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File030 - Exploring the neural basis of motivation2017-012020-03

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology
DocumentImpairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.02
Location: BF-GMS
Title:
Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits
Publication year: 2017
URL:
https://elifesciences.org/articles/25843
Abstract/Results: ABSTRACT:
Ventral tegmental area (VTA) activity is critical for reward/reinforcement and is tightly modulated by the laterodorsal tegmentum (LDT). In utero exposure to glucocorticoids (iuGC) triggers prominent motivation deficits but nothing is known about the impact of this exposure in the LDT-VTA circuit. We show that iuGC-rats have long-lasting changes in cholinergic markers in the LDT, together with a decrease in LDT basal neuronal activity. Interestingly, upon LDT stimulation, iuGC animals present a decrease in the magnitude of excitation and an increase in VTA inhibition, as a result of a shift in the type of cells that respond to the stimulus. In agreement with LDT-VTA dysfunction, we show that iuGC animals present motivational deficits that are rescued by selective optogenetic activation of this pathway. Importantly, we also show that LDT-VTA optogenetic stimulation is reinforcing, and that iuGC animals are more susceptible to the reinforcing properties of LDT-VTA stimulation.
Accessibility: Document exists in file
Language:
eng
Author:
Coimbra, B.
Secondary author(s):
Soares-Cunha, C., Borges, S., Vasconcelos, N. A., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Coimbra, B., Soares-Cunha, C., Borges, S., Vasconcelos, N. A., Sousa, N., & Rodrigues, A. J. (2017). Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits. eLife, 6: e25843. https://doi.org/10.7554/eLife.25843
2-year Impact Factor: 7.616|2017
Times cited: 12|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Electrophysiology / Laterodorsal tegmentum / Motivation / Neuroscience / Optogenetics / Rat / Reward / Ventral tegmental area

Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits

Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits
DocumentNucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.03
Location: BF-GMS
Title:
Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957524/
Abstract/Results: ABSTRACT:
The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement. To answer this question, in this work we combined optogenetic modulation of D2-MSNs with in loco pharmacological delivery of specific neurotransmitter antagonists in rats. First, we showed that optogenetic activation of D2-MSNs increases motivation in a progressive ratio (PR) task. We demonstrated that this behavioral effect relies on cholinergic-dependent modulation of dopaminergic signalling of ventral tegmental area (VTA) terminals, which requires D1R and D2R signalling in the NAc. D2-MSN optogenetic activation decreased ventral pallidum (VP) activity, reducing the inhibitory tone to VTA, leading to increased dopaminergic activity. Importantly, optogenetic activation of D2-MSN terminals in the VP was sufficient to recapitulate the motivation enhancement. In summary, our data suggests that optogenetic stimulation of NAc D2-MSNs indirectly modulates VTA dopaminergic activity, contributing for increased motivation. Moreover, both types of dopamine receptors signalling in the NAc are required in order to produce the positive behavioral effects.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Soares-Cunha, C., Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., & Rodrigues, A. J. (2018). Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation. eNeuro, 5(2), e0386-18. https://doi.org/10.1523/ENEURO.0386-18.2018
2-year Impact Factor: 3.544|2019
Impact factor notes: Impact factor computed since 2019
Times cited: 47|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Basal ganglia / Medium spiny neurons / Motivation / Nucleus accumbens / Optogenetics / Reward

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
DocumentNucleus accumbens medium spiny neurons subtypes signal both reward and aversion2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.04
Location: BF-GMS
Title:
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Publication year: 2020
URL:
https://www.nature.com/articles/s41380-019-0525-y
Abstract/Results: ABSTRACT:
Deficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression
and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the
reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-
expressing medium spiny neurons (D1-MSNs) convey reward signals, while dopamine receptor D2-expressing MSNs (D2-
MSNs) encode aversion. Here, we show that both MSN subpopulations can drive reward and aversion, depending on their
neuronal stimulation pattern. Brief D1- or D2-MSN optogenetic stimulation elicited positive reinforcement and enhanced
cocaine conditioning. Conversely, prolonged activation induced aversion, and in the case of D2-MSNs, decreased cocaine
conditioning. Brief stimulation was associated with increased ventral tegmenta area (VTA) dopaminergic tone either directly
(for D1-MSNs) or indirectly via ventral pallidum (VP) (for D1- and D2-MSNs). Importantly, prolonged stimulation of either
MSN subpopulation induced remarkably distinct electrophysiological effects in these target regions. We further show that
blocking ?-opioid receptors in the VTA (but not in VP) abolishes the behavioral effects induced by D1-MSN prolonged
stimulation. In turn, blocking d-opioid receptors in the VP (but not in VTA) blocks the behavioral effects elicited by D2-
MSN prolonged stimulation. Our findings demonstrate that D1- and D2-MSNs can bidirectionally control reward and
aversion, explaining the existence of controversial studies in the field, and highlights that the proposed striatal functional
opposition needs to be reconsidered.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Vasconcelos, N., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., Gaspar, R., Sotiropoulos, I., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Vasconcelos, N., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., ... Rodrigues, A. J. (2020). Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular Psychiatry, 25(12), 3241-3255. https://doi.org/10.1038/s41380-019-0484-3
2-year Impact Factor: 15.992|2020
Times cited: 98|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Reward

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
DocumentRole of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.05
Location: BF-GMS
Title:
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
Publication year: 2019
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742663/
Abstract/Results: ABSTRACT:
The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Coimbra, B.
Secondary author(s):
Soares-Cunha, C., Vasconcelos, N. A. P. , Domingues, A. V., Borges, S., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Coimbra, B., Soares-Cunha, C., Vasconcelos, N. A. P., Domingues, A. V., Borges, S., Sousa, N., & Rodrigues, A. J. (2019). Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature Communications, 10: 4138. https://doi.org/10.1038/s41467-019-11557-3
2-year Impact Factor: 12.121|2019
Times cited: 26|2024-02-12
Indexed document: Yes
Quartile: Q1
Keywords: Motivation / Neural circuits / Reward

Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
DocumentFinal report - Exploring the neural basis of motivation2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.01
Location: BF-GMS
Title:
Final report - Exploring the neural basis of motivation
Publication year: 2020
URL:
https://www.bial.com/media/3214/exploring-the-neural-basis-of-motivation.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Optimal decision-making requires that individuals evaluate the costs and benefits of potential choices and this is highly dependent on the value attributed to the outcome but also individual motivational status. Evidence in both animal models and humans has highlighted the nucleus accumbens (NAc) as a core brain region in the neural circuitry underlying motivation. One anatomical study has shown that the laterodorsal tegmentum (LDT) directly projects to the NAc, though the nature and biological role of such connections remains completely unknown.
AIMS:
Determine the role of the LDT-NAc network in the modulation of motivation.
METHOD:
We performed a detailed characterization of the LDT-NAc rodent circuit using viral transynaptic markers and in vivo electrophysiological recordings. We also used optogenetics to modulate LDT-NAc different types of projections and evaluate their impact in motivation in rodents.
RESULTS:
Our results show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms in rodents.
CONCLUSIONS:
These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Rodrigues, A. J.
Document type:
Final report
Number of reproductions:
1
Reference:
Rodrigues, A. J. (2020). Final report - Exploring the neural basis of motivation.
Indexed document: No
Keywords: Motivation / Neuronal circuits / Nucleus accumbens / Laterodorsal tegmentum

Final report - Exploring the neural basis of motivation

Final report - Exploring the neural basis of motivation
DocumentMild prenatal stress causes emotional and brain structural modifications in rats of both sexes2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.06
Location: BF-GMS
Title:
Mild prenatal stress causes emotional and brain structural modifications in rats of both sexes
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00129/full
Abstract/Results: ABSTRACT:
Stress or high levels of glucocorticoids (GCs) during developmental periods is known to induce persistent effects in the neuroendocrine circuits that control stress response, which may underlie individuals' increased risk for developing neuropsychiatric conditions later in life, such as anxiety or depression. We developed a rat model (Wistar han) of mild exposure to unpredictable prenatal stress (PS), which consists in a 4-h stressor administered three times per week on a random basis; stressors include strobe lights, noise and restrain. Pregnant dams subjected to this protocol present disrupted circadian corticosterone secretion and increased corticosterone secretion upon acute stress exposure. Regarding progeny, both young adult (2 months old) male and female rats present increased levels of circulating corticosterone and hyperactivity of the hypothalamus-pituitary-adrenal axis to acute stress exposure. Both sexes present anxious- and depressive-like behaviors, shown by the decreased time spent in the open arms of the elevated plus maze (EPM) and in the light side of the light-dark box (LDB), and by increased immobility time in the forced swim test, respectively. Interestingly, these results were accompanied by structural modifications of the bed nucleus of stria terminalis (BNST) and hippocampus, as well as decreased norepinephrine and dopamine levels in the BNST, and serotonin levels in the hippocampus. In summary, we characterize a new model of mild PS, and show that stressful events during pregnancy can lead to long-lasting structural and neurochemical effects in the offspring, which affect behavior in adulthood.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Coimbra, B., Borges, S., Domingues, A. V., Silva, D.,, Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Coimbra, B., Borges, S., Domingues, A. V., Silva, D., Sousa, N., & Rodrigues, A. J. (2018). Mild prenatal stress causes emotional and brain structural modifications in rats of both sexes. Frontiers in Behavioral Neuroscience, 12, 129. https://doi.org/10.3389/fnbeh.2018.00129
2-year Impact Factor: 2.622|2018
Times cited: 50|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Prenatal stress / Anxiety / Depression / BNST / Hippocampus

Mild prenatal stress causes emotional and brain structural modifications in rats of both sexes

Mild prenatal stress causes emotional and brain structural modifications in rats of both sexes
DocumentResilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.07
Location: BF-GMS
Title:
Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S2352289521000102
Abstract/Results: ABSTRACT:
Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders.
Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk labour in order to promote fetal lung maturation. Recently, we reported long-lasting differences in microglia morphology in a model of in utero exposure to DEX (iuDEX), that presents an anxious phenotype. However, it is still unclear if stress differentially affects iuDEX males and females.
In this work, we evaluated how iuDEX animals of both sexes cope with chronic mild stress for 2 weeks. We evaluated emotional behavior and microglia and neuronal morphology in the dorsal hippocampus (dHIP) and nucleus accumbens (NAc), two brain regions involved in emotion-related disorders. We report that males and females prenatally exposed to DEX have better performance in anxiety- and depression-related behavioral tests after chronic stress exposure in adulthood than non-exposed animals. Interestingly, iuDEX animals present sex-dependent changes in microglia morphology in the dHIP (hypertrophy in females) and in the NAc (atrophy in females and hypertrophy in males). After chronic stress, these cells undergo sex-specific morphological remodeling. Paralleled to these alterations in cytoarchitecture of microglia, we report inter-regional differences in dendritic morphology in a sex-specific manner. iuDEX females present fewer complex neurons in the NAc, whereas iuDEX males presented less complex neuronal morphology in the dHIP. Interestingly, these alterations were modified by stress exposure.
Our work shows that stressful events during pregnancy can exert a preserved sex-specific effect in adulthood. Although the role of the observed cellular remodeling is still unknown, sex-specific differences in microglia plasticity induced by long-term stress exposure may anticipate differences in drug efficacy in the context of stress-induced anxiety- or depression-related behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Gaspar, R.
Secondary author(s):
Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., Gomes, C. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Gaspar, R., Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., & Gomes, C. A. (2021). Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia. Neurobiology of Stress, 14, 100302. https://doi.org/10.1016/j.ynstr.2021.100302
2-year Impact Factor: 7.142|2021
Times cited: 20|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Prenatal stress / Chronic stress / Microglia morphology / Sex / Nucleus accumbens / Dorsal hippocampus

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia
DocumentCriticality between cortical states2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.08
Location: BF-GMS
Title:
Criticality between cortical states
Publication year: 2019
URL:
https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.122.208101
Abstract/Results: ABSTRACT:
Since the first measurements of neuronal avalanches, the critical brain hypothesis has gained traction. However, if the brain is critical, what is the phase transition? For several decades, it has been known that the cerebral cortex operates in a diversity of regimes, ranging from highly synchronous states (with higher spiking variability) to desynchronized states (with lower spiking variability). Here, using both new and publicly available data, we test independent signatures of criticality and show that a phase transition occurs in an intermediate value of spiking variability, in both anesthetized and freely moving animals. The critical exponents point to a universality class different from mean-field directed percolation. Importantly, as the cortex hovers around this critical point, the avalanche exponents follow a linear relation that encompasses previous experimental results from different setups and is reproduced by a model.
Accessibility: Document does not exist in file
Language:
eng
Author:
Fontenele, A. J.
Secondary author(s):
Vasconcelos, N., Feliciano, T., Aguiar, L. A. A., Soares-Cunha, C., Coimbra, B., Dalla Porta, L., Ribeiro, S., Rodrigues, A. J., Sousa, N., Carelli, P. V., Copelli, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
3
Reference:
Fontenele, A. J., Vasconcelos, N., Feliciano, T., Aguiar, L. A. A., Soares-Cunha, C., Coimbra, B., Dalla Porta, L., Ribeiro, S., Rodrigues, A. J., Sousa, N., Carelli, P. V., & Copelli, M. (2019). Criticality between cortical states. Physical Review Letters, 122(20): 208101. https://doi.org/10.1103/PhysRevLett.122.208101
2-year Impact Factor: 8.385|2019
Times cited: 123|2024-02-12
Indexed document: Yes
Quartile: Q1
DocumentSignatures of brain criticality unveiled by maximum entropy analysis across cortical states2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.09
Location: BF-GMS
Title:
Signatures of brain criticality unveiled by maximum entropy analysis across cortical states
Publication year: 2020
URL:
https://journals.aps.org/pre/abstract/10.1103/PhysRevE.102.012408
Abstract/Results: ABSTRACT:
It has recently been reported that statistical signatures of brain criticality, obtained from distributions of neuronal avalanches, can depend on the cortical state. We revisit these claims with a completely different and independent approach, employing a maximum entropy model to test whether signatures of criticality appear in urethane-anesthetized rats. To account for the spontaneous variation of cortical states, we parse the time series and perform the maximum entropy analysis as a function of the variability of the population spiking activity. To compare data sets with different numbers of neurons, we define a normalized distance to criticality that takes into account the peak and width of the specific heat curve. We found a universal collapse of the normalized distance to criticality dependence on the cortical state, on an animal by animal basis. This indicates a universal dynamics and a critical point at an intermediate value of spiking variability.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lotfi, N.
Secondary author(s):
Fontenele, A. J., Feliciano, T., Aguiar, L. A. A., de Vasconcelos, N. A. P., Soares-Cunha, C., Coimbra, B., Rodrigues, A. J., Sousa, N., Copelli, M., Carelli, P. V.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Lotfi, N., Fontenele, A. J., Feliciano, T., Aguiar, L. A. A., de Vasconcelos, N. A. P., Soares-Cunha, C., ..., Carelli, P. V. (2020). Signatures of brain criticality unveiled by maximum entropy analysis across cortical states. Physical Review, 102(1): 012408. https://doi.org/10.1103/PhysRevE.102.012408
2-year Impact Factor: 2.529|2020
Times cited: 5|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Neuronal avalanches / Networks / Range
DocumentLaterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.10
Location: BF-GMS
Title:
Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals
Publication year: 2021
URL:
https://onlinelibrary.wiley.com/doi/10.1002/jnr.24931
Abstract/Results: ABSTRACT:
The laterodorsal tegmentum (LDT) is a brainstem nucleus classically involved in REM sleep and attention, and that has recently been associated with reward-related behaviors, as it controls the activity of ventral tegmental area (VTA) dopaminergic neurons, modulating dopamine release in the nucleus accumbens. To further understand the role of LDT-VTA inputs in reinforcement, we optogenetically manipulated these inputs during different behavioral paradigms in male rats. We found that in a two-choice instrumental task, optical activation of LDT-VTA projections shifts and amplifies preference to the laser-paired reward in comparison to an otherwise equal reward; the opposite was observed with inhibition experiments. In a progressive ratio task, LDT-VTA activation boosts motivation, that is, enhances the willingness to work to get the reward associated with LDT-VTA stimulation; and the reverse occurs when inhibiting these inputs. Animals abolished preference if the reward was omitted, suggesting that LDT-VTA stimulation adds/decreases value to the stimulation-paired reward. In addition, we show that LDT-VTA optical activation induces robust preference in the conditioned and real-time place preference tests, while optical inhibition induces aversion. The behavioral findings are supported by electrophysiological recordings and c-fos immunofluorescence correlates in downstream target regions. In LDT-VTA ChR2 animals, we observed an increase in the recruitment of lateral VTA dopamine neurons and D1 neurons from nucleus accumbens core and shell; whereas in LDT-VTA NpHR animals, D2 neurons appear to be preferentially recruited. Collectively, these data show that the LDT-VTA inputs encode positive reinforcement signals and are important for different dimensions of reward-related behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Coimbra, B.
Secondary author(s):
Domingues, A. V., Soares-Cunha, C., Correia, R., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Coimbra, B., Domingues, A. V., Soares-Cunha, C., Correia, R., Pinto, L., Sousa, N., & Rodrigues, A. J. (2021). Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24931
2-year Impact Factor: 4.433|2021
Times cited: 2|2024-02-14
Indexed document: Yes
Quartile: Q2
Keywords: LDT / Motivation / Neuronal circuits / Optogenetics / Reward

Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals

Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals
DocumentDistintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.11
Location: BF-GMS
Title:
Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2211124722001012
Abstract/Results: The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N. & Rodrigues, A. J. (2022). Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports, 38, 7. https://doi.org/10.1016/j.celrep.2022.110380
2-year Impact Factor: 8.800|2022
Times cited: 12|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Ventral pallidum / Reward / Motivation / Medium spiny neurons / D2 / Striatum

Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
DocumentThe duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.12
Location: BF-GMS
Title:
The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia
Publication year: 2022
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940280/
Abstract/Results: Stress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and behavioral responses to chronic stress and also contribute to the development of stress-related psychopathologies. However, little is known about the impact of the duration of stress exposure upon microglia and neurons morphology, particularly considering sex differences. This issue deserves particular investigation, considering that the process of morphologic remodeling of neurons and microglia is usually accompanied by functional changes with behavioral expression. Here, we examine the effects of short and long unpredictable chronic mild stress (uCMS) protocols on behavior, evaluating in parallel microglia and neurons morphology in the dorsal hippocampus (dHIP) and in the nucleus accumbens (NAc), two brain regions involved in the etiology of depression. We report that long-term uCMS induced more behavioral alterations in males, which present anxiety and depression-like phenotypes (anhedonia and helplessness behavior), while females only display anxiety-like behavior. After short-term uCMS, both sexes presented anxiety-like behavior. Microglia cells undergo a process of morphologic adaptation to short-term uCMS, dependent on sex, in the NAc: we observed a hypertrophy in males and an atrophy in females, transient effects that do not persist after long-term uCMS. In the dHIP, the morphologic adaptation of microglia is only observed in females (hypertrophy) and after the protocol of long uCMS. Interestingly, males are more vulnerable to neuronal morphological alterations in a region-specific manner: dendritic atrophy in granule neurons of the dHIP and hypertrophy in the medium spiny neurons of the NAc, both after short- or long-term uCMS. The morphology of neurons in these brain regions were not affected in females. These findings raise the possibility that, by differentially affecting neurons and microglia in dHIP and NAc, chronic stress may contribute for differences in the clinical presentation of stress-related disorders under the control of sex-specific mechanisms.
Accessibility: Document exists in file
Language:
eng
Author:
Gaspar, R.
Secondary author(s):
Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J., Gomes, C. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Gaspar, R., Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J. & Gomes, C. A. (2022). The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia. Frontiers in Behavioral Neuroscience, 16, 834821. https://doi.org/10.3389/fnbeh.2022.834821
2-year Impact Factor: 3.000|2022
Times cited: 4|2024-02-20
Indexed document: Yes
Quartile: Q2
Keywords: Chronic stress / Microglia morphology / Sex differences / Dorsal hippocampus / Nucleus accumbens / Neurons morphology

The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia

The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia
DocumentPerceived stress modulates the activity between the amygdala and the cortex2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.13
Location: BF-GMS
Title:
Perceived stress modulates the activity between the amygdala and the cortex
Publication year: 2022
URL:
https://www.nature.com/articles/s41380-022-01780-8
Abstract/Results: Abstract
The significant link between stress and psychiatric disorders has prompted research on stress’s impact on the brain. Interestingly, previous studies on healthy subjects have demonstrated an association between perceived stress and amygdala volume, although the mechanisms by which perceived stress can affect brain function remain unknown. To better understand what this association entails at a functional level, herein, we explore the association of perceived stress, measured by the PSS10 questionnaire, with disseminated functional connectivity between brain areas. Using resting-state fMRI from 252 healthy subjects spanning a broad age range, we performed both a seed-based amygdala connectivity analysis (static connectivity, with spatial resolution but no temporal definition) and a whole-brain data-driven approach to detect altered patterns of phase interactions between brain areas (dynamic connectivity with spatiotemporal information). Results show that increased perceived stress is directly associated with increased amygdala connectivity with frontal cortical regions, which is driven by a reduced occurrence of an activity pattern where the signals in the amygdala and the hippocampus evolve in opposite directions with respect to the rest of the brain. Overall, these results not only reinforce the pathological effect of in-phase synchronicity between subcortical and cortical brain areas but also demonstrate the protective effect of counterbalanced (i.e., phase-shifted) activity between brain subsystems, which are otherwise missed with correlation-based functional connectivity analysis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Caetano, I.
Secondary author(s):
Ferreira, S., Coelho, A., Amorim, L., Castanho, T. C., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. M., Rodrigues, A. J., Santos, N. C., Morgado, P., Magalhães, R., Picó-Pérez, M., Cabral, J., Sousa, N.
Document type:
Article-d
Number of reproductions:
1
Reference:
Caetano, I., Ferreira, S., Coelho, A., Amorim, L., Castanho, T. C., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. S., Rodrigues, A. J., Santos, N. C., Morgado, P., Magalhães, R., Picó-Pérez, M., Cabral, J., & Sousa, N. (2022). Perceived stress modulates the activity between the amygdala and the cortex. Molecular Psychiatry, 27(12), 4939-4947. https://doi.org/10.1038/s41380-022-01780-8
2-year Impact Factor: 11.000|2022
Times cited: 3|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Predictive markers / Perceived stress / Amygdala / Cortex
DocumentPrenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.14
Location: BF-GMS
Title:
Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates
Publication year: 2022
URL:
https://www.nature.com/articles/s41398-022-02043-4
Abstract/Results: Abstract
Daily, individuals select actions based on cost-benefit to allocate resources into goal-directed actions. Different brain regions coordinate this complex decision, including the nucleus accumbens (NAc), anterior cingulate cortex (ACC), and ventral tegmental area (VTA). In utero exposure to synthetic glucocorticoids (iuGC), such as dexamethasone, triggers prominent motivation deficits but the impact of this exposure in the ACC-NAc and/or ACC-VTA circuits is unknown. Here, we show that iuGC exposure causes decreased motivation for natural rewards (food) and impaired effort-based decision-making. Importantly, reduced neuronal activation (number of c-fos+ neurons) was observed in the NAc core and ACC of iuGC rats in comparison to CTR rats after performing the effort-based decision-making task. In addition, iuGC treatment led to increased NAc and ACC basal neuronal activity. Electrophysiological recordings during optogenetic modulation of ACC terminals in the NAc revealed that the ACC-NAc circuit is dysfunctional in iuGC animals. These data suggest that iuGC animals present motivational and effort-based decision-making deficits that can be associated with the observed ACC-NAc dysfunction.
Accessibility: Document exists in file
Language:
eng
Author:
Domingues, A. V.
Secondary author(s):
Coimbra, B., Correia, R., Deseyve, C., Vieitas-Gaspar, N., Floresco, S., Sousa, N., Soares-Cunha, C., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Domingues, A. V., Coimbra, B., Correia, R., Deseyve, C., Vieitas-Gaspar, N., Floresco, S., Sousa, N., Soares-Cunha, C., & Rodrigues, A. J. (2022). Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates. Translational Psychiatry, 12, 338. https://doi.org/10.1038/s41398-022-02043-4
2-year Impact Factor: 6.800|2022
Times cited: 1|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Anterior cingulate cortex / Functional changes / Decision making
DocumentInvolvement of nucleus accumbens D2-medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.15
Location: BF-GMS
Title:
Involvement of nucleus accumbens D2-medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour
Publication year: 2023
URL:
jpn.ca/content/48/4/E267.long
Abstract/Results: ABSTRACT:
Background: The nucleus accumbens (NAcc) is a crucial brain region for emotionally relevant behaviours. The NAcc is mainly composed of medium spiny neurons (MSNs) expressing either dopamine receptor D1 (D1-MSNs) or D2 (D2-MSNs). The D1-MSNs project to the ventral tegmental area (VTA) and the ventral pallidum (VP), whereas the D2-MSNs project only to the VP. The D1- and D2-MSNs have been associated with depression-like behaviours, but their contribution to anxiety remains to be determined.
Methods: We used optogenetic tools to selectively manipulate D1-MSN projections from the NAcc core to the VP or VTA and D2-MSN projections to the VP during validated anxiety-producing behavioural procedures in naive mice. In addition, we assessed the effects of optical stimulation on neuronal activity using in vivo electrophysiologic recordings in anesthetized animals.
Results: Optogenetic activation of D1-MSN projections to the VTA or VP did not trigger anxiety-like behaviour. However, optical activation of D2-MSN projections to the VP significantly increased anxiety-like behaviour. This phenotype was associated with a decrease in the neuronal activity of putative GABAergic neurons in the VP. Importantly, pretreating D2-MSN–VP animals with the ?-aminobutyric acid modulator diazepam prevented the optically triggered anxiety-like behaviour.
Limitations: The exclusive use of males in the behavioural tests limits broader interpretation of the findings. Although we used optogenetic conditions that trigger quasi-physiologic changes, there are caveats associated with the artificial manipulation of neuronal activity.
Conclusion: The D2-MSN–VP projections contributed to the development of anxiety-like behaviour, through modulation of GABAergic activity in the VP.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2020-175.05
Author: Correia, R.
Secondary author(s):
Coimbra, B., Domingues, A. V., Wezik, M., Vieitas-Gaspar, N., Gaspar, R., Sousa, N., Pinto, L., Rodrigues, A. J., Soares-Cunha, C.
Document type:
Article-d
Number of reproductions:
1
Reference:
Correia, R., Coimbra, B., Domingues, A. V., Wezik, M., Vieitas-Gaspar, N., Gaspar, R., Sousa, N., Pinto, L., Rodrigues, A. J., & Soares-Cunha, C. (2023). Involvement of nucleus accumbens D2-medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour. Journal of Psychiatry & Neuroscience, 48(4), E267–E284. https://doi.org/10.1503/jpn.220111
2-year Impact Factor: 4.1|2023
Times cited: 0|2024-02-16
Indexed document: Yes
Quartile: Q2
Keywords: Nucleus accumbens / Anxiety / Dopaminergic neurons

Involvement of nucleus accumbens D2-medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour

Involvement of nucleus accumbens D2-medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour