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File015 - Pain control from the brain - Gene therapy in the treatment of chronic pain 2005-01 2009-01

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Document283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.06
Location: Arquivo PCA - Pasta 21/2004
Title:
283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus
Publication year: 2007
URL:
http://www.sciencedirect.com/science/article/pii/S109038010700345X
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Araújo, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Araújo, S., Wilson, S. P., Lima, D., Tavares, I. (2007). 283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus. European Journal of Pain, 11(Supplement 1), 125–126. doi: 10.1016/j.ejpain.2007.03.298
Indexed document: Yes
Keywords: Psychophysiology / Pain

DocumentDescending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.07
Location: Arquivo PCA - Pasta 21/2004
Title:
Descending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons
Publication year: 2006
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={2F9BEFE2-C4F9-4FDE-B655-D811DBC6DE6D}&SKey={758FF20A-A555-4CC8-9BB3-3949330452BA}&MKey={D1974E76-28AF-4C1C-8AE8-4F73B56247A7}&AKey={3A7DC0B9-D787-44AA-BD08-FA7BB2FE9004}
Abstract/Results: ABSTRACT:
Secondary hyperalgesia is associated with an imbalance of excitatory and inhibitory effects mediated, respectively, by spinal NK1 and GABAB receptors. In the monoarthritic rat, nociceptive activation of NK1-expressing lamina I neurons increased whereas the opposite occurs with GABAB-expressing neurons. In the present study, we evaluated if the NK1/GABAB imbalance depends on descending modulation from an antinociceptive center or a pronociceptive center, respectively, the lateral part of the caudal ventrolateral medulla (VLMlat) and the dorsal reticular nucleus (DRt). Twelve days after intraarticular injection of Complete´s Freund Adjuvant in the tibiotarsal joint, each medullary region was unilaterally lesioned with quinolinic acid (0.5 µl of a 180 nmol/µl solution). Two days later, one group of animals was behaviourally evaluated by application of Frey filaments to a cutaneous area close to the injected joint whereas other experimental group was subjected to noxious mechanical stimulation of the same skin region, under pendobarbital anaesthesia. In this case, spinal sections from segments T13-L1 (receiving input from the area of secondary hyperalgesia) were immunoreacted for Fos, NK1 and GABAB. After VLMlat lesioning, von Frey thresholds were reverted to control levels. The percentual increase of NK1-immunoreactive neurons expressing Fos and the decrease in the percentage of GABAB-immunoreactive neurons with Fos, detected during secondary hyperalgesia, were reverted to control levels. After DRt lesions, von Frey responses were reverted to control levels and the NK1/GABAB imbalance was attenuated due to a reduction in nociceptive-activation of NK1-expressing neurons. These results suggest that the imbalance between excitatory and inhibitory actions mediated by spinal NK1 and GABAB receptors during secondary hyperalgesia depends on supraspinal modulatory influences, which appear to be differentially exerted according to neurochemical features of lamina I neurons.
Accessibility: Document exists in file (poster)
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Respective poster in attachment
Author: Lima, D.
Secondary author(s):
Castro, A. R., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lima, D., Castro, A. R., & Tavares, I. (2006). Descending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons. Program No. 248.13/R11. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience. Online.
Indexed document: No
Keywords: Psychophysiology / Pain / Secondary hyperalgesia

Novo ficheiro

Novo ficheiro

DocumentGene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.09
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres
Publication year: 2005
URL:
http://www.nature.com/mt/journal/v11/n1s/abs/mt2005278a.html
Abstract/Results: ABSTRACT:
Subcutaneous application of Herpes Simplex Virus type 1 (HSV-1) vectors mediating enkephalin transfer to the sensory neurons of the dorsal root ganglia, were shown to induce analgesia and reduce hyperalgesic reactions. These results prompted to use these vectors in the treatment of chronic intractable pain and human clinical trials based on these approaches are expected in the near future. Since brainstem regions are major pain control centres, HSV-1 mediating gene transfer at supraspinal level could also represent a major breakthrough for pain relief. Taking this into consideration, our purpose is the activation of antinociceptive supraspinal centers and blockade of pronociceptive areas. Before attempting this, we studied the migration dynamics of a replication-defective HSV-1 vector containing the reporter gene lacZ, under control of the cytomegalovirus promoter, from the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt), respectively, antinociceptive and pronociceptive areas.
Male Wistar rats were stereotaxically injected in the VLM or DRt with a viral suspension of HSV-1 (2|[times]|106 PFUs). At 2, 4, 7, 10 and 14 days post-injection, brain sections were immunoreacted for beta-galactosidase (b-gal). To charaterize neurochemically transduced neurons, double-immunodetection of b-gal and tyrosine hydroxylase (TH) or met-enkephalin (m-ENK), the later immunocytochemical procedure using animals that received intraventricular colchicine injections, prior to sacrifice.
Neurons expressing b-gal were numerous in some of the VLM and DRt brain afferent sources, which included pain modulatory regions. After double immunodetection of b-gal and TH, numerous transduced noradrenergic neurons were observed after DRt injections in several pain control areas such as the locus coeruleus and the A5 cell group. The study of b-gal and m-ENK showed that transduced opioidergic neurons projecting to the DRt occurred mainly at deep cerebellar nuclei while those projecting to the VLM occurred at the medullar gigantocellular nucleus, an important pain control area.
These data indicate that restricting transgene expression in the brain is a suitable strategy to selectively target nociceptive pathways controlling the activity of the VLM and DRt namely by including tissue specific promoters in this viral construct. For the DRt, a TH promoter may allow to restrict transgene expression to noradrenergic pain control areas. Similarly, in the case of the VLM, a pre-proenkephalin promoter may be useful to restrict transgene expression to the gigantocellular nucleus. However, restricting opioidergic expression to deep cerebellar nuclei for pain control to modulate DRt activity, should include parallel evaluation of collateral motor effects.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Pereira, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Pereira, S., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres. Molecular Therapy, 11(Supplement 1), S63-S64. doi: 10.1016/j.ymthe.2005.06.162
Indexed document: Yes
Keywords: Psychophysiology / Pain

Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres

Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres

DocumentGene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.10
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways
Publication year: 2005
Accessibility:
Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Tavares-Marques, A., Pereira, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Tavares-Marques, A., Pereira, S., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways. In Abstracts of the 11th World Congress on Pain (p. 306). Seattle, WA: International Association for the Study of Pain.
Indexed document: No
Keywords: Psychophysiology / Pain

DocumentGene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.11
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?
Publication year: 2005
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=1&cad=rja&ved=0CC0QFjAA&url=http%3A%2F%2Fwww.spneurologia.com%2Findex.php%3Foption%3Dcom_docman%26task%3Ddoc_download%26gid%3D40%26Itemid%3D56&ei=kTP5UZjPCa-I7AbB_ICgBA&usg=AFQjCNErqyNXcDOGZAvhf0HogdlL1jvI3Q&sig2=8Og5nL3tGQN91cfW5RArLQ&bvm=bv.49967636,d.ZWU
Abstract/Results: ABSTRACT:
Gene therapy with replication-defective forms of Herpes Simplex Virus, type 1 (HSV-1) has been used in gene therapy for nervous system diseases. In pain control field, several studies reported the benefits of peripheral applications of HSV-1 but equivalent studies were not extended to the supraspinal endogenous pain modulatory system. Since this system contains areas that strongly inhibit pain transmission at the spinal cord along with a few centers that exert pro-nociceptive effects, we reasoned that activation of antinociceptive centers combined with blockade of pronociceptive areas using gene therapy with HSV-1 as a tool may be a valuable strategy for pain relief. Before attempting this strategy, we studied the migration dynamics of HSV-1 containing the reporter gene lacZ, under control of the cytomegalovirus promoter, from the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt), respectively, antinociceptive and pronociceptive areas.
Male Wistar rats were stereotaxically injected in the VLM or DRt with a viral suspension (2x106 PFUs) of HSV-1. After 2, 4, 7, 10 or 14 days, the animals were perfused and brain sections were immunoreacted for beta-galactosidase (ß-gal), the product of lacZ expression. To characterize neurochemically the transduced neurons in the brain, double-immunodetection of ß-gal and tyrosine hydroxylase (TH) or met-enkephalin (m-ENK) was performed, the later immunocytochemical procedure using animals that received an intraventricular colchicine injection.
Neurons expressing ß-gal were numerous in some of the VLM and DRt brain afferent sources, which included pain modulatory regions. After double immunodetection of b-gal and TH, numerous transduced noradrenergic neurons from pain control areas were found to project to the DRt. The study of b-gal and m-ENK showed that transfected opioidergic neurons projecting to the DRt occurred mainly at deep cerebellar nuclei.
The present data show transgene expression upon HSV-1 injection into medullary pain centres, more widespread than expected from previous studies with that vector. Although this could represent a powerful amplification of the synaptic delivery of the transgene product, some of the putatively disadvantages of this widespread transfection may be overcome by directing transgene expression to transduced neurons of pain control areas. In the case of DRt manipulation, the use of TH-promoters in the viral construct may be a suitable strategy to restrict transduction to noradrenergic pathways while the effects of using opioid promoters should be evaluated as to collateral effects of transfecting motor control cerebellar centers.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1? Sinapse, 5(1), 105.
Indexed document: Yes
Keywords: Psychophysiology / Pain / Gene therapy

Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?

Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?

DocumentNociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.13
Location: Arquivo PCA - Pasta 21/2004
Title:
Nociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint
Publication year: 2005
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Neurons in spinal lamina I establish reciprocal loops with brainstem areas involved in descending pain control, namely the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt). Since chronic pain induces plastic changes in neuronal activity both in spinal and supraspinal regions, we evaluated whether stimulation of an arthritic paw induces an activation pattern of lamina I neurons that can be related with those of VLM and DRt neurons.
All the experiments were performed according to the published ethical guidelines. Wistar rats received an intraarticular injection of saline (S) or complete Freund´s adjuvant (monoarthritic animals, MA). Fourteen days later, animals were either not manipulated or subjected to 4 minutes of bending or pinching of the inflamed paw. Animals were perfused immediately or 2h after the stimulation. The numbers of Fos-immunoreactive cells in spinal segments L4- L5, VLM and DRt were counted.
In the absence of stimulation, MA rats presented an increase in Fos numbers in lamina I while no differences occurred in the VLM and DRt. Immediately after bending, MA rats presented increases in Fos in the VLM and DRt, which were not detected in lamina I. Two hours after bending, an increase in Fos numbers was detected in lamina I while the numbers in the VLM and DRt decreased to basal levels. Two hours after pinching, an increase in Fos was detected in lamina I and VLM while no differences were found at the DRt.The different patterns of nociceptive activation in lamina I and modulatory brainstem nuclei during chronic pain suggest the existence of distinct adaptative mechanisms at spinal and supraspinal levels. The distinct patterns of neuronal activation in the VLM and DRt to noxious stimuli are probably related to the opposite roles of these centres in descending pain modulation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Lima, D., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., & Tavares, I. (2005). Nociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint. Program No.623.10. 2005. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Chronic / Brainstem / Spinal cord

DocumentDynamic brain patterns in neocortical areas during interpersonal transactions2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-033
Location: Arquivo PCA - Pasta 15/2004
Title:
033 - Dynamic brain patterns in neocortical areas during interpersonal transactions
Duration: 2005-01 - 2008-07
Researcher(s):
Richard Wennberg, Jose Luis Perez Velazquez
Institution(s): Krembil Neuroscience Centre, Toronto Western Hospital and The Hospital for Sick Children, University of Toronto (Canada)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Wennberg, R.
Secondary author(s):
Perez Velazquez, J. L.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Pain / Emotion / Empathy

Reference code: PT/FB/BL-2004-033.06
Location: Arquivo PCA - Pasta 15/2004
Title:
Dynamic brain patterns in neocortical areas during interpersonal transactions
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
Brain imaging performed during a variety of psychophysical experiments has demonstrated that specific neocortical areas change their activity when subjects are experiencing other subjects. Where in the brain self/other awareness is represented is an emerging area of investigation. We have addressed the neuronal dynamics of interpersonal interactions using simple psychophysical paradigms while recording brain activity using magnetoencephalography (MEG), and analysing the patterns of neuronal synchronization.. We build on current concepts of brain function and propose that the coordinated (synchronized) activity in distinct cortical areas will reveal brain regions involved in "self" versus "others" processing. The analysis of synchronization of cortical regions derived from the MEG recordings revealed enhanced synchronization between the activity of the midline and the prefrontal cortex, and that the midline cortex synchronizes its activity with parietal areas as well. The pattern of synchronization was similar when study participants experienced noxious stimuli (a self-administered painful stimulus to the fingers of the right hand) as when they were watching films of other people or animals experiencing pain. However, these synchronization patterns differed from those obtained when the participants visualised photographs of faces, themselves included. We thus conclude that midline and prefrontal cortices are important in the processing of sensory painful stimulation and in generating empathy towards others' pain. We expect that these studies will serve as preliminary background to undertake the investigation of reflective self-awareness and its relation to interpersonal transactions.
RESULTS:
Enhanced measured synchronization of unsynchronized sources: inspecting the physiological significance of synchronization analysis of whole brain electrophysiological recordings. L. Garcia Dominguez, R. Wennberg, J. L. Perez Velazquez, R. Guevara Erra. International Journal of Physical Sciences, 2(11), 305-317, 2007. Fluctuations in neuronal synchronization in brain activity correlate with the subjective experience of visual recognition. J. L. Perez Velazquez, L. Garcia Dominguez, R. Guevara Erra, Journal of Biological Physics, 33: 49-59 (2007).
CONFERENCE PRESENTATION:
Brain coordination dynamics of the processing of self-referential stimuli. L. Garcia Dominguez, et al. 12th Human Brain Mapping Conference, Florence (Italy), 2006. NeuroImage 31, Supp. 1, S119, 2006.
Accessibility: Document does not exist in file
Language:
eng
Author:
Wennberg, R.
Secondary author(s):
Perez Velazquez, J. L.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Wennberg, R., & Perez Velazquez, J. L. (2008). Dynamic brain patterns in neocortical areas during interpersonal transactions. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Self-reference / Synchronization / Magnetoencephalography / Pain

Dynamic brain patterns in neocortical areas during interpersonal transactions

Dynamic brain patterns in neocortical areas during interpersonal transactions

DocumentA consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.12
Location: Arquivo PCA - Pasta 19/2004
Title:
A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
Uncovering the roles of the orbitofrontal cortex and the amygdala in rewardbased decision-making strategies has relied heavily in studies using discrete brain lesions. However, chronic pain patients also display risk-prone behavior even in the absence of discrete brain lesions. The main objective of this project was to study how chronic pain affects brain areas critical for reward processing.
For this we developed a novel Rodent Gambling Task in which naïve animals make consecutive choices between two levers that attribute rewards of different value and probability. After a prolonged training phase in which both levers give the same reward, in the probe trial we maintain one lever at 1 food pellet with 80% probability of reward - low risk lever – while the other lever gives 3 pellets but at only 30% probability – high risk lever. We found that control animals start the task with a preference for the high-risk lever, but progressively shift to the low-risk option, while animals with orbitofrontal or amigdalar lesions, and animals with chronic pain prefer the high-risk lever. Since no brain lesion is caused by the model of chronic pain, we performed an HPLC analysis and found a decrease in the levels of dopamine and serotonin at the OFC, with no significant changes in the amygdala. We extended these findings by chronically implanting multielectrodes
and recording 96 neurons in awake-behaving animals performing four sessions of the RGT before and after induction of pain. We found that the neuronal instantaneous firing rate was correlated with the probability of choosing a specific lever in the majority of the recorded neurons. Moreover, we found that the fraction of risk-sensitive neurons recorded in each session predicted the overall behavioural risk-bias of the animal.
This project demonstrated that chronic pain changes the reward-aversion circuitry and that these changes are crucial for setting individual levels of risk preference.
PUBLICATIONS:
Pais-Vieira M et al (2009) Neuroscience, 161: 671-679.
Neugebauer V et al (2009) Brain Research Reviews, 60: 226-242.
Pais-Vieira M et al (2007) Neuroscience, 145: 225-231.
Accessibility: Document does not exist in file
Language:
eng
Author:
Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Galhardo, V., Lima, D., Pais-Vieira, M., & Monteiro, C. (2010). A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 190). Porto: Fundação Bial.
Indexed document: No
Keywords: Pain / Multielectrode neurophysiology / Prefrontal cortex / Reward

A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]

A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]

File161 - The relation of mind to body. Psychophysiological studies of the placebo effect2007-012010-05

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

DocumentFinal report - The relation of mind to body. Psychophysiological studies of the placebo effect2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.01
Location: Arquivo PCA - Pasta 12/2006
Title:
Final report - The relation of mind to body. Psychophysiological studies of the placebo effect
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa14406_28012014.pdf
Abstract/Results: ABSTRACT:
Placebo analgesia is the reduction in pain after administration of a placebo with information that it will reduce pain. We have shown that placebo analgesia can be objectively recorded by physiological measures (electromyography, heart rate variability, and event-related potentials (ERP)). Reduced ERPs indicate that placebos activate descending pain inhibitory pathways. The placebo response, or more precisely, the expectation of drug effects, can add to the effect of the drug. There is some evidence that placebo effects are strongest when expectations are reinforced by administration of an active drug. Of special importance to the present project was the investigation of the role of stress and negative emotions in placebo analgesia. Our hypothesis was that the placebo reduced stress and nervousness, and thereby reduced pain. Fear of pain was positively related to stress both during pain and in the anticipation of pain, and negatively related to placebo analgesia. However, other factors also contribute to the placebo analgesia. The present findings suggest that decreased stress may strengthen the placebo response. This may have important clinical consequences, as stress reduction could aid in treatment of pain. Furthermore, male subjects responded with lower stress after placebo medication, and larger placebo responses. These findings suggest that males respond differently to verbal placebo information compared to females. It is not know whether this is due to more effective pain inhibitory mechanisms in males, or to cognitive factors. In sum, there is a contribution of reduced stress to placebo analgesia, and for reasons unknown this effect is larger in males.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Flaten, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Placebo effect / Placebo analgesia / Pain / Event-related potential (ERP) / Emotion / Stress

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

DocumentThe roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.02
Location: Arquivo PCA - Pasta 12/2006
Title:
The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain
Publication year: 2008
URL:
http://www.ncbi.nlm.nih.gov/pubmed/18725424
Abstract/Results: ABSTRACT:
OBJECTIVE:
To examine whether reduction of negative emotions and associated autonomic activity could explain placebo analgesia, and to test the effect of experimenter gender on the placebo analgesic response.
METHODS:
Sixty-three (n = 32 females) students participated in a within-subjects design where subjects were tested on two separate days, one day for the experimental condition (placebo) and one day for the natural history condition. In the experimental condition, the participants received capsules containing lactose with information that the capsules were a high dose of a potent painkiller. In the natural history condition, the procedures were identical except that the placebo capsules were not administrated. The experimenters were blinded to the fact that all participants received placebo. Pain was induced by a thermode holding +46 degrees C with duration of 240 seconds to the forearm. Electrocardiogram was measured to obtain data for analysis of heart rate variability. Subjective measurements consisted of pain intensity, pain unpleasantness, stress, arousal, and mood.
RESULTS:
The results showed a placebo effect on pain intensity and a concomitant reduction in subjective stress and cardiac activity. Stepwise regressions revealed that reduced subjective stress was the only predictor for the placebo analgesic response. Contrary to our hypothesis, male subjects displayed increased placebo analgesia when a male acted as experimenter.
CONCLUSIONS:
The results indicate that reduced negative emotional activation could be a mechanism in placebo analgesia and that experimenter gender is probably not systematically related to placebo analgesia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Aslaksen, P., & Flaten, M. (2008). The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain. Psychosomatic Medicine, 70(7), 811-818. doi: 10.1097/PSY.0b013e31818105ed
2-year Impact Factor: 3.460|2008
Times cited: 73|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Gender / Negative emotions / Autonomic activation

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

DocumentGender differences in placebo analgesia: event-related potentials and emotional modulation2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.05
Location: Arquivo PCA - Pasta 12/2006
Title:
Gender differences in placebo analgesia: event-related potentials and emotional modulation
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21217098
Abstract/Results: ABSTRACT:
OBJECTIVES:
To examine whether there are gender differences in event-related potential (ERP) responses to painful stimulation after administration of placebo medication; and to investigate whether placebo medication reduces anticipatory stress and if this reduction can explain the placebo analgesic response. Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia.
METHODS:
All subjects (n = 33; 17 women) participated in both a natural history and a placebo condition. ERPs were evoked by heat pulses with a peak at 52 °C.
RESULTS:
The results showed that pain unpleasantness and the N2/P2 ERP components were reduced in the placebo condition compared with the natural history condition. Only men displayed placebo responses in pain report and in the P2 component. Anticipatory stress was reduced after placebo administration, and the reduction in anticipatory stress was significantly related to the placebo effect on pain. Regression analyses revealed that the interaction of gender by anticipatory stress was significantly related to the mean placebo response, with men responding with lower stress after placebo medication, and larger placebo responses.
CONCLUSIONS:
A placebo response on pain unpleasantness was observed in men only, and reduced stress after placebo administration was observed in males only. Thus, reduced stress may be a mechanism for placebo responses in pain.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.06
Author: Aslaksen, P.
Secondary author(s):
Vambheim, S., Bystad, M., Flaten, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Aslaksen, P., Vambheim, S., Bystad, M., & Flaten, M. (2011). Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosomatic Medicine, 73(2), 193-199. doi: 10.1097/PSY.0b013e3182080d73
2-year Impact Factor: 3.968|2011
Times cited: 81|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Pain / Placebo analgesia / Event-related potential (ERP) / Gender differences / Emotions

Gender differences in placebo analgesia: event-related potentials and emotional modulation

Gender differences in placebo analgesia: event-related potentials and emotional modulation

DocumentInteraction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.06
Location: Arquivo PCA - Pasta 12/2006
Title:
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21384106
Abstract/Results: ABSTRACT:
RATIONALE:
In a randomised placebo-controlled clinical trial it is assumed that psychosocial effects of the treatment, regression to the mean and spontaneous remission are identical in the drug and placebo group. Consequently, any difference between the groups can be ascribed to the pharmacological effects. Previous studies suggest that side effects of drugs can enhance expectancies of treatment effects in the drug group compared to the placebo group, and thereby increase placebo responses in the drug group compared to the placebo group.
OBJECTIVES:
The hypothesis that side effects of drugs can enhance expectancies and placebo responses was tested.
METHOD:
Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine. The drink was administered either with information that it contained a painkiller or that it was a placebo. Laser-evoked potentials and reports of pain, expectancy, arousal and stress were measured.
RESULTS:
Four milligrammes per kilogramme of caffeine reduced pain. Information that a painkiller was administered increased the analgesic effect of caffeine compared to caffeine administered with no drug information. This effect was mediated by expectancies. Information and expectancies had no effect on pain intensity when 0 mg/kg was administered.
CONCLUSION:
The analgesic effect of caffeine was increased by information that a painkiller was administered. This was due to an interaction of the pharmacological action of the drug and expectancies. Hence, psychosocial effects accompanying a treatment can differ when an active drug is administered compared to a placebo.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.07
Author: Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Bjørkedal, E., & Flaten, M. (2011). Interaction between expectancies and drug effects: An experimental investigation of placebo analgesia with caffeine as an active placebo. Psychopharmacology, 215(3), 537-548. doi: 10.1007/s00213-011-2233-4
2-year Impact Factor: 4.077|2011
Times cited: 31|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Expectancies / Laser-evoked potentials / Active placebo / Caffeine / Arousal / Balanced placebo design

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

DocumentThe relation of emotions to placebo responses2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.07
Location: Arquivo PCA - Pasta 12/2006
Title:
The relation of emotions to placebo responses
Publication year: 2011
URL:
http://rstb.royalsocietypublishing.org/content/366/1572/1818.full.pdf
Abstract/Results: ABSTRACT:
The hypothesis put forth is that expectations of treatment effects reduce negative emotions and thereby reduce symptoms, e.g. pain. Negative emotions increase pain, and it is hypothesized that placebos reduce pain by reducing negative emotions, i.e. feelings of nervousness, fear and anxiety. Placebo analgesia has been shown to be mediated via opioid activity, and relaxation increases opioid activity. The placebo acquires its relaxing effect due to verbal information that pain will be reduced, or due to associations between the placebo and the reduction in pain after effective treatment. Thus, the placebo signals that unpleasantness will be less after administration of the placebo. This involves negative reinforcement which is due to activation of a dopaminergic system that has been found to be activated during placebo analgesia and is involved in positive emotions. The nocebo effect of increased pain is, consistent with this model, because of increased fear and anxiety. The new aspect of the presented model is the hypothesis that expectations reduce negative emotions, and that negative reinforcement that involves the dopaminergic reinforcement system should be a contributor to placebo responses.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.08
Author: Flaten, M.
Secondary author(s):
Aslaksen, P., Lyby, P., Bjørkedal, E.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Flaten, M., Aslaksen, P., Lyby, P., & Bjørkedal, E. (2011). The relation of emotions to placebo responses. Philosophical Transactions of the Royal Society B, 366, 1818–1827. doi: 10.1098/rstb.2010.0407
2-year Impact Factor: 6.401|2011
Times cited: 93|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Placebo effect / Placebo analgesia / Pain / Emotion / Classical conditioning / Operant conditioning

The relation of emotions to placebo responses

The relation of emotions to placebo responses

DocumentThe effect of gender on placebo analgesia after classical conditioning2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.16
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of gender on placebo analgesia after classical conditioning
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={DEE465B2-6FF9-405C-B44F-BFDF087CA098}&SKey={4B674E01-8788-4BD6-89B1-6B8A26E1329D}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Previous studies have shown that placebo analgesia can occur after both classical conditioning and verbal information. Placebo analgesic responding to verbal information has been reported to be increased in males. The effect of subject gender on placebo analgesic responding after conditioning has not been investigated.
METHODS:
69 subjects (38 females) participated. Pain was induced by a thermode attached to the right forearm. Pain was induced 4 times for 2 minutes. In the Conditioned group, temperatures were increased from -100C to 0 and +50C after administration of placebo capsules. A conditioned stimulus (CS) control group received the capsules (CSs) but temperatures were kept constant at -100C after administration of the capsules. An unconditioned stimulus (US) control group did not receive the capsules, but the temperatures were increased as in the Conditioned group. Placebo analgesic responding was assessed when pain at -100C was applied in all groups at the end of the experiment. Placebo analgesic responding, i.e., reports of lower pain to -100C was expected in the Conditioned group, but not in the two control groups. The experimenters (two females and two males) were blind to whether the subjects received a placebo or an actual painkiller.
RESULTS:
There were no significant differences in the pre-test between the groups. There was a main effect of groups in the pain unpleasantness data (p<0.001) due to lower pain ratings in the Conditioned group compared to the US control group (p=0.02). There was no difference in pain unpleasantness between the Conditioned group and the CS control group. Cold pain thresholds were lower in the Conditioned and CS control group compared to the US control group (p=0.036). Females reported lower pain unpleasantness to male experimenters compared to female experimenters in the post-test in the Conditioned group (p=0.005). There were no other significant gender effects of conditioning on placebo analgesia. Male subjects displayed lower cold pain thresholds (p=0.03) than females regardless of group allocation. There was a main effect of gender on stress across groups, with male subjects reporting lower stress than females (p<0.01). There were no significant placebo effects on pain intensity, arousal or cortisol.
CONCLUSIONS:
Administration of placebo capsules in the Conditioned group decreased pain compared to the US control group that received identical pain stimulation but no capsules. However, administration of placebo capsules decreased pain even when the capsules were not related to a decrease in pain. Most likely this was due to the participants previous history with painkillers. There were no effects of subject gender on placebo analgesia after conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Lyby, P., Bjørkedal, E., Flaten, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Aslaksen, P., Lyby, P., Bjørkedal, E., & Flaten, M. (2008, August). The effect of gender on placebo analgesia after classical conditioning. Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retrieved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Placebo analgesia / Pain

DocumentPlacebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.21
Location: Arquivo PCA - Pasta 12/2006
Title:
Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress
Publication year: 2009
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=c1d0bb63-590d-4b97-b41b-1109ba7db4d1&cKey=89a4f0b3-17b0-4dea-8b65-4043ea5c50be&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
Abstract/Results: ABSTRACT:
Placebo analgesia refers to reduced pain report after administration of a placebo with information that it is a painkiller. This study investigated whether placebo analgesia could be observed as a reduced cortical response to pain, and whether placebo analgesia could be related to reduction in stress. Thirty-three participants (17 females) were exposed to phasic contact heat pain at 510C before and 10-30 minutes after administration of capsules containing lactose with information that the capsules contained a powerful painkiller. In a control condition the participants were exposed to the same painful stimuli, but the capsules were not administrated. The placebo and control conditions were separated by a minimum of 24 hours, and the order of the conditions was balanced. Pain report was recorded on a visual analogue scale, and cortical activity to painful stimulation was recorded by electroencephalography from 32 electrodes with linked ears reference. Only data from the Cz electrode are reported here. Phasic painful stimulation reliably generates cortical activity that can be observed as a positive component at about 200-300 ms after stimulus onset in the event related potential. The results showed significantly lower pain unpleasantness, and a significantly reduced P2 component in the placebo condition. Placebo analgesia was also related to a decrease in stress levels. The findings indicate that placebo analgesia is due to a reduced nociceptive signal to the cortex, or to reduced processing of the nociceptive signal in the cortex.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., Aslaksen, P.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lyby, P., Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., & Aslaksen, P. (2009). Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress. Program No. 654.20/Z31. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Placebo analgesia / Electroencephalogram (EEG) / Cortical response

DocumentEvent-related potentials to painful stimulation after caffeine and placebo in a balanced placebo design2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.23
Location: Arquivo PCA - Pasta 12/2006
Title:
Event-related potentials to painful stimulation after caffeine and placebo in a balanced placebo design
Publication year: 2010
URL:
http://www.jpain.org/article/S1526-5900(10)00249-X/fulltext
Abstract/Results: ABSTRACT:
An active placebo is a drug that has subjective side effects, but does not reduce the symptom under investigation. Since the active placebo has subjective effects, it may inform the participant that a drug, and not a placebo, has been administrated. Therefore, it was investigated whether side effects of a drug may provide information that can modulate expectancies towards treatment. Administration of 0 mg/kg bw or 4 mg/kg caffeine was crossed with information that the drink contained a potent painkiller or placebo in a balanced placebo within-subjects design (N=15). Four mg/kg caffeine was administrated to induce side effects, e.g., increased arousal, hypothesized to enhance expectations that an active drug had been administrated. An enhancement of expectations by caffeine, with a consequent increase in the placebo effect, would be evidence that drug side effects could increase the placebo effect. Pain was induced by a Nd:YAP 1340 Stimul laser before, and 30 minutes after administration of the drink. Electroencephalography was recorded from 32 electrodes. The results showed that caffeine heightened arousal, but expectancies of pain reduction were not significantly higher in the active placebo condition compared to the placebo condition. Caffeine did not enhance the credibility of the information, probably because arousal varies during the day and only small changes in arousal were induced by caffeine. Four mg/kg caffeine reduced reported pain, but not P2 amplitude.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Aslaksen, P., Bjørkedal, E.
Document type:
Abstract
Number of reproductions:
1
Reference:
Flaten, M., Aslaksen, P., & Bjørkedal, E. (2010). Event-related potentials to painful stimulation after caffeine and placebo in a balanced placebo design. Journal of Pain, 11(4), Supplement, S56. doi: 10.1016/j.jpain.2010.01.233
Indexed document: Yes
Keywords: Active placebo / Placebo / Caffeine / Pain / Arousal

DocumentGender effects in classical conditioning of placebo analgesia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.24
Location: Arquivo PCA - Pasta 12/2006
Title:
Gender effects in classical conditioning of placebo analgesia
Publication year: 2010
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/meeting2010/abstract2010.pdf
Abstract/Results: ABSTRACT:
PURPOSE:
Studies where placebo analgesia has been induced by verbal information have shown larger placebo analgesic responses in males compared to females. In the present study, the role of subject gender in classical conditioning of placebo analgesia was investigated. The Conditioned group received capsules containing an inactive ingredient with subsequent reduction in the intensity of a painful stimulus. Two other groups controlled for reduced pain intensity, and whether administration of the capsules decreased pain in the absence of programmed pairings of capsules with reduced pain. It was predicted that placebo analgesia should be observed in the Conditioned group compared to the control groups.
SUBJECTS AND METHODS:
Sixty-nine participants (38 females) received -10 degrees C to the arm for two minutes in a pre-test. The subjects were told that the capsules may or may not contain a painkiller. Thereafter, the Conditioned group
received one capsule, followed after 10 minutes by application of 0 degrees C for two minutes. After a brief pause the subjects received one more capsule followed after 10 minutes by application of +5 degrees C to the arm. Thereafter, a third capsule was administrated. Finally, a post-test identical to the pre-test was administrated. The Capsule control group received the same capsules as the Conditioned group, but -10 degrees C in all stimulations. The Pain control group did not receive the capsules, but received the same painful stimulation as the Conditioned group. The post-test was identical in all groups.
RESULTS:
Pain unpleasantness: main effect of Group (F=6.53, p =.003) due to lower pain ratings in the Conditioned group compared to the Pain control group. Similar findings for pain intensity. Lower pain in the Capsule control group compared to the Pain control group. Cortisol: Lower in males in the Conditioned group (F=2.56, p=.043). The results showed no clear relation between gender and placebo analgesic responding. Administration of capsules induced placebo analgesia in the absence of conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Bjørkedal, E., Lyby, P., Figenschau, Y., Aslaksen, P.
Document type:
Abstract
Number of reproductions:
1
Reference:
Flaten, M., Bjørkedal, E., Lyby, P., Figenschau, Y., & Aslaksen, P. (2010). Gender effects in classical conditioning of placebo analgesia. Psychosomatic Medicine, 72(3), A - 91.
Indexed document: Yes
Keywords: Placebo analgesia / Classical conditioning / Subject gender / Pain

Gender effects in classical conditioning of placebo analgesia

Gender effects in classical conditioning of placebo analgesia

File126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão2009-032013-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function