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File361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?2019-04

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

DocumentSpontaneous beta band rhythms in the predictive coding of natural stimuli2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.02
Location: BF-GMS
Title:
Spontaneous beta band rhythms in the predictive coding of natural stimuli
Publication year: 2020
URL:
https://journals.sagepub.com/doi/full/10.1177/1073858420928988
Abstract/Results: ABSTRACT:
The regularity of the physical world and the biomechanics of the human body movements generate distributions of highly probable states that are internalized by the brain in the course of a lifetime. In Bayesian terms, the brain exploits prior knowledge, especially under conditions when sensory input is unavailable or uncertain, to predictively anticipate the most likely outcome of upcoming stimuli and movements. These internal models, formed during development, yet still malleable in adults, continuously adapt through the learning of novel stimuli and movements.
Traditionally, neural beta (ß) oscillations are considered essential for maintaining sensorimotor and cognitive representations, and for temporal coding of expectations. However, recent findings show that fluctuations of ß band power in the resting state strongly correlate between cortical association regions. Moreover, central (hub) regions form strong interactions over time with different brain regions/networks (dynamic core). ß band centrality fluctuations of regions of the dynamic core predict global efficiency peaks suggesting a mechanism for network integration. Furthermore, this temporal architecture is surprisingly stable, both in topology and dynamics, during the observation of ecological natural visual scenes, whereas synthetic temporally scrambled stimuli modify it. We propose that spontaneous ß rhythms may function as a long-term “prior” of frequent environmental stimuli and behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Betti, V.
Secondary author(s):
Penna, S. D., de Pasquale, F. , Corbetta, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Betti, V., Penna, S. D., de Pasquale, F., & Corbetta, M. (2020). Spontaneous beta band rhythms in the predictive coding of natural stimuli. The Neuroscientist. doi: 10.1177/1073858420928988
2-year Impact Factor: 7.519|2020
Times cited: 12|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: Neural oscillations / Beta band / Priors / Spontaneous activity / Natural vision

Spontaneous beta band rhythms in the predictive coding of natural stimuli

Spontaneous beta band rhythms in the predictive coding of natural stimuli

DocumentVisual exploration dynamics are low-dimensional and driven by intrinsic factors2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.03
Location: BF-GMS
Title:
Visual exploration dynamics are low-dimensional and driven by intrinsic factors
Publication year: 2021
URL:
https://www.nature.com/articles/s42003-021-02608-x
Abstract/Results: ABSTRACT:
When looking at visual images, the eyes move to the most salient and behaviourally relevant objects. Saliency and semantic information significantly explain where people look. Less is known about the spatiotemporal properties of eye movements (i.e., how people look). We show that three latent variables explain 60% of eye movement dynamics of more than a hundred observers looking at hundreds of different natural images. The first component explaining 30% of variability loads on fixation duration, and it does not relate to image saliency or semantics; it approximates a power-law distribution of gaze steps, an intrinsic dynamic measure, and identifies observers with two viewing styles: static and dynamic. Notably, these viewing styles were also identified when observers look at a blank screen. These results support the importance of endogenous processes such as intrinsic dynamics to explain eye movement spatiotemporal properties.
Accessibility: Document exists in file
Language:
eng
Author:
Zangrossi, A.
Secondary author(s):
Cona, G., Celli, M., Zorzi, M., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
7|2022-03-19
Reference:
Zangrossi, A., Cona, G., Celli, M., Zorzi, M., & Corbetta, M. (2021). Visual exploration dynamics are low-dimensional and driven by intrinsic factors. Communications Biology, 4(1): 1100. doi: 10.1038/s42003-021-02608-x
2-year Impact Factor: 6.548|2021
Times cited: 1|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: Eye movements / Saliency / Semantic / Spatiotemporal properties

