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File252 - Spiritual states induced by ayahuasca, and the involvement of the reward system

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Researcher(s): Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

DocumentA link between synaptic plasticity and reorganization of brain activity in Parkinson's disease2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Researcher(s): Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.02
Location: BF-GMS
Title:
A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease
Publication year: 2021
URL:
https://www.pnas.org/content/118/3/e2013962118
Abstract/Results: ABSTRACT:
The link between synaptic plasticity and reorganization of brain activity in health and disease remains a scientific challenge. We examined this question in Parkinson’s disease (PD) where functional up-regulation of postsynaptic D2 receptors has been documented while its significance at the neural activity level has never been identified. We investigated cortico-subcortical plasticity in PD using the oculomotor system as a model to study reorganization of dopaminergic networks. This model is ideal because this system reorganizes due to frontal-to-parietal shifts in blood oxygen level–dependent (BOLD) activity. We tested the prediction that functional activation plasticity is associated with postsynaptic dopaminergic modifications by combining positron emission tomography/functional magnetic resonance imaging to investigate striatal postsynaptic reorganization of dopamine D2 receptors (using 11C-raclopride) and neural activation in PD. We used covariance (connectivity) statistics at molecular and functional levels to probe striato-cortical reorganization in PD in on/off medication states to show that functional and molecular forms of reorganization are related. D2 binding across regions defined by prosaccades showed increased molecular connectivity between both caudate/putamen and hyperactive parietal eye fields in PD in contrast with frontal eye fields in controls, in line with the shift model. Concerning antisaccades, parietal-striatal connectivity dominated in again in PD, unlike frontal regions. Concerning molecular–BOLD covariance, a striking sign reversal was observed: PD patients showed negative frontal-putamen functional–molecular associations, consistent with the reorganization shift, in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication PD patients confirmed the negative BOLD–molecular correlation. These results provide a link among BOLD responses, striato-cortical synaptic reorganization, and neural plasticity in PD.
Accessibility: Document exists in file
Language:
eng
Author:
Rebelo, D.
Secondary author(s):
Oliveira, F., Abrunhosa, A., Januário, C., Lemos, J., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Rebelo, D., Oliveira, F., Abrunhosa, A., Januário, C., Lemos, J., & Castelo-Branco, M. (2021). A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 118(3): e2013962118. doi: 10.1073/pnas.2013962118
2-year Impact Factor: 11.205|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 1|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Functional magnetic resonance imaging / Positron emission tomography / Functional connectivity / Molecular imaging

A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease

A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease

DocumentVentral caudate and anterior insula recruitment during value estimation of passionate rewarding cues2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Researcher(s): Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.03
Location: BF-GMS
Title:
Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues
Publication year: 2020
URL:
https://www.frontiersin.org/articles/10.3389/fnins.2020.00678/full
Abstract/Results: ABSTRACT:
“Wanting”, a component of reward processing, is a motivational property that guides decision making in goal-oriented behavior. This includes behavior aiming at supporting relational bonds, even at the group level. Accordingly, group belongingness works as this motivational property, which is fundamentally different from romantic or maternal love. While primary rewards (or learned associations, such as money) have been largely used to study the conceptual framework associated with “wanting,” other cues triggering behavior, such as passionate motives, are less well-studied. We investigated the neural correlates of value estimation of a passion-driven incentive in neuropsychologically defined football fans. We asked the participants (n = 57) to compute the value of football tickets (the cues that trigger passionate behavior in this “tribal love” context). The trials were all different, comprising tickets for different matches. The participants had no restrictions on the amount to be introduced. This enabled a parametric functional magnetic resonance imaging design based on the explicit estimated value given by the participants in a trial-by-trial approach. Using a whole-brain approach (to prevent biased focus on value-related regions), only the activity in the ventral caudate and left anterior insula showed a critical relationship with the reported value. Higher normalized values led to more activity in the striatum and left insula. The parametric map shows that these regions encode the magnitude of incentive by indexing self-relevant value. Other regions were involved in value computation, such as the ventromedial prefrontal cortex, lateral orbitofrontal cortex, and dorsolateral prefrontal cortex, but did not exhibit parametric patterns. The involvement of the nucleus accumbens in value estimation was only found in region of interest -based analysis, which emphasizes the role of the ventral caudate for the presently studied social “reinforcer” cue.
Accessibility: Document exists in file
Language:
eng
Author:
Duarte, I. C.
Secondary author(s):
Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Duarte, I. C., Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M. (2020). Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues. Frontiers in Neuroscience, 14: 678. doi: 10.3389/fnins.2020.00678
2-year Impact Factor: 4.677|2020
Times cited: 0|2021-08-25
Indexed document: Yes
Quartile: Q2
Keywords: Reward / Decision making / Ingroup / Striatum / Insula / Caudate

Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

DocumentIdentification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Researcher(s): Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.04
Location: BF-GMS
Title:
Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S105381192030639X
Abstract/Results: ABSTRACT:
Hysteresis is a well-known phenomenon in physics that relates changes in a system with its prior history. It is also part of human visual experience (perceptual hysteresis), and two different neural mechanisms might explain it: persistence (a cause of positive hysteresis), which forces to keep a current percept for longer, and adaptation (a cause of negative hysteresis), which in turn favors the switch to a competing percept early on. In this study, we explore the neural correlates underlying these mechanisms and the hypothesis of their competitive balance, by combining behavioral assessment with fMRI. We used machine learning on the behavioral data to distinguish between positive and negative hysteresis, and discovered a neural correlate of persistence at a core region of the ventral attention network, the anterior insula. Our results add to the understanding of perceptual multistability and reveal a possible mechanistic explanation for the regulation of different forms of perceptual hysteresis.
Accessibility: Document exists in file
Language:
eng
Author:
Sayal, A.
Secondary author(s):
Sousa, T., Duarte, J. V., Costa, G. N., Martins, R., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Sayal, A., Sousa, T., Duarte, J. V., Costa, G. N., Martins, R., & Castelo-Branco, M. (2020). Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system. Neuroimage, 221: 117153. doi:
10.1016/j.neuroimage.2020.117153
2-year Impact Factor: 6.556|2020
Times cited: 0|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Perceptual decision / Hysteresis / Perceptual history / Bistable visual motion

Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system

Identification of competing neural mechanisms underlying positive and negative perceptual hysteresis in the human visual system

DocumentThe dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Researcher(s): Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.05
Location: BF-GMS
Title:
The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision
Publication year: 2021
URL:
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25339
Abstract/Results: ABSTRACT:
Neuroimaging studies have suggested that hMT+ encodes global motion interpretation, but this contradicts the notion that BOLD activity mainly reflects neuronal input. While measuring fMRI responses at 7 Tesla, we used an ambiguous moving stimulus, yielding the perception of two incoherently moving surfaces—component motion—or only one coherently moving surface—pattern motion, to induce perceptual fluctuations and identify perceptual organization size-matched domains in hMT+. Then, moving gratings, exactly matching either the direction of component or pattern motion percepts of the ambiguous stimulus, were shown to the participants to investigate whether response properties reflect the input or decision. If hMT+ responses reflect the input, component motion domains (selective to incoherent percept) should show grating direction stimulus-dependent changes, unlike pattern motion domains (selective to the coherent percept). This hypothesis is based on the known direction-selective nature of inputs in component motion perceptual domains versus non-selectivity in pattern motion perceptual domains. The response amplitude of pattern motion domains did not change with grating direction (consistently with their non-selective input), in contrast to what happened for the component motion domains (consistently with their selective input). However, when we analyzed relative ratio measures they mirrored perceptual interpretation. These findings are consistent with the notion that patterns of BOLD responses reflect both sensory input and perceptual read-out.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2016-207.09
Author: Sousa, T.
Secondary author(s):
Duarte, J. V., Costa, G. N., Kemper, V. G., Martins, R., Goebel, R., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
3
Reference:
Sousa, T., Duarte, J. V., Costa, G. N., Kemper, V. G., Martins, R., Goebel, R., & Castelo-Branco, M. (2021). The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision. Human Brain Mapping. doi: 10.1002/hbm.25339
2-year Impact Factor: 5.038|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 0|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Ambiguous visual motion / BOLD mechanisms / Direction-selective input / Perceptual bistability

The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision

The dual nature of the BOLD signal: Responses in visual area hMT+ reflect both input properties and perceptual decision