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File279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

DocumentAn expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

Reference code: PT/FB/BL-2016-279.02
Location: BF-GMS
Title:
An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185939/
Abstract/Results: ABSTRACT
Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations in diverse gustatory organs in larvae and adults. We characterise IR56d, which defines two anatomically-distinct neuron classes in the proboscis: one responds to carbonated solutions and fatty acids while the other represents a subset of sugar- and fatty acid-sensing cells. Mutational analysis indicates that IR56d, together with the broadly-expressed co-receptors IR25a and IR76b, is essential for physiological responses to carbonation and fatty acids, but not sugars. We further demonstrate that carbonation and fatty acids both promote IR56d-dependent attraction of flies, but through different behavioural outputs. Our work provides a toolkit for investigating taste functions of IRs, defines a subset of these receptors required for carbonation sensing, and illustrates how the gustatory system uses combinatorial expression of sensory molecules in distinct neurons to coordinate behaviour.
Accessibility: Document exists in file
Language:
eng
Author:
Sánchez-Alcańiz, J. A.
Secondary author(s):
Silbering, A. F., Croset, V., Zappia, G., Sivasubramaniam, A. K., Abuin, L., Sahai, S. Y., Münch, D., Steck, K., Auer, T. O., Cruchet, S., Neagu-Maier, G. L., Sprecher, S. G., Ribeiro, C., Yapici, N., Benton, R.
Document type:
Article
Reference:
Sánchez-Alcańiz, J. A., Silbering, A. F., Croset, V., Zappia, G., Sivasubramaniam, A. K., Abuin, L., ... Benton, R. (2018). An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. Nature Communications, 9(1): 4252. doi: 10.1038/s41467-018-06453-1
2-year Impact Factor: 11.878|2018
Times cited: 13|2020-04-03
Indexed document: Yes
Quartile: Q1

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

DocumentNutrient homeostasis - translating internal states to behaviour2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

Reference code: PT/FB/BL-2016-279.03
Location: BF-GMS
Title:
Nutrient homeostasis - translating internal states to behaviour
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S0959438819301114
Abstract/Results: ABSTRACT:
Behavioral neuroscience aims to describe a causal relationship between neuronal processes and behavior. Animals’ ever-changing physiological needs alter their internal states. Internal states then alter neuronal processes to adapt the behavior of the animal enabling it to meet its needs. Here, we describe nutrient-specific appetites as an attractive framework to study how internal states shape complex neuronal processes and resulting behavioral outcomes. Understanding how neurons detect nutrient states and how these are integrated at the level of neuronal circuits will provide a multilevel description of the mechanisms underlying complex feeding and foraging decisions.
Accessibility: Document exists in file
Language:
eng
Author:
Münch, D.
Secondary author(s):
Ezra-Nevo, G., Francisco, A. P., Tastekin, I., Ribeiro, C.
Document type:
Article
Reference:
Münch, D., Ezra-Nevo, G., Francisco, A. P., Tastekin, I., & Ribeiro, C. (2020). Nutrient homeostasis - translating internal states to behaviour. Current Opinion in Neurobiology, 60, 67–75. doi: 10.1016/j.conb.2019.10.004
2-year Impact Factor: 6.267|2019
Impact factor notes: Impact factor not available yet for 2020
Times cited: 1|2020-08-18
Indexed document: Yes
Quartile: Q1

Nutrient homeostasis - translating internal states to behaviour

Nutrient homeostasis - translating internal states to behaviour

DocumentInternal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

Reference code: PT/FB/BL-2016-279.04
Location: BF-GMS
Title:
Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila
Publication year: 2018
URL:
https://elifesciences.org/articles/31625
Abstract/Results: ABSTRACT:
To optimize fitness, animals must dynamically match food choices to their current needs. For drosophilids, yeast fulfills most dietary protein and micronutrient requirements. While several yeast metabolites activate known gustatory receptor neurons (GRNs) in Drosophila melanogaster, the chemosensory channels mediating yeast feeding remain unknown. Here we identify a class of proboscis GRNs required for yeast intake. Within this class, taste peg GRNs are specifically required to sustain yeast feeding. Sensillar GRNs, however, mediate feeding initiation. Furthermore, the response of yeast GRNs, but not sweet GRNs, is enhanced following deprivation from amino acids, providing a potential basis for protein-specific appetite. Although nutritional and reproductive states synergistically increase yeast appetite, reproductive state acts independently of nutritional state, modulating processing downstream of GRNs. Together, these results suggest that different internal states act at distinct levels of a dedicated gustatory circuit to elicit nutrient-specific appetites towards a complex, ecologically relevant protein source.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2014-283.07
Author: Steck, K.
Secondary author(s):
Walker, S. J., Itskov, P. M., Baltazar, C., Moreira, J.-M., Ribeiro, C.
Document type:
Article-d
Reference:
Steck, K., Walker, S. J., Itskov, P. M., Baltazar, C., Moreira, J.-M., & Ribeiro, C. (2018). Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila. ELife, 7, e31625.
2-year Impact Factor: 7.551|2018
Times cited: 28|2020-04-06
Indexed document: Yes
Quartile: Q1

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

DocumentFinal report - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

Reference code: PT/FB/BL-2016-279.01
Location: BF-GMS
Title:
Final report - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Publication year: 2020
URL:
https://www.bial.com/media/3232/harnessing-the-power-of-closed-loop-neuronal-control-to-identify-the-circuit-basis-of-decision-making.pdf
Abstract/Results: ABSTRACT:
Making the correct decisions is key to our health and wellbeing. This is especially relevant in the context of nutrition. Accordingly, animals have developed behavioral strategies to decide which nutrients to ingest.
In this project we therefore proposed to develop and use a novel closed loop optogenetic behavioral setup (optoPAD) to identify and characterize neurons involved in nutrient decisions.
In this grant we have developed, benchmarked, and published a new experimental behavioral setup called optoPAD to study the circuit basis of food choice in Drosophila (Moreira et al., 2019). The optoPAD allows the closed loop optogenetic manipulation of neurons and the quantitative assessment of the consequences of the manipulations on feeding behavior. In the spirit of open science we have made the design, plans, and software required to build and use the optoPAD freely available (https://github.com/ribeiro-lab). We have used this setup to characterize the taste peg gustatory neurons and shown that they mediate specific aspects of protein homeostasis (Steck et al., 2018). We also developed new behavioral paradigms allowing us to study how Drosophila shapes its behavior contingent on neuronal activity (Moreira et al., 2019).We used the optoPAD system to create dynamic virtual food environments. Finally, we have screened a library of transgenic flies labeling sparse sets of neurons for food choice phenotypes upon silencing the labeled neurons. We have identified sparse lines producing specific and reproducible food choice phenotypes.
Overall this project has allowed us to establish a new technology to link circuit function to behavior and has produced important insights into how specific circuits shape behavioral decisions.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, C.
Document type:
Final report
Reference:
Ribeiro, C. (2020). Final report - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making.

Final report - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making

Final report - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making