Reference code: | PT/FB/BL-2018-356.04 |
Location: | BF-GMS
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Title:
| Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
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Publication year: | 2020
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URL:
| https://www.nature.com/articles/s41467-020-18033-3
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Abstract/Results: | ABSTRACT:
A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. We first quantified shared working memory alterations in a delayed-response task. In both patient groups, we report a markedly reduced influence of previous stimuli on working memory contents, despite preserved memory precision. We then simulated this finding with NMDAR-dependent synaptic alterations in a microcircuit model of prefrontal cortex. Changes in cortical excitation destabilized within-trial memory maintenance and could not account for disrupted serial dependence in working memory. Rather, a quantitative fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism operating on longer timescales, such as short-term potentiation.
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Accessibility: | Document exists in file
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Language:
| eng
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Author:
| Stein, H.
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Secondary author(s):
| Barbosa, J., Rosa-Justicia, M., Prades, L., Morató, A., Galan-Gadea, A., Ariño, H., Martinez-Hernandez, E., Castro-Fornieles, J., Dalmau, J., Compte, A.
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Document type:
| Article
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Number of reproductions:
| 1
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Reference:
| Stein, H., Barbosa, J., Rosa-Justicia, M., Prades, L., Morató, A., Galan-Gadea, A., Ariño, H., Martinez-Hernandez, E., Castro-Fornieles, J., Dalmau, J., & Compte, A. (2020). Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia. Nature communications, 11: 4250. https://doi.org/10.1038/s41467-020-18033-3
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2-year Impact Factor: | 14.919|2020
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Times cited: | 39|2025-02-14
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Indexed document: | Yes
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Quartile: | Q1
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Keywords: | Working memory / Schizophrenia / Autoimmune anti-NMDAR encephalitis
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Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia |