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File253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia2015-112017-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

DocumentSlow dissolving of emotional distress contributes to hyperarousal2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.02
Location: Arquivo PCA - Pasta 25/2012
Title:
Slow dissolving of emotional distress contributes to hyperarousal
Publication year: 2016
URL:
http://www.pnas.org/content/113/9/2538.abstract
Abstract/Results: ABSTRACT:
The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, hyperarousal, self-conscious emotional distress, and thought-like nocturnal mentation that was validated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0.57, P < 0.001; eye movement density: R = 0.46, P < 0.01) in 32 polysomnographically assessed participants. The experience of distress lasting overnight increased with insomnia severity (ß = 0.29, P < 10-23), whereas short-lasting distress did not (ß = -0.02, P = 0.41). Insomnia severity was associated with hyperarousal (ß = 0.47, P < 10-63) and with the thought-like nocturnal mentation that is specifically associated with restless REM sleep (ß = 0.31, P < 10-26). Structural equation modeling showed that 62.4% of the association between these key characteristics of insomnia was mediated specifically by reduced overnight resolution of emotional distress. The model outperformed all alternative mediation pathways. The findings suggest that restless REM sleep reflects a process that interferes with the overnight resolution of distress. Its accumulation may promote the development of chronic hyperarousal, giving clinical relevance to the role of REM sleep in emotion regulation in insomnia, depression, and posttraumatic stress disorder.
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., Van Der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Wassing, R., Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., Van Der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., & Van Someren, E. (2016). Slow dissolving of emotional distress contributes to hyperarousal. Proceedings of the National Academy of Sciences of the United States of America, 113(9), 2538–2543. doi: 10.1073/pnas.1522520113
2-year Impact Factor: 9.661|2016
Times cited: 80|2022-03-08
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia / REM sleep / Hyperarousal / Self-conscious emotion / Shame

Slow dissolving of emotional distress contributes to hyperarousal

Slow dissolving of emotional distress contributes to hyperarousal

DocumentOvernight worsening of emotional distress indicates maladaptive sleep in insomnia2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.03
Location: Arquivo PCA - Pasta 25/2012
Title:
Overnight worsening of emotional distress indicates maladaptive sleep in insomnia
Publication year: 2019
URL:
https://academic.oup.com/sleep/article/42/4/zsy268/5261254
Abstract/Results: ABSTRACT:
Study Objectives Mechanisms underlying the distress of hyperarousal in people with insomnia remain enigmatic. We investigated whether insomnia impedes the overnight adaptation to emotional distress.
Methods We induced the distressful self-conscious emotion of shame four times across three consecutive days by exposing 64 participants to their often embarrassingly out-of-tune singing, recorded earlier during a Karaoke session. Perceived physical, emotional, and social distress was assessed with the Experiential Shame Scale.
Results Compared to exposures followed by wakefulness, exposures followed by sleep resulted in overnight relief of physical component of shame in normal sleepers, but in a striking opposite overnight worsening in people with insomnia.
Conclusions Our findings are the first to experimentally show that the benefits of sleep are not only lost when sleep is poor; people with insomnia experience a maladaptive type of sleep that actually aggravates physically perceived distress. Maladaptive sleep could shed new light on posttraumatic stress disorder (PTSD) and on diurnal mood fluctuation and the counterintuitive favorable effects of sleep deprivation in depression.
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Benjamins, J. S., Talamini, L. M., Schalkwijk, F., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Reference:
Wassing, R., Benjamins, J. S., Talamini, L. M., Schalkwijk, F., & Van Someren, E. J. W. (2019). Overnight worsening of emotional distress indicates maladaptive sleep in insomnia. Sleep, 42(4): zsy268. doi: 10.1093/sleep/zsy268. Erratum in: Sleep. 2019 May 1;42(5): PMID: 30590834.
2-year Impact Factor: 4.805|2019
Times cited: 21|2022-03-08
Indexed document: Yes
Quartile: Q1
Keywords: Shame / Sleep / Insomnia / Self-conscious emotion / Emotion regulation

Overnight worsening of emotional distress indicates maladaptive sleep in insomnia

Overnight worsening of emotional distress indicates maladaptive sleep in insomnia

DocumentFinal report - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.01
Location: Arquivo PCA - Pasta 25/2012
Title:
Final report - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_25312.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
The mechanisms of hyperarousal, the key symptom of insomnia, have remained elusive. Recently, restless REM sleep emerged as a robust signature of insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal.
AIMS
We aimed to investigate whether restless REM sleep impedes overnight distress resolution, and accumulates as hyperarousal.
METHOD
Observational and experimental studies employed psychometrics, EEG and fMRI. We first validated a proxy measure for restless REM sleep, and assessed it in a large sample along with measures of distress dissolving and hyperarousal. We then implemented an internet-protocol to induce self-conscious distress and assessed distress dissipation across 5 consecutive days. The same distress-inducing protocol was used in a MRI scanner while conditioning it to a simultaneously provided odor. The odor was again given during part of the subsequent sleep period, to induce targeted memory reactivation. A second MRI scan of distress induction evaluated how neural correlates of its impact changed overnight.
RESULTS
Of the association between restless REM sleep and hyperarousal, 62.4% was mediated specifically by reduced overnight resolution of emotional distress in insomnia. In people with insomnia, a night's sleep could even increase distress, rather than resolve it. MRI findings indicated activation of the salience network during the induction self-conscious emotions, that ameliorated with sleep but not with a similar interval of being awake.
CONCLUSION
Restless REM sleep interferes with overnight maintenance of balanced salience network activation.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
enG
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: REM-sleep / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion

DocumentInsomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress2017

Reference code: PT/FB/BL-2012-253.03
Location: Arquivo PCA - Pasta 25/2012
Title:
Insomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress
Publication year: 2017
URL:
http://onlinelibrary.wiley.com/doi/10.1111/jsr.12446/epdf
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., van der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., Van Someren, E.
Document type:
Abstract
Number of reproductions:
1
Reference:
Wassing, R., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., van der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., & Van Someren, E. (2017). Insomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress. Journal of Sleep Research, 25(Suppl. 1), 31.
Indexed document: Yes
Keywords: Insomnia / Hyperarousal / REM sleep

Insomnia: restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress

Insomnia: restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress

DocumentIncreased hippocampal-prefrontal functional connectivity in insomnia2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.04
Location: Arquivo PCA - Pasta 25/2012
Title:
Increased hippocampal-prefrontal functional connectivity in insomnia
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S1074742718300194
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is the second-most common mental disorder and has a far-reaching impact on daytime functioning. A meta-analysis indicates that, of all cognitive domains, declarative memory involving the hippocampus is most affected in insomnia. Hippocampal functioning has consistently been shown to be sensitive to experimental sleep deprivation. Insomnia however differs from sleep deprivation in many aspects, and findings on hippocampal structure and function have been equivocal. The present study used both structural and resting-state functional Magnetic Resonance Imaging in a larger sample than previously reported to evaluate hippocampal volume and functional connectivity in ID. Included were 65 ID patients (mean age = 48.3 y ± 14.0, 17 males) and 65 good sleepers (mean age = 44.1 y ± 15.2, 23 males). Insomnia severity was assessed with the Insomnia Severity Index (ISI), subjective sleep with the Consensus Sleep Diary (CSD) and objective sleep by two nights of polysomnography (PSG). Seed-based analysis showed a significantly stronger connectivity of the bilateral hippocampus with the left middle frontal gyrus in ID than in controls (p = .035, cluster based correction for multiple comparisons). Further analyses across all participants moreover showed that individual differences in the strength of this connectivity were associated with insomnia severity (ISI, r = .371, p = 9.3e-5) and with subjective sleep quality (CSD sleep efficiency, r = -.307, p = .009) (all p FDR-corrected). Hippocampal volume did not differ between ID and controls. The findings indicate more severe insomnia and worse sleep quality in people with a stronger functional connectivity between the bilateral hippocampus and the left middle frontal gyrus, part of a circuit that characteristically activates with maladaptive rumination and deactivates with sleep.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2016-190.02
Author: Leerssen, J.
Secondary author(s):
Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Leerssen, J., Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., & Van Someren, E. (2019). Increased hippocampal-prefrontal functional connectivity in insomnia. Neurobiology of Learning and Memory, 160, 144-150. doi: 10.1016/j.nlm.2018.02.006
2-year Impact Factor: 2.768|2019
Times cited: 14|2021-05-21
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia / Sleep / Hippocampus / Middle frontal gyrus / resting-state fMRI / Functional connectivity

DocumentA clinical interpretation of shame regulation in maladaptive perfectionism2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.05
Location: Arquivo PCA - Pasta 25/2012
Title:
A clinical interpretation of shame regulation in maladaptive perfectionism
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S019188691830477X
Abstract/Results: ABSTRACT
Maladaptive perfectionism, a transdiagnostic personality trait, is associated with depression. Shame has been associated with depressive disorders and to negatively impact its treatment. Interestingly, maladaptive perfectionism and maladaptive shame regulation strategies might be both expressions of an internalizing personality style. We applied forward and backward stepwise linear regression modeling to explain maladaptive perfectionism by association of shame coping styles in a highly powered cross-sectional study of 1436 participants. Maladaptive perfectionism was shown to have significant positive associations with the two internalizing coping styles attacking the self, and withdrawing, and negative associations with adaptive coping. Furthermore, a significant positive interaction effect was shown for the two internalizing coping styles.
Our research shows that participants who adopt maladaptive perfectionism, internalize the pain of shame. Clinically, this is especially relevant during treatment: the patterns of maladaptive perfectionism must come into the open, the client feels exposed and, consistent with his shame regulation style, shame grows. Our research might account for the negative responsiveness of perfectionism to brief therapies for depression: there may not be enough focus on and time for working through the evoked shame.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Schalkwijkh, F.
Secondary author(s):
Van Someren, E., Wassing, R.
Document type:
Article
Number of reproductions:
1
Reference:
Schalkwijkh, F., Van Someren, E., & Wassing, R. (2019). A clinical interpretation of shame regulation in maladaptive perfectionism. Personality and Individual Differences, 138, 19-23. doi: 10.1016/j.paid.2018.09.001
2-year Impact Factor: 2.311|2019
Times cited: 2|2021-05-20
Indexed document: Yes
Quartile: Q2
Keywords: Self-conscious emotions / Shame / Perfectionism / Coping / Depression

A clinical interpretation of shame regulation in maladaptive perfectionism

A clinical interpretation of shame regulation in maladaptive perfectionism

DocumentHaunted by the past: old emotions remain salient in insomnia disorder2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.06
Location: Arquivo PCA - Pasta 25/2012
Title:
Haunted by the past: old emotions remain salient in insomnia disorder
Publication year: 2019
URL:
Haunted by the past: old emotions remain salient in insomnia disorder
Abstract/Results: ABSTRACT
Studies suggest that sleep supports persistent changes in the neuronal representation of emotional experiences such that they are remembered better and less distressful when recalled than when they were first experienced. It is conceivable that sleep fragmentation by arousals, a key characteristic of insomnia disorder, could hamper the downregulation of distress. In this study, we sought further support for the idea that insomnia disorder may involve a lasting deficiency to downregulate emotional distress. We used functional MRI in insomnia disorder (n = 27) and normal sleepers (n = 30) to identify how brain activation differs between novel and relived self-conscious emotions. We evaluated whether brain activity elicited by reliving emotional memories from the distant past resembles the activity elicited by novel emotional experiences more in insomnia disorder than in normal sleepers. Limbic areas were activated during novel shameful experiences as compared to neutral experiences in both normal sleepers and insomnia disorder. In normal sleepers, reliving of shameful experiences from the past did not elicit a limbic response. In contrast, participants with insomnia disorder recruited overlapping parts of the limbic circuit, in particular the dorsal anterior cingulate cortex, during both new and relived shameful experiences. The differential activity patterns with new and old emotions in normal sleepers suggest that reactivation of the long-term memory trace does not recruit the limbic circuit. The overlap of activations in insomnia disorder is in line with the hypothesis that the disorder involves a deficiency to dissociate the limbic circuit from the emotional memory trace. Moreover, the findings provide further support for a role of the anterior cingulate cortex in insomnia.
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Schalkwijk, F., Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Mutsaerts, H., Talamini, L., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Wassing, R., Schalkwijk, F., Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Mutsaerts, H., ... Van Someren, E. (2019). Haunted by the past: old emotions remain salient in insomnia disorder. Brain, 142(6), 1783–1796. doi: 10.1093/brain/awz089
2-year Impact Factor: 11.337|2019
Times cited: 16|2021-05-21
Indexed document: Yes
Quartile: Q1
Keywords: Self-conscious emotion / Insomnia disorder / Sleep / ACC / Emotional memory

Haunted by the past: old emotions remain salient in insomnia disorder

Haunted by the past: old emotions remain salient in insomnia disorder

DocumentRestless REM sleep impedes overnight amygdala adaptation2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.07
Location: Arquivo PCA - Pasta 25/2012
Title:
Restless REM sleep impedes overnight amygdala adaptation
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S0960982219307614
Abstract/Results: ABSTRACT:
Animal studies show that insufficient silencing of the locus coeruleus (LC) during REM sleep impairs sleep-related brain plasticity. Restless REM sleep, a characteristic of several psychiatric disorders, likely reflects insufficient LC silencing. We investigated whether endogenous REM sleep interruptions interfere with overnight reorganization of limbic circuits in human volunteers with a wide range of insomnia severity, from no insomnia complaints to fulfilling community-sample criteria for insomnia disorder. We induced a self-conscious emotion during two functional MRI sessions and recorded sleep EEG in between. Amygdala reactivity decreased overnight in proportion to the total duration of consolidated REM sleep. Restless REM sleep, in contrast, impeded overnight amygdala adaptation. Using targeted memory reactivation with odors tagged to the self-conscious emotional stimulus, we could experimentally enhance both the favorable effect of consolidated REM sleep and the unfavorable effect of restless REM sleep. The findings reveal a maladaptive type of sleep, providing a target for interventions in mental disorders characterized by restless REM sleep.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Schalkwijk, F., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Wassing, R., Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Schalkwijk, F., & Van Someren, E. (2019). Restless REM sleep impedes overnight amygdala adaptation. Current Biology, 29(14), 2351-2358.e4. doi: 10.1016/j.cub.2019.06.034
2-year Impact Factor: 9.601|2019
Times cited: 24|2021-05-21
Indexed document: Yes
Quartile: Q1
Keywords: REM sleep fragmentation / Amygdala / Memory reactivation / Self-conscious emotions / Spindles / Transition to REM sleep

DocumentBrain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.08
Location: Arquivo PCA - Pasta 25/2012
Title:
Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S2213158219303699
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probabilistic diffusion tractography to compare the whole-brain structural connectivity networks of people with ID and those of matched controls without sleep complaints.
Diffusion-weighted images and T1-weighed images were acquired in 51 people diagnosed with ID (21–69 years of age, 37 female) and 48 matched controls without sleep complaints (22–70 years of age, 31 female). Probabilistic tractography was performed to construct the whole-brain structural connectivity network of each participant. Case–control differences in connectivity strength and network efficiency were evaluated with permutation tests.
People with ID showed structural hyperconnectivity within a subnetwork that spread over frontal, parietal, temporal, and subcortical regions and was anchored at the right angular gyrus. The result was robust across different edge-weighting strategies. Moreover, converging support was given by the finding of heightened right angular gyrus nodal efficiency (harmonic centrality) across varying graph density in people with ID. Follow-up correlation analyses revealed that subnetwork connectivity was associated with self-reported reactive hyperarousal.
The findings demonstrate that the right angular gyrus is a hub of enhanced structural connectivity in ID. Hyperconnectivity within the identified subnetwork may contribute to increased reactivity to stimuli and may signify vulnerability to ID.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., Foster-Dingleya, J. C.
Document type:
Article-d
Number of reproductions:
1
Reference:
Wei, Y., Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., & Foster-Dingleya, J. C. (2019). Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus. NeuroImage: Clinical, 24: 102019. doi: 10.1016/j.nicl.2019.102019
2-year Impact Factor: 4.350|2019
Impact factor notes: Impact factor not available yet for 2019
Times cited: 4|2021-04-22
Indexed document: Yes
Quartile: Q2
Keywords: Tractography / Diffusion-weighted MRI / Connectome / Angular gyrus / Insomnia disorder / Reactivity

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus

DocumentReduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.09
Location: Arquivo PCA - Pasta 25/2012
Title:
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
Publication year: 2019
URL:
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12953
Abstract/Results: ABSTRACT:
Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2016-190.06
Author: Wei, Y.
Secondary author(s):
Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., Van Someren, E. J. W.
Document type:
Article-d
Number of reproductions:
1
Reference:
Wei, Y., Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., & Van Someren, E. J. W. (2019). Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. Journal of Sleep Research, e12953. doi: 10.1111/jsr.12953
2-year Impact Factor: 3.623|2019
Times cited: 3|2021-05-20
Indexed document: Yes
Quartile: Q2
Keywords: Dynamic functional connectivity / Insomnia disorder / Resting-state functional magnetic resonance imaging / Salience network

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

DocumentIncreased hippocampal-prefrontal functional connectivity in insomnia2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.04
Location: BF-GMS
Title:
Increased hippocampal-prefrontal functional connectivity in insomnia
Publication year: 2018
URL:
https://pubmed.ncbi.nlm.nih.gov/29448003/
Abstract/Results: Abstract
Insomnia Disorder (ID) is the second-most common mental disorder and has a far-reaching impact on
daytime functioning. A meta-analysis indicates that, of all cognitive domains, declarative memory
involving the hippocampus is most affected in insomnia. Hippocampal functioning has consistently
been shown to be sensitive to experimental sleep deprivation. Insomnia however differs from sleep
deprivation in many aspects, and findings on hippocampal structure and function have been
equivocal. The present study used both structural and resting-state functional Magnetic Resonance
Imaging in a larger sample than previously reported to evaluate hippocampal volume and functional
connectivity in ID. Included were 65 ID patients (mean age = 48.3 y ± 14.0, 17 males) and 65 good
sleepers (mean age = 44.1 y ± 15.2, 23 males). Insomnia severity was assessed with the Insomnia
Severity Index (ISI), subjective sleep with the Consensus Sleep Diary (CSD) and objective sleep by
two nights of polysomnography (PSG). Seed-based analysis showed a significantly stronger
connectivity of the bilateral hippocampus with the left middle frontal gyrus in ID than in controls (p =
.035, cluster based correction for multiple comparisons). Further analyses across all participants
moreover showed that individual differences in the strength of this connectivity were associated with
insomnia severity (ISI, r = .371, p = 9.3e-5) and with subjective sleep quality (CSD sleep efficiency, r
= -.307, p = .009) (all p FDR-corrected). Hippocampal volume did not differ between ID and controls.
The findings indicate more severe insomnia and worse sleep quality in people with a stronger
functional connectivity between the bilateral hippocampus and the left middle frontal gyrus, part of a
circuit that characteristically activates with maladaptive rumination and deactivates with sleep.
Accessibility: Document exists in file
Language:
eng
Author:
Leerssen, J.
Secondary author(s):
Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Leerssen, J., Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., & Van Someren, E. (2018). Increased hippocampal-prefrontal functional connectivity in insomnia. Neurobiology of Learning and Memory. doi: 10.1016/j.nlm.2018.02.006
Times cited: 21|2022-03-08
Indexed document: Yes
Quartile: Q2
Keywords: Insomnia / Sleep / Hippocampus / Middle frontal gyrus / Resting-state fMRI / Functional connectivity