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File389 - Demixing and visualizing neural population activity in higher cortical areas2015-012017-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology
DocumentFinal report - Demixing and visualizing neural population activity in higher cortical areas2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.01
Location: BF-GMS
Title:
Final report - Demixing and visualizing neural population activity in higher cortical areas
Publication year: 2017
URL:
https://www.bial.com/imagem/Bolsa%2038914.pdf
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. In this project we developed and demonstrated advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyzed population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a
single figure.
This project also involved some additional work on dimensionality reduction of electrophysiological datasets, including data from auditory cortex and from input areas to dopaminergic system in rats.
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Auditory cortex

Final report - Demixing and visualizing neural population activity in higher cortical areas

Final report - Demixing and visualizing neural population activity in higher cortical areas
DocumentDemixed principal component analysis of neural population data2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.02
Location: BF-GMS
Title:
Demixed principal component analysis of neural population data
Publication year: 2016
URL:
https://elifesciences.org/content/5/e10989
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we demonstrate the advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a single figure.
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z. F., Qi, X.-L., Romo, R., Uchida, N., Machens, C. K.
Document type:
Article
Number of reproductions:
1
Percentiles:
3
Reference:
Kobak, D., Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z. F., Qi, X.-L., Romo, R., Uchida, N., & Machens, C. K. (2016). Demixed principal component analysis of neural population data. eLife 5, e10989. https://doi.org/10.7554/eLife.10989.001
2-year Impact Factor: 7.725|2016
Times cited: 240|2024-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Auditory cortex

Demixed principal component analysis of neural population data

Demixed principal component analysis of neural population data
DocumentDistributed and mixed information in monosynaptic inputs to dopamine neurons2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.03
Location: BF-GMS
Title:
Distributed and mixed information in monosynaptic inputs to dopamine neurons
Publication year: 2016
URL:
https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(16)30510-4
Abstract/Results: ABSTRACT:
Dopamine neurons encode the difference between actual and predicted reward, or reward prediction error (RPE). Although many models have been proposed to account for this computation, it has been difficult to test these models experimentally. Here we established an awake electrophysiological recording system, combined with rabies virus and optogenetic cell-type identification, to characterize the firing patterns of monosynaptic inputs to dopamine neurons while mice performed classical conditioning tasks. We found that each variable required to compute RPE, including actual and predicted reward, was distributed in input neurons in multiple brain areas. Further, many input neurons across brain areas signaled combinations of these variables. These results demonstrate that even simple arithmetic computations such as RPE are not localized in specific brain areas but, rather, distributed across multiple nodes in a brain-wide network. Our systematic method to examine both activity and connectivity revealed unexpected redundancy for a simple computation in the brain.
Accessibility: Document exists in file
Language:
eng
Author:
Tian, J.
Secondary author(s):
Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., Watabe-Uchida, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) Distributed and mixed information in monosynaptic inputs to dopamine neurons. Neuron, 91(6), 1374-1389. https://doi.org/10.1016/j.neuron.2016.08.018
2-year Impact Factor: 14.024|2016
Times cited: 126|2024-02-07
Indexed document: Yes
Quartile: Q1
DocumentGeometry and state-dependence of sound representations in rat auditory cortex2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.04
Location: BF-GMS
Title:
Geometry and state-dependence of sound representations in rat auditory cortex
Publication year: 2016
Contents:
http://areadne.org/2016/pezaris-hatsopoulos-2016-areadne.pdf
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Pardo-Vazquez, J., Valente, M., Machens, C. , Renart, A.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Kobak, D., Pardo-Vazquez, J., Valente, M., Machens, C. , & Renart, A. (2016). Geometry and state-dependence of sound representations in rat auditory cortex. In J. S. Pezaris, N. G. Hatsopoulos (Eds), Proceedings of AREADNE 2016, Santorini, Greece, 22-26 June 2016 (p. 84). Cambridge, Massachusetts, USA: The AREADNE Foundation. http://areadne.org
Indexed document: No
DocumentConstraints on the accuracy of auditory discriminations in rats2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.05
Location: BF-GMS
Title:
Constraints on the accuracy of auditory discriminations in rats
Publication year: 2016
URL:
http://cosyne.org/cosyne16/Cosyne2016_program_book.pdf
Abstract/Results: ABSTRACT:
Does variability of sensory neurons constrain the accuracy of perception? This question has vexed researchers for decades. Answering it requires making sure that an animal’s behavioral accuracy in a sensory discrimination task is exclusively limited by sensory factors, something which to the best of our knowledge has not yet been shown in rodents. Here we first provide evidence that this is the case in a 2AFC inter-aural level difference (ILD) discrimination task in rats. We show that, in this task, behavioral accuracy cannot be improved by manipulations of motivation, and that accuracy is unaffected by past trials in most subjects. Given that performance is apparently Limited by ‘sensory noise’, we then studied the structure of neural variability in auditory cortex. As a first step in this direction, we have quantified neural variability in the absence of behavior. Specifically, we simultaneously recorded the evoked responses of large neural populations (N  100) from the auditory cortex of rats under urethane anesthesia, using the same set of stimuli as in the ILD discrimination task. We made three key observations: (1) although approximately half of the neurons are ILD-selective, single-cell neurometric functions systematically underperform compared to behavior, except for < 1% of the neurons. (2) Population-level neurometric functions can match behavioral performance, but show a strong brain-state dependence, with performance increasing with the level of desynchronization. Finally, we show that this brain-state dependence arises from a reorganization of where signal and noise reside in the high-dimensional space of population firing rates. Our results establish a behavioral paradigm in rats for the investigation of a long-standing question in neuroscience, and constitute one of the first empirical investigations of the relationship between neural variability and behavioral accuracy at the population level.
Accessibility: Document exists in file
Language:
eng
Author:
Renart, A.
Secondary author(s):
Valente, M., Kobak, D., Machens, C., Pardo-Vazquez, J.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Renart, A., Valente, M., Kobak, D., Machens, C., & Pardo-Vazquez, J. (2016). Constraints on the accuracy of auditory discriminations in rats. In Abstract Book of the Computational and Systems Neuroscience (Cosyne) 2016, February 25 - 28 (p. 52). Salt Lake City, USA.
Indexed document: No

Constraints on the accuracy of auditory discriminations in rats

Constraints on the accuracy of auditory discriminations in rats
DocumentDemixed principal component analysis of neural population data2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.06
Location: BF-GMS
Title:
Demixed principal component analysis of neural population data
Publication year: 2015
URL:
http://www.gatsby.ucl.ac.uk/nccd/nccd15/abstracts/kobak.html
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we present a dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the neural representation in terms of task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes all the relevant features of the population response in a single figure. In addition, dPCA highlights several important and seemingly universal features of the population activity in prefrontal cortex; e.g. that most of the neural activity is not related to any of the controlled task parameters, such as stimuli or decision; or that there are no well-separated functional clusters of cells.
Accessibility: Document does not exist in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z., Romo, R., Qi, X.-L., Uchida, N., Machens, C.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Kobak, D., Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., ..., Machens, C. (2015, August-September). Demixed principal component analysis of neural population data. Poster presented at Neural Coding, Computation and Dynamics (NCCD), Bilbao, Spain.
Indexed document: No
Keywords: Principal Component Analysis / Population activity / Prefrontal cortex / Dimensionality reduction / Auditory cortex
DocumentState-dependent geometry of population activity in rat auditory cortex2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.07
Location: BF-GMS
Title:
State-dependent geometry of population activity in rat auditory cortex
Publication year: 2019
URL:
https://elifesciences.org/articles/44526
Abstract/Results: ABSTRACT:
The accuracy of the neural code depends on the relative embedding of signal and noise in the activity of neural populations. Despite a wealth of theoretical work on population codes, there are few empirical characterizations of the high-dimensional signal and noise subspaces. We studied the geometry of population codes in the rat auditory cortex across brain states along the activation-inactivation continuum, using sounds varying in difference and mean level across the ears. As the cortex becomes more activated, single-hemisphere populations go from preferring contralateral loud sounds to a symmetric preference across lateralizations and intensities, gain-modulation effectively disappears, and the signal and noise subspaces become approximately orthogonal to each other and to the direction corresponding to global activity modulations. Level-invariant decoding of sound lateralization also becomes possible in the active state. Our results provide an empirical foundation for the geometry and state-dependence of cortical population codes.
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Pardo-Vazquez, J. L., Valente, M., Machens, C. K., Renart, A.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Kobak, D., Pardo-Vazquez, J. L., Valente, M., Machens, C. K., & Renart, A. (2019). State-dependent geometry of population activity in rat auditory cortex. eLife, 8: e44526. https://doi.org/10.7554/eLife.44526
2-year Impact Factor: 7.080|2019
Times cited: 7|2024-02-12
Indexed document: Yes
Quartile: Q1

State-dependent geometry of population activity in rat auditory cortex

State-dependent geometry of population activity in rat auditory cortex