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DocumentTowards modern post-coma care based on neuroscientific evidence2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-109
Location: BF-GMS
Title:
Towards modern post-coma care based on neuroscientific evidence
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1697260023000066?via%3Dihub
Abstract/Results: ABSTRACT:
Background:
Understanding the mechanisms underlying human consciousness is pivotal to improve the prognostication and treatment of severely brain-injured patients. Consciousness remains an elusive concept and the identification of its neural correlates is an active subject of research, however recent neuroscientific advances have allowed scientists to better characterize disorders of consciousness. These breakthroughs question the historical nomenclature and our current management of post-comatose patients.
Method:
This review examines the contribution of consciousness neurosciences to the current clinical management of severe brain injury. It investigates the major impact of consciousness disorders on healthcare systems, the scientific frameworks employed to identify their neural correlates and how evidence-based data from neuroimaging research have reshaped the landscape of post-coma care in recent years.
Results:
Our increased ability to detect behavioral and neurophysiological signatures of consciousness has led to significant changes in taxonomy and clinical practice. We advocate for a multimodal framework for the management of severely brain-injured patients based on precision medicine and evidence-based decisions, integrating epidemiology, health economics and neuroethics.
Conclusions:
Major progress in brain imaging and clinical assessment have opened the door to a new era of post-coma care based on standardized neuroscientific evidence. We highlight its implications in clinical applications and call for improved collaborations between researchers and clinicians to better translate findings to the bedside.
Accessibility: Document exists in file
Language:
eng
Author:
Sanz, L. R. D.
Secondary author(s):
Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Reference:
Sanz, L. R. D., Laureys, S., & Gosseries, O. (2023). Towards modern post-coma care based on neuroscientific evidence. International Journal of Clinical and Health Psychology, 23(3), 100370. https://doi.org/10.1016/j.ijchp.2023.100370
2-year Impact Factor: 5.3|2023
Times cited: 10|2025-09-26
Indexed document: Yes
Quartile: Q1
Keywords: Disorders of consciousness / Neuroimaging / Coma / Unresponsive wakefulness syndrome / Minimally conscious state

Towards modern post-coma care based on neuroscientific evidence

Towards modern post-coma care based on neuroscientific evidence
DocumentThe current and future contribution of neuroimaging to the understanding of disorders of consciousness2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-111
Location: BF-GMS
Title:
The current and future contribution of neuroimaging to the understanding of disorders of consciousness
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S0755498222000562?via%3Dihub
Abstract/Results: ABSTRACT:
Patients with disorders of consciousness (DoC) represent a group of severely brain-injured patients with varying capacities for consciousness in terms of both wakefulness and awareness. The current state-of-the-art for assessing these patients is through standardised behavioural examinations, but inaccuracies are commonplace. Neuroimaging and electrophysiological techniques have revealed vast insights into the relationships between neural alterations, andcognitive and behavioural features of consciousness in patients with DoC. This has led to the establishment of neuroimaging paradigms for the clinical assessment of DoC patients. Here, we review selected neuroimaging findings on the DoC population, outlining key findings of the dysfunction underlying DoC and presenting the current clinical utility of neuroimaging tools. We discuss that whilst individual brain areas play instrumental roles in generating and supporting consciousness, activation of these areas alone is not sufficient for conscious experience. Instead, for consciousness to arise, we need preserved thalamo-cortical circuits, in addition to sufficient connectivity between distinctly differentiated brain networks, underlined by connectivity both within, and between such brain networks. Finally, we present recent advances and future perspectives in computational methodologies applied to DoC, supporting the notion that progress in the science of DoC will be driven by a symbiosis of these data-driven analyses, and theory-driven research. Both perspectives will work in tandem to provide mechanistic insights contextualised within theoretical frameworks which ultimately inform the practice of clinical neurology.
Accessibility: Document exists in file
Language:
eng
Author:
Alnagger, N.
Secondary author(s):
Cardone, P., Martial, C., Laureys, S., Annen, J., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Reference:
Alnagger, N., Cardone, P., Martial, C., Laureys, S., Annen, J., & Gosseries, O. (2023). The current and future contribution of neuroimaging to the understanding of disorders of consciousness. Presse Medicale, 52(2), 104163. https://doi.org/10.1016/j.lpm.2022.104163
2-year Impact Factor: 3.2|2023
Times cited: 21|2025-09-26
Indexed document: Yes
Quartile: Q2
Keywords: Disorders of consciousness / Coma / Unresponsive wakefulness syndrome / Vegetative state / Minimally conscious state / Electroencephalogram (EEG) / Neuroimaging / Whole brain models

The current and future contribution of neuroimaging to the understanding of disorders of consciousness

The current and future contribution of neuroimaging to the understanding of disorders of consciousness
DocumentMultimodal Integration in Psychiatry: Clinical Potential and Challenges2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-288
Location: BF-GMS
Title:
288 - The origin of the sublime power in the brain: An integrated EEG-TMS study
Duration: 2021-04 - 2025-05
Researcher(s):
Eleonora Maggioni, Paolo Brambilla, Giandomenico Schiena, Alice Chirico, Andrea Gaggioli, Maddalena Mazzocut-Mis
Institution(s): Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan (Italy); Università Cattolica del Sacro Cuore, Milan (Italy); Università degli Studi di Milano (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Maggioni, E.
Secondary author(s):
Brambilla, P., Schiena, G., Chirico, A., Gaggioli, A., Mazzocut-Mis, M.
Number of reproductions:
3
Keywords:
Virtual reality / Sublime / Brain connectivity / EEG-TMS / Parapsychology and Psychophysiology

Reference code: PT/FB/BL-2020-288.05
Location: BF-GMS
Title:
Multimodal Integration in Psychiatry: Clinical Potential and Challenges
Publication year: 2023
URL:
https://link.springer.com/protocol/10.1007/978-1-0716-3230-7_15
Abstract/Results: ABSTRACT:
The integration of complementary neuroimaging and neurosignaling modalities allows us to obtain a comprehensive view of the structural and functional brain properties and to extend the spatiotemporal domain investigated. In this chapter will explore the domains of multimodal integration that seem to be more relevant in the study of the cerebral bases of psychiatric disorders as an essential contribution to the construction of a personalized and broad-spectrum model of brain anatomy and function, useful in the early identification of risk or diagnostic profiles and in the planning of effective treatment strategies.
Accessibility: Document does not exist in file
Language:
eng
Author:
Maggioni, E.
Secondary author(s):
Piani, M. C., Bondi, E., Bianchi, A. M., Brambilla, P.
Document type:
Book chapter
Number of reproductions:
3
Reference:
Maggioni, E., Piani, M. C., Bondi, E., Bianchi, A. M., & Brambilla, P. (2023). Multimodal Integration in Psychiatry: Clinical Potential and Challenges. In: D. Stoyanov, B., Draganski, P., Brambilla, & C., Lamm (Eds), Computational Neuroscience. Neuromethods (Vol 199). Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3230-7_15
Indexed document: Yes
Keywords: Neuroimaging / Electrophysiology / MRI / Electroencephalogram (EEG) / Psychiatry
DocumentEEG microstates: Functional significance and short-term test-retest reliability2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-183
Location: BF-GMS
Title:
183 - Decoding the language of 'now': EEG microstates in experienced meditators, from letters to grammar
Duration: 2017-09 - 2023-09
Researcher(s):
Elena Antonova, Chrystopher Nehaniv
Institution(s): Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London (UK); University of Hertfordshire, Hatfield (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Antonova, E.
Secondary author(s):
Nehaniv, C.
Number of reproductions:
3
Keywords:
Electroencephalogram (EEG) microstates / Meditation / Attention / Consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2016-183.04
Location: BF-GMS
Title:
EEG microstates: Functional significance and short-term test-retest reliability
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2666956022000137?via%3Dihub
Abstract/Results: ABSTRACT:
EEG microstates, reflecting discrete topographical organization of the EEG signal power, may have clinical relevance; however, their functional significance and test-retest reliability remain unclear. To investigate the functional significance of the canonical EEG microstate classes and their pairwise transitions, and to establish their within-session test-retest reliability, we recorded 36-channel EEGs in 20 healthy volunteers during three eyes-closed conditions: mind-wandering, verbalization (silently repeating the word ‘square’ every 2 s), and visualization (visualizing a square every 2 s). Each condition lasted 3 min and the sequence of three conditions was repeated four times (two runs of two sequence repetitions). The participants' alertness and their sense of effort during the experiment were rated using visual-analogue scales. The EEG data were 2–20 Hz bandpass-filtered and analysed into the four canonical microstate classes: A, B, C, and D. EEG microstate classes C and D were persistently more dominant than classes A and B in all conditions. Of the first-order microstate parameters, average microstate duration was most reliable. The duration of class D microstate was longer during mind-wandering (106.8 ms) than verbalization (102.2 ms) or visualization (99.8 ms), with a concomitantly higher coverage (36.4% vs. 34.7% and 35.2%), but otherwise there was no clear association of the four microstate classes to particular mental states. The test-retest reliability was higher at the beginning of each run, together with higher average alpha power and subjective ratings of alertness. Only the transitions between classes C and D (from C to D in particular) were significantly higher than what would be expected from the respective microstates' occurrences. The transition probabilities, however, did not distinguish between conditions, and their test-retest reliability was overall lower than that of the first-order parameters such as duration and coverage. Further studies are needed to establish the functional significance of the canonical EEG microstate classes. This might be more fruitfully achieved by looking at their complex syntax beyond pairwise transitions. To ensure greater test-retest reliability of microstate parameters, study designs should allow for shorter experimental runs with regular breaks, particularly when using EEG microstates as clinical biomarkers.
Accessibility: Document exists in file
Language:
eng
Author:
Antonova, E.
Secondary author(s):
Holding, M., Chak Suen, H., Sumich, A., Maex, R., Nehaniv, C.
Document type:
Article
Number of reproductions:
3
Reference:
Antonova, E., Holding, M., Chak Suen, H., Sumich, A., Maex, R., & Nehaniv, C. (2022). EEG microstates: Functional significance and short-term test-retest reliability. Neuroimage: Reports, 2(2), 100089. https://doi.org/10.1016/j.ynirp.2022.100089
Indexed document: No
Keywords: EEG microstates / Resting-state EEG / Resting-state networks / Neuroimaging / Biomarkers / Mind-wandering

EEG microstates: Functional significance and short-term test-retest reliability

EEG microstates: Functional significance and short-term test-retest reliability
DocumentSwallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-261
Location: BF-GMS
Title:
261 - Phenomenological experience and neurophysiological correlates of shamanic trance in healthy individuals
Duration: 2019-07 - 2021-11
Researcher(s):
Olivia Gosseries
Institution(s): GIGA research center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Gosseries, O.
Number of reproductions:
3
Keywords:
Trance / Phenomenology / Electrophysiology / Consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-261.09
Location: BF-GMS
Title:
Swallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management
Publication year: 2024
URL:
https://doi.org/10.3233/NRE-230135
Abstract/Results: ABSTRACT:
Following severe brain injuries, a subset of patients may remain in an altered state of consciousness; most of these patients require artificial feeding. Currently, a functional oral phase and the presence of exclusive oral feeding may constitute signs of consciousness. Additionally, the presence of pharyngo-laryngeal secretions, saliva aspiration, cough reflex and tracheostomy are related to the level of consciousness. However, the link between swallowing and consciousness is yet to be fully understood. The primary aim of this review is to establish a comprehensive overview of the relationship between an individual's conscious behaviour and swallowing (reflexive and voluntary). Previous studies of brain activation during volitional and non-volitional swallowing tasks in healthy subjects are also reviewed. We demonstrate that the areas activated by voluntary swallowing tasks (primary sensorimotor, cingulate, insula, premotor, supplementary motor, cerebellum, and operculum) are not specific to deglutitive function but are shared with other motor tasks and brain networks involved in consciousness. This review also outlines suitable assessment and treatment methods for dysphagic patients with disorders of consciousness. Finally, we propose that markers of swallowing could contribute to the development of novel diagnostic guidelines for patients with disorders of consciousness.
Accessibility: Document does not exist in file
Language:
eng
Author:
Regnier, A.
Secondary author(s):
Mélotte, E., Aubinet, C., Alnagger, N., Fischer, D, Lagier, A., Thibaut, A., Laureys, S., Kaux, J. F., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Reference:
Regnier, A., Mélotte, E., Aubinet, C., Alnagger, N., Fischer, D., Lagier, A., Thibaut, A., Laureys, S., Kaux, J. F., & Gosseries, O. (2024). Swallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management. NeuroRehabilitation, 54(1), 91–107. https://doi.org/10.3233/NRE-230135
2-year Impact Factor: 1.8|2024
Times cited: 0|2025-09-26
Indexed document: Yes
Quartile: Q2
Keywords: Deglutition / Consciousness disorders / Deglutition disorders / Dysphagia / Neuroimaging / Speech therapy
DocumentFinal report - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-099
Location: BF-GMS
Title:
099 - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
Duration: 2021-03 - 2024-02
Researcher(s):
Matthew Sacchet, Diego Pizzagalli, Remko van Lutterveld, Marta Bianciardi
Institution(s): Center for Depression, Anxiety, and Stress Research - CDASR, McLean Hospital, Belmont (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Sacchet, M.
Secondary author(s):
Pizzagalli, D., van Lutterveld, R., Bianciardi, M.
Number of reproductions:
3
Keywords:
Advanced meditation / Enlightenment / Neuroimaging / Mindfulness meditation / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-099.01
Location: BF-GMS
Title:
Final report - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
Publication year: 2024
Abstract/Results:
ABSTRACT:
Background
Mindfulness meditation is a contemplative practice informed by Buddhism that targets the development of present-focused awareness and non-judgment of experience. Interest in mindfulness is burgeoning, and it has been shown to be effective in improving mental and physical health in clinical and non-clinical contexts.
Aims
In this report, for the first time, we used electroencephalography (EEG) combined with a neurophenomenological approach to examine the neural signature of “cessation” events, which are dramatic experiences of complete discontinuation in awareness similar to the loss of consciousness, which are reported to be experienced by very experienced meditators, and are proposed to be evidence of mastery of mindfulness meditation.
Method
We intensively sampled these cessations as experienced by a single advanced meditator (with over 23,000 hours of meditation training) and analyzed 37 cessation events collected in 29 EEG sessions.
Results
Spectral analyses of the EEG data surrounding cessations showed that these events were marked by a large-scale alpha-power decrease starting around 40 seconds before their onset, and that this alpha-power was lowest immediately following a cessation. Region-of-interest (ROI) based examination of this finding revealed that this alpha-suppression showed a linear decrease in the occipital and parietal regions of the brain during the pre-cessation time period. Additionally, there were modest increases in theta power for the central, parietal, and right temporal ROIs during the pre-cessation timeframe, whereas power in the Delta and Beta frequency bands were not significantly different surrounding cessations.
Conclusions
By relating cessations to objective and intrinsic measures of brain activity (i.e., EEG power) that are related to consciousness and high-level psychological functioning, these results provide evidence for the ability of experienced meditators to voluntarily modulate their state of consciousness and lay the foundation for studying these unique states using a neuroscientific approach.
Accessibility: Document exists in file
Language:
eng
Author:
Sacchet, M.
Secondary author(s):
Pizzagalli, D., van Lutterveld, R., Bianciardi, M.
Document type:
Final report
Number of reproductions:
3
Indexed document:
No
Keywords: Meditation / Advanced meditation / Neuroimaging / Phenomenology / Neurophenomenology

