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File331 - Frontostriatal neurophysiological underpins of decision-making2020-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-331
Location: BF-GMS
Title:
331 - Frontostriatal neurophysiological underpins of decision-making
Duration: 2020-02
Researcher(s):
Hugo Leite-Almeida, Madalena Esteves, Marco Rafael Guimarães, Ana Margarida Cunha, Joana Mendes, Armando Almeida
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Leite-Almeida, H.
Secondary author(s):
Esteves, M., Guimarães, M. R., Cunha, A. M., Mendes, J., Almeida, A.
Number of reproductions:
1
Keywords:
Cognitive flexibility / Impulsivity / Network activity / Local field potentials / Psychophysiology

DocumentAssessing impulsivity in humans and rodents: Taking the translational road2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-331
Location: BF-GMS
Title:
331 - Frontostriatal neurophysiological underpins of decision-making
Duration: 2020-02
Researcher(s):
Hugo Leite-Almeida, Madalena Esteves, Marco Rafael Guimarães, Ana Margarida Cunha, Joana Mendes, Armando Almeida
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Leite-Almeida, H.
Secondary author(s):
Esteves, M., Guimarães, M. R., Cunha, A. M., Mendes, J., Almeida, A.
Number of reproductions:
1
Keywords:
Cognitive flexibility / Impulsivity / Network activity / Local field potentials / Psychophysiology

Reference code: PT/FB/BL-2018-331.02
Location: BF-GMS
Title:
Assessing impulsivity in humans and rodents: Taking the translational road
Publication year: 2021
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.647922/full
Abstract/Results: ABSTRACT:
Impulsivity is a multidimensional construct encompassing domains of behavioral inhibition as well as of decision making. It is often adaptive and associated with fast responses, being in that sense physiological. However, abnormal manifestations of impulsive behavior can be observed in contexts of drug abuse and attention-deficit/hyperactivity disorder (ADHD), among others. A number of tools have therefore been devised to assess the different facets of impulsivity in both normal and pathological contexts. In this narrative review, we systematize behavioral and self-reported measures of impulsivity and critically discuss their constructs and limitations, establishing a parallel between assessments in humans and rodents. The first rely on paradigms that are typically designed to assess a specific dimension of impulsivity, within either impulsive action (inability to suppress a prepotent action) or impulsive choice, which implies a decision that weighs the costs and benefits of the options. On the other hand, self-reported measures are performed through questionnaires, allowing assessment of impulsivity dimensions that would be difficult to mimic in an experimental setting (e.g., positive/negative urgency and lack of premeditation) and which are therefore difficult (if not impossible) to measure in rodents.
Accessibility: Document exists in file
Language:
eng
Author:
Esteves, M.
Secondary author(s):
Moreira, P. S., Sousa, N., Leite-Almeida, H.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Esteves, M., Moreira, P. S., Sousa, N., & Leite-Almeida, H. (2021). Assessing impulsivity in humans and rodents: Taking the translational road. Frontiers in Behavioral Neuroscience, 15, 647922. https://doi.org/10.3389/fnbeh.2021.647922
2-year Impact Factor: 3.617|2021
Times cited: 9|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Impulsivity / Behavior / Self-report / Translation / Back-translation

Assessing impulsivity in humans and rodents: Taking the translational road

Assessing impulsivity in humans and rodents: Taking the translational road

DocumentFinal report - Frontostriatal neurophysiological underpins of decision-making2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-331
Location: BF-GMS
Title:
331 - Frontostriatal neurophysiological underpins of decision-making
Duration: 2020-02
Researcher(s):
Hugo Leite-Almeida, Madalena Esteves, Marco Rafael Guimarães, Ana Margarida Cunha, Joana Mendes, Armando Almeida
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Leite-Almeida, H.
Secondary author(s):
Esteves, M., Guimarães, M. R., Cunha, A. M., Mendes, J., Almeida, A.
Number of reproductions:
1
Keywords:
Cognitive flexibility / Impulsivity / Network activity / Local field potentials / Psychophysiology

Reference code: PT/FB/BL-2018-331.01
Location: BF-GMS
Title:
Final report - Frontostriatal neurophysiological underpins of decision-making
Publication year: 2024
Local:
BF-GMS
Abstract/Results: Abstract:
Background Decision-making processes are critical for adaptive behavior and dysfunctions in these processes underly various neuropsychiatric disorders. Previous studies have shown that the frontostriatal circuits play a vital role in mediating decision-making including inhibitory control and impulsive decision-making.
Aims In this project we investigated frontostriatal neurophysiological mechanisms underpinning impulsive vs timed decisions.
Method Using male rats with chronically implanted electrodes in the prelimbic cortex (PrL), orbitofrontal cortex (OFC), striatum (Str), and nucleus accumbens (NAcc), local field potentials (LFPs) were recorded while performing tasks designed to assess impulsivity and delay tolerance, namely the variable delay-to-signal (VDS) protocol. Data analysis involved power and coherence measurements in frequency ranges (theta, beta, low gamma, high gamma).
Results Key findings include distinct neural signatures associated with timed versus premature responses and a distinct PrL involvement predicting impulsive behavior. Logistic regression models indicated both electrophysiological and behavioral factors, such as high gamma power in the PrL and NAcc, previous session prematurity, and feeding perseverance, influenced premature responses. PrL manipulation using an inhibitory pharmacogenetic strategy (DREADDs) did not show significant effects on behavior and in the neural dynamics through LFPs.
Conclusions The study concludes that frontostriatal activity is crucial for decision-making, particularly the involvement of PrL and NAcc just prior to the decision processes. Future research will focus on refining neural manipulation techniques and further exploring the decision-specific network dynamics.
Accessibility: Document exists in file
Language:
eng
Author:
Leite-Almeida, H.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Behavioral neuroscience / Cognitive control / Impulsivity / Neural dynamics / Rodents

Final report - Frontostriatal neurophysiological underpins of decision-making

Final report - Frontostriatal neurophysiological underpins of decision-making