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File190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep2017-102019-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology
DocumentIncreased hippocampal-prefrontal functional connectivity in insomnia2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.02
Location: BF-GMS
Title:
Increased hippocampal-prefrontal functional connectivity in insomnia
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S1074742718300194
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is the second-most common mental disorder and has a far-reaching impact on daytime functioning. A meta-analysis indicates that, of all cognitive domains, declarative memory involving the hippocampus is most affected in insomnia. Hippocampal functioning has consistently been shown to be sensitive to experimental sleep deprivation. Insomnia however differs from sleep deprivation in many aspects, and findings on hippocampal structure and function have been equivocal. The present study used both structural and resting-state functional Magnetic Resonance Imaging in a larger sample than previously reported to evaluate hippocampal volume and functional connectivity in ID. Included were 65 ID patients (mean age = 48.3 y ± 14.0, 17 males) and 65 good sleepers (mean age = 44.1 y ± 15.2, 23 males). Insomnia severity was assessed with the Insomnia Severity Index (ISI), subjective sleep with the Consensus Sleep Diary (CSD) and objective sleep by two nights of polysomnography (PSG). Seed-based analysis showed a significantly stronger connectivity of the bilateral hippocampus with the left middle frontal gyrus in ID than in controls (p = .035, cluster based correction for multiple comparisons). Further analyses across all participants moreover showed that individual differences in the strength of this connectivity were associated with insomnia severity (ISI, r = .371, p = 9.3e-5) and with subjective sleep quality (CSD sleep efficiency, r = -.307, p = .009) (all p FDR-corrected). Hippocampal volume did not differ between ID and controls. The findings indicate more severe insomnia and worse sleep quality in people with a stronger functional connectivity between the bilateral hippocampus and the left middle frontal gyrus, part of a circuit that characteristically activates with maladaptive rumination and deactivates with sleep.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2012-253.04
Author: Leerssen, J.
Secondary author(s):
Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., Van Someren, E.
Document type:
Article-d
Number of reproductions:
1
Reference:
Leerssen, J., Wassing, R., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., Perrier, J., Bruijel, J., Foster-Dingley, J. C., Aghajani, M., & Van Someren, E. (2019). Increased hippocampal-prefrontal functional connectivity in insomnia. Neurobiology of Learning and Memory, 160, 144-150. https://doi.org/10.1016/j.nlm.2018.02.006
2-year Impact Factor: 2.768|2019
Impact factor notes: Impact factor not available yet for 2019
Times cited: 38|2024-02-12
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia / Sleep / Hippocampus / Middle frontal gyrus / resting-state fMRI / Functional connectivity
DocumentInsomnia really hurts: Effect of a bad night's sleep on pain increases with insomnia severity2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.03
Location: BF-GMS
Title:
Insomnia really hurts: Effect of a bad night's sleep on pain increases with insomnia severity
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121188/
Abstract/Results: ABSTRACT:
Insomnia and chronic pain are highly prevalent conditions and are often comorbid. Somatic complaints other than pain are also often observed in insomnia. Poor sleep and pain are known to mutually reinforce each other. However, it is unknown whether the habitual severity of insomnia modulates the acute effect of a particularly bad night's sleep on the next day's pain severity, and whether it modulates the acute effect of pain on the following night's sleep quality. Using data from 3,508 volunteers (2,684 female, mean age 50.09 y), we addressed these questions in addition to the associations between the habitual severity of insomnia, somatic complaints, and pain. Results indicated that people suffering from more severe habitual insomnia showed stronger mutual acute within-day reactivity of pain and poor sleep quality. The same increased reactivity was found in people with more severe habitual pain. Interestingly, the acute within-day mutual reactivity of pain and sleep quality showed consistent asymmetry. Pain worsened more after a particularly bad night's sleep than it improved after a particularly good night's sleep. Likewise, sleep worsened more after a day with more-than-usual pain than it improved after a day with less-than-usual pain. Future interventions may profit from addressing this asymmetric mutual reactivity especially in people with severe comorbid insomnia and chronic pain.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Blanken, T. F., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Wei, Y., Blanken, T. F., & Van Someren, E. J. W. (2018). Insomnia really hurts: Effect of a bad night's sleep on pain increases with insomnia severity. Frontiers in Psychiatry, 9: 377. https://doi.org/10.3389/fpsyt.2018.00377
2-year Impact Factor: 3.161|2018
Times cited: 34|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Sleep quality / Pain / Insomnia disorder / Somatic complaints / Symptom dynamics / Reactivity / Sensitization

Insomnia really hurts: Effect of a bad night's sleep on pain increases with insomnia severity

Insomnia really hurts: Effect of a bad night's sleep on pain increases with insomnia severity
DocumentEEG microstates indicate heightened somatic awareness in insomnia: Toward objective assessment of subjective mental content2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.04
Location: BF-GMS
Title:
EEG microstates indicate heightened somatic awareness in insomnia: Toward objective assessment of subjective mental content
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00395/full
Abstract/Results: ABSTRACT:
People with Insomnia Disorder (ID) not only experience abundant nocturnal mentation, but also report altered spontaneous mental content during daytime wakefulness, such as an increase in bodily experiences (heightened somatic awareness). Previous studies have shown that resting-state EEG can be temporally partitioned into quasi-stable microstates, and that these microstates form a small number of canonical classes that are consistent across people. Furthermore, the microstate classes have been associated with individual differences in resting mental content including somatic awareness. To address the hypothesis that altered resting mental content in ID would be reflected in an altered representation of the corresponding EEG microstates, we analyzed resting-state high-density EEG of 32 people with ID and 32 age- and sex-matched controls assessed during 5-min eyes-closed wakefulness. Using data-driven topographical k-means clustering, we found that 5 microstate classes optimally explained the EEG scalp voltage map sequences across participants. For each microstate class, 3 dynamic features were obtained: mean duration, frequency of occurrence, and proportional coverage time. People with ID had a shorter mean duration of class C microstates, and more frequent occurrence of class D microstates. The finding is consistent with previously established associations of these microstate properties with somatic awareness, and increased somatic awareness in ID. EEG microstate assessment could provide objective markers of subjective experience dimensions in studies on consciousness during the transition between wake and sleep, when self-report is not possible because it would interfere with the very process under study. Addressing somatic awareness may benefit psychotherapeutic treatment of insomnia.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Ramautar, J. R., Colombo, M. A., Te Lindert, B. H. W., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Wei, Y., Ramautar, J. R., Colombo, M. A., Te Lindert, B. H. W., & Van Someren, E. J. W. (2018). EEG microstates indicate heightened somatic awareness in insomnia: Toward objective assessment of subjective mental content. Frontiers in Psychiatry, 9: 395. https://doi.org/10.3389/fpsyt.2018.00395
2-year Impact Factor: 3.161|2018
Times cited: 21|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Electrical neuroimaging / High-density EEG / Insomnia disorder / Mental content / Microstate / Resting state / Somatic awareness / Wakefulness

EEG microstates indicate heightened somatic awareness in insomnia: Toward objective assessment of subjective mental content

EEG microstates indicate heightened somatic awareness in insomnia: Toward objective assessment of subjective mental content
DocumentFinal report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.01
Location: BF-GMS
Title:
Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Publication year: 2019
Abstract/Results:
ABSTRACT:
BACKGROUND
Sleep and interoception are important regulating processes of physiological homeostasis and of consciousness. However, few studies have investigated the relationship between them. People with insomnia chronically experience their sleep as conscious wakefulness, which we hypothesize could involve interoception-related neural dysfunctions.
AIMS
By incorporating EEG, neuroimaging, and questionnaire data, we aim to establish direct links between interoception and the experience of (un)consciousness during sleep.
METHOD
Measures of brain network activity including EEG microstate properties and BOLD functional connectivity variability, as well as brain connectivity networks derived from diffusion MRI tractography, were compared between people with insomnia and people without sleep complaints. Self-reported measures were collected in a community-based sample and used to investigate the relationship between somatic complaints and insomnia severity.
RESULTS
The mean duration of a particular class of EEG microstates previously linked to salience network activity is reduced in people with insomnia. Functional connectivity variability between the anterior salience network and the left executive control network is reduced in people with insomnia. People with insomnia show brain structural hyperconnectivity in a subnetwork anchored at the right angular gyrus. Poor sleep and somatic complaints mutually reinforce each other while their relationship is modulated by habitual insomnia severity.
CONCLUSIONS
There is a tight relationship between sleep and interoception. Experience of consciousness during sleep involves aberrant dynamics of the salience network, a key network for interoception
Accessibility: Document exists in file
Language:
eng
Author:
Van Someren, E.
Secondary author(s):
Wei, Y.
Document type:
Final report
Number of reproductions:
1
Reference:
Van Someren, E., & Wei, Y. (2019). Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep.
Indexed document: No
Keywords: Sleep / Insomnia / Consciousness / Interoception / Salience network

Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep

Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
DocumentBrain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.07
Location: BF-GMS
Title:
Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S2213158219303699
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probabilistic diffusion tractography to compare the whole-brain structural connectivity networks of people with ID and those of matched controls without sleep complaints.
Diffusion-weighted images and T1-weighed images were acquired in 51 people diagnosed with ID (21–69 years of age, 37 female) and 48 matched controls without sleep complaints (22–70 years of age, 31 female). Probabilistic tractography was performed to construct the whole-brain structural connectivity network of each participant. Case–control differences in connectivity strength and network efficiency were evaluated with permutation tests.
People with ID showed structural hyperconnectivity within a subnetwork that spread over frontal, parietal, temporal, and subcortical regions and was anchored at the right angular gyrus. The result was robust across different edge-weighting strategies. Moreover, converging support was given by the finding of heightened right angular gyrus nodal efficiency (harmonic centrality) across varying graph density in people with ID. Follow-up correlation analyses revealed that subnetwork connectivity was associated with self-reported reactive hyperarousal.
The findings demonstrate that the right angular gyrus is a hub of enhanced structural connectivity in ID. Hyperconnectivity within the identified subnetwork may contribute to increased reactivity to stimuli and may signify vulnerability to ID.
Accessibility: Document exist in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., Foster-Dingleya, J. C.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Wei, Y., Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., & Foster-Dingleya, J. C. (2019). Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus. NeuroImage: Clinical, 24: 102019. https://doi.org/10.1016/j.nicl.2019.102019
2-year Impact Factor: 4.350|2019
Times cited: 18|2024-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Tractography / Diffusion-weighted MRI / Connectome / Angular gyrus / Insomnia disorder / Reactivity

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
DocumentReduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.06
Location: BF-GMS
Title:
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
Publication year: 2019
URL:
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12953
Abstract/Results: ABSTRACT:
Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-253.09
Author: Wei, Y.
Secondary author(s):
Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Wei, Y., Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., & Van Someren, E. J. W. (2019). Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. Journal of Sleep Research, e12953. https://doi.org/10.1111/jsr.12953
2-year Impact Factor: 3.623|2019
Times cited: 21|2024-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Dynamic functional connectivity / Insomnia disorder / Resting-state functional magnetic resonance imaging / Salience network

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
DocumentActigraphic multi-night home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.05
Location: BF-GMS
Title:
Actigraphic multi-night home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers
Publication year: 2019
URL:
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12937
Abstract/Results: ABSTRACT:
People with Insomnia Disorder tend to underestimate their sleep compared with polysomnography or actigraphy, a phenomenon known as paradoxical insomnia or sleep-state misperception. Previous studies suggested that night-to-night variability could be an important feature differentiating subtypes of misperception. This study aimed for a data-driven definition of misperception subtypes revealed by multiple sleep features including night-to-night variability. We assessed features describing the mean and dispersion of misperception and objective and subjective sleep duration from 7-night diary and actigraphy recordings of 181 people with Insomnia Disorder and 55 people without sleep complaints. A minimally collinear subset of features was submitted to latent class analysis for data-driven subtyping. Analysis revealed three subtypes, best discriminated by three of five selected features: an individual’s shortest reported subjective sleep duration; and the mean and standard deviation of misperception. These features were on average 5.4, -0.0 and 0.5 hr in one subtype accommodating the majority of good sleepers; 4.1, -1.4 and 1.0 hr in a second subtype representing the majority of people with Insomnia Disorder; and 1.7, -2.2 and 1.5 hr in a third subtype representing a quarter of people with Insomnia Disorder and hardly any good sleepers. Subtypes did not differ on an individual’s objective sleep duration mean (6.9, 7.2 and 6.9 hr) and standard deviation (0.8, 0.8 and 0.9 hr). Data-driven analysis of naturalistic sleep revealed three subtypes that markedly differed in misperception features. Future studies may include misperception subtype to investigate whether it contributes to the unexplained considerable individual variability in treatment response.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-252.06
Author: Te Lindert, B. H. W.
Secondary author(s):
Blanken, T. F., van der Meijden, W. P., Dekker, K., Wassing, R., van der Werf, Y. D., Ramautar, J. R., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Te Lindert, B. H. W., Blanken, T. F., van der Meijden, W. P., Dekker, K., Wassing, R., van der Werf, Y. D., Ramautar, J. R., & Van Someren, E. J. W. (2019). Actigraphic multi-night home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers. Journal of Sleep Research, e12937. https://doi.org/10.1111/jsr.12937
2-year Impact Factor: 3.623|2019
Times cited: 12|2024-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Clustering analysis / Objective insomnia / Subjective insomnia / Subjective-objective sleep discrepancy

Actigraphic multi-night home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers

Actigraphic multi-night home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers
DocumentInteroception relates to sleep and sleep disorders2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.06
Location: BF-GMS
Title:
Interoception relates to sleep and sleep disorders
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S2352154619301263
Abstract/Results: ABSTRACT:
The central nervous system senses and responds to afferent signals arising from the body. These interoceptive afferents are essential to physiological homeostatic control and are known to influence an individual’s momentary affect, cognition, motivation, and conscious experiences. Both sleep and interoception are tightly connected to physical and mental well-being. This review outlines the current knowledge about the interactions between interoception and sleep. It is demonstrated that there are complex, dynamic relations between sleep and sensory processes within each modality of interoception, including thermoception, nociception, visceral sensations, and subjective feelings about these sensations. A better understanding and appreciation of the intricate interrelations may facilitate management of functional somatic symptoms, chronic pain, insomnia, and other sleep and mental disorders.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Wei, Y., & Van Someren, E. J. W. (2020). Interoception relates to sleep and sleep disorders. Current Opinion in Behavioral Sciences, 33, 1-7. https://doi.org/10.1016/j.cobeha.2019.11.008
2-year Impact Factor: 4.466|2020
Times cited: 21|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Interoception / Sleep

Interoception relates to sleep and sleep disorders

Interoception relates to sleep and sleep disorders
DocumentBrain mechanisms of insomnia: new perspectives on causes and consequences2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.07
Location: BF-GMS
Title:
Brain mechanisms of insomnia: new perspectives on causes and consequences
Publication year: 2020
URL:
https://journals.physiology.org/doi/pdf/10.1152/physrev.00046.2019
Abstract/Results: ABSTRACT:
While insomnia is the second most common mental disorder, progress in our understanding of underlying neurobiological mechanisms has been limited. The present review addresses the definition and prevalence of insomnia and explores its subjective and objective characteristics across the 24-hour day. Subsequently, the review extensively addresses how the vulnerability to develop insomnia is affected by gene variants, early life stress and major life events and brain structure and function. Further supported by the clear mental health risks conveyed by insomnia, the integrated findings suggest that the vulnerability to develop insomnia could rather be found in brain circuits regulating emotion and arousal than in circuits involved in circadian and homeostatic sleep regulation. Finally, a testable model is presented. The model proposes that in people with a vulnerability to develop insomnia, the locus coeruleus is more sensitive to - or receives more input from - the salience network and related circuits, even during REM sleep, when it should normally be sound asleep. This vulnerability may ignite a downwards spiral of insufficient overnight adaptation to distress, resulting in accumulating hyperarousal which in turn impedes restful sleep and moreover increases the risk of other mental health adversity. Sensitized brain circuits are likely to be subjectively experienced as "sleeping with one eye open". The proposed model opens up the possibility for novel intervention studies and animal studies, thus accelerating the ignition of a neuroscience of insomnia, which is direly needed for better treatment.
Accessibility: Document does not exist in file
Language:
eng
Author:
Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
3
Reference:
Van Someren, E. J. W. (2020). Brain mechanisms of insomnia: New perspectives on causes and consequences. Physiological Reviews. https://doi.org/10.1152/physrev.00046.2019
2-year Impact Factor: 37.312|2020
Times cited: 154|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia / Plasticity / Locus coeruleus / Anxiety / Depression
DocumentData-driven analysis of EEG reveals concomitant superficial sleep during deep sleep in insomnia disorder2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.08
Location: BF-GMS
Title:
Data-driven analysis of EEG reveals concomitant superficial sleep during deep sleep in insomnia disorder
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fnins.2019.00598/full
Abstract/Results: ABSTRACT:
Study Objectives: The subjective suffering of people with Insomnia Disorder (ID) is insufficiently accounted for by traditional sleep classification, which presumes a strict sequential occurrence of global brain states. Recent studies challenged this presumption by showing concurrent sleep-and wake-type neuronal activity. We hypothesized enhanced co-occurrence of diverging EEG vigilance signatures during sleep in ID.
Methods: Electroencephalography (EEG) in 55 cases with ID and 64 controls without sleep complaints was subjected to a Latent Dirichlet Allocation topic model describing each 30 s epoch as a mixture of six vigilance states called Topics (T), ranked from N3-related T1 and T2 to wakefulness-related T6. For each stable epoch we determined topic dominance (the probability of the most likely topic), topic co-occurrence (the probability of the remaining topics), and epoch-to-epoch transition probabilities.
Results: In stable epochs where the N1-related T4 was dominant, T4 was more dominant in ID than in controls, and patients showed an almost doubled co-occurrence of T4 during epochs where the N3-related T1 was dominant. Furthermore, patients had a higher probability of switching from T1- to T4-dominated epochs, at the cost of switching to N3-related T2-dominated epochs, and a higher probability of switching from N2-related T3- to wakefulness-related T6-dominated epochs.
Conclusion: Even during their deepest sleep, the EEG of people with ID express more N1-related vigilance signatures than good sleepers do. People with ID are moreover more likely to switch from deep to light sleep and from N2 sleep to wakefulness. The findings suggest that hyperarousal never rests in ID.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-252.07
Author: Christensen, J. A. E.
Secondary author(s):
Wassing, R., Wei, Y., Ramautar, J. R., Lakbila-Kamal, O., Jennum, P. J., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Christensen, J. A. E., Wassing, R., Wei, Y., Ramautar, J. R., Lakbila-Kamal, O., Jennum, P. J., & Van Someren, E. J. W. (2019). Data-driven analysis of EEG reveals concomitant superficial sleep during deep sleep in insomnia disorder. Frontiers in Neuroscience, 13: 598. https://doi.org/10.3389/fnins.2019.00598
2-year Impact Factor: 3.707|2019
Times cited: 19|2024-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Insomnia / Indiscrete labeling of sleep / Vigilance states / Topic modeling / Data-driven analysis / Polysomnography / Latent Dirichlet allocation

Data-driven analysis of EEG reveals concomitant superficial sleep during deep sleep in insomnia disorder

Data-driven analysis of EEG reveals concomitant superficial sleep during deep sleep in insomnia disorder