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DocumentFinal report - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-169
Location: BF-GMS
Title:
169 - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)
Duration: 2017-01 - 2021-11
Researcher(s):
Anna Kis, József Topál, Alin Ciobica, Radu Lefter, Katinka Tóth
Institution(s): Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest (Hungary); Department of Animal Physiology and Behaviour "Alexandru Ioan Cuza" University, Iasi (Romania)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Kis, A.
Secondary author(s):
Topál, J., Ciobica, A., Lefter, R., Tóth, K.
Number of reproductions:
1
Keywords:
Dog (Canis familiaris) / Social stimutation / Oxytocin / Social cognition / Psychophysiology

Reference code: PT/FB/BL-2016-169.01
Location: BF-GMS
Title:
Final report - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)
Publication year: 2021
URL:
https://www.bial.com/media/3531/the-potential-effect-of-behavioral-stimulation-on-social-competence-in-dogs-rev.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Dogs show behaviors analogous to human socio-cognitive skills, and the oxytocin system is related to their human-directed social behavior.
AIMS
It is expected that the combination of different methodological approaches enables us to disentangle this complex relationship.
METHOD
Dog social behaviour was assessed with different methods including behavioural observations and spontaneous interactions, eye-tracking and projected images. This was complemented with physiological measurements using non-invasive polysomnography (sleep EEG and ECG), as well as serum oxytocin measurements and genetical analyses.
RESULTS
Intranasal oxytocin administration was found to effect different forms of human-directed social behaviour in dogs (processing of emotional faces, contagious yawning). Polymorphisms in dogs’ oxytocin receptor gene co-varied with their social behaviour (gaze-following, attachment). Dogs’ serum oxytocin level increased after positive social interaction.
Methodological advancements were made to enable the use of non-invasive canine polysomnography for the study of neural mechanisms related to social cognition (reliability of sleep stage scoring, first-night effect, influence of pre-sleep activity and sleep location). It was found that positive versus negative pre-sleep social interactions have an effect on dogs’ subsequent sleep macrostructure, and such effects are related to subjects’ individual reaction during pre-treatment. Using a selective REM deprivation paradigm, a causal link was found between dogs’ sleep structure and emotion processing in a picture-sound matching paradigm.
CONCLUSIONS
Significant advancements were made in understanding the relationship between dogs’ human-like socio-cognitive skills and their neuro-hormonal regulation.
Accessibility: Document exists in file
Language:
eng
Author:
Kis, A.
Secondary author(s):
Topál, J., Ciobica, A., Lefter, R., Tóth, K.
Document type:
Final report
Number of reproductions:
1
Reference:
Kis, A., Topál, J., Ciobica, A., Lefter, R., & Tóth, K. (2021). Final report - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release).
Indexed document: No
Keywords: Dog (Canis familiaris) / Social stimulation / Oxytocin / Social cognition

Final report - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)

Final report - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)
DocumentTemporal dynamics of intranasal oxytocin in human brain electrophysiology2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.11
Location: BF-GMS
Title:
Temporal dynamics of intranasal oxytocin in human brain electrophysiology
Publication year: 2022
URL:
https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhab404/6494709
Abstract/Results: ABSTRACT:
Oxytocin (OT) is a key modulator of human social cognition, popular in behavioral neuroscience. To adequately design and interpret intranasal OT (IN-OT) research, it is crucial to know for how long it affects human brain function once administered. However, this has been mostly deduced from peripheral body fluids studies, or uncommonly used dosages. We aimed to characterize IN-OT’s effects on human brain function using resting-state EEG microstates across a typical experimental session duration. Nineteen healthy males participated in a double-blind, placebo-controlled, within-subject, cross-over design of 24 IU of IN-OT in 12-min windows 15 min-to-1 h 42min after administration. We observed IN-OT effects on all microstates, across the observation span. During eyes-closed, IN-OT increased duration and contribution of A and contribution and occurrence of D, decreased duration and contribution of B and C; and increased transition probability C-to-B and C-to-D. In eyes-open, it increased A-to-C and A-to-D. As microstates A and D have been related to phonological auditory and attentional networks, respectively, we posit IN-OT may tune the brain for reception of external stimuli, particularly of social nature—tentatively supporting current neurocognitive hypotheses of OT. Moreover, we contrast our overall results against a comprehensive literature review of IN-OT time-course effects in the brain, highlighting comparability issues.
Accessibility: Document exists in file
Language:
eng
Author:
Zelenina, M.
Secondary author(s):
Kosilo, M., da Cruz, J., Antunes, M., Figueiredo, P., Mehta, M. A., Prata, D.
Document type:
Article
Number of reproductions:
1
Reference:
Zelenina, M., Kosilo, M., da Cruz, J., Antunes, M., Figueiredo, P., Mehta, M. A., & Prata, D. (2022). Temporal dynamics of intranasal oxytocin in human brain electrophysiology. Cerebral Cortex, 32(14), 3110-3126. https://doi.org/10.1093/cercor/bhab404
2-year Impact Factor: 3.700|2022
Times cited: 7|2025-09-24
Indexed document: Yes
Quartile: Q2
Keywords: Electroencephalography / Microstates / Oxytocin / Pharmacodynamics / Resting-state

Temporal dynamics of intranasal oxytocin in human brain electrophysiology

Temporal dynamics of intranasal oxytocin in human brain electrophysiology
DocumentSalivary oxytocin after play with parents predicts behavioural problems in preschool children2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-158
Location: Arquivo PCA - Pasta 28/2012
Title:
158 - Neuroendocrine underpinnings of social bonds to parents and peers in preschool children. Oxytocin and Cortisol on adopted children and non-adopted controls
Duration: 2013-09 - 2018-10
Researcher(s):
Nuno Manuel Correia Torres, Manuela Veríssimo, Antonio J. Santos, Jaak Panksepp, Lígia Monteiro, Leandra Marília Marques Coelho
Institution(s): Research Group on Developmental Psychology of UIPCDE (Unidade de Investigação em Psicologia Cognitiva, do Desenvolvimento e da Educação) of ISPA-IU, Lisboa (Portugal) and Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Neuroscience Program. Washington State University (USA)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
1 Article
Language: eng
Author:
Torres, N.
Secondary author(s):
Veríssimo, M., Santos, A., Panksepp, J., Monteiro, L., Coelho, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Developmental psychology / Cognitive development / Psychosocial development / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health

Reference code: PT/FB/BL-2012-158.03
Location: BF-GMS
Title:
Salivary oxytocin after play with parents predicts behavioural problems in preschool children
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0306453021004832?via%3Dihub
Abstract/Results: ABSTRACT:
Background:
Oxytocin (OXT) has attracted research interest for its potential involvement in many of the behavioural problems observed in childhood. Due to its logistical advantages, saliva is an attractive fluid to quantify neuropeptides in children. Salivary OXT has been suggested as a potential biomarker for psychopathology during childhood. However, several questions still remain about the extent to which, and under what conditions, concentrations of OXT in saliva can be reliably measured and are related to behavioural problems in preschool age children.
Methods:
Seven samples of saliva from 30 preschool children (17 girls) were collected in five different days at their homes. Three of the samples were collected by the children's parents at baseline daily routine conditions, and four of the samples were collected by researchers during two home-visits: before and after two 15-minute dyadic play sessions (one with mothers and one fathers) between each individual parent and the child. Oxytocin concentrations were quantified by Radioimmunoassay with prior extraction. Children's behavioural problems were assessed by the Caregiver-Teacher Report Form (C-TRF) questionnaire, completed by the child's' preschool teacher.
Results:
Salivary OXT measured in baseline samples could not predict any of the behavioural problems measured by the C-TRF. However, when measured after playing with parents salivary OXT showed a stronger pattern of negative correlations, specially with the depression and opposition scales of the C-TRF. Furthermore, salivary OXT was unlikely to be reliably measured using single sampling, but acceptable reliabilities were achieved when averaging several samples. Finally, the single measures of salivary OXT evoked after an episode of play with parents showed better reliabilities than collected at baseline.
Conclusion:
Measurements of OXT evoked after positive affect interactions with parents seem to capture aspects of the OXT system in young children that might be relevant for understanding the role of this system in children's social behaviour.
Accessibility: Document exists in file
Language:
eng
Author:
Torres, N.
Secondary author(s):
Martins, D., Monteiro, L., Santos, A. J., Vaughn, B. E., Veríssimo, M.
Document type:
Article
Number of reproductions:
1
Reference:
Torres, N., Martins, D., Monteiro, L., Santos, A. J., Vaughn, B. E., & Veríssimo, M. (2022). Salivary oxytocin after play with parents predicts behavioural problems in preschool children. Psychoneuroendocrinology, 136, 105609. https://doi.org/10.1016/j.psyneuen.2021.105609
2-year Impact Factor: 3.700|2022
Times cited: 2|2025-09-24
Indexed document: Yes
Quartile: Q2
Keywords: Behavioural problems / Children / Oxytocin / Radioimmunoassay / Saliva
DocumentNeuroimaging genetics of oxytocin: A transcriptomics-informed systematic review2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.14
Location: BF-GMS
Title:
Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0149763422004018
Abstract/Results: Abstract
The last couple of decades have witnessed a rapid accumulation of studies implicating oxytocin (OT) in several neurobiological underpinnings of human behaviour and their impairment in psychiatric illness. Specifically, a neuroimaging genetics approach is helping elucidate the impact of variations in OT pathway genes on the human brain. In this review, we provide the first systematic account and discussion of all previous findings arising from human neuroimaging (epi)genetic studies of OT-related genes. To improve our mechanistic interpretation of such findings, we used data from the Genotype-Tissue Expression project to explore the functional impact the genetic variations may have on the human transcriptome. As a result, we provide an up-to-date summary of brain circuits found to be impacted by OT-relevant (epi)genetic variability, map brain pathways linking OT genes to disease, and highlight several (epi)genetic factors that modulate brain responses to intranasal OT. Finally, we provide some suggestions we believe might improve future research in the field.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
Prata, D.
Secondary author(s):
Silva, M.
Document type:
Article
Number of reproductions:
1
Reference:
Prata, D., & Silva, M. (2022). Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review. Neuroscience & Biobehavioral Reviews, 142, 104912. https://doi.org/10.1016/j.neubiorev.2022.104912
2-year Impact Factor: 8.200|2022
Times cited: 3|2025-09-24
Indexed document: Yes
Quartile: Q1
Keywords: Oxytocin / CD38 / Neuroimaging / Genetics / Methylation / Pharmacogenetics / Social cognition / Neuropsychiatry

Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review

Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review
DocumentFinal report - Brain-wide functional connectivity of oxytocin neurons2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-250
Location: BF-GMS
Title:
250 - Brain-wide functional connectivity of oxytocin neurons
Duration: 2017-11 - 2024-09
Researcher(s):
Cristina Marquez, Santiago Canals, Aroa Sanz
Institution(s): Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas - Universidad Miguel Hernández, San Juan de Alicante (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Marquez, C.
Secondary author(s):
Canals, S., Sanz, A.
Number of reproductions:
1
Keywords:
Oxytocin / Functional magnetic resonance imaging (fMRI) / Optogenetics / Rodents / Psychophysiology

Reference code: PT/FB/BL-2016-250.01
Location: BF-GMS
Title:
Final report - Brain-wide functional connectivity of oxytocin neurons
Publication year: 2023
Accessibility:
Document exists in file
Language:
eng
Author:
Caref, K.
Secondary author(s):
Eed, A., Canals, S., Márquez, C.
Document type:
Final report
Number of reproductions:
1
Reference:
Caref, K., Eed, A., Canals, S., & Márquez, C. (2023). Final report - Brain-wide functional connectivity of oxytocin neurons.
Indexed document: No
Keywords: Oxytocin / Optogenetics / Functional magnetic resonance imaging (fMRI) / Social behavior / Rats

Final report - Brain-wide functional connectivity of oxytocin neurons

Final report - Brain-wide functional connectivity of oxytocin neurons
DocumentFinal report - Oxytocin: On the psychophysiology of trust and cooperation2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.01
Location: BF-GMS
Title:
Final report - Oxytocin: On the psychophysiology of trust and cooperation
Publication year: 2023
Abstract/Results:
ABSTRACT:
Background
Trust is a mentalizing process which makes human relationships, social organizations and political and economical systems, possible. Oxytocin (OT) is a neuromodulator well known to facilitate maternal and pair bonding as we reviewed. Consistently, in humans, exogenous intranasal OT enhances mentalizing that facilitates trusting behaviours: from the affective-perceptual, e.g. facial emotion recognition, eye-to-eye gaze, to a higher-order cognitive-evaluative dimension, e.g., social learning, generosity, cooperation and particularly, trust. However, the underlying psychophysiology of OT’s effects is unknown.
Aims
We aimed to understand how oxytocin affect the psychophysiology pf cognitive processes behind trust, such as empathy, cooperation and social salience. This research is key to advance social psychology and neuroscience and to rationally improve our etiological models of psychiatric social symptoms.
Method
For this, we have conducted a series of studies involving placebo-controlled double-blind administration of intranasal oxytocin during tasks of social salience and social dilemma (with sexual objectification targets), with brain imaging, pupillometry, eye-gaze tracking and/or electroencephalography recording in humans.
Results
This project has allowed us to show that:
1) OT’s effects on neural activity may exist irrespective of fear-related social- or reward-contexts;
2) Sexualization impairs cooperative behavior towards women opponents and that this pattern – as well as the associated P300 ERP latency - is counteracted by intranasal oxytocin;
3) Oxytocin’s effect on central and autonomic neurocorrelates of salience attribution (as measured via pupillometry and eye-gaze) depend on both socialness and reward value of stimuli;
4) Oxytocin increases the spatio-temporal salience of social interactions measured via eye-gaze during free-viewing;
5) Oxytocin normalizes the synchronization of brain activity across individuals with psychotic disorders during emotional video watching;
Conclusions
We have thus furthered the: 1) characterization of both autonomous and central neurocorrelates of trust-relevant processes such as cognitive and emotional empathy and social salience attribution; 2) knowledge of OT’s effects on resting state brain networks, and 3) OT’s role in trust-dependent cooperation choices in social dilemmas, including in objectification contexts.
Accessibility: Document exists in file
Language:
eng
Author:
Prata, D.
Document type:
Final report
Number of reproductions:
1
Reference:
Prata, D. (2023). Final report - Oxytocin: On the psychophysiology of trust and cooperation.
Indexed document: No
Keywords: Empathy / Trust / Cooperation / Oxytocin / Salience / Social dilemmas / Electroencephalogram (EEG) / Functional magnetic resonance imaging (fMRI) / Pupillometry / Eye-gaze

Final report - Oxytocin: On the psychophysiology of trust and cooperation

Final report - Oxytocin: On the psychophysiology of trust and cooperation
DocumentOxytocin modulates neural activity during early perceptual salience attribution2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.18
Location: BF-GMS
Title:
Oxytocin modulates neural activity during early perceptual salience attribution
Publication year: 2024
URL:
https://doi.org/10.1016/j.psyneuen.2023.106950
Abstract/Results: ABSTRACT:
Leading hypotheses of oxytocin’s (OT) role in human cognition posit that it enhances salience attribution. However, whether OT exerts its effects predominantly in social (vs non-social) contexts remains debatable, and the time-course of intranasal OT’s effects’ on salience attribution processing is still unknown. We used the social Salience Attribution Task modified (sSAT) in a double-blind, placebo-controlled intranasal OT (inOT) administration, between-subjects design, with 54 male participants, to test existing theories of OT’s role in cognition. Namely, we aimed to test whether inOT would differently affect salience attribution processing of social stimuli (expressing fearfulness) and non-social stimuli (fruits) made relevant via monetary reinforcement, and its neural processing time-course. During electroencephalography (EEG) recording, participants made speeded responses to emotional social (fearful faces) and non-emotional non-social (fruits) stimuli - which were matched for task-relevant motivational salience through their (color-dependent) probability of monetary reinforcement. InOT affected early (rather than late, P3b and LPP) EEG components, increasing N170 amplitude (p = .041) and P2b latency (p .001; albeit not of P1), regardless of stimuli’s (emotional) socialness or reinforcement probability. Fear-related socialness affected salience attribution processing EEG (p .05) across time (N170, P2b and P3b), being later modulated by reinforcement probability (LPP). Our data suggest that OT’s effects on neural activity during early perception, may exist irrespective of fear-related social- or reward-contexts. This partially supports the tri-phasic model of OT (which posits OT enhances salience attribution in an early perception stage regardless of socialness), and not the social salience nor the general approach-withdrawal hypotheses of OT, for early salience processing event-related potentials.
Accessibility: Document exists in file
Language:
eng
Author:
Santiago, A. F.
Secondary author(s):
Kosilo, M., Cogoni, C., Diogo, V., Jerónimo, R., Prata, D.
Document type:
Article
Number of reproductions:
1
Reference:
Santiago, A. F., Kosilo, M., Cogoni, C., Diogo, V., Jerónimo, R., & Prata, D. (2024). Oxytocin modulates neural activity during early perceptual salience attribution. Psychoneuroendocrinology, 161, 106950. https://doi.org/10.1016/j.psyneuen.2023.106950
2-year Impact Factor: 3.6|2024
Times cited: 2|2025-09-26
Indexed document: Yes
Quartile: Q2
Keywords: Oxytocin / Motivation / Emotion / Social salience / Reinforcement learning / Event-related potential (ERP)

Oxytocin modulates neural activity during early perceptual salience attribution

Oxytocin modulates neural activity during early perceptual salience attribution
File007 - Are oxytocin release and altruism influenced by spirituality and trait absorption in medical students? A randomized controlled study2025-05

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2024
Location: BF-GMS
Title:
2024 Grants
Start date: 2025-01

Reference code: PT/FB/BL-2024-007
Location: BF-GMS
Title:
007 - Are oxytocin release and altruism influenced by spirituality and trait absorption in medical students? A randomized controlled study
Duration: 2025-05
Researcher(s):
Marco Aurélio Vinhosa Bastos Jr., Nicolas Rohleder, Giancarlo Lucchetti, Miguel Farias, Rosimeire Aparecida Manoel Seixas, Danielle Bogo, Paulo Roberto Haidamus de Oliveira Bastos
Institution(s): School of Medicine, Federal University of Mato Grosso do Sul - UFMS (Brazil); Department of Psychology, Friedrich-Alexander-Universität, Erlangen-Nürnberg (Germany)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Bastos Jr., M. A. V.
Secondary author(s):
Rohleder, N., Lucchetti, G., Farias, M., Seixas, R. A. M., Bogo, D., De Oliveira Bastos, P. R. H.
Number of reproductions:
3
Keywords:
Spirituality / Oxytocin / Altruism / Absorption / Psychophysiology and Parapsychology