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File277 - Cortical excitability and connectivity in the lifespan: a neurophysiological study2015-092019-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-277
Location: BF-GMS
Title:
277 - Cortical excitability and connectivity in the lifespan: a neurophysiological study
Duration: 2015-09 - 2019-06
Researcher(s):
Anna Fertonani, Cornelia Pirulli
Institution(s): IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C., Bollini, A.
Number of reproductions:
1
Keywords:
Aging / Neuroplasticity / Brain stimulation techniques / TMS-EEG / Psychophysiology
DocumentFinal report - Cortical excitability and connectivity in the lifespan: a neurophysiological study2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-277
Location: BF-GMS
Title:
277 - Cortical excitability and connectivity in the lifespan: a neurophysiological study
Duration: 2015-09 - 2019-06
Researcher(s):
Anna Fertonani, Cornelia Pirulli
Institution(s): IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C., Bollini, A.
Number of reproductions:
1
Keywords:
Aging / Neuroplasticity / Brain stimulation techniques / TMS-EEG / Psychophysiology

Reference code: PT/FB/BL-2014-277.01
Location: BF-GMS
Title:
Final report - Cortical excitability and connectivity in the lifespan: a neurophysiological study
Publication year: 2019
Abstract/Results:
ABSTRACT:
BACKGROUND AND AIM
Transcranial electrical stimulation (tES) seemS a promising technique to improve learning in young and elderly healthy subjects, but its mechanisms of action are not well understood. Here, we aim to demonstrate how tES in combination with a perceptual learning (PL) paradigm modulates cortical excitability and performance in young healthy subjects. Moreover, we want to explore behavioral and neurophysiological tES effects in PL in healthy aging to investigate modifications in cortical excitability and connectivity in the lifespan. Finally, we aim to highlight correlations between excitability, connectivity and behavioral performance.
METHOD
Healthy young (N=45) and elderly (N=36) subjects performed a PL task, before, during and after tES (1.5 mA over Oz) in three stimulation conditions: transcranial random noise stimulation - tRNS, anodal transcranial direct current stimulation - atDCS, sham. TMS-EEG coregistration preceded and followed the PL+tES.
RESULTS
In young, tRNS abolished the behavioral learning effect observed in the sham condition, while A-tDCS had no effect. In elderly, no effect of stimulation was found. The analysis of TMS evoked potentials (TEPs) showed a pre-post modulation in both the age groups (central cluster, ~90-140ms), regardless of the stimulation condition.
CONCLUSIONS
Neurophysiological results (TEPs) suggest that young and elderly have a different baseline visual system connectivity, which may influence tES effects. The presence of neuromodulation effects only in young subjects add evidences about the inadequacy of the young brain as a model to test the effect of tES, when the interest is in developing protocols of stimulation efficacious in aging.
Accessibility: Document exists in file
Language:
eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C.
Document type:
Final report
Number of reproductions:
1
Reference:
Fertonani, A., & Pirulli, C. (2019). Final report - Cortical excitability and connectivity in the lifespan: a neurophysiological study.
Indexed document: No
Keywords: Aging / Neuroplasticity / Brain stimulation techniques / Neuromodulation / TMS-EEG

Final report - Cortical excitability and connectivity in the lifespan: a neurophysiological study

Final report - Cortical excitability and connectivity in the lifespan: a neurophysiological study
DocumentTranscranial electrical stimulation: What we know and do not know about mechanisms2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-277
Location: BF-GMS
Title:
277 - Cortical excitability and connectivity in the lifespan: a neurophysiological study
Duration: 2015-09 - 2019-06
Researcher(s):
Anna Fertonani, Cornelia Pirulli
Institution(s): IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C., Bollini, A.
Number of reproductions:
1
Keywords:
Aging / Neuroplasticity / Brain stimulation techniques / TMS-EEG / Psychophysiology

Reference code: PT/FB/BL-2014-277.02
Location: BF-GMS
Title:
Transcranial electrical stimulation: What we know and do not know about mechanisms
Publication year: 2017
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405830/
Abstract/Results: ABSTRACT:
In recent years, there has been remarkable progress in the understanding and practical use of transcranial electrical stimulation (tES) techniques. Nevertheless, to date, this experimental effort has not been accompanied by substantial reflections on the models and mechanisms that could explain the stimulation effects. Given these premises, the aim of this article is to provide an updated picture of what we know about the theoretical models of tES that have been proposed to date, contextualized in a more specific and unitary framework. We demonstrate that these models can explain the tES behavioral effects as distributed along a continuum from stimulation dependent to network activity dependent. In this framework, we also propose that stochastic resonance is a useful mechanism to explain the general online neuromodulation effects of tES. Moreover, we highlight the aspects that should be considered in future research. We emphasize that tES is not an "easy-to-use" technique; however, it may represent a very fruitful approach if applied within rigorous protocols, with deep knowledge of both the behavioral and cognitive aspects and the more recent advances in the application of stimulation.
Accessibility: Document exists in file
Language:
eng
Author:
Fertonani, A.
Secondary author(s):
Miniussi, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
3
Reference:
Fertonani, A., & Miniussi, C. (2017). Transcranial electrical stimulation: What we know and do not know about mechanisms. Neuroscientist, 23(2), 109-123. https://doi.org/10.1177/1073858416631966
2-year Impact Factor: 7.461|2017
Times cited: 261|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: NIBS / Cognition / Models / Neuroenhancement / Neuromodulation / Noninvasive brain stimulation / Stochastic resonance / tACS / tDCS / tES / tRNS

Transcranial electrical stimulation: What we know and do not know about mechanisms

Transcranial electrical stimulation: What we know and do not know about mechanisms
DocumentAge-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-277
Location: BF-GMS
Title:
277 - Cortical excitability and connectivity in the lifespan: a neurophysiological study
Duration: 2015-09 - 2019-06
Researcher(s):
Anna Fertonani, Cornelia Pirulli
Institution(s): IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C., Bollini, A.
Number of reproductions:
1
Keywords:
Aging / Neuroplasticity / Brain stimulation techniques / TMS-EEG / Psychophysiology

Reference code: PT/FB/BL-2014-277.03
Location: BF-GMS
Title:
Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0197458019302118
Abstract/Results: ABSTRACT:
Transcranial electrical stimulation (tES) is a potentially viable tool for boosting cognitive performance in aging. However, most knowledge on tES effects is based on studies involving young adults. Here, we applied tES (transcranial random noise stimulation [tRNS] as an effective stimulation and anodal transcranial direct current stimulation [atDCS] as a “control” stimulation) to the visual cortex during visual perceptual learning (VPL) in healthy young and older individuals. Moreover, we measured transcranial magnetic stimulation–evoked potentials to investigate the neurophysiological underpinnings of tES effects. We found that only the tRNS in the young, but not in the older, subjects modulated VPL, by decreasing performance. Transcranial magnetic stimulation–evoked potentials revealed age-related changes in connectivity, that is, a stronger activation of the prefrontal cortex after visual cortex stimulation, and a stronger modulation of the prefrontal cortex after VPL in the older subjects. These results may indicate that task performance in older adults relies on the recruitment of a wider network and a crucial contribution of the anterior portion of the brain, which may dramatically influence tES effects in aging.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Fertonani, A.
Secondary author(s):
Pirulli, C., Bollini, A., Miniussi, C., Bortoletto, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Fertonani, A., Pirulli, C., Bollini, A., Miniussi, C., & Bortoletto, M. (2019). Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation. Neurobiology of Aging, 82, 77-87. https://doi.org/10.1016/j.neurobiolaging.2019.07.009
2-year Impact Factor: 4.347|2019
Impact factor notes: Impact factor not available yet for 2019
Times cited: 9|2024-02-12
Indexed document: Yes
Quartile: Q1
Keywords: Learning / TMS-EEG / Visual cortex / Connectivity / Plasticity / Noninvasive brain stimulation