Visual exploration dynamics are low-dimensional and driven by intrinsic factors

Visual exploration dynamics are low-dimensional and driven by intrinsic factors

DocumentBreakdown of specific functional brain networks in clinical variants of Alzheimer’s disease2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.04
Location: BF-GMS
Title:
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S1568163721002294
Abstract/Results: ABSTRACT:
Alzheimer's disease (AD) is characterized by different clinical entities. Although AD phenotypes share a common molecular substrate (i.e., amyloid beta and tau accumulation), several clinicopathological differences exist. Brain functional networks might provide a macro-scale scaffolding to explain this heterogeneity. In this review, we summarize the evidence linking different large-scale functional network abnormalities to distinct AD phenotypes. Specifically, executive deficits in early-onset AD link with the dysfunction of networks that support sustained attention and executive functions. Posterior cortical atrophy relates to the breakdown of visual and dorsal attentional circuits, while the primary progressive aphasia variant of AD may be associated with the dysfunction of the left-lateralized language network. Additionally, network abnormalities might provide in vivo signatures for distinguishing proteinopathies that mimic AD, such as TAR DNA binding protein 43 related pathologies. These network differences vis-a-vis clinical syndromes are more evident in the earliest stage of AD. Finally, we discuss how these findings might pave the way for new tailored interventions targeting the most vulnerable brain circuit at the optimal time window to maximize clinical benefits.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pini, L.
Secondary author(s):
Wennberg, A. M., Salvalaggio, A., Vallesi, A., Pievani, M.,, Corbetta, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Pini, L., Wennberg, A. M., Salvalaggio, A., Vallesi, A., Pievani, M., & Corbetta, M. (2021). Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease. Ageing Research Reviews, 72: 101482. doi: 10.1016/j.arr.2021.101482
2-year Impact Factor: 11.788|2021
Times cited: 6|2022-10-30
Indexed document: Yes
Quartile: Q1
Keywords: Alzheimer's disease / Functional connectivity in atypical AD / Network-symptoms coupling / Early-onset / Posterior cortical atrophy / Language

DocumentA novel stroke lesion network mapping approach: Improved accuracy yet still low deficit prediction2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.05
Location: BF-GMS
Title:
A novel stroke lesion network mapping approach: Improved accuracy yet still low deficit prediction
Publication year: 2021
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633453/
Abstract/Results: Lesion network mapping estimates functional network abnormalities caused by a focal brain lesion. The method requires embedding the volume of the lesion into a normative functional connectome and using the average functional magnetic resonance imaging signal from that volume to compute the temporal correlation with all other brain locations. Lesion network mapping yields a map of potentially functionally disconnected regions. Although promising, this approach does not predict behavioural deficits well. We modified lesion network mapping by using the first principal component of the functional magnetic resonance imaging signal computed from the voxels within the lesioned area for temporal correlation. We measured potential improvements in connectivity strength, anatomical specificity of the lesioned network and behavioural prediction in a large cohort of first-time stroke patients at 2-weeks post-injury (n = 123). This principal component functional disconnection approach localized mainly cortical voxels of high signal-to-noise; and it yielded networks with higher anatomical specificity, and stronger behavioural correlation than the standard method. However, when examined with a rigorous leave-one-out machine learning approach, principal component functional disconnection approach did not perform better than the standard lesion network mapping in predicting neurological deficits. In summary, even though our novel method improves the specificity of disconnected networks and correlates with behavioural deficits post-stroke, it does not improve clinical prediction. Further work is needed to capture the complex adjustment of functional networks produced by focal damage in relation to behaviour.
Accessibility: Document exists in file
Language:
eng
Author:
Pini, L.
Secondary author(s):
Salvalaggio, A., de Grazia, M., Zorzi, M., de Schotten, M., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Pini, L., Salvalaggio, A., de Grazia, M., Zorzi, M., de Schotten, M. & Corbetta, M. (2021). A novel stroke lesion network mapping approach: Improved accuracy yet still low deficit prediction. Brain Communications, 3(4), fcab259. doi: 10.1093/braincomms/fcab259
Times cited: 2|2022-10-30
Indexed document: Yes
Keywords: Stroke / Functional connectivity / Behaviour / Resting-state networks

A novel stroke lesion network mapping approach: Improved accuracy yet still low deficit prediction

A novel stroke lesion network mapping approach: Improved accuracy yet still low deficit prediction

