo analgesia: event-related potentials and emotional modulation2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.05
Location: Arquivo PCA - Pasta 12/2006
Title:
Gender differences in placebo analgesia: event-related potentials and emotional modulation
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21217098
Abstract/Results: ABSTRACT:
OBJECTIVES:
To examine whether there are gender differences in event-related potential (ERP) responses to painful stimulation after administration of placebo medication; and to investigate whether placebo medication reduces anticipatory stress and if this reduction can explain the placebo analgesic response. Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia.
METHODS:
All subjects (n = 33; 17 women) participated in both a natural history and a placebo condition. ERPs were evoked by heat pulses with a peak at 52 °C.
RESULTS:
The results showed that pain unpleasantness and the N2/P2 ERP components were reduced in the placebo condition compared with the natural history condition. Only men displayed placebo responses in pain report and in the P2 component. Anticipatory stress was reduced after placebo administration, and the reduction in anticipatory stress was significantly related to the placebo effect on pain. Regression analyses revealed that the interaction of gender by anticipatory stress was significantly related to the mean placebo response, with men responding with lower stress after placebo medication, and larger placebo responses.
CONCLUSIONS:
A placebo response on pain unpleasantness was observed in men only, and reduced stress after placebo administration was observed in males only. Thus, reduced stress may be a mechanism for placebo responses in pain.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.06
Author: Aslaksen, P.
Secondary author(s):
Vambheim, S., Bystad, M., Flaten, M.
Document type:
Article
Reference:
Aslaksen, P., Vambheim, S., Bystad, M., & Flaten, M. (2011). Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosomatic Medicine, 73(2), 193-199. doi: 10.1097/PSY.0b013e3182080d73
2-year Impact Factor: 3.968|2011
Times cited: 66|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Pain / Placebo analgesia / Event-related potential (ERP) / Gender differences / Emotions

Gender differences in placebo analgesia: event-related potentials and emotional modulation

Gender differences in placebo analgesia: event-related potentials and emotional modulation

DocumentInteraction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.06
Location: Arquivo PCA - Pasta 12/2006
Title:
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21384106
Abstract/Results: ABSTRACT:
RATIONALE:
In a randomised placebo-controlled clinical trial it is assumed that psychosocial effects of the treatment, regression to the mean and spontaneous remission are identical in the drug and placebo group. Consequently, any difference between the groups can be ascribed to the pharmacological effects. Previous studies suggest that side effects of drugs can enhance expectancies of treatment effects in the drug group compared to the placebo group, and thereby increase placebo responses in the drug group compared to the placebo group.
OBJECTIVES:
The hypothesis that side effects of drugs can enhance expectancies and placebo responses was tested.
METHOD:
Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine. The drink was administered either with information that it contained a painkiller or that it was a placebo. Laser-evoked potentials and reports of pain, expectancy, arousal and stress were measured.
RESULTS:
Four milligrammes per kilogramme of caffeine reduced pain. Information that a painkiller was administered increased the analgesic effect of caffeine compared to caffeine administered with no drug information. This effect was mediated by expectancies. Information and expectancies had no effect on pain intensity when 0 mg/kg was administered.
CONCLUSION:
The analgesic effect of caffeine was increased by information that a painkiller was administered. This was due to an interaction of the pharmacological action of the drug and expectancies. Hence, psychosocial effects accompanying a treatment can differ when an active drug is administered compared to a placebo.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.07
Author: Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article
Reference:
Bjørkedal, E., & Flaten, M. (2011). Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo. Psychopharmacology, 215(3), 537-548. doi: 10.1007/s00213-011-2233-4
2-year Impact Factor: 4.077|2011
Times cited: 24|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Expectancies / Laser-evoked potentials / Active placebo / Caffeine / Arousal / Balanced placebo design

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

DocumentThe relation of emotions to placebo responses2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.07
Location: Arquivo PCA - Pasta 12/2006
Title:
The relation of emotions to placebo responses
Publication year: 2011
URL:
http://rstb.royalsocietypublishing.org/content/366/1572/1818.full.pdf
Abstract/Results: ABSTRACT:
The hypothesis put forth is that expectations of treatment effects reduce negative emotions and thereby reduce symptoms, e.g. pain. Negative emotions increase pain, and it is hypothesized that placebos reduce pain by reducing negative emotions, i.e. feelings of nervousness, fear and anxiety. Placebo analgesia has been shown to be mediated via opioid activity, and relaxation increases opioid activity. The placebo acquires its relaxing effect due to verbal information that pain will be reduced, or due to associations between the placebo and the reduction in pain after effective treatment. Thus, the placebo signals that unpleasantness will be less after administration of the placebo. This involves negative reinforcement which is due to activation of a dopaminergic system that has been found to be activated during placebo analgesia and is involved in positive emotions. The nocebo effect of increased pain is, consistent with this model, because of increased fear and anxiety. The new aspect of the presented model is the hypothesis that expectations reduce negative emotions, and that negative reinforcement that involves the dopaminergic reinforcement system should be a contributor to placebo responses.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.08
Author: Flaten, M.
Secondary author(s):
Aslaksen, P., Lyby, P., Bjørkedal, E.
Document type:
Article
Reference:
Flaten, M., Aslaksen, P., Lyby, P., & Bjørkedal, E. (2011). The relation of emotions to placebo responses. Philosophical Transactions of the Royal Society B, 366, 1818–1827. doi: 10.1098/rstb.2010.0407
2-year Impact Factor: 6.401|2011
Times cited: 70|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo effect / Placebo analgesia / Pain / Emotion / Classical conditioning / Operant conditioning

The relation of emotions to placebo responses

The relation of emotions to placebo responses

DocumentVariability in placebo analgesia and the role of fear of pain - an ERP study2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.08
Location: Arquivo PCA - Pasta 12/2006
Title:
Variability in placebo analgesia and the role of fear of pain - an ERP study
Publication year: 2011
URL:
http://www.painjournalonline.com/article/S0304-3959(11)00450-7/abstract
Abstract/Results: ABSTRACT:
Fear of pain (FOP) and its effect on placebo analgesia was investigated. It was hypothesized that FOP should interfere with placebo-mediated pain inhibition and result in weaker placebo responding in pain intensity, pain unpleasantness, stress, and event-related potentials to contact heat pain. Thirty-three subjects participated in a balanced 2 condition (natural history, placebo)×3 test (pretest, posttest 1, posttest 2) within-subject design, tested on 2 separate days. FOP was measured by the Fear of Pain Questionnaire and subjective stress by the Short Adjective Check List. Placebo effects were found on reported pain unpleasantness and N2 and P2 amplitudes. FOP was related to reduced placebo responding in pain unpleasantness, but this was only evident for the subjects who received the placebo condition on day 1. Subjects who received the placebo condition on day 1 experienced more pretest stress than those who received the placebo condition on day 2 (ie, reversed condition order), and this explained the interaction effect on placebo responding. FOP was related to reduced placebo responding on P2 amplitude, whereas placebo responding on N2 amplitude was unaffected by FOP. Higher placebo responses on N2 and P2 amplitudes were both related to higher placebo analgesic magnitude in pain unpleasantness. In conclusion, increased FOP was found to reduce subjective and electrophysiological placebo analgesic responses.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
PT/FB/BL-2010-186.09
Author: Lyby, P.
Secondary author(s):
Aslaksen, P., Flaten, M.
Document type:
Article
Reference:
Lyby, P., Aslaksen, P., & Flaten, M. (2011). Variability in placebo analgesia and the role of fear of pain - an ERP study. Pain, 152(10), 2405-2412. doi: 10.1016/j.pain.2011.07.010
2-year Impact Factor: 5.777|2011
Times cited: 50|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Individual differences / Fear of pain / Event-related potential (ERP) / Contact heat-evoked potentials

