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File192 - Effects of conditional Foxp2 deletion on motor-sequence learning2013-062016-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement
DocumentDifferential contributions of Foxp2 to motor-skill learning 2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.02
Location: Arquivo PCA - Pasta 15/2012
Title:
Differential contributions of Foxp2 to motor-skill learning
Publication year: 2013
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=dc388bc0-82ea-4dda-a9c4-71d192bba159&cKey=0250d446-2966-4a5e-870a-30f81ac2496a&mKey=8d2a5bec-4825-4cd6-9439-b42bb151d1cf
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a severe developmental speech and language disorder. This has been well studied in the KE family where a heterozygous FOXP2 mutation is dominantly inherited. Affected individuals have difficulty producing the sequences of orofacial motor movements necessary for fluent speech. This feature has been proposed to be central to the disorder, although other expressive and receptive language problems also exist. FOXP2 encodes a transcription factor that is expressed in the cortico-striatal and cortico-cerebellar circuits required for sensorimotor integration and motor-skill learning, and imaging studies of the KE family have shown structural abnormalities in the caudate nucleus and ventral cerebellum. The FOXP2 protein is also highly conserved in other vertebrate species, with only 3 amino acid changes between humans and mice. Mice carrying the KE-family mutation (Foxp2-R552H/+) have motor-skill learning deficits and lack striatal long-term depression. We also showed that they have altered in vivo striatal activity during the learning of a motor task. We are now deleting Foxp2 from A. selected brain regions (cortex, striatum or cerebellar Purkinje cells) and B. a defined time point (adulthood). This genetic approach is being combined with an operant motor-sequence learning task which allows us to examine the microstructure of animals' behaviour. In the first phase of training, mice must complete a sequence of 8 lever presses to obtain a food reward. After 12 days a time constraint is added and the sequence must be performed at increasingly high speeds. Surprisingly, initial data showed that the press rate of Foxp2-R552H/+ and heterozygous knockout mice was faster than that of controls, in contrast to cerebellar mutants which had a slower press rate. A decreased press rate was also evident in striatal mutants during the high-speed phase of the task. Histograms of inter-press-intervals revealed more subtle changes and distribution differences were evident in all mutant lines relative to controls. Lever presses were also divided into bouts (sequences of presses) which evolved during training. Foxp2-R552H/+ and heterozygous knockouts produced sequences of a shorter duration with reduced inter-sequence intervals, whereas cerebellar mutants produced sequences of a longer duration with increased inter-sequence intervals. These data suggest that Foxp2 function in distinct subcircuits may differentially affect motor-skill learning.
Accessibility: Document does not exist in file
Language:
eng
Author:
French, C.
Secondary author(s):
Feliciano, C., Correia, M., Paixão, V., Jin, X., Fisher, S. E., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
French, C., Feliciano, C., Correia, M., Paixão, V., Jin, X., Fisher, S. E., & Costa, R. M. (2013, November). Differential contributions of Foxp2 to motor-skill learning. Paper presented at the Society for Neuroscience Annual Meeting, San Diego, California, USA. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=dc388bc0-82ea-4dda-a9c4-71d192bba159&cKey=0250d446-2966-4a5e-870a-30f81ac2496a&mKey=8d2a5bec-4825-4cd6-9439-b42bb151d1cf
Indexed document: No
Keywords: Speech and language / Motor-skill learning / Conditional Foxp2 deletion
DocumentWhat can mice tell us about Foxp2 function?2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.03
Location: Arquivo PCA - Pasta 15/2012
Title:
What can mice tell us about Foxp2 function?
Publication year: 2014
URL:
http://www.sciencedirect.com/science/article/pii/S0959438814001299
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigating the relevant neural pathways. FOXP2 shows remarkably high conservation of sequence and neural expression in diverse vertebrates, suggesting that studies in other species are useful in elucidating its functions. Here we describe how investigations of mice that carry disruptions of Foxp2 provide insights at multiple levels: molecules, cells, circuits and behaviour. Work thus far has implicated the gene in key processes including neurite outgrowth, synaptic plasticity, sensorimotor integration and motor-skill learning.