Final report - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation

Final report - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
DocumentVolitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-099
Location: BF-GMS
Title:
099 - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
Duration: 2021-03 - 2024-02
Researcher(s):
Matthew Sacchet, Diego Pizzagalli, Remko van Lutterveld, Marta Bianciardi
Institution(s): Center for Depression, Anxiety, and Stress Research - CDASR, McLean Hospital, Belmont (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Sacchet, M.
Secondary author(s):
Pizzagalli, D., van Lutterveld, R., Bianciardi, M.
Number of reproductions:
3
Keywords:
Advanced meditation / Enlightenment / Neuroimaging / Mindfulness meditation / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-099.13
Location: BF-GMS
Title:
Volitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana
Publication year: 2024
URL:
https://doi.org/10.1016/j.heliyon.2024.e31223
Abstract/Results: ABSTRACT:
Meditation has been integral to human culture for millennia, deeply rooted in various spiritual and contemplative traditions. While the field of contemplative science has made significant steps toward understanding the effects of meditation on health and well-being, there has been little study of advanced meditative states, including those achieved through intense concentration and absorption. We refer to these types of states as advanced concentrative absorption meditation (ACAM), characterized by absorption with the meditation object leading to states of heightened attention, clarity, energy, effortlessness, and bliss. This review focuses on a type of ACAM known as jhana (ACAM-J) due to its well-documented history, systematic practice approach, recurring phenomenological themes, and growing popularity among contemplative scientists and more generally in media and society. ACAM-J encompasses eight layers of deep concentration, awareness, and internal experiences. Here, we describe the phenomenology of ACAM-J and present evidence from phenomenological and neuroscientific studies that highlight their potential
applications in contemplative practices, psychological sciences, and therapeutics. We additionally propose theoretical ACAM-J frameworks grounded in current cognitive neuroscientific understanding of meditation and ancient contemplative traditions. We aim to stimulate further research on ACAM more broadly, encompassing advanced meditation including meditative development
and meditative endpoints. Studying advanced meditation including ACAM, and specific practices such as ACAM-J, can potentially revolutionize our understanding of consciousness and applications for mental health.
Accessibility: Document exists in file
Language:
eng
Author:
Yang, W. F.
Secondary author(s):
Sparby, T., Wright, M., Kim, E., Sacchet, M. D.
Document type:
Article
Number of reproductions:
3
Reference:
Yang, W. F., Sparby, T., Wright, M., Kim, E., & Sacchet, M. D. (2024). Volitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana. Heliyon, 10(10), e31223. https://doi.org/10.1016/j.heliyon.2024.e31223
2-year Impact Factor: 3.6|2024
Times cited: 16|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Advanced meditation / Advanced concentrative absorption meditation / Jhana / Neuroimaging / MRI / Consciousness / Mental health / Human flourishing

Volitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana

Volitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana
File128 - Delving into subjective perception: The sense of self and environmental factors in mystical experiences2025-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2024
Location: BF-GMS
Title:
2024 Grants
Start date: 2025-01

Reference code: PT/FB/BL-2024-128
Location: BF-GMS
Title:
128 - Delving into subjective perception: The sense of self and environmental factors in mystical experiences
Duration: 2025-10
Researcher(s):
Sjoerd Ebisch
Institution(s): Department of Neuroscience, Imaging and Clinical Sciences, Università degli Studi "G. d'Annunzio" Chieti-Pescara (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Ebisch, S.
Number of reproductions:
3
Keywords:
Mystical experience / Neuroimaging / Sense of self / Psychometrics / Psychophysiology and Parapsychology
DocumentSleep neuroimaging: Review and future directions2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-309
Location: BF-GMS
Title:
309 - Neuroimaging of lucid dreaming
Duration: 2019-09 - 2025-03
Researcher(s):
Martin Dresler, Florian Krause
Institution(s): Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Article
Language: eng
Author:
Dresler, M.
Secondary author(s):
Krause, F.
Number of reproductions:
1
Keywords:
Lucid dreaming / Functional magnetic resonance imaging (fMRI) / Neurofeedback / Psychophysiology

Reference code: PT/FB/BL-2018-309.02
Location: BF-GMS
Title:
Sleep neuroimaging: Review and future directions
Publication year: 2025
URL:
https://doi.org/10.1111/jsr.14462
Abstract/Results: ABSTRACT:
Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well-distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to describe the sleeping brain in much detail, since the 1990s neuroimaging techniques have been applied to uncover the brain organization and functional connectivity of human sleep with greater spatial resolution. The combination of electroencephalography with different neuroimaging modalities such as positron emission tomography, structural magnetic resonance imaging and functional magnetic resonance imaging imposes several challenges for sleep studies, for instance, the need to combine polysomnographic recordings to assess sleep stages accurately, difficulties maintaining and consolidating sleep in an unfamiliar and restricted environment, scanner-induced distortions with physiological artefacts that may contaminate polysomnography recordings, and the necessity to account for all physiological changes throughout the sleep cycles to ensure better data interpretability. Here, we review the field of sleep neuroimaging in healthy non-sleep-deprived populations, from early findings to more recent developments. Additionally, we discuss the challenges of applying concurrent electroencephalography and imaging techniques to sleep, which consequently have impacted the sample size and generalizability of studies, and possible future directions for the field.
Accessibility: Document exists in file
Language:
eng
Author:
Pereira, M.
Secondary author(s):
Chen, X., Paltarzhytskaya, A., Pacheco, Y., Muller, N., Bovy, L., Lei, X., Chen, W., Ren, H., Song, C., Lewis, L. D., Dang-Vu, T. T., Czisch, M., Picchioni, D., Duyn, J., Peigneux, P., Tagliazucchi, E., Dresler, M.
Document type:
Article
Number of reproductions:
1
Reference:
Pereira, M., Chen, X., Paltarzhytskaya, A., Pacheco, Y., Muller, N., Bovy, L., Lei, X., Chen, W., Ren, H., Song, C., Lewis, L. D., Dang-Vu, T. T., Czisch, M., Picchioni, D., Duyn, J., Peigneux, P., Tagliazucchi, E., & Dresler, M. (2025). Sleep neuroimaging: Review and future directions. Journal of Sleep Research, e14462. https://doi.org/10.1111/jsr.14462
2-year Impact Factor: 3.9|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 2|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Functional connectivity / Functional magnetic resonance imaging / Neuroimaging / Positron emission tomography / Regional cerebral blood flow / Sleep

