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File180 - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study2009-102014-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-180
Location: Arquivo PCA - Pasta 20/2008
Title:
180 - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study
Duration: 2009-10 - 2014-07
Researcher(s):
Yoko Nagai, Hugo Critchley, Marcus Gray
Institution(s): Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nagai, Y.
Secondary author(s):
Critchley, H. D. , Gray, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Biopsychological problems / Mental health / Anxiety disorders / Cognitive processes / Attention / Brain structure and function

DocumentFinal report - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-180
Location: Arquivo PCA - Pasta 20/2008
Title:
180 - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study
Duration: 2009-10 - 2014-07
Researcher(s):
Yoko Nagai, Hugo Critchley, Marcus Gray
Institution(s): Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nagai, Y.
Secondary author(s):
Critchley, H. D. , Gray, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Biopsychological problems / Mental health / Anxiety disorders / Cognitive processes / Attention / Brain structure and function

Reference code: PT/FB/BL-2008-180.01
Location: Arquivo PCA - Pasta 20/2008
Title:
Final report - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study
Publication year: 2014
URL:
https://www.bial.com/imagem/Bolsa18008_24042015.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
The processing of emotions from facial expression is an automatic process every day. However, how different emotional expressions affect our performance and social behaviour remains poorly understood.
AIM
The aim of the study is to investigate how the process of different emotional expressions modulate the neural activity supporting attention dependent behavioural responses. Specifically, by defining the mechanisms through which emotional processes interfere with basic cognitive and behavioural functions, we aim to provide a novel insight to the brain basis for Social anxiety.
METHOD
In the current study, we examined the impact of emotional face stimuli (presented in the interval of the forewarned reaction time task) on the Contingent Negative Variation (CNV) and related brain activity. CNV refers to anticipation related slow cortical potential that is a signature of attention related cortical excitation. 15 healthy participants and 5 patients with social anxiety disorder took part in a combined neuroimaging (fMRI) simultaneous EEG study.
RESULTS
Contrary to our prediction, CNV amplitude increased significantly with presentation of both face and non-face stimuli during the delay period of the CNV task. Furthermore, there was a significant modulation of CNV amplitude by emotion type: CNV amplitude was greater for happy and angry compared to fear and disgust face stimuli. Correspondingly, neural activity within thalamus, supplemental motor area (SMA), dorsal anterior cingulate and orbitofrontal cortices was greater for happy and anger compared to fear and disgust CNV conditions. Activity within pons was attenuated for happy and anger conditions relative to fear and disgust. Negative face expressions (fear, disgust and anger) activated the amygdala providing a route for expression of social anxiety on preparatory attention.
CONCLUSION
Specific emotional expressions differentially affect CNV amplitude: specifically a difference is noted between the effects of approach emotions (anger, happiness) compared to withdrawal emotions (fear, disgust).
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Nagai, Y.
Secondary author(s):
Gray, M., Critchley, H. D.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Facial expression / Contingent negative variation (CNV) / Attention / Supplementary motor area

DocumentGalvanic skin response (GSR)/Electrodermal/skin conductance biofeedback on epilepsy: A systematic review and meta-analysis2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-180
Location: Arquivo PCA - Pasta 20/2008
Title:
180 - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study
Duration: 2009-10 - 2014-07
Researcher(s):
Yoko Nagai, Hugo Critchley, Marcus Gray
Institution(s): Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nagai, Y.
Secondary author(s):
Critchley, H. D. , Gray, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Biopsychological problems / Mental health / Anxiety disorders / Cognitive processes / Attention / Brain structure and function

