|Reference code: ||PT/FB/BL-2020-311.03|
|Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum|
|Publication year: ||2021|
|Abstract/Results: ||ABSTRACT: |
Although clinical neuroscience and the neuroscience of consciousness have long sought mechanistic explanations of tactile-awareness disorders, mechanistic insights are rare, mainly because of the difficulty of depicting the fine-grained neural dynamics underlying somatosensory processes.
Here, we combined the stereo-EEG responses to somatosensory stimulation with the lesion mapping of patients with a tactile-awareness disorder, namely tactile extinction.
Whereas stereo-EEG responses present different temporal patterns, including early/phasic and long-lasting/tonic activities, tactile-extinction lesion mapping co-localizes only with the latter. Overlaps are limited to the posterior part of the perisylvian regions, suggesting that tonic activities may play a role in sustaining tactile awareness. To assess this hypothesis further, we correlated the prevalence of tonic responses with the tactile-extinction lesion mapping, showing that they follow the same topographical gradient. Finally, in parallel with the notion that visuotactile stimulation improves detection in tactile-extinction patients, we demonstrated an enhancement of tonic responses to visuotactile stimuli, with a strong voxel-wise correlation with the lesion mapping.
The combination of these results establishes tonic responses in the parietal operculum as the ideal neural correlate of tactile awareness.
|Accessibility: ||Document exists in file|
|Del Vecchio, M.|
|Secondary author(s): |
|Fossataro, C., Zauli, F. M., Sartori, I., Pigorini, A., d'Orio, P., Abarrategui, B., Russo, S., Mikulan, E. P., Caruana, F., Rizzolatti, G., Garbarini, F., Avanzini, P.|
|Document type: |
|Number of reproductions: |
|Del Vecchio, M., Fossataro, C., Zauli, F. M., Sartori, I., Pigorini, A., d'Orio, P., Abarrategui, B., Russo, S., Mikulan, E. P., Caruana, F., Rizzolatti, G., Garbarini, F., & Avanzini, P. (2021). Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum. Brain, 144(12), 3779–3787. doi: 10.1093/brain/awab384|
|2-year Impact Factor: ||13.501|2020|
|Impact factor notes: ||Impact factor not available yet for 2021|
|Times cited: ||1|2022-03-09|
|Indexed document: ||Yes|
|Keywords: ||Tactile extinction / Conscious perception / Perisylvian / Late responses / Brain lesions|
Tonic somatosensory responses and deficits of tactile awareness converge in the parietal operculum