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File063 - Mindful ageing. Avoiding age related cognitive decline2011-042014-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-063
Location: Arquivo PCA - Pasta 9/2010
Title:
063 - Mindful ageing. Avoiding age related cognitive decline
Duration: 2011-04 - 2014-07
Researcher(s):
Isabel Pavão Martins, Nuno Lunet, Carolina Maruta, Clara Loureiro, Vanda Freitas, Joana Morgado, Sofia Reimão, Joana Tavares
Institution(s): Laboratório de Estudos de Linguagem, Unidade Neurologica de Investigação Clínica, Faculdade de Medicina de Lisboa e Instituto de Medicina Molecular, Universidade de Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng / por
Author:
Martins, I. P.
Secondary author(s):
Lunet, N., Maruta, C., Loureiro, C., Freitas, V., Morgado, J., Reimão, S., Tavares, J.
Keywords:
Psychophysiology / Developmental psychology / Cognitive processes / Biopsychological problems / Neurodegenerative disorders / Dementia / Mild cognitive impairment (MCI) / Assessment tools / Brain structure and function

DocumentFinal report - Mindful ageing. Avoiding age related cognitive decline2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-063
Location: Arquivo PCA - Pasta 9/2010
Title:
063 - Mindful ageing. Avoiding age related cognitive decline
Duration: 2011-04 - 2014-07
Researcher(s):
Isabel Pavão Martins, Nuno Lunet, Carolina Maruta, Clara Loureiro, Vanda Freitas, Joana Morgado, Sofia Reimão, Joana Tavares
Institution(s): Laboratório de Estudos de Linguagem, Unidade Neurologica de Investigação Clínica, Faculdade de Medicina de Lisboa e Instituto de Medicina Molecular, Universidade de Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng / por
Author:
Martins, I. P.
Secondary author(s):
Lunet, N., Maruta, C., Loureiro, C., Freitas, V., Morgado, J., Reimão, S., Tavares, J.
Keywords:
Psychophysiology / Developmental psychology / Cognitive processes / Biopsychological problems / Neurodegenerative disorders / Dementia / Mild cognitive impairment (MCI) / Assessment tools / Brain structure and function

Reference code: PT/FB/BL-2010-063.01
Location: SEC PCA - 63/10
Title:
Final report - Mindful ageing. Avoiding age related cognitive decline
Publication year: 2014
URL:
https://www.bial.com/imagem/Bolsa6310.pdf
Abstract/Results: ABSTRACT:
We performed a cognitive reevaluation of 275 community dwelling individuals followed in primary care (64% female, aged 70.4 (±8.3) years and with 7.5 yrs of education on average), who had a baseline assessment 5 years before. 59% performed a structural MRI. Most individuals remained cognitively normal and 41 declined, including 7 with dementia. Subjects with decline were older, had lower formal education, had lower scores on composite measures of executive and episodic memory and more depressive complaints at baseline, compared to those remaining well. General Practitioners (GPs) could only identify as impaired those with more severe decline. Multivariate analysis (Poisson regression) showed that increasing age and baseline lower age &education adjusted Z scores on Executive function increase the risk of decline. Significant correlations were found between executive function and the volume of left pars orbitalis and cingulate cortex and between memory score and inferior parietal, posterior cingulated and pars orbitalis regions. Mid temporal atrophy were associated with poor outcome.
This study suggests that in a primary care setting, executive performance may help to identify subjects at risk of cognitive impairment and structural abnormalities five years before, showing that decline begins much earlier. In spite of their close contact with patients and families primary care doctors are more likely to detect patients in more advanced stages of decline, which stresses the need of early simple cognitive assessment tools. Subjective complaints were not predictive of decline. Literacy and cognitive stimulation seem to be related to cognitive outcome, but it is difficult to disentangle their participation as reserve or compensation.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Martins, I. P.
Secondary author(s):
Maruta, C., Morgado, J., Loureiro, C., Tavares, J., Freitas, V., Reimão, S., Marques, P., Lunet, N.
Document type:
Final report
Indexed document:
No
Keywords: Cognitive aging / Dementia

DocumentPredictors of cognitive stability or decline during aging: A longitudinal study in primary care2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-063
Location: Arquivo PCA - Pasta 9/2010
Title:
063 - Mindful ageing. Avoiding age related cognitive decline
Duration: 2011-04 - 2014-07
Researcher(s):
Isabel Pavão Martins, Nuno Lunet, Carolina Maruta, Clara Loureiro, Vanda Freitas, Joana Morgado, Sofia Reimão, Joana Tavares
Institution(s): Laboratório de Estudos de Linguagem, Unidade Neurologica de Investigação Clínica, Faculdade de Medicina de Lisboa e Instituto de Medicina Molecular, Universidade de Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng / por
Author:
Martins, I. P.
Secondary author(s):
Lunet, N., Maruta, C., Loureiro, C., Freitas, V., Morgado, J., Reimão, S., Tavares, J.
Keywords:
Psychophysiology / Developmental psychology / Cognitive processes / Biopsychological problems / Neurodegenerative disorders / Dementia / Mild cognitive impairment (MCI) / Assessment tools / Brain structure and function

