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File286 - Getting the aging brain to train: A working memory and neurostimulation approach2017-062023-03

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

DocumentReviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.02
Location: BF-GMS
Title:
Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S0149763418308509?via%3Dihub
Abstract/Results: ABSTRACT
The objective of this meta-analytic review was to systematically assess the effects of working memory training on healthy older adults. We identified 552 entries, of which 27 experiments met our inclusion criteria. The final database included 1130 participants. Near- and far-transfer effects were analysed with measures of short-term memory, working memory, and reasoning. Small significant and long-lasting transfer gains were observed in working memory tasks. Effects on reasoning was very small and only marginally significant. The effects of working memory training on both near and far transfer in older adults were moderated by the type of training tasks; the adopted outcome measures; the training duration; and the total number of training hours. In this review we provide an updated review of the literature in the field by carrying out a robust multi-level meta-analysis focused exclusively on WMT in healthy older adults. Recommendations for future research are suggested.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Teixeira-Santos, A. C.
Secondary author(s):
Moreira, C. S., Magalhães, R., Magalhães, C., Pereira, D. R., Leite, J., Carvalho, S., Sampaio, A.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Teixeira-Santos, A. C., Moreira, C. S., Magalhães, R., Magalhães, C., Pereira, D. R., Leite, J., Carvalho, S., & Sampaio, A. (2019). Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes. Neuroscience & Biobehavioral Reviews, 103, 163-177. doi: 10.1016/j.neubiorev.2019.05.009
2-year Impact Factor: 8.330|2019
Times cited: 33|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: Meta-analysis / Working memory training / Cognitive plasticity / Training transfer / Healthy older adults / Healthy ageing

DocumentProbing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.03
Location: BF-GMS
Title:
Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults
Publication year: 2020
URL:
https://www.nature.com/articles/s41598-020-67924-4
Abstract/Results: ABSTRACT:
The world population is rapidly aging, bringing together the necessity to better understand the advancing age. This characterization may be used to aid early diagnosis and to guide individually-tailored interventions. While some event-related potential (ERP) components, such as the P300 and late positive complex (LPC), have been associated with fluid intelligence (Gf) in young population; little is known whether these associations hold for older people. Therefore, the main goal of this study was to assess whether these ERP components are associated with Gf in the elderly. Fifty-seven older adults performed a continuous performance task (CPT) and a visual oddball paradigm while EEG was recorded. Participants were divided into two groups, according to their performance in the Raven’s Advanced Progressive Matrices test: high-performance (HP) and low-performance (LP). Results showed that the HP group, compared to the LP group, had higher LPC amplitudes in the CPT and shorter P300 latencies in the oddball task, highlighting the role of ERP components as a potential electrophysiological proxy of Gf abilities in the elderly.
Accessibility: Document exists in file
Language:
eng
Author:
Teixeira-Santos, A. C.
Secondary author(s):
Pinal, D., Pereira, D. R., Leite, J., Carvalho, S., Sampaio, A.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Teixeira-Santos, A. C., Pinal, D., Pereira, D. R., Leite, J., Carvalho, S., & Sampaio, A. (2020). Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults. Scientific Reports, 10: 11167. doi: 10.1038/s41598-020-67924-4
2-year Impact Factor: 4.379|2020
Times cited: 5|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: Aging / Fluid intelligence / Event-related potential (ERP)

Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults

Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults

DocumentCognitive and physical effects of a multicomponent training in elderly adults: A pilot study2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.04
Location: BF-GMS
Title:
Cognitive and physical effects of a multicomponent training in elderly adults: A pilot study
Publication year: 2020
URL:
http://hdl.handle.net/1822/68589
Abstract/Results: ABSTRACT:
World's population is aging. Successful aging proposes that physical activity and physical exercise may be protective for cognition and the brain. The intensity of physical activity and the characteristics of physical exercise (duration, modality…) that are optimal to maximize cognitive effects are yet to be discovered. Current investigation aims at (1) clarifying cognitive, emotional and physical fitness effects of a multicomponent training intervention in community-dwelling elderly and compare them with an active control group; (2) exploring the association between cognitive function and physical fitness. A double-blind quasi-experimental intervention was conducted with 19 participants aged>60year from the North of Portugal, distributed by order of registration. Multicomponent intervention included aerobic, strength, stretching and balance exercises thrice a week for 50min for 33-weeks. Control intervention occurred once a week with less intensity. Participants were assessed at baseline and after-intervention in physical activity levels (actigraphy), neurocognitive function, emotional status, cardiorespiratory fitness (VO2peak) and anthropometry (DEXA). Multicomponent training was effective in improving moderate-to-vigorous physical activity and diminishing sedentary-time, compared to control group. It presented no significant effects for anthropometry or emotional status. Multicomponent group significantly decreased VO2peak, hence multicomponent training was not effective in improving cardiorespiratory fitness. Both groups significantly decreased performance in semantic fluency and multicomponent group significantly decreased performance in working memory. Thereby, multicomponent training was not effective at improving or maintaining neurocognitive functions. In a secondary-personalized analysis, variations in VO2peak were associated with variations in short-term and long-term memory. Contrarily, variations in body composition were not. Cardiorespiratory fitness hypothesis may contribute to our results. With learning from the pilot study, guidelines for future randomized-controlled trials are suggested.
Accessibility: Document exists in file
Language:
eng
Author:
Ferreira, M. M.
Document type:
Master's thesis
Number of reproductions:
1
Reference:
Ferreira, M. M. (2020). Cognitive and physical effects of a multicomponent training in elderly adults: A pilot study (Master's thesis, Escola de Psicologia, Universidade do Minho, Portugal). Retrieved from http://hdl.handle.net/1822/68589
Indexed document: No
Keywords: Cognition / Elderly / Physical exercise / Physical fitness / Multicomponent training

Cognitive and physical effects of a multicomponent training in elderly adults: A pilot study

Cognitive and physical effects of a multicomponent training in elderly adults: A pilot study

DocumentWorking memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.05
Location: BF-GMS
Title:
Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment
Publication year: 2022
URL:
https://www.frontiersin.org/articles/10.3389/fnagi.2022.827188/full
Abstract/Results: Background: Transcranial direct current stimulation (tDCS) has been employed to boost working memory training (WMT) effects. Nevertheless, there is limited evidence on the efficacy of this combination in older adults. The present study is aimed to assess the delayed transfer effects of tDCS coupled with WMT in older adults in a 15-day follow-up. We explored if general cognitive ability, age, and educational level predicted the effects.
Methods: In this single-center, double-blind randomized sham-controlled experiment, 54 older adults were randomized into three groups: anodal-tDCS (atDCS)+WMT, sham-tDCS (stDCS)+WMT, and double-sham. Five sessions of tDCS (2 mA) were applied over the left dorsolateral prefrontal cortex (DLPFC). Far transfer was measured by Raven’s Advanced Progressive Matrices (RAPM), while the near transfer effects were assessed through Digit Span. A frequentist linear mixed model (LMM) was complemented by a Bayesian approach in data analysis.
Results: Working memory training improved dual n-back performance in both groups submitted to this intervention but only the group that received atDCS+WMT displayed a significant improvement from pretest to follow-up in transfer measures of reasoning (RAPM) and short-term memory (forward Digit Span). Near transfer improvements predicted gains in far transfer, demonstrating that the far transfer is due to an improvement in the trained construct of working memory. Age, formal education, and vocabulary score seem to predict the gains in reasoning. However, Bayesian results do not provide substantial evidence to support this claim.
Conclusion: This study will help to consolidate the incipient but auspicious field of cognitive training coupled with tDCS in healthy older adults. Our findings demonstrated that atDCS may potentialize WMT by promoting transfer effects in short-term memory and reasoning in older adults, which are observed especially at follow-up.
Accessibility: Document exists in file
Language:
eng
Author:
Teixeira-Santos, A. C.
Secondary author(s):
Moreira, C., Pereira, D., Pinal, D., Fregni, F., Leite, J., Carvalho, S., Sampaio, A.
Document type:
Article
Number of reproductions:
1
Reference:
Teixeira-Santos, A. C., Moreira, C., Pereira, D., Pinal, D., Fregni, F., Leite, J., Carvalho, S. & Sampaio, A. (2022). Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment. Frontiers in Aging Neuroscience, 14, 827188. doi: 10.3389/fnagi.2022.827188
2-year Impact Factor: 5.702|2021
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: tDCS / Cognitive training / Working memory / Neuroplasticity / Older adults / Reasoning / Transfer effects

Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment

Working memory training coupled with transcranial direct current stimulation in older adults: A randomized controlled experiment

DocumentWorking memory and neuroplasticity in older people: A behavioral and neurofunctional approach2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.06
Location: BF-GMS
Title:
Working memory and neuroplasticity in older people: A behavioral and neurofunctional approach
Publication year: 2020
URL:
https://repositorium.sdum.uminho.pt/handle/1822/76490
Abstract/Results: ABSTRACT:
Working memory training (WMT) has been used to promote neuroplasticity in older people and tDCS has been proposed to boost WMT effects. Nevertheless, there is not robust evidence of WMT effectiveness and the few studies assessing the combination of tDCS with WMT used cognitive tasks as endpoints. However, the use of different markers, as the event-related potentials (ERPs), can be useful to better understand the combined or individual effects of these interventions. Thus, the studies presented in this dissertation aimed to assess WMT effects, as well as, the add-on effects of tDCS. Given the need to use different endpoints to measures WMT-induced neuroplasticity, an additional aim was to assess if the ERPs can be used as indexes of fluid intelligence (Gf), a commonly assessed constructed to infer generalization of WMT. In the first study, we presented a meta-analysis on the effects of WMT in healthy elderly. Small significant and long-lasting gains were observed in working memory (WM), but not in short-term memory (STM) and Gf tasks. Type of training tasks, the adopted outcome measures, the training duration, and the total number of training hours moderated WMT effects. In the second study, we performed a systematic review on the uses of tDCS to boost WM in healthy older adults. The studies suggest that tDCS may modulate WM in this population, improving the accuracy and shortening the reaction time. In the third study, we performed a randomized double-blind controlled experiment to evaluate the effects of 5-day WMT coupled with tDCS in healthy older adults. Fifty-four participants were assigned to one of three groups: 1) WMT (dual n-back task)+active tDCS (atDCS); 2) WMT+sham tDCS (stDCS); or 3) sham task + sham tDCS. During the training, both groups that performed the dual n-back task (WMT+atDCS; WMT+stDCS) improved throughout sessions, with no significant differences between them. However, the “WMT+atDCS” was the only group that presented gains in Gf and verbal STM after training (i.e., next day after the intervention) and at follow-up (i.e., 15 days follow-up). Finally, in the fourth study, we explored whether ERP components (i.e., P2, P3b and the LPC - late positive complex) are associated with Gf in the elderly. Fifty-seven participants performed a continuous performance task and a visual oddball paradigm while EEG was recorded. They were divided into high-performance (HP) and low performance (LP) groups according to their performance in the Raven’s Advanced Progressive Matrices test (RAPM). HP group presented significant higher LPC amplitudes in the CPT and shorter P3b latencies in the oddball task when compared to the LP group.
Accessibility: Document exists in file
Language:
eng
Author:
Teixeira-Santos, A. C.
Document type:
Doctoral thesis
Number of reproductions:
1
Reference:
Teixeira-Santos, A. C. (2020). Working memory and neuroplasticity in older people: A behavioral and neurofunctional
approach (Doctoral thesis in Basic Psychology, Escola de Psicologia, Universidade do Minho, Braga, Portugal). Retrieved at: https://repositorium.sdum.uminho.pt/handle/1822/76490
Indexed document: No
Keywords: Fluid intelligence / Late positive complex / Older adults / P3b / tDCS / Working memory training

Working memory and neuroplasticity in older people: A behavioral and neurofunctional approach

Working memory and neuroplasticity in older people: A behavioral and neurofunctional approach

DocumentFinal report - Getting the aging brain to train: A working memory and neurostimulation approach2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.01
Location: BF-GMS
Title:
Final report - Getting the aging brain to train: A working memory and neurostimulation approach
Publication year: 2023
Abstract/Results:
ABSTRACT:
BACKGROUND
Transcranial direct current stimulation (tDCS) has been suggested to boost working memory training (WMT) effects. Nevertheless, few studies have explored the effects of WMT coupled with tDCS in older adults.
AIMS
To assess the effects of 5-days WMT coupled with tDCS on near- (Digit Span and Corsi Block Taping) and far- (Raven Advanced Progressive Matrices - RAPM) transfer tasks, as well as, in the event-related potentials (ERPs) and salivary IGF-1. An additional aim was to assess if ERPs are related with fluid intelligence (Gf), a commonly assessed constructed to infer generalization of WMT effects.
METHOD
54 healthy old adults (Mage = 68.6, SDage = 6.0; 32 females) were randomly assigned to one of three groups: 1) WMT (dual n-back task) + atDCS (anodal, 2 mA; 20min; placed over left dorsolateral prefrontal cortex); 2) WMT + sham tDCS; 3) double-placebo. Assessments were carried out at baseline; post-training; 15 days follow-up. An EEG study was performed using baseline data to explore whether ERP components (i.e., P2, P3b and the LPC - late positive complex) were associated with Gf in the elderly.
RESULTS
The analyses showed that only atDCS+WMT group displayed a significant improvement in Gf and short-term memory (forward digit span). Those results are in line with studies performed in the context of this project. First, our meta-analysis showed small significant and long-lasting near transfer effects of WMT, which was not the case for far transfer effects measured in Gf tasks. We also suggested that tDCS may modulate WM in older adults boosting cognitive processes involved in WM, by conducting a systematic review. Finally, our last study showed that high performance participants presented significant higher LPC amplitudes and shorter P3b latencies elicited by attention tasks when compared to the LP group.
CONCLUSIONS
WMT yielded transfer effects restricted to WM ability, while tDCS boosted its effects producing far transfer to Gf. Our results also suggested that the ERPs are associated with the Gf performance in older adults.
Accessibility: Document exists in file
Language:
eng
Document type:
Final report
Number of reproductions:
1
Reference:
Sampaio, A. (2023). Final report - Getting the aging brain to train: A working memory and neurostimulation approach.
Indexed document: No
Keywords: tDCS / Working memory training / Neuroplasticity aging