Reference code: PT/FB/BL-2008-180.02
Location: Arquivo PCA - Pasta 20/2008
Title:
Galvanic skin response (GSR)/Electrodermal/skin conductance biofeedback on epilepsy: A systematic review and meta-analysis
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2019.00377/full
Abstract/Results: ABSTRACT:
Objectives: Dynamic changes in psychophysiological arousal are directly expressed in the sympathetic innervation of the skin. This activity can be measured as tonic and phasic fluctuations in electrodermal activity [Galvanic Skin Response (GSR)/skin conductance]. Biofeedback training can enable an individual to gain voluntary control over this autonomic response and its central correlates. Theoretically, control of psychophysiological arousal may be harnessed as a therapy for epilepsy, to mitigate pre-ictal states. Evidence is accumulating for the clinical efficacy of GSR biofeedback training in the management of drug resistant epilepsy. In this review, we analyse current evidence of efficacy with GSR biofeedback and evaluate the methodology of each study.
Method: We searched published literature pertaining to interventional studies of GSR biofeedback for epilepsy, through MEDLINE and Cochrane databases (1950-2018). Using percentage seizure reduction as an indicator of therapeutic efficacy induced by GSR biofeedback, we used meta-analytic methods to summarize extant findings. We also compare and contrast study design with relevance to the interpretation of outcomes.
Results: Out of 21 articles retrieved for GSR/EDA/Skin conductance biofeedback, four studies were identified as interventional trials, involving 99 patients with drug-resistant epilepsy in total. Three of these studies included a control group and a positive therapeutic effect of biofeedback was reported in each of these. The difference in seizure frequency percentage (Biofeedback-Control) was between -54.4 and -74.0% with an overall weighted mean difference of -64.3% (95% CI: -85.4 to -43.2%). The response rates (proportion of patients manifesting > 50% reduction in seizure frequency) varied from 45 to 66% across studies.
Significance: This timely evaluation highlights the potential value of GSR biofeedback therapy, and informs the optimal study design of larger scale studies that are now required to more definitively establish the utility of this non-invasive, non-pharmacological interventional approach for drug-resistant epilepsy.
Accessibility: Document exists in file
Language:
eng
Author:
Nagai, Y.
Secondary author(s):
Jones, C. I., Sen, A.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Nagai, Y., Jones, C. I., & Sen, A. (2019). Galvanic skin response (GSR)/Electrodermal/skin conductance biofeedback on epilepsy: A systematic review and meta-analysis. Frontiers in Neurology, 10: 377. doi: 10.3389/fneur.2019.00377
2-year Impact Factor: 2.889|2019
Times cited: 12|2022-05-21
Indexed document: Yes
Quartile: Q2
Keywords: Epilepsy / Biofeedback / Galvanic skin response / Skin conductance / Electrodermal activity / Autonomic activity / Behavioral therapy

Galvanic skin response (GSR)/Electrodermal/skin conductance biofeedback on epilepsy: A systematic review and meta-analysis

Galvanic skin response (GSR)/Electrodermal/skin conductance biofeedback on epilepsy: A systematic review and meta-analysis

DocumentModulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-180
Location: Arquivo PCA - Pasta 20/2008
Title:
180 - Emotional influences on psychophysiological indices of focused attention and response anticipation in social anxiety: A combined neuroimaging and electroencephalographic study
Duration: 2009-10 - 2014-07
Researcher(s):
Yoko Nagai, Hugo Critchley, Marcus Gray
Institution(s): Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nagai, Y.
Secondary author(s):
Critchley, H. D. , Gray, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Biopsychological problems / Mental health / Anxiety disorders / Cognitive processes / Attention / Brain structure and function

Reference code: PT/FB/BL-2008-180.03
Location: Arquivo PCA - Pasta 20/2008
Title:
Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome
Publication year: 2015
URL:
https://www.frontiersin.org/articles/10.3389/fnins.2015.00278/full
Abstract/Results: ABSTRACT:
This manuscript considers the central but neglected role of the autonomic nervous system in the expression and control of seizures in epilepsy (small) and tics in burette Syndrome (TS). In epilepsy, consideration of autonomic involvement is typically confined to differential diagnoses (e.g., syncope), or in relation to Sudden Unexpected Death in Epilepsy (SUDEP). Investigation is more limited in burette Syndrome. The role of the autonomic nervous system in the generation and prevention of epileptic seizures is largely overlooked. Emotional stimuli such as anxiety and stress are potent causes of seizures and tic activity in epilepsy and TS, respectively. This manuscript will describe a possible neural mechanism by which afferent autonomic projections linked to cognition and behavior influence central thalamo-cortical regulation, which appears to be an important means for controlling both seizure and tic activity. It also summarizes the link between the integrity of the default mode network and autonomic regulation in patients with epilepsy as well as the link between impaired motor control and autonomic regulation in patients with TS. Two neurological conditions; epilepsy and TS were chosen, as seizures and tics represent parameters that can be easily measured to investigate influences of autonomic functions. The FDA biofeedback approach is anticipated to gain a strong position within the next generation of treatment for epilepsy, as a non-invasive technique with minimal side effects. This approach also takes advantage of the current practical opportunity to utilize growing digital health technology.
Accessibility: Document exists in file
Language:
eng
Author:
Nagai, Y.
Document type:
Article
Number of reproductions:
1
Percentiles:
7|2022-03-19
Reference:
Nagai, Y. (2015). Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome. Frontiers in Neuroscience, 9: 278. doi: 10.3389/fnins.2015.00278
2-year Impact Factor: 3.398|2015
Times cited: 8|2022-05-21
Indexed document: Yes
Quartile: Q2
Keywords: Biofeedback / Electrodermal activity / Sympathetic activity / Behavioral control / Epilepsy / burette Syndrome

Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome

Modulation of autonomic activity in neurological conditions: Epilepsy and Tourette Syndrome