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File196 - Emotional responses in patients with disconnection of the left and right brain hemispheres2011-042012-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

DocumentFinal report - Emotional responses in patients with disconnection of the left and right brain hemispheres2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.01
Location: Arquivo PCA - Pasta 5/2010
Title:
Final report - Emotional responses in patients with disconnection of the left and right brain hemispheres
Publication year: 2012
URL:
http://www.bial.com/imagem/Bolsa19610_04022014.pdf
Abstract/Results: RESULTS:
We examined the impact of disrupted brain connectivity on social cognition, by studying adults born with isolated agenesis of the corpus callosum (AgCC). 17 neutral and 17 negative images from the International Affective Picture System were shown to 15 adults with AgCC and 10 healthy controls (matched for age and intelligence). Images were presented for 6 seconds, during which eye-movements were recorded. After each image, participants rated emotional valence (negative = 1 to positive = 9) and arousal level (calm = 1 to exciting = 9).
On valence ratings, adults with AgCC tended to over-estimate the negativity in emotionally ambiguous images, but accurately recognized it in clearly negative scenes.
On arousal ratings, the AgCC group tended to under-estimate emotional intensity of negative scenes. This pattern was most evident for images of people. Relative to matched controls, the adults with AgCC gave lower arousal ratings overall for slides containing people, with a significant bias toward under-appreciating arousal in negative slides containing people.
Eye-tracking results suggest that individuals with AgCC may spend less time focused on faces and eyes, particularly for negative images.
It is possible that the social deficits in AgCC are a direct result of impaired coordination of the hemispheres. For example, according to the ‘valence hypothesis,’ the right hemisphere is relatively more specialized for processing negative emotions. In which case, verbal labelling of those emotions would depend most heavily on intact callosal connections and, as we found, would be most impaired in AgCC.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Paul, L. K.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Emotion / Agenesis of the corpus callosum (AgCC) / Interhemispheric / Laterality

Final report - Emotional responses in patients with disconnection of the left and right brain hemispheres

Final report - Emotional responses in patients with disconnection of the left and right brain hemispheres

DocumentDecision-making in individuals with agenesis of the corpus callosum: expectancy-valence in the Iowa Gambling Task2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.02
Location: Arquivo PCA - Pasta 5/2010
Title:
Decision-making in individuals with agenesis of the corpus callosum: expectancy-valence in the Iowa Gambling Task
Publication year: 2012
URL:
http://acn.oxfordjournals.org/content/27/5/532.short
Abstract/Results: ABSTRACT:
Individuals with agenesis of the corpus callosum (ACC) can have intelligence within the normal range, but nevertheless have deficiencies in decision-making and complex novel problem-solving. The specific nature of these problems is not yet clearly understood. The Iowa Gambling Task was used to test decision-making ability and problem-solving in 40 individuals with complete or partial ACC (full-scale intelligence quotient >80) and 26 control participants. The expectancy-valence (EV) model was applied to the trial-by-trial responses of each participant to elucidate differences in decision processes utilized by each group. The ACC group had a lower overall net gain and fewer advantageous choices than controls, but these differences were not statistically significant. Within the EV model, individuals with ACC exhibited significantly higher attention to losses, less consistency in their choice strategy, and greater frequency of switching between decks. They also showed a tendency to be more influenced by recent trials. This outcome is similar to that seen in individuals with Asperger's disorder. Taken together, these results suggest that individuals with ACC have difficulty in inferring game contingencies and forming a coherent selection strategy, implicating the corpus callosum in these decision processes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Brown, W. S.
Secondary author(s):
Anderson, L. B., Symington, M. F., Paul, L. K.
Document type:
Article
Reference:
Brown, W. S., Anderson, L. B., Symington, M. F., & Paul, L. K. (2012). Decision-making in individuals with agenesis of the corpus callosum: expectancy-valence in the Iowa Gambling Task. Archives of Clinical Neuropsychology, 27(5), 532-544. doi: 10.1093/arclin/acs052
2-year Impact Factor: 2.000|2012
Times cited: 12|2020-03-11
Indexed document: Yes
Quartile: Q2
Keywords: Executive function / Problem-solving / Strategy formation / Loss aversion