DocumentEdge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.06
Location: BF-GMS
Title:
Edge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2213158222001206
Abstract/Results: Most neuroimaging studies of post-stroke recovery rely on analyses derived from standard node-centric functional connectivity to map the distributed effects in stroke patients. Here, given the importance of nonlocal and diffuse damage, we use an edge-centric approach to functional connectivity in order to provide an alternative description of the effects of this disorder. These techniques allow for the rendering of metrics such as normalized entropy, which describes the diversity of edge communities at each node. Moreover, the approach enables the identification of high amplitude co-fluctuations in fMRI time series. We found that normalized entropy is associated with stroke lesion severity and continually increases across the time of patients’ recovery. Furthermore, high amplitude co-fluctuations not only relate to the lesion severity but are also associated with patients’ level of recovery. The current study is the first edge-centric application for a clinical population in a longitudinal dataset and demonstrates how a different perspective for functional data analysis can further characterize topographic modulations of brain dynamics.
Accessibility: Document exists in file
Language:
eng
Author:
Idesis, S.
Secondary author(s):
Faskowitz, J., Betzel, R., Corbetta, M., Sporns, O., Deco, G.
Document type:
Article
Number of reproductions:
1
Reference:
Idesis, S., Faskowitz, J., Betzel, R., Corbetta, M., Sporns, O. & Deco, G. (2022). Edge-centric analysis of stroke patients. An alternative approach for biomarkers of lesion recovery. NeuroImage: Clinical, 35, 103055. doi: 10.1016/j.nicl.2022.103055
2-year Impact Factor: 4.891|2021
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-10-30
Quartile: Q2
Keywords: Stroke / Edge-centric / Functional connectivity / Entropy / Brain dynamics / Longitudinal

Edge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery

Edge-centric analysis of stroke patients: An alternative approach for biomarkers of lesion recovery

DocumentPresurgical preditors of early cognitive outcome after brain tumor resection in glioma patients2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.07
Location: BF-GMS
Title:
Presurgical preditors of early cognitive outcome after brain tumor resection in glioma patients
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2213158222002844
Abstract/Results: Abstract
Gliomas are commonly characterized by neurocognitive deficits that strongly impact patients’ and caregivers’ quality of life. Surgical resection is the mainstay of therapy, and it can also cause cognitive impairment. An important clinical problem is whether patients who undergo surgery will show post-surgical cognitive impairment above and beyond that present before surgery. The relevant rognostic factors are largely unknown.
This study aims to quantify the cognitive impairment in glioma patients 1-week after surgery and to compare different pre-surgical information (i.e., cognitive performance, tumor volume, grading, and lesion topography) towards predicting early post-surgical cognitive outcome.
We retrospectively recruited a sample of N = 47 patients affected by high-grade and low-grade glioma undergoing brain surgery for tumor resection. Cognitive performance was assessed before and immediately after (~1 week) surgery with an extensive neurocognitive battery. Multivariate linear regression models highlighted the combination of predictors that best explained post-surgical cognitive impairment.
The impact of surgery on cognitive functioning was relatively small (i.e., 85% of test scores across the whole sample indicated no decline), and pre-operative cognitive performance was the main predictor of early post-surgical cognitive outcome above and beyond information from tumor topography and volume. In fact, structural lesion information did not significantly improve the accuracy of prediction made from cognitive data before surgery.
Our findings suggest that post-surgery neurocognitive deficits are only partially explained by preoperative brain damage. The present results suggest the possibility to make reliable, individualized, and clinically relevant predictions from relatively easy-to-obtain information.
Accessibility: Document exists in file
Language:
eng
Author:
Zangrossi, A.
Secondary author(s):
Silvestri, E., Bisio, M., Bertoldo, A., De Pellegrin, S., Vallesi, A., Della Puppa, A., D'Avella, D., Denaro, L., Scienza, R., Mondini, S., Semenza, C., Corbetta, M.
Document type:
Article
Marks:
1
Reference:
Zangrossi, A., Silvestri, E., Bisio, M., Bertoldo, A., De Pellegrin, S., Vallesi, A., Della Puppa, A., D'Avella, D., Denaro, L., Scienza, R., Mondini, S., Semenza, C., & Corbetta (2022). Presurgircal predictors of early cognitive outcome afetr brain tumor resection in glioma patients. NeuroImage: Clinical, 36, 103219. https://doi.org/10.1016/j.nicl.2022.103219
Indexed document: No
Keywords: Cognition / Glioma / Neurosurgery / Precision medicine / Neuropsychological testing

Presurgical preditors of early cognitive outcome after brain tumor resection in glioma patients

Presurgical preditors of early cognitive outcome after brain tumor resection in glioma patients

DocumentSpontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.08
Location: BF-GMS
Title:
Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements
Publication year: 2022
URL:
https://www.nature.com/articles/s41598-022-20866-5
Abstract/Results: Abstract
Spontaneous brain activity, measured with resting state fMRI (R-fMRI), is correlated among regions that are co-activated by behavioral tasks. It is unclear, however, whether spatial patterns of spontaneous activity within a cortical region correspond to spatial patterns of activity evoked by specific stimuli, actions, or mental states. The current study investigated the hypothesis that spontaneous activity in motor cortex represents motor patterns commonly occurring in daily life. To test this hypothesis 15 healthy participants were scanned while performing four different hand movements. Three movements (Grip, Extend, Pinch) were ecological involving grip and grasp hand movements; one control movement involving the rotation of the wrist was not ecological and infrequent (Shake). They were also scanned at rest before and after the execution of the motor tasks (resting-state scans). Using the task data, we identified movement-specific patterns in the primary motor cortex. These task-defined patterns were compared to resting-state patterns in the same motor region. We also performed a control analysis within the primary visual cortex. We found that spontaneous activity patterns in the primary motor cortex were more like task patterns for ecological than control movements. In contrast, there was no difference between ecological and control hand movements in the primary visual area. These findings provide evidence that spontaneous activity in human motor cortex forms fine-scale, patterned representations associated with behaviors that frequently occur in daily life.
Accessibility: Document exists in file
Language:
eng
Author:
Livne, T.
Secondary author(s):
Kim, D., Metcalf, N., Zhang, L., Pini, L., Shulman, G., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Liven, T., Kim, D., Metcalf, N., Zhang, L., Pini, L., Shulman, G., & Corbetta, M. (2022). Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements. Scientific Reports, 12, 16867. https://doi.org/10.1038/s41598-022-20866-5
2-year Impact Factor: 4.997|2021
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-10-30
Indexed document: Yes
Keywords: Neural circuits / Activity patterns / resting state fMRI / Primary motor cortex

Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements

Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements

DocumentMapping correlated neurological deficits after stroke to distributed brain networks2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.09
Location: BF-GMS
Title:
Mapping correlated neurological deficits after stroke to distributed brain networks
Publication year: 2022
URL:
https://link.springer.com/article/10.1007/s00429-022-02525-7
Abstract/Results: Abstract
Understanding the relationships between brain organization and behavior is a central goal of neuroscience. Traditional teaching emphasizes that the human cerebrum includes many distinct areas for which damage or dysfunction would lead to a unique and specific behavioral syndrome. This teaching implies that brain areas correspond to encapsulated modules that are specialized for specific cognitive operations. However, empirically, local damage from stroke more often produces one of a small number of clusters of deficits and disrupts brain-wide connectivity in a small number of predictable ways (relative to the vast complexity of behavior and brain connectivity). Behaviors that involve shared operations show correlated deficits following a stroke, consistent with a low-dimensional behavioral space. Because of the networked organization of the brain, local damage from a stroke can result in widespread functional abnormalities, matching the low dimensionality of behavioral deficit. In alignment with this, neurological disease, psychiatric disease, and altered brain states produce behavioral changes that are highly correlated across a range of behaviors. We discuss how known structural and functional network priors in addition to graph theoretical concepts such as modularity and entropy have provided inroads to understanding this more complex relationship between brain and behavior. This model for brain disease has important implications for normal brain-behavior relationships and the treatment of neurological and psychiatric diseases.
Accessibility: Document exists in file
Language:
eng
Author:
Siegel, J. S.
Secondary author(s):
Shulman, G. L., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Siegel, J. S., Shulman, G. L., & Corbetta, M. (2022). Mapping correlated neurological deficits after stroke to distributed brain networks. Brain Structure and Function. doi: 10.1007/s00429-022-02525-7
2-year Impact Factor: 3.748|2021
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-10-11
Indexed document: Yes
Quartile: Q1
Keywords: Stroke / Functional connectivity / Structural connectivity / Lesion-symptom mapping / Modularity

Mapping correlated neurological deficits after stroke to distributed brain networks

Mapping correlated neurological deficits after stroke to distributed brain networks

DocumentInferring the dynamical effects of stroke lesions through whole-brain modeling2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.10
Location: BF-GMS
Title:
Inferring the dynamical effects of stroke lesions through whole-brain modeling
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2213158222002984?via%3Dihub
Abstract/Results: ABSTRACT:
Understanding the effect of focal lesions (stroke) on brain structure-function traditionally relies on behavioral analyses and correlation with neuroimaging data. Here we use structural disconnection maps from individual lesions to derive a causal mechanistic generative whole-brain model able to explain both functional connectivity alterations and behavioral deficits induced by stroke. As compared to other models that use only the local lesion information, the similarity to the empirical fMRI connectivity increases when the widespread structural disconnection information is considered. The presented model classifies behavioral impairment severity with higher accuracy than other types of information (e.g.: functional connectivity). We assessed topological measures that characterize the functional effects of damage. With the obtained results, we were able to understand how network dynamics change emerge, in a nontrivial way, after a stroke injury of the underlying complex brain system. This type of modeling, including structural disconnection information, helps to deepen our understanding of the underlying mechanisms of stroke lesions.
Accessibility: Document exists in file
Language:
eng
Author:
Idesis, S.
Secondary author(s):
Favaretto, C., Metcalf, N. V., Griffis, J. C., Shulman, G. L., Corbetta, M., Deco, G.
Document type:
Article
Number of reproductions:
1
Reference:
Idesis, S., Favaretto, C., Metcalf, N. V., Griffis, J. C., Shulman, G. L., Corbetta, M., & Deco, G. (2022). Inferring the dynamical effects of stroke lesions through whole-brain modeling. NeuroImage: Clinical, 36, 103233. doi: 10.1016/j.nicl.2022.103233
Indexed document: Yes
Keywords: Dynamical effects / Generative model / Stroke / Structural disconnection / Whole-brain model

Inferring the dynamical effects of stroke lesions through whole-brain modeling

Inferring the dynamical effects of stroke lesions through whole-brain modeling

DocumentThe subcortical and neurochemical organization of the ventral and dorsal attention networks2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.11
Location: BF-GMS
Title:
The subcortical and neurochemical organization of the ventral and dorsal attention networks
Publication year: 2022
URL:
https://www.nature.com/articles/s42003-022-04281-0
Abstract/Results: ABSTRACT:
Attention is a core cognitive function that filters and selects behaviourally relevant information in the environment. The cortical mapping of attentional systems identified two segregated networks that mediate stimulus-driven and goal-driven processes, the Ventral and the Dorsal Attention Networks (VAN, DAN). Deep brain electrophysiological recordings, behavioral data from phylogenetic distant species, and observations from human brain pathologies challenge purely corticocentric models. Here, we used advanced methods of functional alignment applied to resting-state functional connectivity analyses to map the subcortical architecture of the Ventral and Dorsal Attention Networks. Our investigations revealed the involvement of the pulvinar, the superior colliculi, the head of caudate nuclei, and a cluster of brainstem nuclei relevant to both networks. These nuclei are densely connected structural network hubs, as revealed by diffusion-weighted imaging tractography. Their projections establish interrelations with the acetylcholine nicotinic receptor as well as dopamine and serotonin transporters, as demonstrated in a spatial correlation analysis with a normative atlas of neurotransmitter systems. This convergence of functional, structural, and neurochemical evidence provides a comprehensive framework to understand the neural basis of attention across different species and brain diseases.
Accessibility: Document exists in file
Language:
eng
Author:
Alves, P. N.
Secondary author(s):
Forkel, S. J., Corbetta, M., Thiebaut de Schotten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Alves, P. N., Forkel, S. J., Corbetta, M., & Thiebaut de Schotten, M. (2022). The subcortical and neurochemical organization of the ventral and dorsal attention networks. Communications Biology, 5(1), 1343. doi: 10.1038/s42003-022-04281-0
Indexed document: Yes
Keywords: Attention / Ventral Attention Network / Dorsal Attention Network

The subcortical and neurochemical organization of the ventral and dorsal attention networks

The subcortical and neurochemical organization of the ventral and dorsal attention networks

DocumentOne-year-later spontaneous EEG features predict visual exploratory human phenotypes2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.12
Location: BF-GMS
Title:
One-year-later spontaneous EEG features predict visual exploratory human phenotypes
Publication year: 2022
Abstract/Results:
ABSTRACT:
During visual exploration, eye movements are controlled by multiple stimulus- and goal-driven factors. We recently showed that the dynamics of eye movements -how/when the eye move- during natural scenes' free viewing were similar across individuals and identified two viewing styles: static and dynamic, characterized respectively by longer or shorter fixations. Interestingly, these styles could be revealed at rest, in the absence of any visual stimulus. This result supports a role of intrinsic activity in eye movement dynamics. Here we hypothesize that these two viewing styles correspond to different spontaneous patterns of brain activity. One year after the behavioural experiments, static and dynamic viewers were called back to the lab to record high density EEG activity during eyes open and eyes closed. Static viewers show higher cortical inhibition, slower individual alpha frequency peak, and longer memory of alpha oscillations. The opposite holds for dynamic viewers. We conclude that some properties of spontaneous activity predict exploratory eye movement dynamics during free viewing.
Accessibility: Document exists in file
Language:
eng
Author:
Celli, M.
Secondary author(s):
Mazzonetto, I., Zangrossi, A., Bertoldo, A., Cona, G., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Celli, M., Mazzonetto, I., Zangrossi, A., Bertoldo, A., Cona, G., & Corbetta, M. (2022). One-year-later spontaneous EEG features predict visual exploratory human phenotypes. Communications Biology, 5(1), 1361. doi: 10.1038/s42003-022-04294-9
Indexed document: Yes
Keywords: Eye movement dynamics / Static viewers / Dynamic viewers / Spontaneous patterns of brain activity

One-year-later spontaneous EEG features predict visual exploratory human phenotypes

One-year-later spontaneous EEG features predict visual exploratory human phenotypes

DocumentThe pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.13
Location: BF-GMS
Title:
The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1568163723000260?via=ihub
Abstract/Results: ABSTRACT:
he study of pollutant effects is extremely important to address the epochal challenges we are facing, where world populations are increasingly moving from rural to urban centers, revolutionizing our world into an urban world. These transformations will exacerbate pollution, thus highlighting the necessity to unravel its effect on human health. Epidemiological studies have reported that pollution increases the risk of neurological diseases, with growing evidence on the risk of neurodegenerative disorders. Air pollution and water pollutants are the main chemicals driving this risk. These chemicals can promote inflammation, acting in synergy with genotype vulnerability. However, the biological underpinnings of this association are unknown. In this review, we focus on the link between pollution and brain network connectivity at the macro-scale level. We provide an updated overview of epidemiological findings and studies investigating brain network changes associated with pollution exposure, and discuss the mechanistic insights of pollution-induced brain changes through neural networks. We explain, in detail, the pollutome-connectome axis that might provide the functional substrate for pollution-induced processes leading to cognitive impairment and neurodegeneration. We describe this model within the framework of two pollutants, air pollution, a widely recognized threat, and polyfluoroalkyl substances, a large class of synthetic chemicals which are currently emerging as new neurotoxic source.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pini, L.
Secondary author(s):
Salvalaggio, A., Wennberg, A. M., Dimakou, A., Matteoli, M., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Pini, L., Salvalaggio, A., Wennberg, A. M., Dimakou, A., Matteoli, M., & Corbetta, M. (2023). The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration. Ageing Research Reviews, 86, 101867. doi: 10.1016/j.arr.2023.101867
Indexed document: Yes
Keywords: Alzheimer's disease / Brain connectivity / Connectome / Neurodegeneration / Parkinson's disease / Pollutome

DocumentCase report: Multiple disconnection patterns revealed by a multi-modal analysis explained behavior after a focal frontal damage2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.14
Location: BF-GMS
Title:
Case report: Multiple disconnection patterns revealed by a multi-modal analysis explained behavior after a focal frontal damage
Publication year: 2023
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2023.1142734/full
Abstract/Results: ABSTRACT:
Introduction:
There is overwhelming evidence that focal lesions cause structural, metabolic, functional, and electrical disconnection of regions directly and indirectly connected with the site of injury. Unfortunately, methods to study disconnection (positron emission tomography, structural and functional magnetic resonance imaging, electroencephalography) have been applied primarily in isolation without capturing their interaction. Moreover, multi-modal imaging studies applied to focal lesions are rare.
Case report:
We analyzed with a multi-modal approach the case of a patient presenting with borderline cognitive deficits across multiple domains and recurrent delirium. A post-surgical focal frontal lesion was evident based on the brain anatomical MRI. However, we were able to acquire also simultaneous MRI (structural and functional) and [18F]FDG using a hybrid PET/MRI scan along with EEG recordings. Despite the focality of the primary anatomical lesion, structural disconnection in the white matter bundles extended far beyond the lesion and showed a topographical match with the cortical glucose hypometabolism seen both locally and remotely, in posterior cortices. Similarly, a right frontal delta activity near/at the region of structural damage was associated with alterations of distant occipital alpha power. Moreover, functional MRI revealed even more widespread local and distant synchronization, involving also regions not affected by the structural/metabolic/electrical impairment.
Conclusion:
Overall, this exemplary multi-modal case study illustrates how a focal brain lesion causes a multiplicity of disconnection and functional impairments that extend beyond the borders of the anatomical irrecoverable damage. These effects were relevant to explain patient’s behavior and may be potential targets of neuro-modulation strategies.
Accessibility: Document exists in file
Language:
eng
Author:
Monai, E.
Secondary author(s):
Silvestri, E., Bisio, M., Cagnin, A., Aiello, M., Cecchin, D, Bertoldo, A., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Reference:
Monai, E., Silvestri, E., Bisio, M., Cagnin, A., Aiello, M., Cecchin, D., Bertoldo, A., & Corbetta, M. (2023). Case report: Multiple disconnection patterns revealed by a multi-modal analysis explained behavior after a focal frontal damage. Frontiers in Neurology, 14, 1142734. doi: 10.3389/fneur.2023.1142734
Indexed document: Yes
Keywords: Disconnection / Multi-modal mapping / Networks / Brain lesion / Behavior

Case report: Multiple disconnection patterns revealed by a multi-modal analysis explained behavior after a focal frontal damage

Case report: Multiple disconnection patterns revealed by a multi-modal analysis explained behavior after a focal frontal damage

DocumentOxford cognitive screen: A critical review and independent psychometric evaluation2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Universitŕ di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.15
Location: BF-GMS
Title:
Oxford cognitive screen: A critical review and independent psychometric evaluation
Publication year: 2023
URL:
https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/jnp.12318
Abstract/Results: ABSTRACT:
The Oxford cognitive screen (OCS) is a stroke-specific cognitive screening assessment. Although the test developers have provided psychometric information for the assessment, the OCS has received minimal external scrutiny, with which to triangulate the underpinning psychometrics. The purpose of this study is to provide a critical review and independent validation of the OCS. This study analysed data from an anonymised clinical database, which consisted of 316 patients who were assessed using the OCS on an Acute Stroke Unit. The rates of impairment on tests of memory and receptive communication were lower than expectation, suggesting that these subtests may be relatively insensitive. Patients with aphasia were more likely to be unable to categorised as impaired on non-language tests, suggesting that they remain sensitive to language processing or non-dominant hand usage. Some of the subtests of the OCS achieve high retest reliability, which makes them good candidates for measuring cognitive change over time. Although the OCS has many advantages, it is also important to adequately consider its limitations, that is insensitivity to memory problems, the potential confounding impact of non-dominant hand usage, and the potential that some tests may sample overall cognitive ability instead of domain-specific functioning.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Murphy, D.
Secondary author(s):
Cornfield, E., Higginson, A., Norman, A., Long, R., Noad, R.
Document type:
Article
Reference:
Murphy, D., Cornfield, E., Higginson, A., Norman, A., Long, R., & Noad, R. (2023). Oxford cognitive screen: A critical review and independent psychometric evaluation. Journal of Neuropsychology. Advance online publication. doi: 10.1111/jnp.12318
Indexed document: Yes
Keywords: Stroke / Prediction / Behavior / Neuropsychology