Accessibility: Document does not exist in file
Language:
eng
Author:
French, C. A.
Secondary author(s):
Fisher, S. E.
Document type:
Article
Number of reproductions:
1
Reference:
French, C. A., & Fisher, S. E. (2014). What can mice tell us about Foxp2 function? Current Opinion in Neurobiology, 28, 72–79. https://doi.org/10.1016/j.conb.2014.07.003
2-year Impact Factor: 6.628|2014
Times cited: 50|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Foxp2 / Speech and language / Motor learning / Plasticity
DocumentEffects of Foxp2 disruption in selected brain regions and in adulthood 2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.04
Location: Arquivo PCA - Pasta 15/2012
Title:
Effects of Foxp2 disruption in selected brain regions and in adulthood
Publication year: 2014
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=4c006652-77a4-47b0-88ee-abcc10f86f2d&cKey=97f4a710-c929-47d4-acfd-c5e0a54fc9db&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a rare speech and language disorder. A core feature of this disorder is difficulty in producing the sequences of orofacial motor movements necessary for fluent speech, although other expressive and receptive language problems are also present. Imaging studies have shown structural abnormalities in the caudate nucleus and ventral cerebellum, as well as altered patterns of activation during language-based tasks. FOXP2 encodes a transcription factor which is expressed in the cortico-striatal and cortico-cerebellar circuits required for sensorimotor integration and motor-skill learning. This neural expression pattern, and the FOXP2 protein sequence, are highly conserved in other vertebrate species such as mice and songbirds. Mice carrying a heterozygous point mutation in Foxp2 (the KE-family mutation) have motor-skill learning deficits and lack striatal long-term depression. We also found aberrant striatal activity in vivo during the learning of a motor task. Juvenile zebra finches show increased FoxP2 expression in AreaX of the striatum during the song learning-period, and FoxP2 knockdown in AreaX results in inaccurate and incomplete imitation of the tutor bird's song. FoxP2 knockdown in AreaX of mature birds abolishes the mediation of song by social context and suggests that FoxP2 function is important in adulthood as well as during development. We previously generated a conditional Foxp2 line and have used it to disrupt Foxp2 in selected brain regions (cortex, striatum or cerebellar Purkinje cells), and at a defined time point (adulthood). This genetic approach is being combined with an operant motor-sequence learning task where mice must complete a sequence of 8 lever presses to obtain a food reward. After 12 days a time constraint is added and the sequence must be performed at increasingly high speeds. Both cerebellar and striatal Foxp2 mutants show a reduced rate of lever pressing during training compared to controls. However, analyses of behavioural microstructure revealed that whilst pressing of all speeds is altered in cerebellar mutants, in striatal mutants it is primarily rapid pressing that is affected. These data indicate that Foxp2 function in distinct subcircuits differentially affects motor-skill learning. We disrupted Foxp2 globally in adult mice using a tamoxifen-inducible Cre. Preliminary data indicate that homozygous adult knockouts are viable, unlike other Foxp2 homozygous mutants which die at 3-4 weeks of age. Work is ongoing to investigate motor-sequence learning and other aspects of behaviour in these animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
French, C.
