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File413 - The role of dopamine in behavioral exploration and action selection2015-032018-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology
DocumentVolitional modulation of primary visual cortex activity requires the basal ganglia2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.02
Location: BF-GMS
Title:
Volitional modulation of primary visual cortex activity requires the basal ganglia
Publication year: 2018
URL:
https://www.sciencedirect.com/science/article/pii/S089662731830076X#ack0010
Abstract/Results: ABSTRACT:
Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Neely, R.
Secondary author(s):
Koralek, A., Athalye, V. R., Costa, R. M., Carmena, J. M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Neely, R., Koralek, A., Athalye, V. R., Costa, R. M., & Carmena, J. M. (2018). Volitional modulation of primary visual cortex activity requires the basal ganglia. Neuron, 97(6),1356–1368.e4. https://doi.org/10.1016/j.neuron.2018.01.051
2-year Impact Factor: 14.403|2018
Times cited: 25|2024-02-09
Indexed document: Yes
Quartile: Q1
Keywords: Brain-machine interface / Visual cortex / Striatum / Learning / Optogenetics / Instrumental conditioning
DocumentFinal report - The role of dopamine in behavioral exploration and action selection2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.01
Location: BF-GMS
Title:
Final report - The role of dopamine in behavioral exploration and action selection
Publication year: 2018
URL:
https://www.bial.com/imagem/Grant_41314.pdf
Abstract/Results: ABSTRACT:
We are constantly faced with the trade-off between exploiting past actions with known outcomes and exploring novel actions whose outcomes may be better. This exploration-exploitation balance is thought to be influenced by dopaminergic neurons of the substantia nigra pars compacta (SNc) and noradrenergic neurons of the locus coeruleus (LC). However, little is known about SNc and LC network dynamics during exploration. We aimed to characterize dopaminergic and noradrenergic signaling during these distinct behavioral states. We developed a novel behavioral paradigm in mice to investigate exploratory and exploitative behavioural states. Mice were presented with three equidistant nose poke ports and had to explore the environment to discover a sequence of three nose pokes that was rewarded. We then performed calcium imaging in either the SNc or LC of freely behaving mice during performance of this task. Actions were variable as mice explored to find the rewarded sequence, but became stable as they learned to exploit the rewarded sequence. When the rewarded sequence was changed, mice returned to a more variable state. Dopaminergic networks expressed higher levels of sustained activity when mice were exploiting relative to exploring, and these differences could not be accounted for by low-level differences in reward occurrence. Conversely, noradrenergic networks exhibited higher levels of sustained activity when mice were exploring relative to exploiting. These experiments suggest that exploitation is associated with higher sustained levels of dopaminergic activity and lower sustained levels or noradrenergic activity, with potentially important consequences for downstream circuits.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Dopamine / Exploration / Action selection / Basal ganglia

Final report - The role of dopamine in behavioral exploration and action selection

Final report - The role of dopamine in behavioral exploration and action selection
DocumentDopaminergic network dynamics during behavioral exploration 2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.03
Location: BF-GMS
Title:
Dopaminergic network dynamics during behavioral exploration
Publication year: 2016
Abstract/Results:
ABSTRACT:
We are constantly faced with the trade-off between exploiting past actions with known outcomes and exploring novel actions whose outcomes may be better. When environmental rewards are stable, it is preferable to perform actions known to be rewarding. However, when environmental rewards are changeable, it is adaptive to explore alternative actions and revisit previous actions whose value may have changed. This exploration-exploitation balance is thought to be coded by dopaminergic neurons of the substantia nigra pars compacta (SNc). However, little is known about the ways in which environmental changes impact action selection, and even less is known about SNc network dynamics during exploration. We developed a novel behavioral paradigm in mice to investigate how changes in environmental stability affect behavioral variability. Mice were placed in environments with three equidistant nose poke ports and had to explore the environment to discover which sequence of three nose pokes was rewarded. Actions were variable as mice explored to find the rewarded sequence, but became stable as they learned to exploit the rewarded sequence. We then performed calcium imaging in freely behaving mice during task performance, which allowed us to simultaneously record activity in large populations of genetically-identified neurons and track the same populations throughout training. We saw an evolution of single-cell responses associated with task-relevant events over the course of learning. In addition, we observed changes in SNc network dynamics during periods of exploration versus periods of exploitation. These experiments support a role for dopaminergic networks in behavioral exploration.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Koralek, A. C., & Costa, R. M. (2016). Dopaminergic network dynamics during behavioral exploration. Poster presented at the Annual meeting of the Society for Neuroscience 2016, San Diego, CA. Abstract retrieved at http://www.abstractsonline.com/pp8/index.html#!/4071/presentation/29642
Indexed document: No
Keywords: Dopamine / Exploration / Exploitation
DocumentDopaminergic network dynamics during behavioral exploration2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.04
Location: BF-GMS
Title:
Dopaminergic network dynamics during behavioral exploration
Publication year: 2016
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=0ahUKEwiVpfvo8dXbAhXJPBQKHXqjBm8QFgg9MAM&url=http%3A%2F%2Fareadne.org%2F2016%2Fpezaris-hatsopoulos-2016-areadne.pdf&usg=AOvVaw0R4Q3L9_gZpmO16OyVV1HH
Accessibility: Document exist in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Koralek, A. C., & Costa, R. M. (2016). Dopaminergic network dynamics during behavioral exploration. in Pezaris , J. S. & Hatsopoulos, N. G. (Eds.), AREADNE Research in Encoding and Decoding of Neural Ensembles, Nomikos Conference Centre Santorini, Greece, 22-26 June 2016 (p. 85). Cambridge, Massachusetts, USA: The AREADNE Foundation, Inc.
Indexed document: No
Keywords: Dopamine / Exploration

Dopaminergic network dynamics during behavioral exploration

Dopaminergic network dynamics during behavioral exploration
DocumentDichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states 2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.05
Location: BF-GMS
Title:
Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states
Publication year: 2021
URL:
https://advances.sciencemag.org/content/7/30/eabh2059
Abstract/Results: ABSTRACT:
The balance between exploiting known actions and exploring alternatives is critical for survival and hypothesized to rely on shifts in neuromodulation. We developed a behavioral paradigm to capture exploitative and exploratory states and imaged calcium dynamics in genetically identified dopaminergic and noradrenergic neurons. During exploitative states, characterized by motivated repetition of the same action choice, dopamine neurons in SNc encoding movement vigor showed sustained elevation of basal activity that lasted many seconds. This sustained activity emerged from longer positive responses, which accumulated during exploitative action-reward bouts, and hysteretic dynamics. Conversely, noradrenergic neurons in LC showed sustained inhibition of basal activity due to the accumulation of longer negative responses in LC. Chemogenetic manipulation of these sustained dynamics revealed that dopaminergic activity mediates action drive, whereas noradrenergic activity modulates choice diversity. These data uncover the emergence of sustained neural states in dopaminergic and noradrenergic networks that mediate dissociable aspects of exploitative bouts.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Koralek, A. C., & Costa, R. M. (2021). Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states. Science Advances, 7(30): eabh2059. https://doi.org/10.1126/sciadv.abh2059
2-year Impact Factor: 14.980|2021
Times cited: 3|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Dopamine / Exploration / Action selection / Basal ganglia