Reference code: | PT/FB/BL-2008-126.03 |
Location: | Arquivo PCA - Pastas 16 a 17/2008
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Title:
| Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making
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Publication year: | 2011
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URL:
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189637/
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Abstract/Results: | ABSTRACT:
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain. To ensure progress in the understanding of the neuropathophysiology of these disorders, animal models with good construct and predictive validity are indispensable. Many human studies aimed at measuring decision-making capacities use the Iowa gambling task (IGT), a task designed to model everyday life choices through a conflict between immediate gratification and long-term outcomes. Recently, new rodent models based on the same principle have been developed to investigate the neurobiological mechanisms underlying IGT-like decision-making on behavioral, neural, and pharmacological levels. The comparative strengths, as well as the similarities and differences between these paradigms are discussed. The contribution of these models to elucidate the neurobehavioral factors that lead to poor decision-making and to the development of better treatments for psychiatric illness is considered, along with important future directions and potential limitations.
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Accessibility: | Document exists in file
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Copyright/Reproduction:
| By permission
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Language:
| eng
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Author:
| De Visser, L.
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Secondary author(s):
| Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., Fitoussi, A., Galhardo, V., Van den Boos, R., Winstanley, C., Dellu-Hagedorn, F.
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Document type:
| Article
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Number of reproductions:
| 1
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Reference:
| De Visser, L., Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., ..., Dellu-Hagedorn, F. (2011). Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making. Frontiers in Neuroscience, 5, 109. https://doi.org/10.3389/fnins.2011.00109
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2-year Impact Factor: | N/A
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Impact factor notes: | Impact factor computed since 2014
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Times cited: | 85|2024-02-01
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Indexed document: | Yes
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Quartile: | N/A
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Keywords: | Iowa gambling task (IGT) / Animal models / Validity / Dopamine / Serotonin / Neurobiology
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