Variability in placebo analgesia and the role of fear of pain—an ERP study

Variability in placebo analgesia and the role of fear of pain—an ERP study

DocumentThe effect of experimenter gender on autonomic and subjective responses to pain stimuli2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.09
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of experimenter gender on autonomic and subjective responses to pain stimuli
Publication year: 2007
URL:
http://www.sciencedirect.com/science/article/pii/S0304395906005562
Abstract/Results: ABSTRACT:
Several studies have shown that male subjects report lower pain intensity to female compared to male experimenters. The present experiment examined whether experimenter gender also modulated autonomic pain responses. Sixty-four students (32 females) participated in a 2 Subject gender x 2 Experimenter gender x 15 Pain Tests mixed design. Six experimenters, three females and three males collected data. Heat pain was +48 degrees C induced to the right volar forearm. Subjective measurements consisted of pain intensity, pain unpleasantness, stress, arousal and mood. Autonomic responses were heart rate variability and skin conductance levels. The results revealed significant interactions between experimenter gender and subject gender on pain intensity and arousal, but there were no interactions in the physiological data. In conclusion, the lower pain report in male subjects to female experimenters is not mediated by changes in autonomic parameters, and the effect of experimenter gender is probably due to psychosocial factors.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2002-28.04
Author: Aslaksen, P.
Secondary author(s):
Myrbakk, I., Høifødt, R., Flaten, M.
Document type:
Article-d
Reference:
Aslaksen, P., Myrbakk, I., Høifødt, R., & Flaten, M. (2007). The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain, 129(3), 260-268. doi: 10.1016/j.pain.2006.10.011
2-year Impact Factor: 5.249|2007
Times cited: 100|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Experimenter gender / Pain report / Autonomic pain responses / Heart rate variability (HRV) / Gender roles / Heat pain / Subjective emotions / Stepwise regression

DocumentFear potentiated startle at short intervals following conditioned stimulus onset during delay but not trace conditioning2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.10
Location: Arquivo PCA - Pasta 12/2006
Title:
Fear potentiated startle at short intervals following conditioned stimulus onset during delay but not trace conditioning
Publication year: 2009
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8986.2009.00809.x/abstract
Abstract/Results: ABSTRACT:
The latency of conditioned fear after delay and trace conditioning was investigated. Some argue that delay conditioning is not dependent on awareness. In contrast, trace conditioning, where there is a gap between the conditioned stimulus (CS) and the unconditioned stimulus (US), is assumed to be dependent on awareness. In the present study, a tone CS signaled a noise US presented 1000 ms after CS onset in the delay conditioning group. In the trace conditioning group, a 200-ms tone CS was followed by an 800-ms gap prior to US presentation. Fear-potentiated startle should be seen at shorter intervals after delay conditioning compared to trace conditioning. Analyses showed increased startle at 30, 50, 100, and 150 ms after CS onset following delay conditioning compared to trace conditioning. This implies that fear-relevant stimuli elicit physiological reactions before extended processing of the stimuli occur, following delay, but not trace conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Åsli, O.
Secondary author(s):
Kulvedrøsten, S., Solbakken, L., Flaten, M.
Document type:
Article
Reference:
Åsli, O., Kulvedrøsten, S., Solbakken, L., & Flaten, M. (2009). Fear potentiated startle at short intervals following conditioned stimulus onset during delay but not trace conditioning. Psychophysiology, 46(4), 880-888. doi: 10.1111/j.1469-8986.2009.00809.x
2-year Impact Factor: 3.926|2009
Times cited: 9|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Emotion / Learning and memory / Unconscious processes / Normal volunteers / Startle blink

