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File180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity2011-05 2013-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-180
Location: Arquivo PCA - Pasta 16/2010
Title:
180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Duration: 2011-05 - 2013-07
Researcher(s):
Kensaku Nomoto, Susana Quelhas Lima
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Keywords:
Psychophysiology / Affective and social behavior / Animal behavior / Sexual behavior / Brain structure and function

DocumentFinal report - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-180
Location: Arquivo PCA - Pasta 16/2010
Title:
180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Duration: 2011-05 - 2013-07
Researcher(s):
Kensaku Nomoto, Susana Quelhas Lima
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Keywords:
Psychophysiology / Affective and social behavior / Animal behavior / Sexual behavior / Brain structure and function

Reference code: PT/FB/BL-2010-180.01
Location: Arquivo PCA - Pasta 16/2010
Title:
Final report - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Publication year: 2013
URL:
http://www.bial.com/imagem/180-10-20131212.pdf
Abstract/Results: RESULTS:
Animals should choose appropriate actions at the right time in order to survive or reproduce successfully. During social interactions, animals must choose either being affiliative or antagonistic. It is well established that the reproductive cycle modulates this choice, and that female rodents show increased sexual receptivity when they are fertile. The ventrolateral part of the ventromedial hypothalamus (VMHvl) is thought to be involved in the neural control of such behavioral change. However, it remains unclear how the orchestrated activity of the VMHvl neurons produces different behaviors depending on the reproductive phase. To address this issue, we performed multiple single-unit recording experiments across the reproductive cycle in female mice during social interactions. We found that the proportion of male responsive neurons in the VMHvl increases during the sexually receptive phase. This was not the case with the female-evoked responses. These results suggest that a change in the proportion of male-responsive neurons facilitates transmission of male information to the downstream brain regions, which may lead to increased sexual receptivity.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Document type:
Final report
Indexed document:
No
Keywords: Social behavior and relationships / Reproductive cycle / Sexual receptivity / Hypothalamus

Final report - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity

Final report - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity

DocumentSocial signals in the ventromedial hypothalamus of female mice: influence of the reproductive cycle2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-180
Location: Arquivo PCA - Pasta 16/2010
Title:
180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Duration: 2011-05 - 2013-07
Researcher(s):
Kensaku Nomoto, Susana Quelhas Lima
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Keywords:
Psychophysiology / Affective and social behavior / Animal behavior / Sexual behavior / Brain structure and function

Reference code: PT/FB/BL-2010-180.02
Location: Arquivo PCA - Pasta 16/2010
Title:
Social signals in the ventromedial hypothalamus of female mice: influence of the reproductive cycle
Publication year: 2013
URL:
http://ras.ni.brain.riken.jp/neuro2013/php/searchKeyword.php?search_keyword=%20Nomoto%20Kensaku&key_disp_num=10&key_start_disp_num=0&chk_hidden_treasure=0#$$doument_id$$
Abstract/Results: ABSTRACT:
Choosing the right actions at the proper time is crucial for animals to survive, especially during social interactions. One such example is reproductive behavior in female rodents. When a male attempts to mount a female, she refuses the mounting attempts if she is not in the fertile phase of the reproductive cycle. By contrast, when fertile, she displays a receptive posture permitting copulation. Although this behavioral switch has long been described, very little is known regarding the neural mechanisms underlying it.
To address this issue, we performed extracellular single-unit recordings from freely behaving female mice across the reproductive cycle. We targeted the ventrolateral region of the ventromedial hypothalamus (VMHvl) as the recording site. First, the VMHvl is involved in the control of social behavior between conspecifics such as male aggression and female sexual behavior. Second, the VMHvl has access to olfactory information, which is important for rodent social behavior. Third, the VMHvl has rich expression of receptors for sex hormone, thereby it can mediate behavioral changes across the reproductive cycle.
In the present behavioral assay, the test female was allowed to freely interact with the stimulus animals, while the activity of VMHvl neurons was recorded. The stimulus animal was either a female or a male. In agreement with a previous study in male mice, we found VMHvl neurons whose activity was gender specific. Many neurons showed sustained activity changes in response to the stimulus animals, while some neurons responded to specific behavioral events (e.g., sniffing anogenital area of a female mouse). Furthermore, we found that the proportion of male-responsive neurons during the most sexually receptive phase was higher than those during the other phases. These preliminary results suggest that increased neuronal responsiveness may underlie behavioral changes across the reproductive cycle.
Accessibility: Document does not exist in file
Language:
eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Document type:
Online abstract
Reference:
Nomoto, K., & Lima, S. (2013, June). Social signals in the ventromedial hypothalamus of female mice: influence of the reproductive cycle. Paper presented at the The 36th annual Meeting of the Japan Neuroscience Society, Japan. Abstract retrieved from http://ras.ni.brain.riken.jp/neuro2013/php/searchKeyword.php?search_keyword=%20Nomoto%20Kensaku&key_disp_num=10&key_start_disp_num=0&chk_hidden_treasure=0#$$doument_id$$
Indexed document: No
Keywords: Reproductive cycle / Social behavior and relationships / Sexual receptivity / Hypothalamus

DocumentSocial-stimulus-evoked activity in the female mouse hypothalamus: Influence of the reproductive cycle 2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-180
Location: Arquivo PCA - Pasta 16/2010
Title:
180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Duration: 2011-05 - 2013-07
Researcher(s):
Kensaku Nomoto, Susana Quelhas Lima
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Keywords:
Psychophysiology / Affective and social behavior / Animal behavior / Sexual behavior / Brain structure and function