Reference code: PT/FB/BL-2010-063.02
Location: SEC PCA - 63/10
Title:
Predictors of cognitive stability or decline during aging: A longitudinal study in primary care
Publication year: 2018
URL:
https://www.tandfonline.com/doi/abs/10.1080/23279095.2018.1476866
Abstract/Results: ABSTRACT:
We aimed to identify the early predictors of cognitive decline, and primary care physicians’ (PCP) ability to diagnose cognitively impaired subjects, in a cohort of individuals recruited in primary care centers. Independent adults, aged =50?years at inception, with an overall low level of education, undertook a prospective clinical and cognitive evaluation targeting memory, attention and executive functions. At follow-up subjects were classified as cognitively normal (CN) or impaired (CI). Of 275 subjects (70.4?±?8.3?years old, 176 females, 7.5?±?4.4 education, 162 with MRI), 31 (11.2%) presented CI 4.9?years later, the majority (64.5%) presenting subjective cognitive complaints. PCP could correctly identify 40% of CI individuals, particularly if they presented current cognitive complaints. Male sex (OR =?3.117; CI95%: 1.007–9.645), age (OR =?1.063; CI95%: 1.004–1.126) and baseline scores on TMT-B (OR =?0.225; CI95%: 0.073–0.688) and Vocabulary (OR =??0.940; 95% CI: 0.894–0.986) predicted CI. This study shows that measures indicating poor cognitive reserve and low executive performance (as shown by low vocabulary and executive test scores, respectively) can be early indicators of the risk of decline, stressing the role of cognitive assessment as part of prevention/early intervention programs. The results also underline the need to help PCP to improve the detection of subjects with cognitive decline.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Martins, I. P.
Secondary author(s):
Maruta, C., Morgado, J., Loureiro, C., Tavares, J., Freitas, V., Lunet, N., Viana, P., Marques, P.
Document type:
Article
Reference:
Martins, I. P., Maruta, C., Morgado, J., Loureiro, C., Tavares, J., Freitas, V., Lunet, N., Viana, P., & Marques, P. (2018). Predictors of cognitive stability or decline during aging: A longitudinal study in primary care. Applied Neuropsychology: Adult, 5, 1-13. doi: 10.1080/23279095.2018.1476866
2-year Impact Factor: 1.548|2018
Times cited: 2|2020-04-02
Indexed document: Yes
Quartile: Q3
Keywords: Cognitive aging / Cognitive decline / Primary care diagnosis / Risk factors for dementia

DocumentCognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-063
Location: Arquivo PCA - Pasta 9/2010
Title:
063 - Mindful ageing. Avoiding age related cognitive decline
Duration: 2011-04 - 2014-07
Researcher(s):
Isabel Pavão Martins, Nuno Lunet, Carolina Maruta, Clara Loureiro, Vanda Freitas, Joana Morgado, Sofia Reimão, Joana Tavares
Institution(s): Laboratório de Estudos de Linguagem, Unidade Neurologica de Investigação Clínica, Faculdade de Medicina de Lisboa e Instituto de Medicina Molecular, Universidade de Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng / por
Author:
Martins, I. P.
Secondary author(s):
Lunet, N., Maruta, C., Loureiro, C., Freitas, V., Morgado, J., Reimão, S., Tavares, J.
Keywords:
Psychophysiology / Developmental psychology / Cognitive processes / Biopsychological problems / Neurodegenerative disorders / Dementia / Mild cognitive impairment (MCI) / Assessment tools / Brain structure and function

Reference code: PT/FB/BL-2010-063.03
Location: SEC PCA - 63/10
Title:
Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study
Publication year: 2020
URL:
https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01100-x#Fun
Abstract/Results: ABSTRACT:
OBJECTIVES AND BACKGROUND:
The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches modify the rates of decline on different cognitive measures, during a 5-year interval.
DESIGN AND METHOD:
A cohort of community dwelling adults (>?50?years) with migraine (MH), non-migraine headaches (NMH) and controls without headache (WoH), was assessed by a comprehensive neuropsychological battery with tests of memory, language and executive functions, repeated 5?years apart. Change in performance between baseline and reevaluation was compared between groups, and controlled for age, gender, literacy and depressive symptoms.
RESULTS:
A total of 275 participants (78.5% WoH, 12.7% MH, 8.7% NMH) were reevaluated (average age 70.40?+?8.34?years, 64% females). Cognitive decline or dementia occurred in 11.4%, with a similar proportion among the three groups. Although MH participants had significantly more subjective cognitive complaints (p =?0.030, 95%CI:]-3.929,-0.014[), both MH and NMH subjects showed an age-associated decline identical to controls. Furthermore, migraine features (disease and attack duration, frequency and aura) were unrelated with cognitive performance.
CONCLUSION:
Migraine and non-migraine headache are not associated with increasing risk of dementia or cognitive decline at an older age although subjects with migraine have more cognitive complaints. Longer longitudinal studies are necessary to understand if this pattern persists for more than 5?years.
Accessibility: Document exists in file
Language:
eng
Author:
Martins, I. P.
Secondary author(s):
Maruta, C., Alves, P. N., Loureiro, C., Morgado, J., Tavares, J., Gil-Gouveia, R.
Document type:
Article
Reference:
Martins, I. P., Maruta, C., Alves, P. N., Loureiro, C., Morgado, J., Tavares, J., & Gil-Gouveia, R. (2020). Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study. The Journal of Headache and Pain, 21(1): 31. doi: 10.1186/s10194-020-01100-x
2-year Impact Factor: 4.797|2020
Impact factor notes: Impact factor not available yet for 2020
Times cited: 0|2020-07-30
Indexed document: Yes
Quartile: Q1
Keywords: 5-year follow-up / Cognitive performance / Executive deficits / Migraine headache / Pain

Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study