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File206 - Developing a neurofunctional intervention for emotion regulation under stress2017-012023-01

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology
DocumentThe efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.02
Location: BF-GMS
Title:
The efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S0165178118316391?via%3Dihub
Abstract/Results: ABSTRACT:
Biofeedback is applied to target excessive and/or deficient physiological signals to help patients identifying and self-managing their symptoms. Biofeedback has been employed in psychiatric disorders, including obsessive-compulsive disorder (OCD), mainly by using neural signals - neurofeedback. Recently, OCD has been integrated into the obsessive-compulsive and related disorders (OCD&RD) category (body dysmorphic, hoarding, trichotillomania/hair-pulling, and excoriation/skin-picking disorders). The efficacy of biofeedback for OCD&RD is still unknown. Our work provides a complete overview of publications assessing the therapeutic efficacy of biofeedback in OCD&RD with a systematic review and meta-analysis. We found ten studies involving 102 OCD participants (three randomized controlled trials) mostly applying neurofeedback (one publication used thermal biofeedback). Five neurofeedback studies were selected for meta-analysis (89 patients; two randomized controlled trials). The overall effect size within the treatment group varied between medium to large, but high heterogeneity and inconsistency values were found. The methodological quality was low indicating a high risk of bias. In conclusion, a beneficial effect of neurofeedback for OCD patients was found but also critical limitations on methodology, high heterogeneity among studies, and a putative reporting bias. Future research following high-quality guidelines should be conducted to address the efficacy of biofeedback approaches for OCD&RD.
Accessibility: Document does not exist in file
Language:
eng
Author:
Ferreira, S.
Secondary author(s):
Pêgo, J. M., Morgado, P.
Document type:
Article
Number of reproductions:
1
Reference:
Ferreira, S., Pêgo, J. M., & Morgado, P. (2019). The efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis. Psychiatry Research, 272, 237–245. https://doi.org/10.1016/j.psychres.2018.12.096
2-year Impact Factor: 2.118|2019
Times cited: 8|2025-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Electroencephalography / Functional magnetic resonance imaging / Human / Neurofeedback / Obsessive-compulsive disorder / Self-regulation / Treatment outcome
DocumentEditorial: The impact of stress on cognition and motivation2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.03
Location: BF-GMS
Title:
Editorial: The impact of stress on cognition and motivation
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00326/full
Accessibility: Document exists in file
Language:
eng
Author:
Morgado, P.
Secondary author(s):
Cerqueira, J. J.
Document type:
Article
Number of reproductions:
1
Reference:
Morgado, P., & Cerqueira, J. J. (2018). Editorial: The impact of stress on cognition and motivation. Frontiers in Behavioral Neuroscience, 12: 326. https://doi.org/10.3389/fnbeh.2018.00326
2-year Impact Factor: 2.622|2018
Times cited: 17|2025-02-11
Indexed document: Yes
Quartile: Q2
Keywords: Cognition / Stress / Motivation / Behavior / Decision-making

Editorial: The impact of stress on cognition and motivation

Editorial: The impact of stress on cognition and motivation
DocumentRelationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.04
Location: BF-GMS
Title:
Relationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0924977X19308752?via%3Dihub
Abstract/Results: ABSTRACT:
Altered stress response and consequent elevated levels of circulating glucocorticoids have been found in neuropsychiatric disorders such as depression or anxiety disorders and proposed to also play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Despite the observation that stressful events may precede the disease onset or even exacerbate its symptoms, studies in this field do not always report consistent results regarding the cortisol profile of OCD patients. As such, a systematic review and meta-analysis was developed to clarify this issue. This systematic review and meta-analysis was elaborated according to the PRISMA method. The analytical procedures were implemented using Metafor package in R software. Nineteen studies were included in the systematic review and 18 were included in the meta-analysis. The meta-analytic results demonstrated that OCD patients had significantly higher cortisol levels compared to controls (d?=?0.76, SE = 0.146, p < 0.001). For studies using the average of multiple assessments, the standardized coefficient was significantly higher when compared to studies focusing on single measurements. Both the systematic review and meta-analysis suggest that cortisol levels are significantly higher in OCD patients than healthy individuals.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Sousa-Lima, J.
Secondary author(s):
Moreira, P. S., Raposo-Lima, C., Sousa, N., Morgado, P.
Document type:
Article
Number of reproductions:
1
Reference:
Sousa-Lima, J., Moreira, P. S., Raposo-Lima, C., Sousa, N., & Morgado, P. (2019). Relationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis. European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2019.09.001
2-year Impact Factor: 3.853|2019
Times cited: 28|2025-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Glucocorticoids / Hypothalamic-pituitary-adrenal axis / OCD / Stress
DocumentReduced Hedonic Valuation of Rewards and Unaffected Cognitive Regulation in Chronic Stress2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.05
Location: BF-GMS
Title:
Reduced Hedonic Valuation of Rewards and Unaffected Cognitive Regulation in Chronic Stress
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fnins.2019.00724/full
Abstract/Results: ABSTRACT:
Cognition can influence choices by modulation of decision-making processes. This cognitive regulation is defined as processing information, applying knowledge, and changing preferences to consciously modulate decisions. While cognitive regulation of emotions has been extensively studied in psychiatry, few works have detailed cognitive regulation of decision-making. Stress may influence emotional behavior, cognition, and decision-making. In addition, the brain regions responsible for decision-making are sensitive to stress-induced changes. Thus, we hypothesize that chronic stress may disrupt the ability to regulate choices. Herein, we used a functional magnetic resonance imaging task where fourteen control and fifteen chronically stressed students had to cognitively upregulate or downregulate their craving before placing a bid to obtain food. We found that stressed participants placed lower bids to get the reward and chose less frequently higher bid values for food. Nevertheless, we did not find neural and behavioral differences during cognitive regulation of craving. Our outcomes revealed that chronic stress impacts decision-making after cognitive regulation of craving by reducing the valuation of food rewards but not cognitive modulation itself. Importantly, our results need further validation with larger sample sizes.
Accessibility: Document exists in file
Language:
eng
Author:
Ferreira, S.
Secondary author(s):
Veiga, C., Moreira, P., Magalhães, R., Coelho, A., Marques, P., Portugal-Nunes, C., Sousa, N., Morgado, P.
Document type:
Article
Number of reproductions:
1
Reference:
Ferreira, S., Veiga, C., Moreira, P., Magalhães, R., Coelho, A., Marques, P., …, Morgado, P. (2019). Reduced Hedonic Valuation of Rewards and Unaffected Cognitive Regulation in Chronic Stress. Frontiers in Neuroscience, 13: 724. https://doi.org/10.3389/fnins.2019.00724
2-year Impact Factor: 3.707|2019
Times cited: 8|2025-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Stress / Decision-making / Cognition / magnetic resonance imaging / fMRI / Reward / Human / Food

Reduced Hedonic Valuation of Rewards and Unaffected Cognitive Regulation in Chronic Stress