Sleep neuroimaging: Review and future directions

Sleep neuroimaging: Review and future directions
DocumentResidual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-145
Location: BF-GMS
Title:
Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review
Publication year: 2022
URL:
https://doi.org/10.1016/j.neubiorev.2021.12.001
Abstract/Results: ABSTRACT:
Language assessment in post-comatose patients is difficult due to their limited behavioral repertoire; yet associated language deficits might lead to an underestimation of consciousness levels in unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS; -/+) diagnoses. We present a systematic review of studies from 2002 assessing residual language abilities with neuroimaging, electrophysiological or behavioral measures in patients with severe brain injury. Eighty-five articles including a total of 2278 patients were assessed for quality. The median percentages of patients showing residual implicit language abilities (i.e., cortical responses to specific words/sentences) were 33 % for UWS, 50 % for MCS- and 78 % for MCS + patients, whereas explicit language abilities (i.e., command-following using brain-computer interfaces) were reported in 20 % of UWS, 33 % of MCS- and 50 % of MCS + patients. Cortical responses to verbal stimuli increased along with consciousness levels and the progressive recovery of consciousness after a coma was paralleled by the reappearance of both implicit and explicit language processing. This review highlights the importance of language assessment in patients with disorders of consciousness.
Accessibility: Document exists in file
Language:
eng
Author:
Aubinet, C.
Secondary author(s):
Chatelle, C., Gosseries, O., Carrière, M., Laureys, S., Majerus, S.
Document type:
Article
Number of reproductions:
3
Reference:
Aubinet, C., Chatelle, C., Gosseries, O., Carrière, M., Laureys, S., & Majerus, S. (2022). Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review. Neuroscience and Biobehavioral Reviews, 132, 391–409. https://doi.org/10.1016/j.neubiorev.2021.12.001
2-year Impact Factor: 8.2|2022
Times cited: 16|2025-09-24
Indexed document: Yes
Quartile: Q1
Keywords: Language / Disorders of consciousness / Brain injury / Behavioral assessment / Neuroimaging / Electrophysiology / Aphasia

Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review

Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review
DocumentFinal report - Neuroimaging of lucid dreaming2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-309
Location: BF-GMS
Title:
309 - Neuroimaging of lucid dreaming
Duration: 2019-09 - 2025-03
Researcher(s):
Martin Dresler, Florian Krause
Institution(s): Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Article
Language: eng
Author:
Dresler, M.
Secondary author(s):
Krause, F.
Number of reproductions:
1
Keywords:
Lucid dreaming / Functional magnetic resonance imaging (fMRI) / Neurofeedback / Psychophysiology