Final report - Getting the aging brain to train: A working memory and neurostimulation approach

Final report - Getting the aging brain to train: A working memory and neurostimulation approach

DocumentProcessing speed mediates the association between physical activity and executive functioning in elderly adults2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-286
Location: BF-GMS
Title:
286 - Getting the aging brain to train: A working memory and neurostimulation approach
Duration: 2017-06 - 2023-03
Researcher(s):
Adriana Sampaio, Ana Teixeira Santos, Sandra Carvalho, Jorge Leite, Ana Raquel, Felipe Fregni
Institution(s): Psychology Research Center (CIPsi), School of Psychology, University of Minho, Braga (Portugal); Spaulding-Labuschange Neuromodulation Center, Spaulding Rehabilitation Hospital & Massachusetts General Hospital/Harvard Medical School, Charlestown (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Sampaio, A.
Secondary author(s):
Teixeira-Santos, A. C., Carvalho, S., Leite, J., Mesquita, A. R., Fregni, F.
Number of reproductions:
1
Keywords:
Working memory training / Aging / Brain plasticity / Cognitive plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-286.07
Location: BF-GMS
Title:
Processing speed mediates the association between physical activity and executive functioning in elderly adults
Publication year: 2022
URL:
https://www.frontiersin.org/articles/10.3389/fpsyg.2022.958535/full
Abstract/Results: ABSTRACT:
Advanced aging is associated with cognitive decline. To decrease the healthcare system and socio-economic burdens as well as to promote better quality of life, is important to uncover the factors that may be related to the delay of cognitive impairments in older adults. This study investigated the relationship between physical activity levels, sedentary behavior and cardiorespiratory fitness with cognitive functioning in healthy older adults. Furthermore, it examined the mediating role of processing speed on the association between physical activity and executive functions and long-term memory. Thirty-two individuals aged between 63 and 77 years (M = 68.16, SD = 3.73) underwent measurements of maximal oxygen uptake (VO2peak), 1-week of PA accelerometer measurement and a comprehensive cognitive assessment. Significant associations were observed between MVPA and cognitive processing speed. Equally, a significant positive indirect effect of MVPA on executive functioning and long-term memory was mediated by processing speed. Also, MVPA levels differentiated cognitive functioning in older adults - the physical active group outperformed the physical inactive group in processing speed, executive functions, and language abilities. Our results contribute to the literature on the MVPA levels as an important tool to promote healthier cognitive aging.
Accessibility: Document exists in file
Language:
eng
Author:
Silva-Fernandes, A.
Secondary author(s):
Cruz, S., Moreira, C. S., Pereira, D. R., Sousa, S. S., Sampaio, A., Carvalho, J.
Document type:
Article
Number of reproductions:
1
Reference:
Silva-Fernandes, A., Cruz, S., Moreira, C. S., Pereira, D. R., Sousa, S. S., Sampaio, A., & Carvalho, J. (2022). Processing speed mediates the association between physical activity and executive functioning in elderly adults. Frontiers in Psychology, 13, 958535. doi: 10.3389/fpsyg.2022.958535
Indexed document: Yes
Keywords: MVPA / Aging / Executive functions / Physical activity / Processing speed

Processing speed mediates the association between physical activity and executive functioning in elderly adults

Processing speed mediates the association between physical activity and executive functioning in elderly adults