DocumentEmotional responses in patients with disconnection of the left and right brain hemispheres2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.03
Location: Arquivo PCA - Pasta 5/2010
Title:
Emotional responses in patients with disconnection of the left and right brain hemispheres
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Social interaction is one of the most complex activities processed by the human brain. It requires complex interactions between many different cognitive systems, therefore the connections between these brain regions are likely to play a very important role in social competence. We examined brain connectivity in social cognition by studying eye-movements, social judgments, and psychophysiology in people born without the fibers connecting the left and right cerebral hemispheres, a condition called agenesis of the corpus callosum (AgCC).
METHODS:
Participants were 15 adults with complete AgCC (9 males, aged 16 - 52) and 10 healthy controls (all males, aged 19 - 48). Groups were matched on age (t = .22, p = .82). The control group had significantly higher FSIQ scores than the AgCC group (t = 2.77, p = .01). We recorded visual attention and physiological arousal as participants viewed 34 social and nonsocial images. Based on normative data, 17 slides were identified as “negative” and 17 as “neutral”. 11 of 17 negative slides and 6 of 17 neutral slides contained people. Participants rated images on Valence (9-point scale from negative=1 to positive=9) and Arousal (from calm=1 to exciting=9).
RESULTS:
Group differences on ratings depended on slide type. On negative images, the AgCC group gave lower arousal ratings (t=2.74, p < .05), but did not differ from controls on valence ratings. In contrast with neutral images, the groups did not differ on arousal ratings, but the AgCC group gave significantly more positive valence ratings than controls (t = 2.44, p < .05). Groups did not differ in number of fixations to negative images, but the AgCC group exhibited a trend toward significantly fewer fixations than controls on neutral images (t = 1.73, p = .10). With respect to people in the images, there were no group differences on rating of unpeopled
slides and no difference on valence ratings of peopled slides. However relative to controls, the AgCC group gave lower arousal ratings on peopled slides (t = 1.34, p = .028), primarily due to lower arousal ratings on negative slides with people.
CONCLUSIONS:
Despite intact visual attention to both social and nonsocial scenes, adults with AgCC appear to under-appreciate the intensity of negative emotions in people they observe. This may contribute to a positive-interpretation-bias in neutral situations. This study suggests that intact corpus callosum development is critical to development of social skills.
Accessibility: Document does not exist in file
Language:
eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Document type:
Conference abstract
Reference:
Paul, L. K., Adolphs, R., & Nair, R. (2012). Emotional responses in patients with disconnection of the left and right brain hemispheres. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 63/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Corpus callosum / Interhemispheric / Laterality / Emotion

Emotional responses in patients with disconnection of the left and right brain hemispheres

Emotional responses in patients with disconnection of the left and right brain hemispheres

DocumentProcessing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.04
Location: Arquivo PCA - Pasta 5/2010
Title:
Processing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum
Publication year: 2012
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605885/
Abstract/Results: ABSTRACT:
Corpus callosum malformation and dysfunction are increasingly recognized causes of cognitive and behavioral disability. Individuals with agenesis of the corpus callosum (AgCC) offer unique insights regarding the cognitive skills that depend specifically upon callosal connectivity. We examined the impact of AgCC on cognitive inhibition, flexibility, and processing speed using the Color-Word Interference Test (CWIT) and Trail Making Test (TMT) from the Delis-Kaplan Executive Function System. We compared 36 individuals with AgCC and IQs within the normal range to 56 matched controls. The AgCC cohort was impaired on timed measures of inhibition and flexibility; however, group differences on CWIT Inhibition, CWIT Inhibition/Switching and TMT Number-Letter Switching appear to be largely explained by slow performance in basic operations such as color naming and letter sequencing. On CWIT Inhibition/Switching, the AgCC group was found to commit significantly more errors which suggests that slow performance is not secondary to a cautious strategy. Therefore, while individuals with agenesis of the corpus callosum show real deficits on tasks of executive function, this impairment appears to be primarily a consequence of slow cognitive processing. Additional studies are needed to investigate the impact of AgCC on other aspects of higher order cortical function.
Accessibility: Document does not exist in file
Language:
eng
Author:
Marco, E. J.
Secondary author(s):
Harrell, K. M., Brown, W. S., Hill, S. S., Jeremy, R. J., Kramer, J. H., Sherr, E. H., Paul, L. K.
Document type:
Article
Reference:
Marco, E. J., Harrell, K. M., Brown, W. S., Hill, S. S., Jeremy, R. J., Kramer, J. H., . . . Paul, L. K. (2012). Processing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum. Journal of the International Neuropsychological Society, 18(3), 521-529. doi: 10.1017/s1355617712000045
2-year Impact Factor: 2.697|2012
Times cited: 28|2020-03-11
Indexed document: Yes
Quartile: Q2
Keywords: Absence of the corpus callosum / Human information processing / Inhibition / Stroop paradigm / Trail making test / Cognition

DocumentIntact Bilateral Resting-State Networks in the Absence of the Corpus Callosum2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.05
Location: Arquivo PCA - Pasta 5/2010
Title:
Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum
Publication year: 2011
URL:
http://www.jneurosci.org/content/31/42/15154.abstract
Abstract/Results: ABSTRACT:
Temporal correlations between different brain regions in the resting-state BOLD signal are thought to reflect intrinsic functional brain connectivity (Biswal et al., 1995; Greicius et al., 2003; Fox et al., 2007). The functional networks identified are typically bilaterally distributed across the cerebral hemispheres, show similarity to known white matter connections (Greicius et al., 2009), and are seen even in anesthetized monkeys (Vincent et al., 2007). Yet it remains unclear how they arise. Here we tested two distinct possibilities: (1) functional networks arise largely from structural connectivity constraints, and generally require direct interactions between functionally coupled regions mediated by white-matter tracts; and (2) functional networks emerge flexibly with the development of normal cognition and behavior and can be realized in multiple structural architectures. We conducted resting-state fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intelligence, and compared their data to those from eight healthy matched controls. We performed three main analyses: anatomical region-of-interest-based correlations to test homotopic functional connectivity, independent component analysis (ICA) to reveal functional networks with a data-driven approach, and ICA-based interhemispheric correlation analysis. Both groups showed equivalently strong homotopic BOLD correlation. Surprisingly, almost all of the group-level independent components identified in controls were observed in AgCC and were predominantly bilaterally symmetric. The results argue that a normal complement of resting-state networks and intact functional coupling between the hemispheres can emerge in the absence of the corpus callosum, favoring the second over the first possibility listed above.
Accessibility: Document does not exist in file
Language:
eng
Author:
Tyszka, J. M.
Secondary author(s):
Kennedy, D. P., Adolphs, R., Paul, L. K.
Document type:
Article
Reference:
Tyszka, J. M., Kennedy, D. P., Adolphs, R., & Paul, L. K. (2011). Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum. Journal of Neuroscience, 31(42), 15154-15162. doi: 10.1523/jneurosci.1453-11.2011
2-year Impact Factor: 7.115|2011
Times cited: 95|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Corpus callosum / Agenesis of the corpus callosum (AgCC)

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DocumentDevelopmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-196
Location: Arquivo PCA - Pasta 5/2010
Title:
196 - Emotional responses in patients with disconnection of the left and right brain hemispheres
Duration: 2011-04 - 2012-02
Researcher(s):
Lynn Kerlin Paul, Ralph Adolphs, Remya Nair
Institution(s): Caltech Emotion and Social Cognition Laboratory, California Institute of Technology, California (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Paul, L. K.
Secondary author(s):
Adolphs, R., Nair, R.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Agenesis of the corpus callosum (AgCC) / Emotion / Affective and social behavior / Social cognition

Reference code: PT/FB/BL-2010-196.06
Location: Arquivo PCA - Pasta 5/2010
Title:
Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163989/
Abstract/Results: ABSTRACT:
This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)—the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome).
Accessibility: Document does not exist in file
Language:
eng
Author:
Paul, L. K.
Document type:
Article
Reference:
Paul , L. K. (2011). Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement. Journal of Neurodevelopmental Disorders, 3(1), 3-27. doi: 10.1007/s11689-010-9059-y
2-year Impact Factor: 3.062|2011
Times cited: 108|2020-03-11
Indexed document: Yes
Quartile: Q2
Keywords: Corpus callosum / White matter / Brain connectivity / Neuroanatomy / Interhemispheric