Reduced Hedonic Valuation of Rewards and Unaffected Cognitive Regulation in Chronic Stress
DocumentPoor insight in obsessive compulsive disorder (OCD): Associations with empathic concern and emotion recognition2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.06
Location: BF-GMS
Title:
Poor insight in obsessive compulsive disorder (OCD): Associations with empathic concern and emotion recognition
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/abs/pii/S016517812100425X
Abstract/Results: ABSTRACT:
PURPOSE
Insight is currently considered to be responsible for 20% to 40% of the cases of ineffective obsessive-compulsive disorder (OCD) treatment. As 15% to 36% of patients with OCD have reduced insight, we aimed to identify some of the clinical determinants of insight in OCD.
RESULTS
Our sample consisted of 57 OCD patients, of which 34 men (59%) and 23 women (41%). All individuals completed a two-phase interview consisting of a clinical assessment, emotional awareness evaluation and insight measurement, using the Brown Assessment of Beliefs Scale (BABS). The insight score correlated significantly with negative emotion recognition (p < 0.0001) and empathic concern (p = 0.003).
MAJOR CONCLUSIONS
Our results support the hypothesis that insight in OCD is related to emotional awareness, specifically emotion recognition and empathic concern. Future research should investigate the extent to which poor insight and impaired emotional awareness can be modified by psychological or pharmacological therapies and whether this will enhance treatment response.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Manarte, L.
Secondary author(s):
Andrade, A. R., Rosário, L., Sampaio, D., Figueira, M. L., Langley, C., Morgado, P., Sahakian, B. J.
Document type:
Article
Number of reproductions:
1
Reference:
Manarte, L., Andrade, A. R., Rosário, L., Sampaio, D., Figueira, M. L., Langley, C., Morgado, P., & Sahakian, B. J. (2021). Poor insight in obsessive compulsive disorder (OCD): Associations with empathic concern and emotion recognition. Psychiatry Research, 304, 114129. https://doi.org/10.1016/j.psychres.2021.114129
2-year Impact Factor: 11.225|2021
Times cited: 9|2025-02-14
Indexed document: Yes
Quartile: Q2
Keywords: Empathic concern / Emotional awareness / Emotion recognition / Face recognition / Insight / Obsessive-compulsive disorder
DocumentAn fMRI study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.07
Location: BF-GMS
Title:
An fMRI study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
Publication year: 2022
URL:
https://www.cambridge.org/core/journals/european-psychiatry/article/an-fmri-study-of-frontal-networks-in-obsessivecompulsive-disorder-during-cognitive-reappraisal/697DB9AD2D2D07EAA546BCB1ED1EDC96
Abstract/Results: Abstract
Background: Patients with Obsessive-Compulsive Disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related with emotion regulation alterations observed during cognitive reappraisal in OCD.
Methods: Adult patients with OCD (n=31) and healthy controls (HC; n=30) were compared during performance of a functional magnetic resonance imaging (fMRI) cognitive reappraisal protocol. We used a free Independent Component Analysis (ICA) approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored.
Results: Analyses were focused on 6 networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network (LFPN).
Conclusions: The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
De la Peña-Arteaga, V.
Secondary author(s):
Morgado, P., Couto, B., Ferreira, S., Castro, I., Sousa, N., Soriano-Mas, C., Picó-Pérez, M.
Document type:
Article
Number of reproductions:
1
Reference:
De la Peña-Arteaga, V., Morgado, P., Couto, B., Ferreira, S., Castro, I., Sousa, N., Soriano-Mas, C., & Picó-Pérez, M. (2022). An fMRI study of frontal newtworks in obsessive-compulsive disorder during cognitive reappraisal. European Psychiatry, 1-22, https://doi.org/10.1192/j.eurpsy.2022.2322
2-year Impact Factor: 7.800|2022
Times cited: 2|2025-02-17
Indexed document: Yes
Quartile: Q1
Keywords: Frontal networks / fMRI / OCD / Cognitive reappraisal / Emotion regulation

An fMRI study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal

An fMRI study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
DocumentPerceived stress modulates the activity between the amygdala and the cortex2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.08
Location: BF-GMS
Title:
Perceived stress modulates the activity between the amygdala and the cortex
Publication year: 2022
URL:
https://www.nature.com/articles/s41380-022-01780-8#citeas
Abstract/Results: Abstract
The significant link between stress and psychiatric disorders has prompted research on stress’s impact on the brain. Interestingly, previous studies on healthy subjects have demonstrated an association between perceived stress and amygdala volume, although the mechanisms by which perceived stress can affect brain function remain unknown. To better understand what this association entails at a functional level, herein, we explore the association of perceived stress, measured by the PSS10 questionnaire, with disseminated functional connectivity between brain areas. Using resting-state fMRI from 252 healthy subjects spanning a broad age range, we performed both a seed-based amygdala connectivity analysis (static connectivity, with spatial resolution but no temporal definition) and a whole-brain data-driven approach to detect altered patterns of phase interactions between brain areas (dynamic connectivity with spatiotemporal information). Results show that increased perceived stress is directly associated with increased amygdala connectivity with frontal cortical regions, which is driven by a reduced occurrence of an activity pattern where the signals in the amygdala and the hippocampus evolve in opposite directions with respect to the rest of the brain. Overall, these results not only reinforce the pathological effect of in-phase synchronicity between subcortical and cortical brain areas but also demonstrate the protective effect of counterbalanced (i.e., phase-shifted) activity between brain subsystems, which are otherwise missed with correlation-based functional connectivity analysis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Caetano, I.
Secondary author(s):
Ferreira, S., Coelho, A., Amorim, L., Castanho, T. C., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. S., Rodrigues, A. J., Santos, N. C., Morgado, P., Magalhães, R., Picó-Pérez, M., Cabral, J., Sousa, N.
Document type:
Article
Number of reproductions:
1
Reference:
Caetano, I., Ferreira, S., Coelho, A., Amorim, L., Castanho, T. C., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. S., Rodrigues, A. J., Santos, N. C., Morgado, P., Magalhães, R., Picó-Pérez, M., Cabral, J., & Sousa, N. (2022). Perceived stress modulates the activity between the amygdala and the cortex. Molecular Psychiatry, 27(12), 4939–4947. https://doi.org/10.1038/s41380-022-01780-8
2-year Impact Factor: 11.000|2022
Times cited: 7|2025-02-17
Indexed document: Yes
Quartile: Q1
Keywords: Predictive markers / Perceived stress / Amygdala / Cortex
DocumentFinal report - Developing a neurofunctional intervention for emotion regulation under stress2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.01
Location: BF-GMS
Title:
Final report - Developing a neurofunctional intervention for emotion regulation under stress
Publication year: 2023
Abstract/Results:
ABSTRACT:
Background
Stress may influence emotional behaviour, cognition, and decision-making. In addition, the brain regions responsible for decision-making are sensitive to stress-induced changes. Thus, chronic stress may disrupt the ability to cognitively regulate choices.
On contrary, neuromodulation strategies can successfully increase neural activity in prefrontal-parietal regions, which will help in increasing cognitive reappraisal capacities. Among the different neuromodulation techniques, neurofeedback (NFB) is certainly the less invasive approach, although further research is warranted to fully develop its anticipated possibilities in intervention contexts. Functional magnetic resonance imaging (fMRI)-neurofeedback (NFB) is a non-invasive approach which allows real-time monitoring and self-regulation of regional brain activity. However, it lacks generalizability to ecological contexts, and the costs of such an intervention prevent its wide use. Electroencephalography (EEG)-NFB, by contrast, overcomes these limitations, but lacks the regional resolution of fMRI.
In this work we intended to explore the effects of chronic stress on cognitive regulation of decision making and to develop a neurofunctional intervention protocol using fMRI-EEG-NFB to regulate the levels of stress.
Aims
1. To study the impact of chronic stress on cognitive regulation of decisions using an fMRI task.
2. To develop a neurofunctional intervention protocol based on the combined use of fMRI- and EEG-NFB for increasing cognitive reappraisal capacities in subjects with different levels of perceived stress.
Method
Task 1
We used a fMRI task where fourteen control and fifteen chronically stressed students had to cognitively upregulate or downregulate their craving before placing a bid to obtain food. The task consisted of two parts: a pre-scan rating task that provided us with a measure of the baseline value for food, and an in-scan bidding and regulation task that measured the food value under the influence of regulation. Subjects also filled the Perceived Stress Scale (PSS), the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI).
Task 2
The protocol consists of a combined fMRI (Siemens 3T) and EEG (Brain Vision BrainAmp MR 64 channels) acquisition, including a resting state; a localizer cognitive reappraisal task; NFB runs; and another resting-state. During the cognitive reappraisal task, images are shown for the conditions ‘observe’ (neutral images), ‘experience’ (negative images letting their feelings flow), and ‘regulate’ (negative images to be regulated). During the NFB runs, when they successfully regulate their emotions (increasing prefronto-parietal network activation), the image slowly disappears. Subjects also filled the PSS.
Results
Task 1
The stress group revealed higher levels of perceived stress. No statistically significant differences were found for BAI and BDI between groups. Stressed participants placed lower bids to get the reward and chose less frequently higher bid values for food. Nevertheless, we did not find neural and behavioral differences during cognitive regulation of craving. We found a main effect of the cognitive regulation condition in the left hemisphere in the superior (Brodmann area 22) and middle temporal gyrus (Brodmann area 21), the rolandic operculum, and the precentral gyrus (Brodmann area 6).
Task 2
After NFB training we found increased functional connectivity within the salience network (middle/inferior frontal and precentral gyrus). These connectivity values were negatively correlated with the effort self-reported during NFB (Spearman r = -0.834, p = 0.008). PSS scores ranged between 11 and 29 (N=16).
Conclusions
Our results revealed that chronic stress impacts decision-making after cognitive regulation of craving by reducing the valuation of food rewards but not cognitive modulation itself. We also described a technique to successfully regulate cognitive stress appraisal.
Accessibility: Document exists in file
Language:
eng
Author:
Morgado, P.
Secondary author(s):
Fernández-Rodríguez, M., Ferreira, S., Picó-Pérez, M., Reis, J., Costa, N., Soriano-Mas, C.
Document type:
Final report
Number of reproductions:
1
Reference:
Morgado, P., Fernández-Rodríguez, M., Ferreira, S., Picó-Pérez, M., Reis, J., Costa, N., & Soriano-Mas, C. (2023). Final report - Developing a neurofunctional intervention for emotion regulation under stress.
Indexed document: No
Keywords: Cognitive regulation / Neurofeedback / EEG-fingerprint / Stress / fMRI

Final report - Developing a neurofunctional intervention for emotion regulation under stress

Final report - Developing a neurofunctional intervention for emotion regulation under stress
DocumentAssociation of amygdala size with stress perception: Findings of a transversal study across the lifespan2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.09
Location: BF-GMS
Title:
Association of amygdala size with stress perception: Findings of a transversal study across the lifespan
Publication year: 2022
URL:
https://doi.org/10.1111/ejn.15809
Abstract/Results: ABSTRACT:
Daily routines are getting increasingly stressful. Interestingly, associations between stress perception and amygdala volume, a brain region implicated in emotional behaviour, have been observed in both younger and older adults. Life stress, on the other hand, has become pervasive and is no longer restricted to a specific age group or life stage. As a result, it is vital to consider stress as a continuum across the lifespan. In this study, we investigated the relationship between perceived stress and amygdala size in 272 healthy participants with a broad age range. Participants were submitted to a structural magnetic resonance imaging (MRI) to extract amygdala volume, and the Perceived Stress Scale (PSS) scores were used as the independent variable in volumetric regressions. We found that perceived stress is positively associated with the right amygdala volume throughout life.
Accessibility: Document does not exist in file
Language:
eng
Author:
Caetano, I.
Secondary author(s):
Amorim, L., Castanho, T. C., Coelho, A., Ferreira, S., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. S., Rodrigues, A. J., Santos, N. C., Morgado, P., Esteves, M., Magalhães, R., Picó-Pérez, M., Sousa, N.
Document type:
Article
Number of reproductions:
1
Reference:
Caetano, I., Amorim, L., Castanho, T. C., Coelho, A., Ferreira, S., Portugal-Nunes, C., Soares, J. M., Gonçalves, N., Sousa, R., Reis, J., Lima, C., Marques, P., Moreira, P. S., Rodrigues, A. J., Santos, N. C., Morgado, P., Esteves, M., Magalhães, R., Picó-Pérez, M., & Sousa, N. (2022). Association of amygdala size with stress perception: Findings of a transversal study across the lifespan. The European Journal of Neuroscience, 56(8), 5287–5298. https://doi.org/10.1111/ejn.15809
2-year Impact Factor: 3.4|2022
Times cited: 2|2025-02-27
Indexed document: Yes
Quartile: Q2
Keywords: MRI / Amygdala / Healthy subjects / Perceived stress / Stress / Volumetry