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BIAL Foundation
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File003 - The power of imagination: Neural effects of imagined placebo intake2023-03

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-003
Location: BF-GMS
Title:
003 - The power of imagination: Neural effects of imagined placebo intake
Duration: 2023-03
Researcher(s):
Anne Schienle
Institution(s): Clinical Psychology, University of Graz (Austria)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Article
Language: eng
Notes:
Ongoing project
Author: Schienle, A.
Number of reproductions:
1
Keywords:
Open-label placebo / Affective processing / Imagination / Brain imaging / Psychophysiology
DocumentThe pill you don’t have to take that is still effective: Neural correlates of imaginary placebo intake for regulating disgust2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-003
Location: BF-GMS
Title:
003 - The power of imagination: Neural effects of imagined placebo intake
Duration: 2023-03
Researcher(s):
Anne Schienle
Institution(s): Clinical Psychology, University of Graz (Austria)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Article
Language: eng
Notes:
Ongoing project
Author: Schienle, A.
Number of reproductions:
1
Keywords:
Open-label placebo / Affective processing / Imagination / Brain imaging / Psychophysiology

Reference code: PT/FB/BL-2022-003.02
Location: BF-GMS
Title:
The pill you don’t have to take that is still effective: Neural correlates of imaginary placebo intake for regulating disgust
Publication year: 2024
URL:
https://doi.org/10.1093/scan/nsae021
Abstract/Results: ABSTRACT:
A commonly established protocol for the administration of open-label placebos (OLPs)—placebos honestly prescribed—emphasizes the necessity of ingesting the pill for the placebo effect to manifest. The current functional magnetic resonance imaging study used a novel approach to OLP administration: the imaginary intake of an OLP pill for regulating disgust. A total of 99 females were randomly allocated to one of three groups that either swallowed a placebo pill (OLP Pill), imagined the intake of a placebo pill (Imaginary Pill) or passively viewed (PV) repulsive and neutral images. The imaginary pill reduced reported disgust more effectively than the OLP pill and was also perceived as a more plausible method to reduce emotional distress. Relative to the OLP pill, the imaginary pill lowered neural activity in a region of interest involved in disgust processing: the pallidum. No signifcant differences in brain activation were found when comparing the OLP pill with PV. These fndings highlight that imagining the intake of an OLP emerged as a superior method for regulating feelings of disgust compared to the actual ingestion of a placebo pill. The study’s innovative approach sheds new light on the potential of placebo interventions in emotion regulation.
Accessibility: Document exists in file
Language:
eng
Author:
Schienle, A.
Secondary author(s):
Kogler, W., Seibel, A., Wabnegger, A.
Document type:
Article
Number of reproductions:
1
Reference:
Schienle, A., Kogler, W., Seibel, A., & Wabnegger, A. (2023). The pill you don’t have to take that is still effective: Neural correlates of imaginary placebo intake for regulating disgust. Social Cognitive and Affective Neuroscience, 19(1), nsae021. https://doi.org/10.1093/scan/nsae021
2-year Impact Factor: 1.16|2022
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2024-05-10
Indexed document: Yes
Quartile: Q1
Keywords: Open-label placebo / Imagery / Disgust / Plausibility / fMRI

The pill you don’t have to take that is still effective: Neural correlates of imaginary placebo intake for regulating disgust

The pill you don’t have to take that is still effective: Neural correlates of imaginary placebo intake for regulating disgust
DocumentNeural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-003
Location: BF-GMS
Title:
003 - The power of imagination: Neural effects of imagined placebo intake
Duration: 2023-03
Researcher(s):
Anne Schienle
Institution(s): Clinical Psychology, University of Graz (Austria)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Article
Language: eng
Notes:
Ongoing project
Author: Schienle, A.
Number of reproductions:
1
Keywords:
Open-label placebo / Affective processing / Imagination / Brain imaging / Psychophysiology

Reference code: PT/FB/BL-2022-003.03
Location: BF-GMS
Title:
Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress
Publication year: 2024
URL:
https://doi.org/10.1016/j.brainresbull.2024.111121
Abstract/Results: ABSTRACT:
Background
Treatment expectations for open-label placebos (OLPs) - placebos prescribed transparently - refer to what a person anticipates will happen as a result of taking the placebo. The actual outcome of OLP treatment may deviate from the initial expectation.
Method
A total of 108 participants received OLP treatment for reducing visually induced emotional distress during functional magnetic resonance imaging. They rated the expected effect of the OLP before the experiment, and evaluated the perceived effect after the experiment. Ratings reflecting the degree of outcome deviation from expectation were correlated with brain activity in regions of interest (dorsolateral/ventrolateral prefrontal cortex, anterior cingulate cortex (ACC), insula, inferior parietal cortex).
Results
Activity in the ACC, the insula, and parietal regions (region-of-interest findings), as well as the parahippocampus (whole-brain finding) was lower when the perceived treatment outcome met or even exceeded expectations.
Conclusions
A positive expectation-outcome evaluation for the OLP was associated with reduced activity in brain regions decoding the salience (insula, ACC) and context of stimuli (parahippocampus). These findings shed light on the mechanisms through which OLPs influence emotion regulation.
Accessibility: Document exists in file
Language:
eng
Author:
Schienle, A.
Secondary author(s):
Wabnegger, A.
Document type:
Article
Number of reproductions:
1
Reference:
Schienle, A., & Wabnegger, A. (2024). Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress. Brain Research Bulletin, 219, 111121. https://doi.org/10.1016/j.brainresbull.2024.111121
2-year Impact Factor: 3.70|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2024-11-12
Indexed document: Yes
Quartile: Q2
Keywords: Treatment expectations / Treatment efficacy / Open-label placebos / FMRI / Emotion regulation

Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress

Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress