YGGYWeb - BIAL Foundation Archives

History

Processing, please wait...

Database

Filter year from

Language

Country

Search Suggestions

Enter your search phrase in the search box.
General search:

The Boolean operator AND between the terms is assumed by default. If you enter the words European Union in the search box, the system returns all records in which both words occur, regardless of their order.
When entering a set of words in quotes, e.g "european union", all records containing the literal term "European Union" will be retrieved.

Search by access fields (e.g. author, title, etc.):

To direct your search, choose the field in which you want to search the word or expression.
Search in the field assumes by default the expression in quotes, e.g. European union will retrieve all records containing the literal term "European Union"

To perform more complex searches, additional words or expressions may be added.
If you want to refine the search results, you can always access the link "search" in the upper left corner of the page of search results.
The search engine is not case sensitive. For example, the word congress has the same meaning that Congress or CONGRESS.
To truncate your search expression, use the $ character
You can filter the results of your search by a date or date range, filling the appropriate boxes.

Base:

BIAL Foundation

Search:

cod:"PT/FB/BL-2016-193$"

Results

from

found.

View

Selection

Description

Type

Title

Begin

End

Document

The neural basis of timing: Distributed mechanisms for diverse functions

2018

BIAL Foundation Archive
- BIAL Grants
  - 2016 Grants
    - 193 - How do dopamine neurons and striatal populations interact during decision-making?
      - The neural basis of timing: Distributed mechanisms for diverse functions

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2016
Location:	BF-GMS
Title:	2016 Grants
Start date:	2017-01

Reference code:	PT/FB/BL-2016-193
Location:	BF-GMS
Title:	193 - How do dopamine neurons and striatal populations interact during decision-making?
Duration:	2017-07 - 2022-10
Researcher(s):	Joseph Paton, Sofia Soares, Asma Motiwala, Bruno Cruz
Institution(s):	Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Progress report Final report Article
Author:	Paton, J. J.
Secondary author(s):	Soares, S., Motiwala, A.
Number of reproductions:	1
Keywords:	Animal behavior / Cognitive processes / Decision-making / Movement / Perception / Psychophysiology

Reference code:	PT/FB/BL-2016-193.02
Location:	BF-GMS
Title:	The neural basis of timing: Distributed mechanisms for diverse functions
Publication year:	2018
URL:	https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(18)30251-4
Abstract/Results:	ABSTRACT: Timing is critical to most forms of learning, behavior, and sensory-motor processing. Converging evidence supports the notion that, precisely because of its importance across a wide range of brain functions, timing relies on intrinsic and general properties of neurons and neural circuits; that is, the brain uses its natural cellular and network dynamics to solve a diversity of temporal computations. Many circuits have been shown to encode elapsed time in dynamically changing patterns of neural activity-so-called population clocks. But temporal processing encompasses a wide range of different computations, and just as there are different circuits and mechanisms underlying computations about space, there are a multitude of circuits and mechanisms underlying the ability to tell time and generate temporal patterns.
Accessibility:	Document exists in file
Language:	eng
Author:	Patton, J. J.
Secondary author(s):	Buonomano, D. V.
Document type:	Article
Number of reproductions:	1
Percentiles:	3
Reference:	Patton, J. J., & Buonomano, D. V. (2018). The neural basis of timing: Distributed mechanisms for diverse functions. Neuron, 98(4), 687-705. https://doi.org/10.1016/j.neuron.2018.03.045
2-year Impact Factor:	14.403\|2018
Times cited:	188\|2024-02-09
Indexed document:	Yes
Quartile:	Q1
Keywords:	Timing
The neural basis of timing: Distributed mechanisms for diverse functions The neural basis of timing: Distributed mechanisms for diverse functions

Document

Final report - How do dopamine neurons and striatal populations interact during decision-making?

2022

BIAL Foundation Archive
- BIAL Grants
  - 2016 Grants
    - 193 - How do dopamine neurons and striatal populations interact during decision-making?
      - Final report - How do dopamine neurons and striatal populations interact during decision-making?

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2016
Location:	BF-GMS
Title:	2016 Grants
Start date:	2017-01

Reference code:	PT/FB/BL-2016-193
Location:	BF-GMS
Title:	193 - How do dopamine neurons and striatal populations interact during decision-making?
Duration:	2017-07 - 2022-10
Researcher(s):	Joseph Paton, Sofia Soares, Asma Motiwala, Bruno Cruz
Institution(s):	Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Progress report Final report Article
Author:	Paton, J. J.
Secondary author(s):	Soares, S., Motiwala, A.
Number of reproductions:	1
Keywords:	Animal behavior / Cognitive processes / Decision-making / Movement / Perception / Psychophysiology

Reference code:	PT/FB/BL-2016-193.01
Location:	BF-GMS
Title:	Final report - How do dopamine neurons and striatal populations interact during decision-making?
Publication year:	2022
Abstract/Results:	ABSTRACT: BACKGROUND Striatal dynamics and dopamine (DA) neuron activity have been shown to correlate with animals’ judgments of duration. AIMS To determine whether DA projecting to different regions of the striatum carry similar signals, To test hypothesis that DA neurons and striatal population functionally interact during timing judgments, to causally test hypotheses emerging from aim 2 by ontogenetically activating DA neuron terminals while recording from local striatal populations. METHOD A combination of behavior, fiber photometry, optogenetics, computational modeling, and electrophysiological recordings. RESULTS We found that while DA neurons in the SNc that project to dorsal striatum correlate with and can cause changes in animals’ timing judgments, DA neurons in the VTA that project to ventral striatum do not correlate with or cause changes in judgments. Furthermore, computational reinforcement learning modeling (RL) demonstrates that DA responses in SNc are explained if mice used efficient and compressed representations of task variables. Furthermore, subsets of striatal neurons belonging to the direct and indirect pathways subserve broadly opponent aspects of action suppression and production during the task, with the indirect pathway being necessary for accurate decisions. These data suggest that the influence of DA neurons on striatal populations may act through D2 type dopamine receptors on indirect pathway striatal neurons. Lastly, we have found that optogenetically activating dopamine neurons can cause a slowing of striatal response dynamics, consistent with DA’s effect on decision-making being mediated by a direct effect of DA on striatal populations. CONCLUSIONS In sum, in line with the broad aims of the grant, we have collected multiple types of data that have helped refine our understanding of how dopamine neurons act on striatal populations of neurons during decision-making, and in doing so have revealed fundamental new principles of both cognition (efficient coding) and motor control (action suppression and production).
Accessibility:	Document exists in file
Language:	eng
Author:	Paton, J. J.
Document type:	Final report
Number of reproductions:	1
Reference:	Paton, J. (2022). Final report - How do dopamine neurons and striatal populations interact during decision-making?
Indexed document:	No
Keywords:	Neuroscience / Basal ganglia / Decision-making / Timing / Reinforcement learning
Final report - How do dopamine neurons and striatal populations interact during decision-making? Final report - How do dopamine neurons and striatal populations interact during decision-making?