Secondary author(s):
Gomez-Marin, A., Correia, M., Feliciano, C., Paixão, V., Jin, X., Fisher, S. E., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
French, C., Gomez-Marin, A., Correia, M., Feliciano, C., Paixão, V., Jin, X., Fisher, S. E., & Costa, R. M. (2014, November). Effects of Foxp2 disruption in selected brain regions and in adulthood. Poster presented at the Society for Neuroscience Annual Meeting, Washington, DC, USA. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=4c006652-77a4-47b0-88ee-abcc10f86f2d&cKey=97f4a710-c929-47d4-acfd-c5e0a54fc9db&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Indexed document: No
Keywords: Foxp2 / Speech and language / Motor-sequence learning

DocumentConditional Foxp2 deletions differentially affect motor-skill learning2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.05
Location: Arquivo PCA - Pasta 15/2012
Title:
Conditional Foxp2 deletions differentially affect motor-skill learning
Publication year: 2015
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&uact=8&ved=0CCgQFjABahUKEwjpjL6ztuLGAhXBFtsKHTfPC3Q&url=http%3A%2F%2Fwww.ibmc.up.pt%2Fspn2015%2Fabstract_book_04.06.2015.pdf&ei=vBepVem-HMGt7Aa3nq-gBw&usg=AFQjCNGZI4FQ_pCcLqX1KG1_YiZCz1Ez0Q&sig2=XB4pwMCQn3GDwOaDl8VYzw&bvm=bv.98197061,d.ZGU
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a rare speech and language disorder. In the KE family a heterozygous FOXP2 mutation is dominantly inherited and affected individuals have difficulty producing the sequences of orofacial motor movements necessary for fluent speech. This is considered a core deficit of the disorder, although other expressive and receptive language problems also exist. The FOXP2 transcription factor is expressed in cortico-striatal/ -cerebellar circuits required for sensorimotor integration and motor-skill learning, and imaging studies have identified structural abnormalities in several of these regions in affected KEfamily members. FOXP2 is also highly conserved in a number of other vertebrate species, where expression is seen both during development and in adulthood. Mice carrying the KE-family mutation have motor-skill learning deficits and lack striatal long-term depression. They also have abnormally high striatal activity in vivo which is aberrantly modulated during the learning of a motor task. Juvenile zebra finches show increased FoxP2 expression during the song learning period in striatal nucleus Area X, and FoxP2 knockdown in this region results in inaccurate and incomplete song imitation. FoxP2 knockdown in Area X of mature birds renders song more variable and abolishes the mediation of song by social context. We used a conditional Foxp2 mouse line to selectively delete Foxp2 from the cortex, striatum or cerebellar Purkinje cells. This genetic approach was combined with an operant task where a sequence of 8 lever presses must be completed to obtain a food reinforcer. After 12 days a time constraint was added and the sequence had to be performed at increasingly high speeds. Both cerebellar and striatal Foxp2 mutants showed a reduced rate of lever pressing during training compared to controls. However, analyses of behavioural microstructure revealed that in cerebellar mutants pressing of all speeds is altered, whereas in striatal and cortical mutants rapid pressing is primarily affected. Furthermore, in striatal mutants rapid pressing also becomes more variable. In a separate experiment we used a tamoxifen-inducible Cre to disrupt Foxp2 globally in adult mice. Around one third of Cre positive animals died, with the first deaths occurring 6 weeks after tamoxifen administration. Surviving animals appeared healthy but showed a reduced press rate on the motor-sequence learning task.
Accessibility: Document exists in file
Language:
eng
Author:
French, C.
Secondary author(s):
Correia, M., Gomez-Marin, A., Feliciano, C., Paixão, V., Jin, X., Fisher, S. E., Costa, R. M.
Document type:
Abstract book
Number of reproductions:
1
Reference:
French, C., Correia, M., Gomez-Marin, A., Feliciano, C., Paixão, V., Jin, X., Fisher, S. E., & Costa, R. M. (2015). Abstract book of the XIV Meeting of the Portuguese Neuroscience Society,4-5th June 2015, Póvoa de Varzim, Portugal (p. 127).
Indexed document: No
Keywords: Motor-skill learning / Foxp2

Conditional Foxp2 deletions differentially affect motor-skill learning

Conditional Foxp2 deletions differentially affect motor-skill learning
DocumentFoxp2 function in the adult brain 2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.07
Location: Arquivo PCA - Pasta 15/2012
Title:
Foxp2 function in the adult brain
Publication year: 2015
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=2c9efb03-eec2-435f-a2a2-8a7986b29cee&cKey=bafafdf0-1140-4af2-a429-ac6e288933ce&mKey=d0ff4555-8574-4fbb-b9d4-04eec8ba0c84
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a rare speech and language disorder. In the KE family a heterozygous FOXP2 mutation is dominantly inherited and affected individuals have difficulty producing the sequences of orofacial motor movements necessary for fluent speech. This is considered a core deficit of the disorder, although other expressive and receptive language problems also exist. The FOXP2 transcription factor is expressed in cortico-striatal/ -cerebellar circuits required for sensorimotor integration and motor-skill learning, and imaging studies have identified structural abnormalities in several of these regions in affected KE-family members. FOXP2 is also highly conserved in a number of other vertebrate species, where expression is seen during development and in adulthood. Mice carrying the KE-family mutation have motor-skill learning deficits and lack striatal long-term depression. They also have abnormally high striatal activity in vivo which is aberrantly modulated during the learning of a motor task. Juvenile zebra finches show increased FoxP2 expression during the song learning period in striatal nucleus Area X, and FoxP2 knockdown in this region results in inaccurate and incomplete song imitation. More recently, FoxP2 knockdown in Area X of mature birds was shown to render song more variable and abolished the mediation of song by social context, implicating FoxP2 in adult as well as developmental neural function. We used a conditional Foxp2 line and a tamoxifen-inducible Cre (CAGGS-CreER) to disrupt Foxp2 globally in adult mice. Tamoxifen was administered at 10 weeks of age and substantial Foxp2 deletion was seen 60 days thereafter. Around one third of Foxp2-flox/flox; CAGGS-Cre animals died, with the first deaths occurring 6 weeks after tamoxifen administration. Surviving animals appeared healthy and their performance was indistinguishable from that of littermate controls on the accelerating rotarod. An operant lever-pressing task was used to examine motor-sequence learning in detail in the surviving group. In this task mice must complete 8 lever presses to trigger the release of a sucrose reinforcer. Initially the task is self-paced, but after 12 days of training a time constraint is added and the 8 presses must be completed at increasingly high speeds. Foxp2-flox/flox; CAGGS-Cre mice were able to learn the lever-pressing skill but rates of reinforcer delivery and lever pressing were reduced during both phases of training. Results are compared and contrasted with those from mice carrying aetiological and region-specific Foxp2 disruptions.
Accessibility: Document does not exist in file
Language:
eng
Author:
French, C.
Secondary author(s):
Correia, M., Fisher, S. E., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
French, C., Correia, M., Fisher, S. E., & Costa, R. M. (2015, October). Foxp2 function in the adult brain. Paper presented at the Society for Neuroscience Annual Meeting, Chicago, USA. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=2c9efb03-eec2-435f-a2a2-8a7986b29cee&cKey=bafafdf0-1140-4af2-a429-ac6e288933ce&mKey=d0ff4555-8574-4fbb-b9d4-04eec8ba0c84
Indexed document: No
Keywords: Adult Foxp2 inactivation / Speech and language / Motor-skill learning

DocumentFoxp2 functions in motor-skill learning2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.08
Location: Arquivo PCA - Pasta 15/2012
Title:
Foxp2 functions in motor-skill learning
Publication year: 2016
Abstract/Results:
ABSTRACT:
A significant number of children fail to acquire normal speech and language skills, despite adequate intelligence and opportunity. Foxp2 was the first gene directly implicated in these difficulties, and offers a unique entry point into the underlying neural mechanisms. Disruptions of Foxp2 cause a rare speech and language disorder, a core feature of which is problems in sequencing orofacial movements. The gene encodes a transcription factor which is expressed in cortico-striatal/ -cerebellar circuits required for sensorimotor integration and motor-skill learning, and imaging studies have identified structural abnormalities in these same regions in affected individuals. Foxp2 is also highly conserved in several other vertebrate species, where expression is seen both during development and in adulthood. Mice carrying an aetiological Foxp2 mutation have motor-skill learning deficits and lack striatal long-term depression. They also show abnormally high striatal activity in vivo which is aberrantly modulated during acquisition of a motor task. In zebra finches, Foxp2 knockdown in the striatal song nucleus Area X disrupts developmental and social modulation of song variability. We generated a conditional mouse to disrupt Foxp2 in specific brain regions (cortex, striatum or cerebellar Purkinje cells), or at a defined time point (adulthood). This genetic approach was combined with an operant
task where a sequence of 8 lever presses must be completed to obtain a reward. After 12 days a time constraint was added and the sequence had to be performed at increasingly high speeds. We found that Foxp2 in discrete circuits contributes differentially to motor-sequencing speed and stereotypy. Cerebellar mutants executed press sequences of all speeds more slowly than controls, whereas impairments in striatal and cortical mutants were typically seen when the task became more difficult. Interestingly, striatal mutants also executed some press sequences more variably. Global Foxp2 disruption in adulthood was achieved using a tamoxifen-inducible Cre. Tamoxifen was administered at 10 weeks of age and around one third of Foxp2 knockdown animals died in the following weeks. Surviving animals were healthy and showed normal motor-sequence learning, despite appearing to be less motivated. This indicates that developmental Foxp2 expression is critical for the learning of motor-skills in adult animals.
Accessibility: Document exists in file
Language:
eng
Author:
French, C.
Secondary author(s):
Correia, M., Fisher, S. E., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
French, C., Correia, M., Fisher, S. E., & Costa, R. M. (2016). Foxp2 functions in motor-skill learning. Abstract book of the Neurobiology of Mental Health Conference - NCR Synapsy (p. 65).
Indexed document: No
Keywords: Foxp2 / Speech and language / Motor-skill learning

Foxp2 functions in motor-skill learning

Foxp2 functions in motor-skill learning
DocumentFinal report - Effects of conditional Foxp2 deletion on motor-sequence learning2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.01
Location: Arquivo PCA - Pasta 15/2012
Title:
Final report - Effects of conditional Foxp2 deletion on motor-sequence learning
Publication year: 2016
URL:
https://www.bial.com/imagem/Grant19212.pdf
Abstract/Results: ABSTRACT:
Disruptions of FOXP2 cause a speech and language disorder, a core deficit of which are problems in sequencing orofacial movements. The gene encodes a transcription factor that is expressed in cortico-striatal/ -cerebellar circuits which are required for sensorimotor integration and motor-skill learning, and imaging studies of affected individuals have identified structural abnormalities in these regions. FOXP2 is also highly conserved in several other vertebrate species including mice, where expression is seen in comparable brain areas during development and in adulthood. The aims of this study were to 1) establish the contributions of Foxp2 in specific brain regions to motor-sequence learning 2) examine Foxp2 functions in adulthood. We generated conditional mice with selective Foxp2 disruptions in the cortex, striatum or cerebellar Purkinje cells, and assessed effects on motor-sequence learning using an operant lever-pressing task. Foxp2 in each of the circuits contributed differentially to the speed and variability of lever-press sequences. Pronounced deficits were seen in cerebellar Purkinje cell mutants and, in collaboration with Prof. Chris De Zeeuw, we showed that Purkinje cells lacking Foxp2 have increased excitability and are atypically modulated in vivo during locomotion. We also used an inducible Cre to disrupt Foxp2 globally in adulthood. This resulted in the deaths of around one third of mutant mice, although surviving animals appeared healthy and executed lever-press sequences normally. In sum, we found that early Foxp2 expression is critical for motor-sequence learning and model-based decision making, but continued expression in mature animals is important for other behaviours such as sociability.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
French, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Motor-sequence learning / Foxp2 / Speech and language / Conditional gene disruption / in vivo electrophysiology
DocumentDifferential effects of Foxp2 disruption in distinct motor circuits2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.09
Location: Arquivo PCA - Pasta 15/2012
Title:
Differential effects of Foxp2 disruption in distinct motor circuits
Publication year: 2019
URL:
https://www.nature.com/articles/s41380-018-0199-x
Abstract/Results: ABSTRACT:
Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequencing orofacial
movements. FOXP2 is expressed in cortico-striatal and cortico-cerebellar circuits important for fine motor skills, and
affected individuals show abnormalities in these brain regions. We selectively disrupted Foxp2 in the cerebellar Purkinje
cells, striatum or cortex of mice and assessed the effects on skilled motor behaviour using an operant lever-pressing task.
Foxp2 loss in each region impacted behaviour differently, with striatal and Purkinje cell disruptions affecting the variability
and the speed of lever-press sequences, respectively. Mice lacking Foxp2 in Purkinje cells showed a prominent phenotype
involving slowed lever pressing as well as deficits in skilled locomotion. In vivo recordings from Purkinje cells uncovered an
increased simple spike firing rate and decreased modulation of firing during limb movements. This was caused by increased
intrinsic excitability rather than changes in excitatory or inhibitory inputs. Our findings show that Foxp2 can modulate
different aspects of motor behaviour in distinct brain regions, and uncover an unknown role for Foxp2 in the modulation of
Purkinje cell activity that severely impacts skilled movements.
Accessibility: Document exists in file
Language:
eng
Author:
French, C. A.
Secondary author(s):
Vinueza Veloz, M. F., Zhou, K., Peter, S., Fisher S. E. , Costa, R. M., De Zeeuw, C. I.
Document type:
Article
Number of reproductions:
1
Reference:
French C. A., Vinueza Veloz M. F., Zhou K., Peter S., Fisher S. E., Costa R.M. & De Zeeuw, C. I. (2019). Differential effects of Foxp2 disruption in distinct motor circuits. Molecular Psychiatry, 24(3), 447-462. https://doi.org/10.1038/s41380-018-0199-x
2-year Impact Factor: 12.384|2019
Times cited: 25|2025-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Motor-sequence learning / Foxp2 / Speech and language / Conditional gene disruption

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Novo ficheiro
DocumentSalivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
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Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.11
Location: BF-GMS
Title:
Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
Publication year: 2025
URL:
https://doi.org/10.1016/j.psyneuen.2025.107283
Abstract/Results: ABSTRACT:
Background
Studies of salivary cortisol levels in psychosis have yielded inconsistent findings, which may be attributable to heterogeneity in cortisol measurement, illness stage, and approaches to dealing with sampling factors and potential confounders. To address these issues, we performed an individual participant data (IPD) meta-analysis comparing individuals at different stages of psychosis to controls using five different salivary cortisol measures and explored potential effect modifiers.
Methods
Salivary cortisol data from five London-based cohorts were used to derive the cortisol awakening response, total daytime cortisol output, basal cortisol, and diurnal slope measures (wake-to-evening and peak-to-evening). Linear regression models were first performed to obtain standardised beta coefficients (ß), representing the difference in each cortisol metric between each clinical stage group (cases) and healthy individuals (controls) after accounting for relevant sampling factors; we then used random-effects meta-analyses and meta-regression models to investigate the effect of psychosis stage and sample characteristics on effect sizes.
Results
Data were available for 352 individuals distributed across psychosis clinical stages (1a – distress disorder: N = 35; 1b – clinical high-risk for psychosis: N = 90; 2a – first-episode psychosis: N = 197; 2b – single episode remitted: N = 5; 3 – relapsing/remitting illness: N = 18; 4 – severe and persistent illness: N = 7) and 292 controls. A significant overall main effect of clinical stage on peak-to-evening diurnal slope was observed (?2=12.83, p = 0.025), with both the clinical high-risk (ß=0.21, 95 % CI: 0.06, 0.36) and first-episode psychosis (ß=0.20, 95 % CI: 0.10, 0.31) groups characterised by flatter slopes than controls. The clinical stage groups and controls did not differ on any other cortisol measure. Several sample characteristics were significantly associated with diurnal slope effect sizes, but after accounting for clinical stage, only the association between mean age in cases and wake-to-evening diurnal slope retained significance.
Conclusion
Clinical high-risk and first-episode psychosis participants differed from healthy controls in the peak-to-evening diurnal cortisol slope. This measure has not been examined in these populations before, and its potential predictive and prognostic utility for psychotic disorders merits further investigation.
Accessibility: Document exists in file
Language:
eng
Author:
Haussler, S. M.
Secondary author(s):
Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., Cullen, A. E.
Document type:
Article
Number of reproductions:
1
Reference:
Haussler, S. M., Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., & Cullen, A. E. (2025). Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis. Psychoneuroendocrinology, 173, 107283. https://doi.org/10.1016/j.psyneuen.2025.107283
2-year Impact Factor: 3.4|2023
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2025-02-28
Indexed document: Yes
Quartile: Q2
Keywords: Cortisol / Schizophrenia / Psychosis / Stress neurobiology / Meta-analysis

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis