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File252 - Spiritual states induced by ayahuasca, and the involvement of the reward system2019-102022-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

DocumentA link between synaptic plasticity and reorganization of brain activity in Parkinson's disease2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.02
Location: BF-GMS
Title:
A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease
Publication year: 2021
URL:
https://www.pnas.org/content/118/3/e2013962118
Abstract/Results: ABSTRACT:
The link between synaptic plasticity and reorganization of brain activity in health and disease remains a scientific challenge. We examined this question in Parkinson’s disease (PD) where functional up-regulation of postsynaptic D2 receptors has been documented while its significance at the neural activity level has never been identified. We investigated cortico-subcortical plasticity in PD using the oculomotor system as a model to study reorganization of dopaminergic networks. This model is ideal because this system reorganizes due to frontal-to-parietal shifts in blood oxygen level–dependent (BOLD) activity. We tested the prediction that functional activation plasticity is associated with postsynaptic dopaminergic modifications by combining positron emission tomography/functional magnetic resonance imaging to investigate striatal postsynaptic reorganization of dopamine D2 receptors (using 11C-raclopride) and neural activation in PD. We used covariance (connectivity) statistics at molecular and functional levels to probe striato-cortical reorganization in PD in on/off medication states to show that functional and molecular forms of reorganization are related. D2 binding across regions defined by prosaccades showed increased molecular connectivity between both caudate/putamen and hyperactive parietal eye fields in PD in contrast with frontal eye fields in controls, in line with the shift model. Concerning antisaccades, parietal-striatal connectivity dominated in again in PD, unlike frontal regions. Concerning molecular–BOLD covariance, a striking sign reversal was observed: PD patients showed negative frontal-putamen functional–molecular associations, consistent with the reorganization shift, in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication PD patients confirmed the negative BOLD–molecular correlation. These results provide a link among BOLD responses, striato-cortical synaptic reorganization, and neural plasticity in PD.
Accessibility: Document exists in file
Language:
eng
Author:
Rebelo, D.
Secondary author(s):
Oliveira, F., Abrunhosa, A., Januário, C., Lemos, J., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Rebelo, D., Oliveira, F., Abrunhosa, A., Januário, C., Lemos, J., & Castelo-Branco, M. (2021). A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 118(3): e2013962118. https://doi.org/10.1073/pnas.2013962118
2-year Impact Factor: 12.799|2021
Times cited: 12|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Functional magnetic resonance imaging / Positron emission tomography / Functional connectivity / Molecular imaging

A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease

A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease

DocumentVentral caudate and anterior insula recruitment during value estimation of passionate rewarding cues2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.03
Location: BF-GMS
Title:
Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues
Publication year: 2020
URL:
https://www.frontiersin.org/articles/10.3389/fnins.2020.00678/full
Abstract/Results: ABSTRACT:
“Wanting”, a component of reward processing, is a motivational property that guides decision making in goal-oriented behavior. This includes behavior aiming at supporting relational bonds, even at the group level. Accordingly, group belongingness works as this motivational property, which is fundamentally different from romantic or maternal love. While primary rewards (or learned associations, such as money) have been largely used to study the conceptual framework associated with “wanting,” other cues triggering behavior, such as passionate motives, are less well-studied. We investigated the neural correlates of value estimation of a passion-driven incentive in neuropsychologically defined football fans. We asked the participants (n = 57) to compute the value of football tickets (the cues that trigger passionate behavior in this “tribal love” context). The trials were all different, comprising tickets for different matches. The participants had no restrictions on the amount to be introduced. This enabled a parametric functional magnetic resonance imaging design based on the explicit estimated value given by the participants in a trial-by-trial approach. Using a whole-brain approach (to prevent biased focus on value-related regions), only the activity in the ventral caudate and left anterior insula showed a critical relationship with the reported value. Higher normalized values led to more activity in the striatum and left insula. The parametric map shows that these regions encode the magnitude of incentive by indexing self-relevant value. Other regions were involved in value computation, such as the ventromedial prefrontal cortex, lateral orbitofrontal cortex, and dorsolateral prefrontal cortex, but did not exhibit parametric patterns. The involvement of the nucleus accumbens in value estimation was only found in region of interest -based analysis, which emphasizes the role of the ventral caudate for the presently studied social “reinforcer” cue.
Accessibility: Document exists in file
Language:
eng
Author:
Duarte, I. C.
Secondary author(s):
Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Duarte, I. C., Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M. (2020). Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues. Frontiers in Neuroscience, 14: 678. https://doi.org/10.3389/fnins.2020.00678
2-year Impact Factor: 4.677|2020
Times cited: 5|2025-02-14
Indexed document: Yes
Quartile: Q2
Keywords: Reward / Decision making / Ingroup / Striatum / Insula / Caudate

Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

DocumentIdentification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.04
Location: BF-GMS
Title:
Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S105381192030639X
Abstract/Results: ABSTRACT:
Hysteresis is a well-known phenomenon in physics that relates changes in a system with its prior history. It is also part of human visual experience (perceptual hysteresis), and two different neural mechanisms might explain it: persistence (a cause of positive hysteresis), which forces to keep a current percept for longer, and adaptation (a cause of negative hysteresis), which in turn favors the switch to a competing percept early on. In this study, we explore the neural correlates underlying these mechanisms and the hypothesis of their competitive balance, by combining behavioral assessment with fMRI. We used machine learning on the behavioral data to distinguish between positive and negative hysteresis, and discovered a neural correlate of persistence at a core region of the ventral attention network, the anterior insula. Our results add to the understanding of perceptual multistability and reveal a possible mechanistic explanation for the regulation of different forms of perceptual hysteresis.
Accessibility: Document exists in file
Language:
eng
Author:
Sayal, A.
Secondary author(s):
Sousa, T., Duarte, J. V., Costa, G. N., Martins, R., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Sayal, A., Sousa, T., Duarte, J. V., Costa, G. N., Martins, R., & Castelo-Branco, M. (2020). Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system. Neuroimage, 221: 117153. https://doi.org/10.1016/j.neuroimage.2020.117153
2-year Impact Factor: 6.556|2020
Times cited: 12|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Perceptual decision / Hysteresis / Perceptual history / Bistable visual motion

Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system

Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system

DocumentThe dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.05
Location: BF-GMS
Title:
The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision
Publication year: 2021
URL:
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25339
Abstract/Results: ABSTRACT:
Neuroimaging studies have suggested that hMT+ encodes global motion interpretation, but this contradicts the notion that BOLD activity mainly reflects neuronal input. While measuring fMRI responses at 7 Tesla, we used an ambiguous moving stimulus, yielding the perception of two incoherently moving surfaces—component motion—or only one coherently moving surface—pattern motion, to induce perceptual fluctuations and identify perceptual organization size-matched domains in hMT+. Then, moving gratings, exactly matching either the direction of component or pattern motion percepts of the ambiguous stimulus, were shown to the participants to investigate whether response properties reflect the input or decision. If hMT+ responses reflect the input, component motion domains (selective to incoherent percept) should show grating direction stimulus-dependent changes, unlike pattern motion domains (selective to the coherent percept). This hypothesis is based on the known direction-selective nature of inputs in component motion perceptual domains versus non-selectivity in pattern motion perceptual domains. The response amplitude of pattern motion domains did not change with grating direction (consistently with their non-selective input), in contrast to what happened for the component motion domains (consistently with their selective input). However, when we analyzed relative ratio measures they mirrored perceptual interpretation. These findings are consistent with the notion that patterns of BOLD responses reflect both sensory input and perceptual read-out.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2016-207.09
Author: Sousa, T.
Secondary author(s):
Duarte, J. V., Costa, G. N., Kemper, V. G., Martins, R., Goebel, R., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
3
Reference:
Sousa, T., Duarte, J. V., Costa, G. N., Kemper, V. G., Martins, R., Goebel, R., & Castelo-Branco, M. (2021). The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision. Human Brain Mapping. https://doi.org/10.1002/hbm.25339
2-year Impact Factor: 5.399|2021
Times cited: 3|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Ambiguous visual motion / BOLD mechanisms / Direction-selective input / Perceptual bistability

