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File316 - Psychophysiological aspects of the doctor-patient relationship: The role of nonverbal behaviors in placebo and nocebo effects2025-04

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2024
Location: BF-GMS
Title:
2024 Grants
Start date: 2025-01

Reference code: PT/FB/BL-2024-316
Location: BF-GMS
Title:
316 - Psychophysiological aspects of the doctor-patient relationship: The role of nonverbal behaviors in placebo and nocebo effects
Duration: 2025-04
Researcher(s):
Magne Arve Flaten, Hojjat Daniali, Ghazaleh Akbarzadeh, Mollie Ruben, Charlotte Fiskum
Institution(s): Department of Psychology, Norwegian University of Science and Technology, Trondheim (Norway); Department of Psychology, Rhode Island University (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Flaten, M. A.
Secondary author(s):
Daniali, H., Akbarzadeh, G., Ruben, M., Fiskum, C.
Number of reproductions:
1
Keywords:
Placebo effects / Nocebo effects / Heart rate variability / Electromyography / Psychophysiology
DocumentUnderstanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-261
Location: BF-GMS
Title:
261 - Phenomenological experience and neurophysiological correlates of shamanic trance in healthy individuals
Duration: 2019-07 - 2021-11
Researcher(s):
Olivia Gosseries
Institution(s): GIGA research center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Gosseries, O.
Number of reproductions:
3
Keywords:
Trance / Phenomenology / Electrophysiology / Consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-261.14
Location: BF-GMS
Title:
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system
Publication year: 2025
URL:
https://doi.org/10.1016/j.ijchp.2025.100552
Abstract/Results: ABSTRACT:
Non-ordinary states of consciousness offer a unique opportunity to explore the interplay between phenomenological experiences and physiological processes. This study investigated individual differences in phenomenological and autonomic nervous system changes between a resting state condition and a non-ordinary state of consciousness (auto-induced cognitive trance, AICT). Specifically, it examined the relationship between self-reported experiences (e.g., absorption, visual representations) and heart rate variability (HRV).
Twenty-seven participants underwent electrocardiography recordings and completed self-report questionnaires during rest and AICT. A machine learning framework distinguished the rest and AICT states based on self-reported measures and HRV metrics. A linear mixed-effects model assessed inter-individual differences in HRV and self-reported phenomenology between the two states. Finally, the relationship between relative change in HRV and self-reported experiences was explored.
Results showed changes in self-reported phenomenology (accuracy=86 %; p<.001) and HRV (accuracy=73 %; p<.001) characterizing the AICT state compared to rest. The baseline level in phenomenology or HRV was associated with change amplitude during AICT. Moreover, relative change in HRV was associated with change in phenomenology.
The findings suggest that inter-individual differences at rest revealed a functional mechanism between phenomenology and the autonomic nervous system during non-ordinary states of consciousness, offering a novel perspective on how physiological mechanisms shape subjective experiences.
Accessibility: Document exists in file
Language:
eng
Author:
Oswald, V.
Secondary author(s):
Jerbi, K., Sombrun, C., Jitka, A., Martial, C., Gosseries, O., Vanhaudenhuyse, A.
Document type:
Article
Number of reproductions:
3
Reference:
Oswald, V., Jerbi, K., Sombrun, C., Jitka, A., Martial, C., Gosseries, O., & Vanhaudenhuyse, A. (2025). Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system. International Journal of Clinical and Health Psychology, 25(1), 100552. https://doi.org/10.1016/j.ijchp.2025.100552
2-year Impact Factor: 4.4|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Non-ordinary states of consciousness / Auto-induced cognitive trance / Heart rate variability / Phenomenological experiences / Machine learning / Inter-individual differences

Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system

Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system
DocumentElectroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: Results from a preregistered fully factorial randomized controlled trial2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-140
Location: BF-GMS
Title:
140 - Stimulating compassion: Using transcutaneous vagus nerve stimulation (tVNS) to probe compassionate behaviour
Duration: 2022-02 - 2024-07
Researcher(s):
Sunjeev Kamboj
Institution(s): Department Clinical, Educational and Health Psychology, University College London (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Kamboj, S.
Number of reproductions:
3
Keywords:
Compassion / Vagus nerve / Transcutaneous vagus nerve stimulation / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-140.03
Location: BF-GMS
Title:
Electroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: Results from a preregistered fully factorial randomized controlled trial
Publication year: 2025
URL:
https://doi.org/10.1017/S0033291725101013
Abstract/Results: ABSTRACT:
Background
Physiological signals conveyed by the vagus nerve may generate quiescent psychological states conducive to contemplative practices. This suggests that vagal neurostimulation could interact with contemplative psychotherapies (e.g. mindfulness and compassion-based interventions) to augment their efficacy.
Methods
In a fully factorial experimental trial, healthy adults (n = 120) were randomized to transcutaneous vagus nerve stimulation (tVNS) plus Self-Compassion-Mental-Imagery Training (SC-MIT) or alternative factorial combinations of stimulation (tVNS or sham) plus mental imagery training (MIT: SC-MIT or Control-MIT). Primary outcomes were self-reported state self-compassion, self-criticism, and heart rate variability (HRV). Exploratory outcomes included state mindfulness and oculomotor attentional bias to compassion-expressing faces. Most outcomes were assessed acutely on session 1 at the pre-stimulation (T1), peri-stimulation (T2), and post-MIT + stimulation (T3) timepoints, and after daily stimulation+MIT sessions (eight sessions).
Results
During session 1, a significant Timepoint × Stimulation × MIT interaction (p = 0.025) was observed, reflecting a larger acute T1?T3 increase in state self-compassion after tVNS+SC-MIT, with similar rapid effects on state mindfulness. Additionally, significant Session × MIT and Session × Stimulation interactions (p = 0.027) on state mindfulness (but not self-compassion) suggested that tVNS+SC-MIT’s effects may accumulate across sessions for some outcomes. By contrast, changes in state self-criticism and compassion-related attentional bias were only moderated by MIT (not stimulation) condition. HRV was unaffected by stimulation or MIT condition.
Conclusion
tVNS augmented the effects of SC-MIT and might, therefore, be a useful strategy for enhancing meditation-based psychotherapies. Our findings also highlight the value of oculomotor attentional metrics as responsive markers of self-compassion training and the continued need for sensitive indices of successful vagal stimulation.
Accessibility: Document exists in file
Language:
eng
Author:
Kamboj, S. K.
Secondary author(s):
Peniket, M., Norman, J., Robshaw, R., Soni-Tricker, A., Falconer, C., Gilbert, P., Simeonov, L.
Document type:
Article
Number of reproductions:
3
Reference:
Kamboj, S. K., Peniket, M., Norman, J., Robshaw, R., Soni-Tricker, A., Falconer, C., Gilbert, P., & Simeonov, L. (2025). Electroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: Results from a preregistered fully factorial randomized controlled trial. Psychological Medicine, 55, e223, 1–11. https://doi.org/10.1017/S0033291725101013
2-year Impact Factor: 5.5|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Compassion / Mindfulness / Transcutaneous vagus nerve stimulation / Neurostimulation / Compassion-focused therapy / Attentional bias / Heart rate variability

Electroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: Results from a preregistered fully factorial randomized controlled trial

Electroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: Results from a preregistered fully factorial randomized controlled trial
DocumentThe relationship between heart rate variability and affective disorders: Associations with symptomatic improvement and therapeutic alliance2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-178
Location: Arquivo PCA - Pasta 22/2012
Title:
178 - How collaboration in psychotherapy becomes therapeutic: a study of interactive and psychophysiological processes in good and poor outcome cases
Duration: 2013-06 - 2017-01
Researcher(s):
Eugénia Maria Ribeiro Pereira, Adriana Sampaio, Cledna Patricia Silva, António P. Ribeiro, Adam O. Horvath, William B. Stiles, Inês Sousa, Joana Mourão, Dulce Pinto, Zita Sousa
Institution(s): Centro de Investigação em Psicologia (CIPsi/UM), School of Psychology, Universidade do Minho (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Master theses
PhD theses
Article
Language: eng
Author:
Pereira, E.
Secondary author(s):
Sampaio, A., Silva, C. P., Ribeiro, A., Horvath, A., Stiles, W., Sousa, I., Mourão, J., Pinto, D., Sousa, Z.
Number of reproductions:
1
Keywords:
Psychophysiology / Intervention / Assessment tools

Reference code: PT/FB/BL-2012-178.23
Location: BF-GMS
Title:
The relationship between heart rate variability and affective disorders: Associations with symptomatic improvement and therapeutic alliance
Publication year: 2025
URL:
https://doi.org/10.1186/s40359-025-02960-1
Abstract/Results: ABSTRACT:
Background
Heart rate variability (HRV) is a cardiac measure that reflects individuals’ ability to adjust their physiological activation at a given time and has been associated with several psychological conditions, including affective disorders like depression and anxiety disorders. The objective of this study was to gain insight into the relationship between HRV and depression and anxiety disorders, and to explore how this association may be reflected in the establishment of the therapeutic alliance (TA) with patients diagnosed with these disorders. We hypothesize that lower levels of symptomatology will be associated with higher HRV, and that the decrease in psychological symptomatology over time will be associated with changes in HRV. Also, drawing on Polyvagal Theory, we hypothesize that higher HRV will be related to stronger TA ratings.
Methods
The study included 42 participants - 21 individuals with depression or anxiety and 21 healthy controls. HRV was measured during a baseline task and throughout all the psychotherapy sessions. The Outcome Questionnaire and the Working Alliance Inventory were administered at the beginning and at the end of each session respectively for process and outcome and therapeutic alliance assessment. Comparisons of means and mixed generalized linear models were used to test our hypothesis.
Results
We found that HRV differed between groups at baseline, and we also found evidence for an increase in HRV over the course of therapy. However, the hypothesis that an increase in HRV throughout the therapy would be accompanied by an increase in the TA was not corroborated.
Conclusions
Our findings support the role of the HRV as an important psychophysiological measure for differentiating emotional disorders from healthy subjects, as well as for tracking changes in clinical symptoms over time.
Accessibility: Document exists in file
Language:
eng
Author:
Gonçalves, A. F.
Secondary author(s):
Ribeiro, E., Sampaio, A., Couto-Pereira, N. S.
Document type:
Article
Number of reproductions:
1
Reference:
Gonçalves, A. F., Ribeiro, E., Sampaio, A., Couto-Pereira, N. S., Moreira, P., & Coutinho, J. F. (2025). The relationship between heart rate variability and affective disorders: Associations with symptomatic improvement and therapeutic alliance. BMC Psychology, 13, 1129. https://doi.org/10.1186/s40359-025-02960-1
2-year Impact Factor: 3|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2025-11-06
Indexed document: Yes
Quartile: Q1
Keywords: Social anxiety disorder / Major depressive disorder / Heart rate variability / Psychotherapy / Therapeutic alliance

The relationship between heart rate variability and affective disorders: Associations with symptomatic improvement and therapeutic alliance

The relationship between heart rate variability and affective disorders: Associations with symptomatic improvement and therapeutic alliance