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BIAL Foundation
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Type Title Begin End
DocumentHippocampal structural alterations in ealry-stage psychosis: Specificty and relationship to clinical outcomes2022

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-203
Location: BF-GMS
Title:
203 - Dynamic eye-movement encoding in human cortex using ultra-high field fMRI (7Tesla)
Duration: 2021-10 - 2023-09
Researcher(s):
Alessio Fracasso
Institution(s): Institute of Neuroscience and Psychology, University of Glasgow, Scotland (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Fracasso, A.
Number of reproductions:
1
Keywords:
Gain-field / Modelling / Saccades / Ultra high-field MRI / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-203.05
Location: BF-GMS
Title:
Hippocampal structural alterations in ealry-stage psychosis: Specificty and relationship to clinical outcomes
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2213158222001528
Abstract/Results: Hippocampal dysfunctions are a core feature of schizophrenia, but conflicting evidence exists whether volumetric and morphological changes are present in early-stage psychosis and to what extent these deficits are related to clinical trajectories. In this study, we recruited individuals at clinical high risk for psychosis (CHR-P) (n=108), patients with a first episode of psychosis (FEP) (n=37), healthy controls (HC) (n=70) as well as a psychiatric control group with substance abuse and affective disorders (CHR-N: n=38). MRI-data at baseline were obtained and volumetric as well as vertex analyses of the hippocampus were carried out. Moreover, volumetric changes were examined in the amygdala, caudate, nucleus accumbens, pallidum, putamen and thalamus. In addition, we obtained follow-up functional and symptomatic assessments in CHR-P individuals to examine the question whether anatomical deficits at baseline predicted clinical trajectories. Our results show that the hippocampus is the only structure showing significant volumetric decrease in early-stage psychosis, with FEPs showing significantly smaller hippocampal volumes bilaterally alongside widespread shape changes in the vertex analysis. For the CHR-P group, volumetric decreases were confined to the left hippocampus. However, hippocampal alterations in the CHR-P group were not robustly associated with clinical outcomes, including the persistence of attenuated psychotic symptoms and functional trajectories. Accordingly, our findings highlight that dysfunctions in hippocampal anatomy are an important feature of early-stage psychosis which may, however, not be related to clinical outcomes in CHR-P participants.
Accessibility: Document exists in file
Language:
eng
Author:
Brunner, G.
Secondary author(s):
Gajwani, R., Gross, J., Gumley, A., Krishnadas, R., Lawrie, S., Schwannauer, M., Schultze-Lutter, F., Fracasso, A., Uhlhaas, P.
Document type:
Article
Number of reproductions:
1
Percentiles:
47.12|0.71
Reference:
Brunner, G., Gajwani, R., Gross, J., Gumley, A., Krishnadas, R., Lawrie, S., Schwannauer M., Schultze-Lutter, F., Fracasso, A. & Uhlhaas, P. (2022). Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes. NeuroImage: Clinical, 35, 103087. https://doi.org/10.1016/j.nicl.2022.103087
Impact Factor: 4.200|2022
Times cited: 9|2026-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Hippocampus / Psychosis / Clinical high risk / Subcortex / Morphometry

<!-- mm occ=1 guid=[df8ab9a7f9fbaf77960ef59368bcd029] WebBehavior$=[0] -->

Hippocampal structural alterations in ealry-stage psychosis: Specificty and relationship to clinical outcomes

Hippocampal structural alterations in ealry-stage psychosis: Specificty and relationship to clinical outcomes
DocumentMachine learning methods to predict outcomes of pharmacological treatment in psychosis2023

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-288
Location: BF-GMS
Title:
288 - The origin of the sublime power in the brain: An integrated EEG-TMS study
Duration: 2021-04 - 2025-05
Researcher(s):
Eleonora Maggioni, Paolo Brambilla, Giandomenico Schiena, Alice Chirico, Andrea Gaggioli, Maddalena Mazzocut-Mis
Institution(s): Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan (Italy); Università Cattolica del Sacro Cuore, Milan (Italy); Università degli Studi di Milano (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Maggioni, E.
Secondary author(s):
Brambilla, P., Schiena, G., Chirico, A., Gaggioli, A., Mazzocut-Mis, M.
Number of reproductions:
3
Keywords:
Virtual reality / Sublime / Brain connectivity / EEG-TMS / Parapsychology and Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-288.02
Location: BF-GMS
Title:
Machine learning methods to predict outcomes of pharmacological treatment in psychosis
Publication year: 2023
URL:
https://www.nature.com/articles/s41398-023-02371-z
Abstract/Results: ABSTRACT:
In recent years, machine learning (ML) has been a promising approach in the research of treatment outcome prediction in psychosis. In this study, we reviewed ML studies using different neuroimaging, neurophysiological, genetic, and clinical features to predict antipsychotic treatment outcomes in patients at different stages of schizophrenia. Literature available on PubMed until March 2022 was reviewed. Overall, 28 studies were included, among them 23 using a single-modality approach and 5 combining data from multiple modalities. The majority of included studies considered structural and functional neuroimaging biomarkers as predictive features used in ML models. Specifically, functional magnetic resonance imaging (fMRI) features contributed to antipsychotic treatment response prediction of psychosis with good accuracies. Additionally, several studies found that ML models based on clinical features might present adequate predictive ability. Importantly, by examining the additive effects of combining features, the predictive value might be improved by applying multimodal ML approaches. However, most of the included studies presented several limitations, such as small sample sizes and a lack of replication tests. Moreover, considerable clinical and analytical heterogeneity among included studies posed a challenge in synthesizing findings and generating robust overall conclusions. Despite the complexity and heterogeneity of methodology, prognostic features, clinical presentation, and treatment approaches, studies included in this review suggest that ML tools may have the potential to predict treatment outcomes of psychosis accurately. Future studies need to focus on refining feature characterization, validating prediction models, and evaluate their translation in real-world clinical practice.
Accessibility: Document exists in file
Language:
eng
Author:
Del Fabro, L.
Secondary author(s):
Bondi, E., Serio, F.
Document type:
Article
Number of reproductions:
3
Percentiles:
86.19|1.84
Reference:
Del Fabro, L., Bondi, E., Serio, F., Maggioni, E., D'Agostino, A., & Brambilla, P. (2023). Machine learning methods to predict outcomes of pharmacological treatment in psychosis. Translational Psychiatry, 13, 75. https://doi.org/10.1038/s41398-023-02371-z
Impact Factor: 5.8|2023
Times cited: 28|2026-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Machine learning / Psychosis / Antipsychotic treatments / Review

<!-- mm occ=1 guid=[4bc1437fa633dbd2c1c25c62495f95ed] WebBehavior$=[0] -->

Machine learning methods to predict outcomes of pharmacological treatment in psychosis

Machine learning methods to predict outcomes of pharmacological treatment in psychosis
DocumentThe European Portuguese Version of the Brief Negative Symptom Scale2024

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-292.17
Location: BF-GMS
Title:
The European Portuguese Version of the Brief Negative Symptom Scale
Publication year: 2024
URL:
https://karger.com/psp/article/doi/10.1159/000530705/844596/The-European-Portuguese-Version-of-the-Brief
Abstract/Results: ABSTRACT:
Negative symptoms reflect a currently much-untreated loss of normal functioning and are frequently found in psychotic disorders. We present the first translation of the Brief Negative Symptom Scale (BNSS) to European Portuguese and evaluate its validity in a sample of Portuguese male patients with a psychotic spectrum disorder. The Portuguese BNSS showed excellent internal consistency, high convergent validity (i.e., strong correlation with the PANSS negative factor), and high discriminant validity (i.e., a lack of association with the PANSS positive factor). In sum, the present European Portuguese BNSS has shown to be reliable, thus extending this instrument's clinical availability worldwide.
Accessibility: Document exists in file
Language:
eng
Author:
Santos, H. C.
Secondary author(s):
Rodrigues, A., Ferreira, S., Martins, J. M., Baptista, T., Gama Marques, J., Kirkpatrick, B., Prata, D.
Document type:
Article
Number of reproductions:
1
Percentiles:
39.13|0.46
Reference:
Santos, H. C., Rodrigues, A., Ferreira, S., Martins, J. M., Baptista, T., Gama Marques, J., Kirkpatrick, B., & Prata, D. (2024). The European Portuguese Version of the Brief Negative Symptom Scale. Psychopathology, 57(1), 76–80. https://doi.org/10.1159/000530705
Impact Factor: 2.2|2024
Times cited: 4|2026-02-16
Indexed document: Yes
Quartile: Q3
Keywords: Negative symptoms / Psychosis / Positive and Begative Syndrome Scale / Schizophrenia / Schizoaffective disorder

<!-- mm occ=1 guid=[673aac4cf2a7408ba541e9889e16d46b] WebBehavior$=[0] -->

The European Portuguese Version of the Brief Negative Symptom Scale

The European Portuguese Version of the Brief Negative Symptom Scale
DocumentAn exploration of blood-based biomarkers of negative symptoms of psychosis in men2024

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-292.19
Location: BF-GMS
Title:
An exploration of blood-based biomarkers of negative symptoms of psychosis in men
Publication year: 2024
URL:
https://doi.org/10.1016/j.jpsychires.2024.06.050
Abstract/Results: ABSTRACT:
Negative symptoms in the context of psychosis are still poorly understood and diagnosed, which impairs the treatment efficacy of current therapies and patient's integration in society. In this study, we aimed to test hypothesis-based and exploratory associations of negative symptom domains, as defined by the Brief Negative Symptom Scale (BNSS), with hormonal and hematological variables, and, complementarily, with standard psychological/cognitive and psychopathological measures. Fifty-one male patients diagnosed with a psychotic disorder underwent a structured interview and blood collection. Standard Spearmen bivariate correlations were used for data analysis. We obtained evidence of hypothesis-based associations between specific negative symptoms and oxytocin, thyroid stimulating hormone levels and neutrophil-to-lymphocyte ratio; as well as novel and hypothesis-free associations with erythrocyte and lymphocyte count, mean corpuscular volume and red cell distribution width. Complementarily, we also obtained some validation of previous associations of negative symptoms with illness resolution, cognitive symptom severity and social performance, and a novel association with anger contagion. We hope our results can generate new hypotheses in psychosis research. Our work suggests further avenues in research on erythrocytic, inflammatory, thyroid and oxytocin-related markers and abnormalities in psychosis, especially in regards to specific negative symptoms, towards more precise and comprehensive etiological, diagnostic and therapeutic models.
Accessibility: Document exists in file
Language:
eng
Author:
Rodrigues, A.
Secondary author(s):
Santos, H. C., Ferreira, S., Diogo, V., Costa, M., Brissos, S., Marques, J. G., Prata, D.
Document type:
Article
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Rodrigues, A., Santos, H. C., Ferreira, S., Diogo, V., Costa, M., Brissos, S., Marques, J. G., & Prata, D. (2024). An exploration of blood-based biomarkers of negative symptoms of psychosis in men. Journal of Psychiatric Research, 177, 256–263. https://doi.org/10.1016/j.jpsychires.2024.06.050
Impact Factor: 3.2|2024
Times cited: 0|2026-02-16
Indexed document: Yes
Quartile: Q2
Keywords: Asociality / Avolition / BNSS / Negative symptoms / Psychosis

<!-- mm occ=1 guid=[1b303c163e83bfa81370711c40cedbd1] WebBehavior$=[0] -->

An exploration of blood-based biomarkers of negative symptoms of psychosis in men

An exploration of blood-based biomarkers of negative symptoms of psychosis in men
DocumentSalivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis2025

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-192.11
Location: BF-GMS
Title:
Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
Publication year: 2025
URL:
https://doi.org/10.1016/j.psyneuen.2025.107283
Abstract/Results: ABSTRACT:
Background
Studies of salivary cortisol levels in psychosis have yielded inconsistent findings, which may be attributable to heterogeneity in cortisol measurement, illness stage, and approaches to dealing with sampling factors and potential confounders. To address these issues, we performed an individual participant data (IPD) meta-analysis comparing individuals at different stages of psychosis to controls using five different salivary cortisol measures and explored potential effect modifiers.
Methods
Salivary cortisol data from five London-based cohorts were used to derive the cortisol awakening response, total daytime cortisol output, basal cortisol, and diurnal slope measures (wake-to-evening and peak-to-evening). Linear regression models were first performed to obtain standardised beta coefficients (ß), representing the difference in each cortisol metric between each clinical stage group (cases) and healthy individuals (controls) after accounting for relevant sampling factors; we then used random-effects meta-analyses and meta-regression models to investigate the effect of psychosis stage and sample characteristics on effect sizes.
Results
Data were available for 352 individuals distributed across psychosis clinical stages (1a – distress disorder: N = 35; 1b – clinical high-risk for psychosis: N = 90; 2a – first-episode psychosis: N = 197; 2b – single episode remitted: N = 5; 3 – relapsing/remitting illness: N = 18; 4 – severe and persistent illness: N = 7) and 292 controls. A significant overall main effect of clinical stage on peak-to-evening diurnal slope was observed (?2=12.83, p = 0.025), with both the clinical high-risk (ß=0.21, 95 % CI: 0.06, 0.36) and first-episode psychosis (ß=0.20, 95 % CI: 0.10, 0.31) groups characterised by flatter slopes than controls. The clinical stage groups and controls did not differ on any other cortisol measure. Several sample characteristics were significantly associated with diurnal slope effect sizes, but after accounting for clinical stage, only the association between mean age in cases and wake-to-evening diurnal slope retained significance.
Conclusion
Clinical high-risk and first-episode psychosis participants differed from healthy controls in the peak-to-evening diurnal cortisol slope. This measure has not been examined in these populations before, and its potential predictive and prognostic utility for psychotic disorders merits further investigation.
Accessibility: Document exists in file
Language:
eng
Author:
Haussler, S. M.
Secondary author(s):
Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., Cullen, A. E.
Document type:
Article
Number of reproductions:
1
Percentiles:
86.67|2.59
Reference:
Haussler, S. M., Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., & Cullen, A. E. (2025). Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis. Psychoneuroendocrinology, 173, 107283. https://doi.org/10.1016/j.psyneuen.2025.107283
Impact Factor: 3.4|2025
Times cited: 2|2026-07-22
Indexed document: Yes
Quartile: Q2
Keywords: Cortisol / Schizophrenia / Psychosis / Stress neurobiology / Meta-analysis

<!-- mm occ=1 guid=[9a1507d91442d661329fd777a1271a60] WebBehavior$=[0] -->

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
DocumentSalivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis2025

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006.035.32
Location: BF-GMS
Title:
Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
Publication year: 2025
URL:
https://doi.org/10.1016/j.psyneuen.2025.107283
Abstract/Results: ABSTRACT:
Background
Studies of salivary cortisol levels in psychosis have yielded inconsistent findings, which may be attributable to heterogeneity in cortisol measurement, illness stage, and approaches to dealing with sampling factors and potential confounders. To address these issues, we performed an individual participant data (IPD) meta-analysis comparing individuals at different stages of psychosis to controls using five different salivary cortisol measures and explored potential effect modifiers.
Methods
Salivary cortisol data from five London-based cohorts were used to derive the cortisol awakening response, total daytime cortisol output, basal cortisol, and diurnal slope measures (wake-to-evening and peak-to-evening). Linear regression models were first performed to obtain standardised beta coefficients (ß), representing the difference in each cortisol metric between each clinical stage group (cases) and healthy individuals (controls) after accounting for relevant sampling factors; we then used random-effects meta-analyses and meta-regression models to investigate the effect of psychosis stage and sample characteristics on effect sizes.
Results
Data were available for 352 individuals distributed across psychosis clinical stages (1a – distress disorder: N = 35; 1b – clinical high-risk for psychosis: N = 90; 2a – first-episode psychosis: N = 197; 2b – single episode remitted: N = 5; 3 – relapsing/remitting illness: N = 18; 4 – severe and persistent illness: N = 7) and 292 controls. A significant overall main effect of clinical stage on peak-to-evening diurnal slope was observed (?2=12.83, p = 0.025), with both the clinical high-risk (ß=0.21, 95 % CI: 0.06, 0.36) and first-episode psychosis (ß=0.20, 95 % CI: 0.10, 0.31) groups characterised by flatter slopes than controls. The clinical stage groups and controls did not differ on any other cortisol measure. Several sample characteristics were significantly associated with diurnal slope effect sizes, but after accounting for clinical stage, only the association between mean age in cases and wake-to-evening diurnal slope retained significance.
Conclusion
Clinical high-risk and first-episode psychosis participants differed from healthy controls in the peak-to-evening diurnal cortisol slope. This measure has not been examined in these populations before, and its potential predictive and prognostic utility for psychotic disorders merits further investigation.
Accessibility: Document exists in file
Language:
eng
Author:
Haussler, S. M.
Secondary author(s):
Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., Cullen, A. E.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
86.67|2.59
Reference:
Haussler, S. M., Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C., Fisher, H. L., Laurens, K. R., Di Forti, M., Wood, S. J., Murray, R. M., McGuire, P., Mondelli, V., & Cullen, A. E. (2025). Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis. Psychoneuroendocrinology, 173, 107283. https://doi.org/10.1016/j.psyneuen.2025.107283
Impact Factor: 3.4|2025
Times cited: 2|2026-07-22
Indexed document: Yes
Quartile: Q2
Keywords: Cortisol / Schizophrenia / Psychosis / Stress neurobiology / Meta-analysis