The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision

The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision

DocumentThe Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.06
Location: BF-GMS
Title:
The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies
Publication year: 2021
URL:
https://www.frontiersin.org/articles/10.3389/fphar.2021.739053/full
Abstract/Results: ABSTRACT:
There is an increasing interest in the neural effects of psychoactive drugs, in particular tryptamine psychedelics, which has been incremented by the proposal that they have potential therapeutic benefits, based on their molecular mimicry of serotonin. It is widely believed that they act mainly through 5HT2A receptors but their effects on neural activation of distinct brain systems are not fully understood. We performed a quantitative meta-analysis of brain imaging studies to investigate the effects of substances within this class (e.g., LSD, Psilocybin, DMT, Ayahuasca) in the brain from a molecular and functional point of view. We investigated the question whether the changes in activation patterns and connectivity map into regions with larger 5HT1A/5HT2A receptor binding, as expected from indolaemine hallucinogens (in spite of the often reported emphasis only on 5HT2AR). We did indeed find that regions with changed connectivity and/or activation patterns match regions with high density of 5HT2A receptors, namely visual BA19, visual fusiform regions in BA37, dorsal anterior and posterior cingulate cortex, medial prefrontal cortex, and regions involved in theory of mind such as the surpramarginal gyrus, and temporal cortex (rich in 5HT1A receptors). However, we also found relevant patterns in other brain regions such as dorsolateral prefrontal cortex. Moreover, many of the above-mentioned regions also have a significant density of both 5HT1A/5HT2A receptors, and available PET studies on the effects of psychedelics on receptor occupancy are still quite scarce, precluding a metanalytic approach. Finally, we found a robust neuromodulatory effect in the right amygdala. In sum, the available evidence points towards strong neuromodulatory effects of tryptamine psychedelics in key brain regions involved in mental imagery, theory of mind and affective regulation, pointing to potential therapeutic applications of this class of substances.
Accessibility: Document exists in file
Language:
eng
Author:
Castelhano, J.
Secondary author(s):
Lima, G., Teixeira, M., Soares, C., Pais, M., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
5
Reference:
Castelhano, J., Lima, G., Teixeira, M., Soares, C., Pais, M., & Castelo-Branco, M. (2021). The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies. Frontiers in Pharmacology, 12, 739053. https://doi.org/10.3389/fphar.2021.739053
2-year Impact Factor: 5.988|2021
Times cited: 8|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: 5-hydroxytryptamine receptor 1A / 5-hydroxytryptamine receptor 2A / Cognition / Functional magnetic resonance imaging / Positron emission tomography / Psychedelic agents / Serotonin

The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies

The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies

Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.07
Location: BF-GMS
Title:
Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks
Publication year: 2022
URL:
https://www.nature.com/articles/s41598-022-07225-0
Abstract/Results: Abstract
Invasive brain recordings using many electrodes across a wide range of tasks provide a unique opportunity to study the role of oscillatory patterning and functional connectivity. We used large-scale recordings (stereo EEG) within and beyond the human hippocampus to investigate the role of distinct frequency oscillations during real-time execution of visual, attention and memory tasks in eight epileptic patients. We found that activity patterns in the hippocampus showed task and frequency dependent properties. Importantly, we found distinct connectivity signatures, in particular concerning parietal-hippocampal connectivity, thus revealing large scale synchronization of networks involved in memory tasks. Comparing the power per frequency band, across tasks and hippocampal regions (anterior/posterior) we confirmed a main effect of frequency band (p = 0.002). Gamma band activity was higher for visuo-spatial memory tasks in the anterior hippocampus. Further, we found that alpha and beta band activity in posterior hippocampus had larger modulation for high memory load visual tasks (p = 0.004). Three functional connectivity task related networks were identified: (dorsal) parietal-hippocampus (visual attention and memory), ventral stream- hippocampus and hippocampal-frontal connections (mainly tasks involving face recognition or object based search). These findings support the critical role of oscillatory patterning in the hippocampus during visual and memory tasks and suggests the presence of task related spectral and functional connectivity signatures. These results show that the use of large scale human intracranial recordings can validate the role of oscillatory and functional connectivity patterns across a broad range of cognitive domains.
Accessibility: Document exists in file
Language:
eng
Author:
Castelhano, J.
Secondary author(s):
Duarte, I., Bernardino, I., Pelle, F., Francione, S., Sales, F., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Castelhano, J., Duarte, I., Bernardino, I., Pelle, F., Francione, S., Sales, F., & Castelo-Branco, M. (2022). Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks. Scientific Reports, 12(1), 3488. https://doi.org/10.1038/s41598-022-07225-0
2-year Impact Factor: 4.600|2022
Times cited: 4|2024-02-15
Indexed document: Yes
Quartile: Q2

Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks

Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks

DocumentPositive hysteresis in emotion recognition: Face processing visual regions are involved in perceptual persistence, which mediates interactions between anterior insula and medial prefrontal cortex2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.08
Location: BF-GMS
Title:
Positive hysteresis in emotion recognition: Face processing visual regions are involved in perceptual persistence, which mediates interactions between anterior insula and medial prefrontal cortex
Publication year: 2022
URL:
https://link.springer.com/article/10.3758/s13415-022-01024-w
Abstract/Results: Abstract
Facial emotion perception can be studied from the point of view of dynamic systems whose output may depend not only on current input but also on prior history — a phenomenon known as hysteresis. In cognitive neuroscience, hysteresis has been described as positive (perceptual persistence) or negative (fatigue of current percept) depending on whether perceptual switching occurs later or earlier than actual physical stimulus changes. However, its neural correlates remain elusive. We used dynamic transitions between emotional expressions and combined behavioral assessment with functional magnetic resonance imaging (fMRI) to investigate the underlying circuitry of perceptual hysteresis in facial emotion recognition. Our findings revealed the involvement of face-selective visual areas — fusiform face area (FFA) and superior temporal sulcus (STS) — in perceptual persistence as well as the right anterior insula. Moreover, functional connectivity analyses revealed an interplay between the right anterior insula and medial prefrontal cortex, which showed to be dependent on the presence of positive hysteresis. Our results support the hypothesis that high-order regions are involved in perceptual stabilization and decision during perceptual persistence (positive hysteresis) and add evidence to the role of the anterior insula as a hub of sensory information in perceptual decision-making.
Accessibility: Document exists in file
Language:
eng
Author:
Verdade, A.
Secondary author(s):
Sousa, T., Castelhano, J., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Verdade, A., Sousa, T., Castelhano, J., & Castelo-Branco, M. (2022). Positive hysteresis in emotion recognition: Face processing visual regions are involved in perceptual persistence, which mediates interactions between anterior insula and medial prefrontal cortex. Cognitive, Affective, & Behavioral Neuroscience. https://doi.org/10.3758/s13415-022-01024-w
2-year Impact Factor: 2.900|2022
Times cited: 2|2024-02-15
Indexed document: Yes
Quartile: Q2
Keywords: Decision-making / Dynamic facial expression / Emotion perception / fMRI / Perceptual history

Positive hysteresis in emotion recognition: Face processing visual regions are involved in perceptual persistence, which mediates interactions between anterior insula and medial prefrontal cortex

Positive hysteresis in emotion recognition: Face processing visual regions are involved in perceptual persistence, which mediates interactions between anterior insula and medial prefrontal cortex

DocumentFinal report - Spiritual states induced by ayahuasca, and the involvement of the reward system2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.01
Location: BF-GMS
Title:
Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system
Publication year: 2022
Abstract/Results:
ABSTRACT:
BACKGROUND
DMT is an indole alkaloid best known by its presence in ayahuasca. It is a psychedelic tryptamine associated with intense visual phenomena, perception changes and profound spiritual
experiences.
AIMS
In this study we explored the neural correlates of these altered brain states during the experience produced by DMT using resting state fMRI and periodic visual stimuli.
METHOD
A within-subject design study with control and active treatment conditions was conducted, in 2 separate sessions: Control (no treatment) or Active treatment (inhaled DMT). In both sessions, pre and post measures of subjective experience were collected with the Spiritual Well Being Questionnaire, the Vividness of Visual Imagery Questionnaire, the Mystical Experience Questionnaire (MEQ-30) and the Hallucinogen Rating Scale (HRS). fMRI included resting state,
block design with a visual hallucination inducer paradigm, and visual population receptive field
(pRF) mapping.
RESULTS
Significant behavioural and psychological effects were observed for hallucinogen and mystical subjective experiences. A surprising intrinsic hyperconnectivity pattern was found within functionally segregated regions of the DMN and Salience networks.
Mean pRF size in V1 was statistically significantly higher in the DMT condition. Visual stimulation yielded increased BOLD activity in visual areas BA18, 19 and Precuneus for the active condition. This may explain perceptual distortions induced by psychedelics such as field blurring and the enlargement of nearby visual space, particularly at the visual periphery.
CONCLUSIONS
These results suggest a neural basis for the hallucinations evoked by Ayahuasca which occur concomitantly with significant behavioural and psychological effects.
Accessibility: Document exists in file
Language:
eng
Author:
Pais, M. L.
Secondary author(s):
Soares, C., Teixeira, M., Lima, G., Cabral, C., Petrella, L., Castelo-Branco, M.
Document type:
Final report
Number of reproductions:
3
Reference:
Pais, M. L., Soares, C., Teixeira, M., Lima, G., Cabral, C., Petrella, L., & Castelo-Branco, M. (2022). Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system
Indexed document: No
Keywords: Cognition / functional magnetic resonance imaging (fMRI) / Psychedelic agents / Serotonin / Spiritual states / Hallucinations

Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system

Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system

DocumentThe relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.09
Location: BF-GMS
Title:
The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S0149763423002944?via%3Dihub
Abstract/Results: ABSTRACT:
The Default Mode Network (DMN) and the Theory of Mind (ToM) networks play a crucial role in our understanding of the neurocognition of the self. The DMN is commonly associated with introspection, while the ToM is involved in perspective-taking. There is no research investigating the overlap between the DMN and ToM in relation to causal effects such as induced by psychedelics, and their precise relationship remains therefore unknown. Psychedelics alter self-perception and modulate these networks, providing a unique opportunity to shed light on this relationship. We performed a quantitative meta-analysis of 88 studies with a total of 2122 participants to investigate the overlap between DMN and ToM and whether psychedelics affect their neural relationship. We found that the cingulate cortex (BA23 and BA31) plays a crucial role in the overlap between these networks which is substantiated by the effects of psychedelics. These compounds affect the neural basis of ToM and social cognition, which may underlie their therapeutic potential and deepen our understanding of the neural correlates of the self.
Accessibility: Document exists in file
Language:
eng
Author:
Soares, C.
Secondary author(s):
Gonzalo, G., Castelhano, J., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Soares, C., Gonzalo, G., Castelhano, J., & Castelo-Branco, M. (2023). The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis. Neuroscience and Biobehavioral Reviews, 152, 105325. https://doi.org/10.1016/j.neubiorev.2023.105325
2-year Impact Factor: 3.1|2023
Times cited: 1|2024-02-16
Indexed document: Yes
Quartile: Q1
Keywords: Default mode network / Theory of mind / Psychedelics / Meta-analysis

The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis

The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis

DocumentRapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.10
Location: BF-GMS
Title:
Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields
Publication year: 2024
URL:
https://doi.org/10.1016/j.neuroimage.2024.120718
Abstract/Results: Abstract:
N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A serotonin receptors, which is associated with intense visual hallucinatory phenomena and perceptual changes such as distortions in visual space. The neural underpinnings of these effects remain unknown. We hypothesised that changes in population receptive field (pRF) properties in the primary visual cortex (V1) might underlie visual perceptual experience. We tested this hypothesis using magnetic resonance imaging (MRI) in a within-subject design. We used a technique called pRF mapping, which measures neural population visual response properties and retinotopic maps in early visual areas. We show that in the presence of visual effects, as documented by the Hallucinogen
Rating Scale (HRS), the mean pRF sizes in V1 significantly increase in the peripheral visual field for active condition (inhaled DMT) compared to the control. Eye and head movement differences were absent across conditions. This evidence for short-term effects of DMT in pRF may explain perceptual distortions induced by psychedelics such as field blurring, tunnel vision (peripheral vision becoming blurred while central vision remains sharp) and the enlargement of nearby visual space, particularly at the visual locations surrounding the fovea. Our findings are also consistent with a mechanistic framework whereby gain control of ongoing and evoked activity in the visual cortex is controlled by activation of 5-HT2A receptors.
Accessibility: Document exists in file
Language:
eng
Author:
Pais, M. L.
Secondary author(s):
Teixeira, M., Soares, C., Lima, G., Rijo, P., Cabral, C., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Pais, M. L., Teixeira, M., Soares, C., Lima, G., Rijo, P., Cabral, C., & Castelo-Branco, M. (2024). Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields. NeuroImage, 297, 120718. https://doi.org/10.1016/j.neuroimage.2024.120718
2-year Impact Factor: 4.7|2023
Times cited: 0|2024-07-29
Indexed document: Yes
Quartile: Q1
Keywords: Serotonin / 5-HT2A receptors / Psychedelics / Visual hallucinations / Population responses / Visual cortex

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields

DocumentPsychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.11
Location: BF-GMS
Title:
Psychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices
Publication year: 2024
URL:
https://doi.org/10.1111/bcp.16264
Abstract/Results: ABSTRACT:
Recent years have witnessed an unprecedented increase in the search for the use of psychedelics in improving physical and mental health. Anaesthesia has evolved since very early times, born from the need to eliminate pain and reduce suffering and there are reports of the use of anaesthetics to achieve mystical states since the nineteenth century. Nowadays, the renaissance of psychedelics in anaesthesia has been inspired by their potential in the treatment of chronic pain syndromes, palliative care and in the emergency department and pre-hospital care with the administration of psychedelics in cases of ischaemia, given their potential in neuroprotection. Although there are already some published protocols for the administration of psychedelics in patients with mental illness, little has been addressed concerning non-mental medical applications. In this sense, in patients with multiple comorbidities, functional limitations and polymedicated, the anaesthetist may play a fundamental role, not only in clinical practice, but also in translational research. This article focuses on the description of psychedelics, with a particular focus on dimethyltryptamine (DMT) and ayahuasca pharmacology, effects, safety and toxicity. A detailed description of the role of the anaesthetist in clinical and experimental research is provided, from participant's screening to preparation and dosing session, expected adverse effects and how to manage them, based on the protocol and standard procedures of a current study with neuroimaging during the psychedelic experience. Specific considerations regarding the management of psychedelic toxicity are also provided as well as future directions for safe psychedelic use in clinical practice.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, G.
Secondary author(s):
Soares, C., Teixeira, M., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Lima, G., Soares, C., Teixeira, M., & Castelo-Branco, M. (2024). Psychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices. British Journal of Clinical Pharmacology, 10.1111/bcp.16264. Advance online publication. https://doi.org/10.1111/bcp.16264
2-year Impact Factor: 0.81|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2024-10-15
Indexed document: Yes
Quartile: Q2
Keywords: Anaesthesia / Ayahuasca / Dimethyltryptamine / Psychedelic research / Psychedelic toxicity / Serotonin toxicity

DocumentIncreased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.12
Location: BF-GMS
Title:
Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)
Publication year: 2024
URL:
https://doi.org/10.3389/fphar.2024.1454628
Abstract/Results: ABSTRACT:
The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorders involving socio-emotional and reward processing deficits. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) can be used to detect changes in brain connectivity during psychedelic-induced states. Thus, this pharmacoimaging study investigates the effects of N,N-Dimethyltryptamine (DMT) on functional connectivity in brain areas relevant to social cognition, using a within-subject design in eleven healthy experienced users. The study included both an active and a control condition, conducted at different time points. The active condition involved DMT inhalation, while the control condition did not. Seed-based connectivity was measured for the two core regions involved in theory of mind and emotional processing, respectively, the posterior supramarginal gyrus and the amygdala. DMT increased supramarginal gyrus connectivity with the precuneus, posterior cingulate gyrus, amygdala, and orbitofrontal cortex. Additionally, increased connectivity emerged between the amygdala and orbitofrontal cortex. These results demonstrate that DMT modulates brain connectivity in socio-emotional and affective-value circuits, advancing our understanding of the neural mechanisms underlying the psychedelic experience and its potential therapeutic action.
Accessibility: Document exists in file
Language:
eng
Author:
Soares, C.
Secondary author(s):
Lima, G., Pais, M. L., Teixeira, M., Cabral, C., Castelo-Branco, M.
Document type:
Article
Reference:
Soares, C., Lima, G., Pais, M. L., Teixeira, M., Cabral, C., & Castelo-Branco, M. (2024). Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT). Frontiers in Pharmacology, 15, 1454628. https://doi.org/10.3389/fphar.2024.1454628
2-year Impact Factor: 1.15|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2024-11-27
Indexed document: Yes
Quartile: Q1
Keywords: N,N-Dimethyltryptamine (DMT) / fMRI / Functional connectivity / Pharmacoimaging / Psychedelics / Social cognition

Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)

Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)