Reference code: PT/FB/BL-2018-309.01
Location: BF-GMS
Title:
Final report - Neuroimaging of lucid dreaming
Publication year: 2024
Abstract/Results:
ABSTRACT:
Background
The neurobiology of dreaming is still poorly understood. In particular neuroimaging of dreaming is sparse, for both regular REM sleep dreaming and lucid dreaming, as its rarity and instability make neuroscientific experimentation challenging. Lucid dreaming is of interest in particular due to its potential application in nightmare disorder.
Aims
The project aimed to elucidate the neural correlates of different dream experiences with combined EEG/fMRI, paving the way towards real-time neurofeedback approaches to induce lucid dreaming.
Method
Healthy participants with regular dream recall were recorded in the late night to early morning hours with combined EEG/fMRI, leveraging new developments in acquisition sequences, active noise cancelling and acoustic shielding. In addition, large-scale fMRI datasets acquired during resting wakefulness were analyzed to investigate trait brain correlates of dream experiences.
Results
Alternative acquisition sequences and active noise canceling yielded at best incremental advantages for REM sleep imaging, with the scanner noise and fixed supine sleeping position still preventing many participants reaching REM sleep in the scanner. At the end of the project period, sleep of n=24 participants were successfully recorded, with n=10 participants reaching non-lucid REM sleep. Also, neuroimaging analysis of trait dream recall turned out to be more difficult than suggested in previous literature, with nightmare frequency showing an association only with cerebellar regions, but not predicted regions such as the amygdala or medial prefrontal cortex.
Conclusions
Functional neuroimaging of different dream experiences remains challenging. These difficulties with different analysis strategies restricts options for the direct application of this imaging modality in lucid dream induction strategies or their application in nightmare disorder on a broader scale. Nevertheless, incremental progress is encouraging for the basic neuroscience of dreaming.
Accessibility: Document exists in file
Language:
eng
Author:
Dresler, M.
Secondary author(s):
Krause, F.
Document type:
Final report
Number of reproductions:
1
Reference:
Dresler, M., & Krause, F. (2024). Final report - Neuroimaging of lucid dreaming.
Indexed document: No
Keywords: Neuroimaging / Sleep imaging / Dream imaging / Lucid dreaming

Final report - Neuroimaging of lucid dreaming

Final report - Neuroimaging of lucid dreaming
DocumentBrain-based classification of youth with anxiety disorders: Transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-288
Location: BF-GMS
Title:
288 - The origin of the sublime power in the brain: An integrated EEG-TMS study
Duration: 2021-04 - 2025-05
Researcher(s):
Eleonora Maggioni, Paolo Brambilla, Giandomenico Schiena, Alice Chirico, Andrea Gaggioli, Maddalena Mazzocut-Mis
Institution(s): Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan (Italy); Università Cattolica del Sacro Cuore, Milan (Italy); Università degli Studi di Milano (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Maggioni, E.
Secondary author(s):
Brambilla, P., Schiena, G., Chirico, A., Gaggioli, A., Mazzocut-Mis, M.
Number of reproductions:
3
Keywords:
Virtual reality / Sublime / Brain connectivity / EEG-TMS / Parapsychology and Psychophysiology

Reference code: PT/FB/BL-2020-288.11
Location: BF-GMS
Title:
Brain-based classification of youth with anxiety disorders: Transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning
Publication year: 2024
URL:
https://doi.org/10.1038/s44220-023-00173-2
Abstract/Results: ABSTRACT:
Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case–control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10–25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but also transdiagnostically for all anxiety disorders when patients were subgrouped according to their sex, medication status and symptom severity (area under the receiver operating characteristic curve, 0.59–0.63). Classifications were driven by neuroanatomical features (cortical thickness, cortical surface area and subcortical volumes) in fronto-striato-limbic and temporoparietal regions. This benchmark study within a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bruin, W. B.
Secondary author(s):
Zhutovsky, P., van Wingen, G. A., Bas-Hoogendam, J. M., Groenewold, N. A., Hilbert, K., Winkler, A. M., Zugman, A., Agosta, F., Åhs, F., Andreescu, C., Antonacci, C., Asami, T., Assaf, M., Barber, J. P., Bauer, J., Bavdekar, S. Y., Beesdo-Baum, K., Benedetti, F., ..., Aghajani, M.
Document type:
Article
Number of reproductions:
1
Reference:
Bruin, W. B., Zhutovsky, P., van Wingen, G. A., Bas-Hoogendam, J. M., Groenewold, N. A., Hilbert, K., Winkler, A. M., Zugman, A., Agosta, F., Åhs, F., Andreescu, C., Antonacci, C., Asami, T., Assaf, M., Barber, J. P., Bauer, J., Bavdekar, S. Y., Beesdo-Baum, K., Benedetti, F., ... Aghajani, M. (2024). Brain-based classification of youth with anxiety disorders: Transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning. Nature Mental Health, 2(104–118). https://doi.org/10.1038/s44220-023-00173-2
2-year Impact Factor: 8.7|2024
Times cited: 4|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Anxiety Disorders / Youth / Machine Learning / Neuroimaging