Reference code: PT/FB/BL-2010-180.03
Location: Arquivo PCA - Pasta 16/2010
Title:
Social-stimulus-evoked activity in the female mouse hypothalamus: Influence of the reproductive cycle
Publication year: 2012
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=8f618c5a-55eb-4fdc-9857-ba3eeb69220a&cKey=8496f7fc-39f7-48ce-ad0e-ac19bc1fbac6&mKey=%7b70007181-01C9-4DE9-A0A2-EEBFA14CD9F1%7d
Abstract/Results: ABSTRACT:
In many mammalian species, ovarian hormones fluctuate during the reproductive cycle, heavily influencing female behavior. In rodents, changes in sexual receptivity are one of the most fundamental changes across the reproductive cycle. While, for instance, a female rodent is sexually receptive during the proestrous phase, she rejects copulation during all other phases of the reproductive cycle. It is well accepted that the ventromedial hypothalamus (VMH) plays a critical role in the control of female sexual behavior. However it is poorly understood how the activity of VMH neurons is coordinated and mediates behavioral changes across the reproductive cycle. To address this issue, we performed extracellular single-unit recording experiments in behaving female mice across the reproductive cycle. The test animal was allowed to interact freely with the stimulus animals that were introduced into the arena sequentially. In agreement with a previous study in male mice, we found VMH neurons that significantly responded with increased or decreased activity during social investigation compared to the activity during the control period. We classified VMH neurons based on their response pattern against the male stimuli: excited, inhibited, or no response. Our results showed that the proportion of male-inhibited neurons during the proestrous phase (7/20, 35%) was higher than those during the estrous and diestrous phases (4/29, 14% and 4/26, 15%, respectively). These preliminary results suggest that changes in the balance of excitation and inhibition in VMH neurons may underlie behavioral changes across the reproductive cycle.
Accessibility: Document does not exist in file
Language:
eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Document type:
Online abstract
Reference:
Nomoto, K., & Lima, S. (2012). Social-stimulus-evoked activity in the female mouse hypothalamus: Influence of the reproductive cycle. Program No. 401.09/FFF47. Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=8f618c5a-55eb-4fdc-9857-ba3eeb69220a&cKey=8496f7fc-39f7-48ce-ad0e-ac19bc1fbac6&mKey=%7b70007181-01C9-4DE9-A0A2-EEBFA14CD9F1%7d
Indexed document: No
Keywords: Hypothalamus / Sexual behavior / Electrophysiology

DocumentEnhanced male-evoked responses in the ventromedial hypothalamus of sexually receptive female mice2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-180
Location: Arquivo PCA - Pasta 16/2010
Title:
180 - Neuronal mechanisms underlying sex hormone-dependent switching of sexual receptivity
Duration: 2011-05 - 2013-07
Researcher(s):
Kensaku Nomoto, Susana Quelhas Lima
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Keywords:
Psychophysiology / Affective and social behavior / Animal behavior / Sexual behavior / Brain structure and function

Reference code: PT/FB/BL-2010-180.04
Location: SEC PCA - 180/10
Title:
Enhanced male-evoked responses in the ventromedial hypothalamus of sexually receptive female mice
Publication year: 2015
URL:
http://www.cell.com/current-biology/abstract/S0960-9822%2814%2901651-0
Abstract/Results: ABSTRACT:
Social encounters often start with routine investigatory behaviors before developing into distinct outcomes, such as affiliative or aggressive actions. For example, a female mouse will initially engage in investigatory behavior with a male but will then show copulation or rejection, depending on her reproductive state. To promote adaptive social behavior, her brain must combine internal ovarian signals and external social stimuli, but little is known about how socially evoked neural activity is modulated across the reproductive cycle [ 1 ]. To investigate this, we performed single-unit recordings in the ventrolateral region of the ventromedial hypothalamus (VMHvl) in freely behaving, naturally cycling, female mice interacting with conspecifics of both genders. The VMHvl has been implicated in rodent sociosexual behavior [ 2, 3 ]: it has access to social sensory stimuli [ 4–8 ] and is involved in aggression and mating [ 9–11 ]. Furthermore, many VMHvl neurons express ovarian hormone receptors [ 12, 13 ], which play a central role in female sociosexual behavior [ 14–16 ]. We found that a large fraction of VMHvl neurons was activated in the presence of conspecifics with preference to male stimuli and that the activity of most VMHvl neurons was modulated throughout social interactions rather than in response to specific social events. Furthermore, neuronal responses to male, but not female, conspecifics in the VMHvl were enhanced during the sexually receptive state. Thus, male-evoked VMHvl responses are modulated by the reproductive state, and VMHvl neural activity could drive gender-specific and reproductive state-dependent sociosexual behavior.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Nomoto, K.
Secondary author(s):
Lima, S.
Document type:
Article
Reference:
Nomoto, K., & Lima, S. (2015). Enhanced male-evoked responses in the ventromedial hypothalamus of sexually receptive female mice. Current Biology, 25(5),589-594. doi: 10.1016/j.cub.2014.12.048
2-year Impact Factor: 8.983|2015
Times cited: 21|2020-03-12
Indexed document: Yes
Quartile: Q1
Keywords: Sexual behavior / Hypothalamus

Enhanced male-evoked responses in the ventromedial hypothalamus of sexually receptive female mice

Enhanced male-evoked responses in the ventromedial hypothalamus of sexually receptive female mice