DocumentPlacebo analgesia and heart rate variability2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.11
Location: Arquivo PCA - Pasta 12/2006
Title:
Placebo analgesia and heart rate variability
Publication year: 2007
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/2007Abstracts.pdf
Abstract/Results: ABSTRACT:
The present experiment investigated whether administration of placebo affected heart rate variability during heat pain. It was hypothesized that the ratio of low frequent to high frequent (LF/HF) heart rate variability would decrease after administration of an inert substance together with information that it was a powerful painkiller. In a within subjects design, 20 participants (10 females) were tested on two separate days, one day for the placebo condition and one day for control. In the placebo condition, the participants received two capsules containing 75mg lactose each during the second of five pain tests, with information that the pills were a high dose of a standard overthe-counter analgesic with high pain analgesic effect on heat pain. In the
control condition, the same subjects underwent the same five pain tests, but without placebo administration. Pain tests consisted of heat pain (+46C, duration 240 seconds) to the forearm. ECG was recorded continuously for spectral analysis of heart rate variability. Subjective pain intensity, pain unpleasantness, stress and arousal were measured on VAS scales during each pain test. In addition, mood was measured by the SAM. Results revealed that the LF/HF ratio during painful stimulation decreased significantly in the
placebo condition compared to the control condition after placebo administration (F(1,19)=8.76, p<.01), but this effect was only significant for the first two pain tests after placebo administration. Moreover, a main effect of placebo on heart rate variability was found (F(1,19)=8.43, p<.01), with lower ratio of LF/HF in the placebo condition. There was lower pain intensity (F(1,19=14.99, p<.01) and pain unpleasantness (F(1,19)=4.74, p=.04) in the placebo condition compared to the control condition. Subjective stress during pain was decreased after placebo administration, and there was lower subjective stress in the placebo condition compared to the control condition (F(1,19)=13.06, p<.01). There were no significant effects on arousal or mood. The results from the present experiment suggest that placebo analgesia is accompanied by a reduction in cardiac autonomic activation and a reduction of subjective negative emotions.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract
Reference:
Aslaksen, P., & Flaten, M. (2007). Placebo analgesia and heart rate variability. Meeting abstracts. Psychosomatic Medicine, 69(1), A-32.
2-year Impact Factor: 4.236|2009
Indexed document: Yes
Keywords: Psychophysiology / Heat pain / Heart rate variability (HRV) / Placebo

Placebo analgesia and heart rate variability

Placebo analgesia and heart rate variability

DocumentThe role of subject and experimenter gender in pain and placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.12
Location: Arquivo PCA - Pasta 12/2006
Title:
The role of subject and experimenter gender in pain and placebo analgesia
Publication year: 2007
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/2007Abstracts.pdf
Abstract/Results: ABSTRACT:
In a previous experiment (Flaten et al. 2006, J Psychosom Res) placebo analgesia was observed in males only, whereas females did not display a placebo response. One possible explanation for this may have been the social context since all procedures were administrated by female experimenters. Follow-up studies showed that reported pain was significantly reduced in males when the report was given to a female experimenter compared to pain reported to a male experimenter. Pain report in females, on the other hand,
was not modulated by social context. Verbal report of arousal was also modulated the same way as pain, i.e., males reported being more calm in the presence of a female experimenter compared to arousal reported in the presence of a male experimenter. However, heart rate variability indicated increased sympathetic activation in males when a female experimenter was present. These results suggest that verbal report in males is heavily influenced by social context, and that additional measures, less affected by social context,
need to be used in the study of pain and placebo analgesia. Data will be presented showing the roles of subject and experimenter gender in placebo analgesia.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Document type:
Abstract
Reference:
Flaten, M. (2007). The role of subject and experimenter gender in pain and placebo analgesia. Meeting abstracts. Psychosomatic Medicine, 69(1), A-78.
2-year Impact Factor: 4.236|2009
Indexed document: Yes
Keywords: Experimenter gender / Pain report / Heart rate variability (HRV) / Placebo analgesia / Gender roles

The role of subject and experimenter gender in pain and placebo analgesia

The role of subject and experimenter gender in pain and placebo analgesia

DocumentThe effect of subject and experimenter gender on pain and placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.13
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of subject and experimenter gender on pain and placebo analgesia
Publication year: 2007
URL:
http://www.placebo-vw.unito.it/Immagini/Tutzing-program.pdf
Abstract/Results: ABSTRACT:
Pain report has in several reports been shown to be modulated by the interaction of subject gender with experimenter gender. Our studies showed that male subjects reported less pain to female experimenters compared with pain reported to male experimenters. The social context also modulated subjective reports of stress and arousal, with male subjects reporting less stress and arousal to female experimenters. These findings show the importance of objective measurement of pain and stress, alternatively that relevant controls for social context are used in the experiment.
As the pain report is a central element in placebo analgesia, gender could also play a role in placebo analgesia. Two experiments tested whether gender modulated placebo analgesia induced by verbal information or by classical conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract book
Reference:
Aslaksen, P., & Flaten, M. (2007). The effect of subject and experimenter gender on pain and placebo analgesia. In Abstract book of the Symposium on Mechanisms of Placebo/Nocebo Responses (p. 18). Tutzing, Germany.
Indexed document: No
Keywords: Experimenter gender / Pain report / Stress / Arousal / Placebo analgesia

The effect of subject and experimenter gender on pain and placebo analgesia

The effect of subject and experimenter gender on pain and placebo analgesia

DocumentEmotional factors in placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.14
Location: Arquivo PCA - Pasta 12/2006
Title:
Emotional factors in placebo analgesia
Publication year: 2007
URL:
http://www.placebo-vw.unito.it/Immagini/Tutzing-program.pdf
Abstract/Results: ABSTRACT:
Treatment for pain induces an expectation that pain will be reduced after the treatment. Research has shown that the expectation alone can reduce pain, and this has been termed placebo analgesia. However, expectation of reduced pain may also have other consequences, one of them being a reduction in stress or negative emotion. Stress and negative emotions have been found to increase pain, and it could be hypothesized that placebo analgesia is mediated via a reduction in stress. Experiments that test the hypothesis will be presented. Subjects scoring high on the Fear of Pain questionnaire displayed high levels of stress before application of the pain stimuli, as expected, and data from these subjects are of special interest for the hypothesis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Aslaksen, P.
Document type:
Abstract book
Reference:
Flaten, M., & Aslaksen, P. (2007). Emotional factors in placebo analgesia. In Abstract book of the Symposium on Mechanisms of Placebo/Nocebo Responses (p. 22). Tutzing, Germany.
Indexed document: No
Keywords: Placebo analgesia / Fear of pain / Stress / Negative emotions

Emotional factors in placebo analgesia

Emotional factors in placebo analgesia

Document(133) The relation of stress and heart rate variability to placebo analgesia2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.15
Location: Arquivo PCA - Pasta 12/2006
Title:
(133) The relation of stress and heart rate variability to placebo analgesia
Publication year: 2008
URL:
http://download.journals.elsevierhealth.com/pdfs/journals/1526-5900/PIIS1526590008000539.pdf
Abstract/Results: ABSTRACT:
The present experiment investigated whether administration of placebo affected heart rate variability during heat pain. It was hypothesized that the ratio of low frequent to high frequent (LF/HF) heart rate variability would decrease after administration of an inert substance together with information that it was a powerful painkiller. In a within subjects design, 63 participants (32 females) were tested on two separate days, one day for the placebo condition and one day for control. In the placebo condition, the participants received two capsules containing 75mg lactose each during the second of five pain tests, with information that the capsules were a high dose of a standard analgesic with high pain analgesic effect on heat pain. In the control condition, the same subjects underwent the same five pain tests, but without placebo administration. Pain tests consisted of heat pain (+46C, duration 240 seconds) to the forearm. ECG was recorded continuously. Subjective pain intensity, pain unpleasantness, stress and arousal were measured on VAS scales during each pain test. In addition, mood was measured by the SAM. Results revealed that the LF/HF ratio during painful stimulation decreased significantly in the placebo condition after placebo administration (F (1, 57) = 7.08, p = 0.01). There was lower pain intensity (F (1,62) = 20.53, p = 0.01) in the placebo condition compared to the control condition. Subjective stress during pain was decreased after placebo administration (F (1, 62) = 7.45, p = 0.01), and there was lower subjective stress in the placebo condition compared to the control condition (F (1, 62) = 5.39, p = 0.02). There were no significant effects on pain unpleasantness, arousal or mood. The results from the present experiment suggest that placebo analgesia is accompanied by a reduction in cardiac autonomic activation and a reduction of subjective stress.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract
Reference:
Aslaksen, P., & Flaten, M. (2008). (133) The relation of stress and heart rate variability to placebo analgesia. Journal of Pain, 9(4), Supplement 2, S9. doi: 10.1016/j.jpain.2008.01.052
2-year Impact Factor: 4.851|2010
Indexed document: Yes
Keywords: Psychophysiology / Heat pain / Heart rate variability (HRV) / Placebo / Stress / Arousal / Mood

(133) The relation of stress and heart rate variability to placebo analgesia

(133) The relation of stress and heart rate variability to placebo analgesia

DocumentThe effect of gender on placebo analgesia after classical conditioning2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.16
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of gender on placebo analgesia after classical conditioning
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={DEE465B2-6FF9-405C-B44F-BFDF087CA098}&SKey={4B674E01-8788-4BD6-89B1-6B8A26E1329D}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Previous studies have shown that placebo analgesia can occur after both classical conditioning and verbal information. Placebo analgesic responding to verbal information has been reported to be increased in males. The effect of subject gender on placebo analgesic responding after conditioning has not been investigated.
METHODS:
69 subjects (38 females) participated. Pain was induced by a thermode attached to the right forearm. Pain was induced 4 times for 2 minutes. In the Conditioned group, temperatures were increased from -100C to 0 and +50C after administration of placebo capsules. A conditioned stimulus (CS) control group received the capsules (CSs) but temperatures were kept constant at -100C after administration of the capsules. An unconditioned stimulus (US) control group did not receive the capsules, but the temperatures were increased as in the Conditioned group. Placebo analgesic responding was assessed when pain at -100C was applied in all groups at the end of the experiment. Placebo analgesic responding, i.e., reports of lower pain to -100C was expected in the Conditioned group, but not in the two control groups. The experimenters (two females and two males) were blind to whether the subjects received a placebo or an actual painkiller.
RESULTS:
There were no significant differences in the pre-test between the groups. There was a main effect of groups in the pain unpleasantness data (p<0.001) due to lower pain ratings in the Conditioned group compared to the US control group (p=0.02). There was no difference in pain unpleasantness between the Conditioned group and the CS control group. Cold pain thresholds were lower in the Conditioned and CS control group compared to the US control group (p=0.036). Females reported lower pain unpleasantness to male experimenters compared to female experimenters in the post-test in the Conditioned group (p=0.005). There were no other significant gender effects of conditioning on placebo analgesia. Male subjects displayed lower cold pain thresholds (p=0.03) than females regardless of group allocation. There was a main effect of gender on stress across groups, with male subjects reporting lower stress than females (p<0.01). There were no significant placebo effects on pain intensity, arousal or cortisol.
CONCLUSIONS:
Administration of placebo capsules in the Conditioned group decreased pain compared to the US control group that received identical pain stimulation but no capsules. However, administration of placebo capsules decreased pain even when the capsules were not related to a decrease in pain. Most likely this was due to the participants previous history with painkillers. There were no effects of subject gender on placebo analgesia after conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Lyby, P., Bjørkedal, E., Flaten, M.
Document type:
Online abstract
Reference:
Aslaksen, P., Lyby, P., Bjørkedal, E., & Flaten, M. (2008, August). The effect of gender on placebo analgesia after classical conditioning. Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retrieved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Placebo analgesia / Pain

DocumentA review of the effect of active placebo compared to placebo2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.17
Location: Arquivo PCA - Pasta 12/2006
Title:
A review of the effect of active placebo compared to placebo
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={886F130B-3ED2-4331-877C-A6B4EE093C91}&SKey={4B674E01-8788-4BD6-89B1-6B8A26E1329D}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Active placebos are pharmacologically active substances with subjective effects, but are without effects on the dependent variable of interest. It has been suggested that placebo effects are larger when subjects are given an active placebo compared to an inert placebo, since administration of a drug (i.e., an active placebo) increases expectations of drug effects, and thereby increases the placebo effect. A literature review was performed that investigated this hypothesis.
METHODS:
The ISI Web of Knowledge and Pub Med Databases were searched using “active-placebo” and “balanced-placebo-design” as search criteria. Inclusion criteria were studies where an active placebo response could be compared to an inert placebo response. Relevant studies were: experimental studies of active placebo, clinical trials using active placebos + inert placebos, and studies using the balanced placebo design. The active placebo response was compared to the inert placebo response for each study. In experimental studies of active placebo and in clinical trials these responses were compared directly. In the balanced placebo design the separate and interacting effects of expectancies and active placebo were tested. If the effect in the given drug/told drug group exceeded the added effects of the drug and placebo groups it must have been due to the active placebo effect. 70 studies fit the inclusion criteria.
RESULTS:
Forty one of 70 reports are reviewed so far. Instructions or expectations had variable effects. Only when responses to placebo administration were in the direction suggested by the instruction did we report them as placebo or active placebo responses. Hence, drug compensatory responses were not considered placebo responses even if they were responses to instructions or expectations. There were placebo effects in 20 of 41 reports and active placebo effects in 14. However, in only 4 of the studies were an active placebo effect was found was it an enhancement of an inert placebo effect. Therefore, there were 16 cases of placebo effects without an active placebo effect and 10 cases of active placebo effects without an inert placebo effect. Active placebo effects were found in 25% of the clinical trials, in 32% of the balanced placebo designs and in 60% of the remaining reports. The fact that active placebo effects were found in relation to 8 different drugs makes it unlikely that all of them resulted from unknown pharmacological effects of the drug on the dependent variable.
CONCLUSIONS:
Active placebo effects are more likely to occur when there is no previous placebo effect - suggesting that expectations can be enhanced through internal stimuli when confidence in the verbal information given is low. Active placebo effects are more likely to occur in designs constructed with the intent of producing placebo effects or were placebo effects are the main target of analysis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Online abstract
Reference:
Bjørkedal, E., & Flaten, M. (2008, August). A review of the effect of active placebo compared to placebo. Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retireved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Active placebo effects / Literature review

DocumentIs there a placebo responder?2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.18
Location: Arquivo PCA - Pasta 12/2006
Title:
Is there a placebo responder?
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={B3B9FDB9-2CE9-4F65-968D-B9668D1589B2}&SKey={140A3D71-1A65-43A4-BA8D-1D19B9481117}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Both verbally induced expectation and conditioning procedures have been reported as important underlying psychological mechanisms of placebo analgesia. There is great variability in this analgesic response, suggesting a role for individual differences. The present study investigated the relation of personality factors to placebo analgsia. Placebo analgesic responses were classically conditioned by pairing administration of placebo capsules with surreptitious lowering of pain intensity in one group. In one control group, placebo capsules were administrated while pain intensity was kept unchanged. In a second control group, placebo capsules were not administrated while pain intensity was lowered.
METHODS:
69 subjects (38 females) participated in the study. The subjects were randomly assigned to three groups where cold pain was induced by a thermode attached to the right volar forearm. Cold pain was delivered four times, each exposure lasting for 2 minutes. In the conditioned group temperatures increased from -100C to 00C to +50C across the three first pain exposures after the administration of placebo capsules. A conditioned stimulus (CS) control group also received the capsules but the temperatures were kept constant (-100C) after the administration of the capsules. An unconditioned (US) control group received the same temperatures as the conditioned group but did not receive the capsules. The placebo analgesic response was assessed by adding a fourth cold pain induction at -100C at the end of the experiments in all three groups. We hypothesized that placebo analgesic responding would occur in the conditioned group but not in the other two. The Cattell 16PF and the Fear of Pain Questionnaire were administered prior to the experimental procedures. Placebo analgesia was defined as a reduction in pain from the first to the last pain induction.
RESULTS:
Placebo analgesia was observed in the conditioned group, and somewhat surprisingly also in the CS control group, compared to the US control group. No personality factors predicted the placebo analgesic response. The anxiety factor on the 16PF inventory positively predicted cortisol levels (ß = .26, t = 2.2, p = .031). Fear of pain positively predicted pain intensity (ß = .2, t = 2.51, p = .014), pain unpleasantness (ß = .25, t = 2.16, p = .034), and stress scores (ß = .27, t = 2.3, p = .024).
CONCLUSIONS:
A placebo responder subtype could not be identified in the personality tests used in the present study. This supports the idea that variability in placebo responses are not due to personality traits, but are due to past experiences and situational factors.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Bjørkedal, E., Aslaksen, P., Flaten, M.
Document type:
Online abstract
Reference:
Lyby, P., Bjørkedal, E., Aslaksen, P., & Flaten, M. (2008). Is there a placebo responder? Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retireved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Placebo analgesia / Classical conditioning / Fear of pain / Personality / Stress

DocumentEvent-related potentials to painful stimuli are reduced during placebo analgesia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.19
Location: Arquivo PCA - Pasta 12/2006
Title:
Event-related potentials to painful stimuli are reduced during placebo analgesia
Publication year: 2009
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/meeting2009/meetingAbstract2009.pdf
Abstract/Results: ABSTRACT:
PURPOSE:
Placebo analgesia refers to a reduction in recorded pain after administration of a capsule containing an inactive ingredient, with the information that it is a powerful painkiller. The present study investigated if placebo analgesia could be observed as reduced cortical response to heat stimuli. If placebo analgesia was associated with a reduced cortical response, this would indicate that the pain signal was reduced prior to cortical processing. A capsule containing an inactive ingredient was administrated with information that it was a powerful painkiller in the Placebo condition. Contact heat stimulation was administrated to the arm before and after the administration of the capsule. In the Natural History condition, heat stimuli were administrated without the capsule and the information.
SUBJECTS:
Forty (20 females) healthy volunteers aged 19 to 40 years.
METHODS:
Painful heat stimuli at 51 C with abrupt rise time and duration of less than 0.1sec were administrated by a thermode applied to the lower arm. Pain was recorded by a visual analogue scale, and by 32 channel electroencephalography. Event-related potentials (ERPs) to painful stimulation were computed by the Vision Analyzer software. A withinsubject design was used. All subjects were run in a Placebo condition where pain was applied before and after administration of a capsule with information that it was a painkiller, and a Natural History condition where pain was applied, but no capsule was administrated. The order of the conditions was counterbalanced.
RESULTS:
Pain unpleasantness was reduced in the Placebo condition compared to the Natural History condition (F = 7.95, p = .01). The P2 component in the ERP data was reduced in the Placebo condition compared to the Natural History condition (F = 3.39, p = .045).
CONCLUSIONS:
Placebo analgesic responding was observed as reduced pain report and as reduced cortical response to painful stimuli. This indicates that the pain signal to the brain is reduced by information that a powerful painkiller has been administrated, and that the placebo response is not due to response bias.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract
Reference:
Aslaksen, P., & Flaten, M. (2009). Event-related potentials to painful stimuli are reduced during placebo analgesia. Psychosomatic Medicine, 71(3), A - 103.
2-year Impact Factor: 3.968|2011
Indexed document: Yes
Keywords: Placebo analgesia / Heat pain / Cortical response / Event-related potential (ERP)

Event-related potentials to painful stimuli are reduced during placebo analgesia

Event-related potentials to painful stimuli are reduced during placebo analgesia