<!-- mm occ=1 guid=[9a1507d91442d661329fd777a1271a60] WebBehavior$=[0] -->

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
DocumentThe Hitchhiker's guide to hallucination research2025

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-146
Location: BF-GMS
Title:
146 - The me and the I: Dissociating ownership and agency in sensorimotor processing
Duration: 2021-09
Researcher(s):
Ana Pinheiro, Sonja Kotz, Michael Schwartze
Institution(s): Centro de Investigação em Ciência Psicológica - CICPSI, Faculdade de Psicologia da Universidade de Lisboa (Portugal); Faculty of Psychology and Neuroscience, University of Maastricht (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Article
Language: eng
Notes:
Ongoing project
Author: Pinheiro, A. P.
Secondary author(s):
Kotz, S., Schwartze, M.
Number of reproductions:
1
Keywords:
Self / Agency / Ownership / Electroencephalogram (EEG) / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2020-146.13
Location: BF-GMS
Title:
The Hitchhiker's guide to hallucination research
Publication year: 2025
URL:
https://doi.org/10.1016/j.concog.2025.103941
Abstract/Results: ABSTRACT:
Hallucination research is a fast-growing, inherently interdisciplinary field bridging psychology, neuroscience, psychiatry, and philosophy. This article maps out key conceptual and methodological issues underlying the study of hallucinations. We begin by unpacking core theoretical issues - how hallucinations differ from other perceptual alterations, whether they form a single construct or several, and how these distinctions influence study design and interpretation. Next, we review the most commonly used experimental paradigms. A clear distinction is drawn between tasks that measure enduring hallucinatory tendencies and those that capture hallucinations in real time. We also review the most widely used rating instruments - including confidence scales - and discuss the phenomenological approach, which foregrounds participants' first-person experience. The final section offers a concise, though not exhaustive, checklist of variables researchers must account for - ranging from sensory modality and context to cognitive style, affective state, and cultural background. Taken together, the article serves as an entry-level guide, posing critical questions that every researcher should answer before designing a study on hallucinations.
Accessibility: Document exists in file
Language:
eng
Author:
Abalo-Rodríguez, I.
Secondary author(s):
Pinheiro, A. P.
Document type:
Article
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Abalo-Rodríguez, I., & Pinheiro, A. P. (2025). The Hitchhiker's guide to hallucination research. Consciousness and Cognition, 136, 103941. https://doi.org/10.1016/j.concog.2025.103941
Impact Factor: 2.5|2025
Times cited: 0|2026-07-23
Indexed document: Yes
Quartile: Q2
Keywords: Experimental tasks / Hallucinations / Interdisciplinarity / Methodology / Phenomenology / Psychosis

<!-- mm occ=1 guid=[4948ad184bd9620860154036f8f97895] WebBehavior$=[0] -->

The Hitchhiker's guide to hallucination research

The Hitchhiker's guide to hallucination research
DocumentDifferentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence2025

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-192.12
Location: BF-GMS
Title:
Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
Publication year: 2025
URL:
https://doi.org/10.1016/j.schres.2025.07.001
Abstract/Results: ABSTRACT:
Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (n = 114) over ages 9–20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents. Both ASz and FHx youth demonstrated early deficits (age ~11 years) in verbal intelligence relative to TD youth, which remained stable into young adulthood. FHx youth additionally showed this stable developmental deficit relative to TD youth in performance intelligence. In exploratory supplementary analyses, verbal intelligence improved with age toward TD performance among ASz children whose psychopathological symptoms remitted during follow-up. Uniquely among FHx youth, those with a low familial loading (one second-degree affected relative only) and none/one of the three antecedents did not evidence the stable developmental deficits in verbal and performance intelligence. These distinct developmental trajectories of verbal and performance intelligence among youth presenting different profiles of schizophrenia risk may signify potential for targeted preventative interventions. Further research is needed to determine whether these trajectories distinguish later transition to schizophrenia from a cognitive vulnerability that normalises among at-risk individuals who do not transition.
Accessibility: Document exists in file
Language:
eng
Author:
Carpendale, E. J.
Secondary author(s):
Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Carpendale, E. J., Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H. L., & Laurens, K. R. (2025). Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence. Schizophrenia Research, 283, 144–151. https://doi.org/10.1016/j.schres.2025.07.001
Impact Factor: 3.7|2025
Times cited: 1|2026-07-23
Indexed document: Yes
Quartile: Q2
Keywords: Psychosis / Genetic liability / High-risk / Cognition / IQ / Vocabulary / Matrix reasoning

<!-- mm occ=1 guid=[f95a77b4ccccf4fe886815473a58c9fb] WebBehavior$=[0] -->

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
DpcumentDifferentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence2015

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

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Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

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Reference code: PT/FB/BL-2006.035.34
Location: BF-GMS
Title:
Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
Publication year: 2015
URL:
https://doi.org/10.1016/j.schres.2025.07.001
Abstract/Results: ABSTRACT:
Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (n = 114) over ages 9–20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents. Both ASz and FHx youth demonstrated early deficits (age ~11 years) in verbal intelligence relative to TD youth, which remained stable into young adulthood. FHx youth additionally showed this stable developmental deficit relative to TD youth in performance intelligence. In exploratory supplementary analyses, verbal intelligence improved with age toward TD performance among ASz children whose psychopathological symptoms remitted during follow-up. Uniquely among FHx youth, those with a low familial loading (one second-degree affected relative only) and none/one of the three antecedents did not evidence the stable developmental deficits in verbal and performance intelligence. These distinct developmental trajectories of verbal and performance intelligence among youth presenting different profiles of schizophrenia risk may signify potential for targeted preventative interventions. Further research is needed to determine whether these trajectories distinguish later transition to schizophrenia from a cognitive vulnerability that normalises among at-risk individuals who do not transition.
Accessibility: Document exists in file
Language:
eng
Author:
Carpendale, E. J.
Secondary author(s):
Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H., Laurens, K. R.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Carpendale, E. J., Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H. L., & Laurens, K. R. (2025). Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence. Schizophrenia Research, 283, 144–151. https://doi.org/10.1016/j.schres.2025.07.001
Impact Factor: 3.5|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2026-02-20
Indexed document: Yes
Quartile: Q1
Keywords: Psychosis / Genetic liability / High-risk / Cognition / IQ / Vocabulary / Matrix reasoning

<!-- mm occ=1 guid=[f95a77b4ccccf4fe886815473a58c9fb] WebBehavior$=[0] -->

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
DocumentTrajectories of grey and white matter volume in children at elevated risk for schizophrenia2026

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-194.19
Location: BF-GMS
Title:
Trajectories of grey and white matter volume in children at elevated risk for schizophrenia
Publication year: 2026
URL:
https://doi.org/10.1017/S1092852926101047
Abstract/Results: ABSTRACT:
Objective: Longitudinal investigation of brain alterations in children putatively at-risk of developing schizophrenia may identify early markers of pathophysiology associated with vulnerability for the disorder.
Methods: Children aged 9-12 years with multiple antecedents of schizophrenia (psychoticlike experiences; speech and/or motor delays; and social, emotional, and/or behavioural difficulties; ASz, n=31), with a family history of schizophrenia/schizoaffective disorder (FHx, n=21), and typically developing children (TD, n=35) were recruited through community screening using questionnaires. T1-weighted structural MRI scans were obtained at baseline, and after approximately 2- and 4-years of follow-up, and processed using the FreeSurfer longitudinal pipeline. Across these three assessment waves, total grey matter (GM) and white matter (WM) volume, and regional GM volumes in twelve regions of interest, were compared among the groups using linear mixed models.
Results: Children from three groups were 11.21 (±1.61) years at baseline and the average lapse-of-time between each assessment was 1.76 (±0.36) years. The ASz group exhibited consistently higher total WM volume (b=29.45) compared to the TD group, with no statistically significant time-related volumetric WM or GM differences in any region. The FHx group also demonstrated higher total WM volume (b=36.49), and time-related total and regional GM volume changes were observed; however, these effects were attenuated after correction.
Conclusion: Global and regionally-specific brain abnormalities distinguished children with different risk profiles for schizophrenia relative to their typically developing peers. Follow-up is required to determine how these changes may relate to later schizophrenia.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2006.035.35
Author: Si, S.
Secondary author(s):
Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Si, S., Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., & Laurens, K. R. (2026). Trajectories of gray and white matter volume in children at elevated risk for schizophrenia. CNS spectrums, 31(1), e23. https://doi.org/10.1017/S1092852926101047
Impact Factor: 4.6|2025
Impact factor notes: Impact factor not available yet for 2026
Times cited: 0|2026-07-24
Indexed document: Yes
Quartile: Q1
Keywords: High-risk / Psychosis / Structural MRI / Community screening / Early detection / Longitudinal study

<!-- mm occ=1 guid=[c5d129cdf565018aed09bf7c4d6f572c] WebBehavior$=[0] -->

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia
DocumentTrajectories of gray and white matter volume in children at elevated risk for schizophrenia2026

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006.035.35
Location: BF-GMS
Title:
Trajectories of gray and white matter volume in children at elevated risk for schizophrenia
Publication year: 2026
URL:
https://doi.org/10.1017/S1092852926101047
Abstract/Results: ABSTRACT:
Objective: Longitudinal investigation of brain alterations in children putatively at-risk of developing schizophrenia may identify early markers of pathophysiology associated with vulnerability for the disorder.
Methods: Children aged 9-12 years with multiple antecedents of schizophrenia (psychoticlike experiences; speech and/or motor delays; and social, emotional, and/or behavioural difficulties; ASz, n=31), with a family history of schizophrenia/schizoaffective disorder (FHx, n=21), and typically developing children (TD, n=35) were recruited through community screening using questionnaires. T1-weighted structural MRI scans were obtained at baseline, and after approximately 2- and 4-years of follow-up, and processed using the FreeSurfer longitudinal pipeline. Across these three assessment waves, total grey matter (GM) and white matter (WM) volume, and regional GM volumes in twelve regions of interest, were compared among the groups using linear mixed models.
Results: Children from three groups were 11.21 (±1.61) years at baseline and the average lapse-of-time between each assessment was 1.76 (±0.36) years. The ASz group exhibited consistently higher total WM volume (b=29.45) compared to the TD group, with no statistically significant time-related volumetric WM or GM differences in any region. The FHx group also demonstrated higher total WM volume (b=36.49), and time-related total and regional GM volume changes were observed; however, these effects were attenuated after correction.
Conclusion: Global and regionally-specific brain abnormalities distinguished children with different risk profiles for schizophrenia relative to their typically developing peers. Follow-up is required to determine how these changes may relate to later schizophrenia.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-194.19
Author: Si, S.
Secondary author(s):
Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., Laurens, K. R.
Document type:
Article-d
Number of reproductions:
1
Reference:
Si, S., Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., & Laurens, K. R. (2026). Trajectories of gray and white matter volume in children at elevated risk for schizophrenia. CNS spectrums, 31(1), e23. https://doi.org/10.1017/S1092852926101047
Impact Factor: 4.6|2025
Impact factor notes: Impact factor not available yet for 2026
Times cited: 0|2026-07-24
Indexed document: Yes
Quartile: Q1
Keywords: High-risk / Psychosis / Structural MRI / Community screening / Early detection / Longitudinal study

<!-- mm occ=1 guid=[c5d129cdf565018aed09bf7c4d6f572c] WebBehavior$=[0] -->

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia