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File356 - Neural mechanisms underlying unconscious working memory2019-052021-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

DocumentInterplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.02
Location: BF-GMS
Title:
Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory
Publication year: 2020
URL:
https://pubmed.ncbi.nlm.nih.gov/32572236/
Abstract/Results: ABSTRACT:
Persistent neuronal spiking has long been considered the mechanism underlying working memory, but recent proposals argue for alternative 'activity-silent' substrates. Using monkey and human electrophysiology data, we show here that attractor dynamics that control neural spiking during mnemonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC). This interaction allows memory reactivations, which enhance serial biases in spatial working memory. Stimulus information was not decodable between trials, but remained present in activity-silent traces inferred from spiking synchrony in the PFC. Just before the new stimulus, this latent trace was reignited into activity that recapitulated the previous stimulus representation. Importantly, the reactivation strength correlated with the strength of serial biases in both monkeys and humans, as predicted by a computational model that integrates activity-based and activity-silent mechanisms. Finally, single-pulse transcranial magnetic stimulation applied to the human PFC between successive trials enhanced serial biases, thus demonstrating the causal role of prefrontal reactivations in determining working-memory behavior.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Barbosa, J.
Secondary author(s):
Stein, H., Martinez, R. L., Galan-Gadea, A., Li, S., Dalmau, J., Adam, K. C., Valls-Solé, J., Constantinidis, C., Compte, A.
Document type:
Article
Number of reproductions:
1
Reference:
Barbosa, J., Stein, H., Martinez, R. L., Galan-Gadea, A., Li, S., Dalmau, J., ... Compte, A. (2020). Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory. Nature Neuroscience, 23, 1016-1024. doi: 10.1038/s41593-020-0644-4
2-year Impact Factor: 24.884|2020
Times cited: 20|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Working memory / Prefrontal cortex / Neural spiking

DocumentBuild-up of serial dependence in color working memory2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.03
Location: BF-GMS
Title:
Build-up of serial dependence in color working memory
Publication year: 2020
URL:
https://www.nature.com/articles/s41598-020-67861-2
Abstract/Results: ABSTRACT:
Serial dependence, how immediately preceding experiences bias our current estimations, has been described experimentally during delayed-estimation of many different visual features, with subjects tending to make estimates biased towards previous ones. It has been proposed that these attractive biases help perception stabilization in the face of correlated natural scene statistics, although this remains mostly theoretical. Color, which is strongly correlated in natural scenes, has never been studied with regard to its serial dependencies. Here, we found significant serial dependence in 7 out of 8 datasets with behavioral data of humans (total n?=?760) performing delayed-estimation of color with uncorrelated sequential stimuli. Moreover, serial dependence strength built up through the experimental session, suggesting metaplastic mechanisms operating at a slower time scale than previously proposed (e.g. short-term synaptic facilitation). Because, in contrast with natural scenes, stimuli were temporally uncorrelated, this build-up casts doubt on serial dependencies being an ongoing adaptation to the stable statistics of the environment.
Accessibility: Document exists in file
Language:
eng
Author:
Barbosa, J.
Secondary author(s):
Compte, A.
Document type:
Article
Number of reproductions:
1
Reference:
Barbosa, J., & Compte, A. (2020). Build-up of serial dependence in color working memory. Scientific Reports, 10: 10959. doi: 10.1038/s41598-020-67861-2
2-year Impact Factor: 4.379|2020
Times cited: 1|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Serial dependence / Working memory / Perception

Build-up of serial dependence in color working memory

Build-up of serial dependence in color working memory

DocumentReduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.04
Location: BF-GMS
Title:
Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Publication year: 2020
URL:
https://www.nature.com/articles/s41467-020-18033-3
Abstract/Results: ABSTRACT:
A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. We first quantified shared working memory alterations in a delayed-response task. In both patient groups, we report a markedly reduced influence of previous stimuli on working memory contents, despite preserved memory precision. We then simulated this finding with NMDAR-dependent synaptic alterations in a microcircuit model of prefrontal cortex. Changes in cortical excitation destabilized within-trial memory maintenance and could not account for disrupted serial dependence in working memory. Rather, a quantitative fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism operating on longer timescales, such as short-term potentiation.
Accessibility: Document exists in file
Language:
eng
Author:
Stein, H.
Secondary author(s):
Barbosa, J., Rosa-Justicia, M., Prades, L., Morató, A., Galan-Gadea, A., Ariño, H., Martinez-Hernandez, E., Castro-Fornieles, J., Dalmau, J., Compte, A.
Document type:
Article
Number of reproductions:
1
Reference:
Stein, H., Barbosa, J., Rosa-Justicia, M., Prades, L., Morató, A., Galan-Gadea, A., Ariño, H., Martinez-Hernandez, E., Castro-Fornieles, J., Dalmau, J., & Compte, A. (2020). Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia. Nature communications, 11: 4250. doi: 10.1038/s41467-020-18033-3
2-year Impact Factor: 14.919|2020
Times cited: 3|2021-08-25
Indexed document: Yes
Quartile: Q1
Keywords: Working memory / Schizophrenia / Autoimmune anti-NMDAR encephalitis

Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

DocumentPinging the brain with visual impulses reveals electrically active, not activity-silent working memories2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.05
Location: BF-GMS
Title:
Pinging the brain with visual impulses reveals electrically active, not activity-silent working memories
Publication year: 2021
URL:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001436
Abstract/Results: ABSTRACT:
Persistently active neurons during mnemonic periods have been regarded as the mechanism underlying working memory maintenance. Alternatively, neuronal networks could instead store memories in fast synaptic changes, thus avoiding the biological cost of maintaining an active code through persistent neuronal firing. Such “activity-silent” codes have been proposed for specific conditions in which memories are maintained in a nonprioritized state, as for unattended but still relevant short-term memories. A hallmark of this “activity-silent” code is that these memories can be reactivated from silent, synaptic traces. Evidence for “activity-silent” working memory storage has come from human electroencephalography (EEG), in particular from the emergence of decodability (EEG reactivations) induced by visual impulses (termed pinging) during otherwise “silent” periods. Here, we reanalyze EEG data from such pinging studies. We find that the originally reported absence of memory decoding reflects weak statistical power, as decoding is possible based on more powered analyses or reanalysis using alpha power instead of raw voltage. This reveals that visual pinging EEG “reactivations” occur in the presence of an electrically active, not silent, code for unattended memories in these data. This crucial change in the evidence provided by this dataset prompts a reinterpretation of the mechanisms of EEG reactivations. We provide 2 possible explanations backed by computational models, and we discuss the relationship with TMS-induced EEG reactivations.
Accessibility: Document exists in file
Language:
eng
Author:
Barbosa, J.
Secondary author(s):
Soldevilla, D. L., Compte, A.
Document type:
Article
Number of reproductions:
1
Reference:
Barbosa, J., Lozano-Soldevilla, D., & Compte, A. (2021). Pinging the brain with visual impulses reveals electrically active, not activity-silent working memories. PLoS Biology, 19(10): e3001436. doi: 10.1371/journal.pbio.3001436
2-year Impact Factor: 8.029|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 0|2021-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Working memory

Pinging the brain with visual impulses reveals electrically active, not activity-silent working memories

Pinging the brain with visual impulses reveals electrically active, not activity-silent working memories

DocumentFinal report - Neural mechanisms underlying unconscious working memory2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.01
Location: BF-GMS
Title:
Final report - Neural mechanisms underlying unconscious working memory
Publication year: 2021
URL:
https://www.bial.com/media/3777/neural-mechanisms-underlying-unconscious-working-memory.pdf
Abstract/Results: ABSTRACT:
Working memory is not always accurate in its representations and can be biased by previously encountered stimuli, the so-called serial dependence. This effect has been viewed in consciously perceived memories, but it is unclear whether it also affects subliminally presented cues, which subjects rate as unseen but still report in the correct location above chance. Here, the serial dependence in subliminal working memory is examined experimentally and possible neural mechanisms are explored in silico. Specifically, we tested if the same activity-silent mechanism can account for both subliminal working memory and serial dependence. We performed behavioral experiments which elicited subliminal and supraliminal representations in participants by masking a briefly presented stimulus and by analyzing serial dependence between consecutive trials. In computational models, we tested two types of synaptic mechanisms, synaptic facilitation and short-term potentiation, in bump attractor networks, a well-established framework for modeling working memory on a neural level. The network model predictions were compared to the behavioral results in humans to evaluate the feasibility of explaining both serial dependence and subliminal working memory on the basis of shared activity-silent mechanisms. We found that activity-silent mechanisms can indeed account for single trial behavior of human subjects in both supraliminal and subliminal trials. However, network models could not account for serial dependence observed experimentally in subliminal trials. We conclude that serial dependence and subliminal working memory are unlikely to stem from common activity-silent mechanisms.
Accessibility: Document exists in file
Language:
eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Document type:
Final report
Number of reproductions:
1
Reference:
Compte, A., Barbosa, J., & Valls-Sole, J. (2021). Final report - Neural mechanisms underlying unconscious working memory.
Indexed document: No
Keywords: Working memory / Subliminal perception / Serial dependence / Activity-silent mechanism / Bump-attractor model / Pupil size

Final report - Neural mechanisms underlying unconscious working memory

Final report - Neural mechanisms underlying unconscious working memory

DocumentAcross-area synchronization supports feature integration in a biophysical network model of working memory2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-356
Location: BF-GMS
Title:
356 - Neural mechanisms underlying unconscious working memory
Duration: 2019-05 - 2021-09
Researcher(s):
Albert Compte, João Barbosa, Josep Valls-Sole
Institution(s): Institut d'investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Compte, A.
Secondary author(s):
Barbosa, J., Valls-Sole, J.
Number of reproductions:
1
Keywords:
Working memory / Consciousness / Transcranial magnetic stimulation (TMS) / Psychophysiology

Reference code: PT/FB/BL-2018-356.06
Location: BF-GMS
Title:
Across-area synchronization supports feature integration in a biophysical network model of working memory
Publication year: 2021
URL:
https://www.frontiersin.org/articles/10.3389/fncir.2021.716965/full
Abstract/Results: ABSTRACT:
Working memory function is severely limited. One key limitation that constrains the ability to maintain multiple items in working memory simultaneously is so-called swap errors. These errors occur when an inaccurate response is in fact accurate relative to a non-target stimulus, reflecting the failure to maintain the appropriate association or “binding” between the features that define one object (e.g., color and location). The mechanisms underlying feature binding in working memory remain unknown. Here, we tested the hypothesis that features are bound in memory through synchrony across feature-specific neural assemblies. We built a biophysical neural network model composed of two one-dimensional attractor networks – one for color and one for location – simulating feature storage in different cortical areas. Within each area, gamma oscillations were induced during bump attractor activity through the interplay of fast recurrent excitation and slower feedback inhibition. As a result, different memorized items were held at different phases of the network’s oscillation. These two areas were then reciprocally connected via weak cortico-cortical excitation, accomplishing binding between color and location through the synchronization of pairs of bumps across the two areas. Encoding and decoding of color-location associations was accomplished through rate coding, overcoming a long-standing limitation of binding through synchrony. In some simulations, swap errors arose: “color bumps” abruptly changed their phase relationship with “location bumps.” This model, which leverages the explanatory power of similar attractor models, specifies a plausible mechanism for feature binding and makes specific predictions about swap errors that are testable at behavioral and neurophysiological levels.
Accessibility: Document exits in file
Language:
eng
Author:
Barbosa, J.
Secondary author(s):
Babushkin, V., Temudo, A., Sreenivasan, K. K., Compte, A.
Document type:
Article
Number of reproductions:
1
Reference:
Barbosa, J., Babushkin, V., Temudo, A., Sreenivasan, K. K., & Compte, A. (2021). Across-area synchronization supports feature integration in a biophysical network model of working memory. Frontiers in Neural Circuits, 15, 716965. doi: 10.3389/fncir.2021.716965
2-year Impact Factor: 3.492|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 0|2021-10-21
Indexed document: Yes
Quartile: Q3
Keywords: Working memory / Binding / Oscillations / Multi-area / Attractor network

Across-area synchronization supports feature integration in a biophysical network model of working memory

Across-area synchronization supports feature integration in a biophysical network model of working memory