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File057 - Neurophysiological mechanisms of aging: novel view of old concepts2014-032017-01

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-057
Location: Arquivo PCA - Pasta 21/2012
Title:
057 - Neurophysiological mechanisms of aging: novel view of old concepts
Duration: 2014-03 - 2017-01
Researcher(s):
Maria José de Oliveira Diógenes Nogueira, Alexandre de Mendoça, Antonina Pereira, Bruno Teixeira da Silva, Raquel Dias
Institution(s): Instituto de Medicina Molecular, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
2 submitted papers
1 poster
1 Article
Language: eng
Author:
Diógenes, M. J.
Secondary author(s):
Mendonça, A., Pereira, A., Silva, B., Lopes, L., Dias, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Neurodegenerative disorders

DocumentFinal report - Neurophysiological mechanisms of aging: novel view of old concepts2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-057
Location: Arquivo PCA - Pasta 21/2012
Title:
057 - Neurophysiological mechanisms of aging: novel view of old concepts
Duration: 2014-03 - 2017-01
Researcher(s):
Maria José de Oliveira Diógenes Nogueira, Alexandre de Mendoça, Antonina Pereira, Bruno Teixeira da Silva, Raquel Dias
Institution(s): Instituto de Medicina Molecular, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
2 submitted papers
1 poster
1 Article
Language: eng
Author:
Diógenes, M. J.
Secondary author(s):
Mendonça, A., Pereira, A., Silva, B., Lopes, L., Dias, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Neurodegenerative disorders

Reference code: PT/FB/BL-2012-057.01
Location: Arquivo PCA - Pasta 21/2012
Title:
Final report - Neurophysiological mechanisms of aging: novel view of old concepts
Publication year: 2016
URL:
https://www.bial.com/imagem/Bolsa%205712.pdf
Abstract/Results: ABSTRACT:
Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats.
Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 µM, 4hours), and hippocampal LTP was evaluated. The results show that memantine significantly decreases the larger LTP magnitude recorded in hippocampal slices from aged rats without compromising LTP recorded in slices from young and adult animals.
To unveil the impact of in vivo administration of memantine, different doses (1,5 and 10 mg/kg/day) or saline vehicle solution were intraperitoneally administered, for 15-20 days, to both young and aged animals. Memantine did not significantly affect neither the place learning of young animals, evaluated by Morris Water Maze, nor LTP recorded from hippocampal slices from the same group of animals. However, memantine (5 and 10 mg/kg/day) significantly decreased the large LTP recorded in hippocampal slices from aged animals. Moreover, aged animals treated with memantine (10 mg/Kg/day) showed a significantly compromised place learning when compared to aged control animals.
Overall, these results suggest that the larger LTP observed in aged animals is a compensatory phenomenon, rather than pathological. The finding that age-dependent blockade of LTP by a NMDAR antagonist leads to learning deficits, implies that the increased LTP observed upon aging may be playing an important role in the learning process.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Diógenes, M. J.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Synaptic plasticity / Aging / Hippocampus / Memory / NMDA receptors

DocumentNeuronal communication and synaptopathies2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-057
Location: Arquivo PCA - Pasta 21/2012
Title:
057 - Neurophysiological mechanisms of aging: novel view of old concepts
Duration: 2014-03 - 2017-01
Researcher(s):
Maria José de Oliveira Diógenes Nogueira, Alexandre de Mendoça, Antonina Pereira, Bruno Teixeira da Silva, Raquel Dias
Institution(s): Instituto de Medicina Molecular, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
2 submitted papers
1 poster
1 Article
Language: eng
Author:
Diógenes, M. J.
Secondary author(s):
Mendonça, A., Pereira, A., Silva, B., Lopes, L., Dias, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Neurodegenerative disorders

Reference code: PT/FB/BL-2012-057.02
Location: Arquivo PCA - Pasta 21/2012
Title:
Neuronal communication and synaptopathies
Publication year: 2015
Accessibility:
Document exists in file
Language:
eng
Author:
Diógenes, M. J.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Diógenes, M. J. (2015). Neuronal communication and synaptopathies. Poster presented at the IMM retreat. Cascais, Portugal.
Indexed document: No

Neuronal communication and synaptopathies

Neuronal communication and synaptopathies

DocumentEnhanced LTP in aged rats: Detrimental or compensatory?2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-057
Location: Arquivo PCA - Pasta 21/2012
Title:
057 - Neurophysiological mechanisms of aging: novel view of old concepts
Duration: 2014-03 - 2017-01
Researcher(s):
Maria José de Oliveira Diógenes Nogueira, Alexandre de Mendoça, Antonina Pereira, Bruno Teixeira da Silva, Raquel Dias
Institution(s): Instituto de Medicina Molecular, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
2 submitted papers
1 poster
1 Article
Language: eng
Author:
Diógenes, M. J.
Secondary author(s):
Mendonça, A., Pereira, A., Silva, B., Lopes, L., Dias, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Neurodegenerative disorders

Reference code: PT/FB/BL-2012-057.03
Location: Arquivo PCA - Pasta 21/2012
Title:
Enhanced LTP in aged rats: Detrimental or compensatory?
Publication year: 2017
URL:
http://www.sciencedirect.com/science/article/pii/S0028390816305147
Abstract/Results: ABSTRACT:
Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats. Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 µM, 4 h), and hippocampal LTP was evaluated. The results show that memantine significantly decreases the larger LTP magnitude recorded in hippocampal slices from aged rats without compromising LTP recorded in slices from young and adult animals. To unveil the impact of in vivo administration of memantine, different doses (1, 5 and 10 mg/kg/day) or saline vehicle solution were intraperitoneally administered, for 15-20 days, to both young and aged animals. Memantine did not significantly affect neither the place learning of young animals, evaluated by Morris Water Maze, nor LTP recorded from hippocampal slices from the same group of animals. However, memantine (5 and 10 mg/kg/day) significantly decreased the large LTP recorded in hippocampal slices from aged animals. Moreover, aged animals treated with memantine (10 mg/kg/day) showed a significantly compromised place learning when compared to aged control animals. Overall, these results suggest that the larger LTP observed in aged animals is a compensatory phenomenon, rather than pathological. The finding that age-dependent blockade of LTP by a NMDAR antagonist leads to learning deficits, implies that the increased LTP observed upon aging may be playing an important role in the learning process.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pinto, J.
Secondary author(s):
Vale, R., Batalha, V. L., Costenla, A. R., Dias, R., Rombo, D., Sebastião, A., de Mendonça, A., Diógenes, M. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Pinto, J., Vale, R., Batalha, V. L., Costenla, A. R., Dias, R., Rombo, D., Sebastião, A., de Mendonça, A., & Diógenes, M. J. (2017). Enhanced LTP in aged rats: Detrimental or compensatory? Neuropharmacology, 114, 12–19. doi: 10.1016/j.neuropharm.2016.11.017
2-year Impact Factor: 4.249|2017
Impact factor notes: Impact factor not available yet for 2019
Times cited: 11|2022-05-22
Indexed document: Yes
Quartile: Q1
Keywords: Aging / Long-term potentiation / Spatial learning / Hippocampus / Watermaze