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Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

2007

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
      - Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-168
Location:	Arquivo PCA - Pasta 13/2004
Title:	168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration:	2005-02 - 2007-07
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s):	National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code:	PT/FB/BL-2004-168.01
Location:	Arquivo PCA - Pasta 13/2004
Title:	Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Publication year:	2007
URL:	http://www.bial.com/imagem/Bolsa%2016804.pdf
Abstract/Results:	RESULTS: Using the opportunity to record parahippocampal activity with foramen ovale electrodes in epilepsy patients we examined high-frequency activity and its relation to NREM sleep-slow oscillations and sleep spindles. Parahippocampal high-frequency activity was organized into bursts which were consistently associated with interictal epileptic spikes. Ripple density was higher during Non-REM than REM sleep (p<0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (p<0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (p<0.001). Coordinated occurrence of hippocampal ripples, sleep spindles and slow oscillations have already been reported in animals yet the present results provide first evidence for such a temporal coupling in humans. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Halász, P.
Secondary author(s):	Borbély, C., Fabó, D., Eross, L., Entz, L.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Epilepsy / Sleep / Hippocampus
Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

Document

Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

2007

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
      - Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-168
Location:	Arquivo PCA - Pasta 13/2004
Title:	168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration:	2005-02 - 2007-07
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s):	National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code:	PT/FB/BL-2004-168.02
Location:	Arquivo PCA - Pasta 13/2004
Title:	Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans
Publication year:	2007
URL:	http://www.ncbi.nlm.nih.gov/pubmed/17615093
Abstract/Results:	ABSTRACT: Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the depolarized up-state. The temporal coupling between slow oscillations, spindles and ripples has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation during sleep. Here, we examined whether a similar coupling exists between these oscillatory phenomena in humans. In sleep recordings from seven epileptic patients, scalp-recorded slow oscillations and spindles as well as parahippocampal ripples recorded from foramen ovale electrodes were identified by automatic algorithms. Additionally, ripple and spindle root mean square activity was determined for relevant frequency bands. Ripple density was higher during Non-REM than REM sleep (P < 0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (P < 0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (P < 0.001). Ripples were consistently associated with interictal spikes suggesting that spike-ripple complexes represent an epileptic transformation of sharp wave-ripple complexes in the epileptic hippocampus. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Clemens, Z.
Secondary author(s):	Mölle, M., Eross, L., Barsi, P., Halász, P., Born, J.
Document type:	Article
Number of reproductions:	1
Reference:	Clemens, Z., Mölle, M., Eross, L., Barsi, P., Halász, P., & Born, J. (2007). Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. Brain, 130, 2868-2878. https://doi.org/10.1093/brain/awm146
2-year Impact Factor:	8.568\|2007
Times cited:	306\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Sleep / Hippocampus / Sharp-wave ripples / Slow oscillation / Epilepsy
Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

Document

Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
      - Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-168
Location:	Arquivo PCA - Pasta 13/2004
Title:	168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration:	2005-02 - 2007-07
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s):	National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code:	PT/FB/BL-2004-168.04
Location:	Arquivo PCA - Pasta 13/2004
Title:	Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans
Publication year:	2006
URL:	http://fens2006.neurosciences.asso.fr/abstracts/R1/A018_3.html
Abstract/Results:	ABSTRACT: Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviours and rapid-eye-movement (REM) sleep is a characteristic and salient oscillatory rhythm in animals. By contrast, much controversy exists regarding the existence and the characteristics of this activity in humans. Some studies argued that human hippocampal theta activity appears in short and phasic bursts. On the contrary, earlier we showed that REM-dependent RSA recorded from the parahippocampal region is continuous like in animals but instead of the theta it falls in the delta frequency range. Here, we examined parahippocampal activity in 10 epilepsy patients implanted with foramen ovale electrodes while they were engaged in a virtual navigation task. Navigation was tested according to three conditions: an acquisition, a recall and a non-learning route-following condition. Recordings were also sampled from resting and REM sleep. For analyses, spectral power densities (SPD) were calculated for each 1 Hz wide frequency bin up to 10 Hz. During acquisition, SPD significantly increased in the 1 Hz, 2 Hz and the 3 Hz frequency bins when compared with resting. A similar but more robust increase was present in the 1 Hz, 2 Hz, 3 Hz, 4 Hz and 5 Hz frequency bins during REM sleep. Thus, increase was present in similar frequencies during the two conditions and these frequency ranges were below the traditional theta band. At the same time, other features of this activity, such as state-dependency and tonicity made this activity comparable to that seen in animals and suggest this activity to be the human analogue hippocampal theta in animals.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Clemens, Z.
Secondary author(s):	Borbély, C., Fabó, D., Halász, P.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Clemens, Z., Borbély, C., Fabó, D., & Halász P. (2006). Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans. FENS Abstr., vol.3, A018.3, 2006. Abstract retrieved from http://fens2006.neurosciences.asso.fr/abstracts/R1/A018_3.html
Indexed document:	No
Keywords:	Parahippocampal activity / Epilepsy / Virtual navigation / Sleep / Learning

Document

Temporal coupling of parahippocampal ripples and sleep spindles in humans

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
      - Temporal coupling of parahippocampal ripples and sleep spindles in humans

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-168
Location:	Arquivo PCA - Pasta 13/2004
Title:	168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration:	2005-02 - 2007-07
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s):	National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code:	PT/FB/BL-2004-168.05
Location:	Arquivo PCA - Pasta 13/2004
Title:	Temporal coupling of parahippocampal ripples and sleep spindles in humans
Publication year:	2006
URL:	http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2006.00540_57.x/pdf
Abstract/Results:	ABSTRACT: Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during NREM sleep. In rodents they occur in association with sharp waves and are known to be grouped by the cortical slow oscillation such that their occurrence is maximal during the surface positive, up states. Ripples were also shown to be temporally linked to sleep spindles. Importantly, coordinated spindleripple events have been suggested to provide a framework for information transfer between the hippocampus and the neocortex underlying memory consolidation. Our aim was to examine whether ripples recorded via parahippocampal electrocorticography are also temporally linked with slow oscillations and sleep spindles in epileptic humans. Whole-night recordings from seven epilepsy patients implanted with foramen ovale (FO) electrodes were analysed. Negative half waves of the slow oscillation and sleep spindles recorded on the scalp as well as ripples in FO recordings were detected by an automatic algorithm. Ripple activity was also measured as root mean square (RMS) of the 80–140 Hz activity. Compared to baseline both ripple measures showed a significant increase time-locked to sleep spindles. In the three patients without temporal structural alterations ripple activity decreased time-locked to slow oscillation negative half waves. In the four other patients exhibiting hippocampal sclerosis, modulation of ripple activity by the negative half waves was much less clear. Ripples significantly increased during NREM sleep and were consistently associated with interictal epileptic spikes. This suggests that ripple/spike complexes represent an epileptic exaggeration of ripple/sharp wave complexes in the human epileptic hippocampus. Whether ripples are epileptically transformed or not, the present data provide first evidence for a temporal coupling between hippocampal ripples and neocortical spindles in humans.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Clemens, Z.
Secondary author(s):	Mölle, M., Eröss, L., Barsi, P., Halász, P., Born, J.
Document type:	Abstract
Number of reproductions:	1
Reference:	Clemens, Z., Molle, M., Eross, L., Barsi, P., Halasz, P., & Born, J. (2006). Temporal coupling of parahippocampal ripples and sleep spindles in humans. Journal of Sleep Research, 15(Suppl. 1), 242-242. https://doi.org/10.1111/j.1365-2869.2006.00540_57.x
Indexed document:	Yes
Keywords:	Sleep / Hippocampus / Sharp-wave ripples / Epilepsy
Temporal coupling of parahippocampal ripples and sleep spindles in humans

Document

An investigation of effects of dreams on physiological measures of stress

2008

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 093 - An investigation of effects of dreams on physiological measures of stress
      - An investigation of effects of dreams on physiological measures of stress

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-093
Location:	Arquivo PCA - Pasta 15/2004
Title:	093 - An investigation of effects of dreams on physiological measures of stress
Duration:	2005-06 - 2007-09
Researcher(s):	Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s):	Psychopharmacology Unit, Bristol (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final report
Language:	eng
Author:	Wilson, S. J.
Secondary author(s):	Nutt, D. J., Lightman, S.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code:	PT/FB/BL-2004-093.05
Location:	Arquivo PCA - Pasta 15/2004
Title:	An investigation of effects of dreams on physiological measures of stress
Publication year:	2008
URL:	http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results:	ABSTRACT: OBJECTIVES: Part 1 - to compare morning salivary cortisol response, sleep questionnaires and dream reports between patients with parasomnias, normal subjects and patients with insomnia. Part 2 – to pilot the use of automatic blood sampling overnight for cortisol assay synchronized with polysomnography in 6 normal subjects, to assess the minute by minute effect of sleep stage on cortisol measures, and to compare morning dream reports with plasma cortisol and salivary cortisol on awakening. METHODS: Part 1 - patients with sleep disorders and healthy good sleepers were provided with a pack containing cotton swabs for saliva sampling and overnight sleep and dreaming questionnaires. Patients with parasomnias were sent sample kits for 2 nights, 1 with and 1 without an episode (eg night terror). 16 patients and 15 healthy good sleepers returned the packs and salivary cortisol concentration was measured in-house using radio-immunoassay. Part 2 - 6 healthy volunteers slept in the sleep laboratory. An automated sampling machine has been developed at Bristol University to minimise interference with study subjects when taking blood samples. They were prepared for polysomnography (PSG) and had an indwelling cannula connected ‘through the wall’ to the sampling machine. Blood samples (1ml) were taken every 10 minutes, synchronised with the PSG recording. Samples were later assayed for cortisol. Sleep was scored and the cortisol levels related to different sleep stages. RESULTS: Part 1- morning cortisol response was as expected in healthy normal sleepers with a rise between waking and 30 minutes later. Insomnia patients and parasomnia patients on a ‘good’ night had a similar response with both readings being slightly higher. On the ‘bad’ nights readings were very variable with no consistent rise between the 2 time periods. Waking cortisol levels correlated with complaints of waking too early. Dream report analysis will be presented. Part 2 – synchronized hypnograms and cortisol profiles will be presented. Cortisol levels fell during the first few hours of sleep and then showed a rise independent of sleep stage about halfway through the night, consistent with the literature. In addition, both awakenings and REM sleep tended to increase cortisol level. Awakening cortisol response occurred from any stage of sleep and at any time of day. CONCLUSIONS: Part 1 - Insomnia and parasomnia subjects had higher cortisol levels than controls but this was not statistically significant. However we demonstrated a significant relationship between cortisol levels and subjective measures of sleep quality and early awakening. Dreaming effects will be discussed. Part 2 – The automatic sampling method was reliable and effective in obtaining frequent cortisol samples without interfering with sleep. There was evidence of both circadian and sleep-stage-dependent regulation of night-time cortisol level.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Wilson, S. J.
Secondary author(s):	Nutt, D. J., Lightman, S.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Wilson, S. J., Nutt, D. J., & Lightman, S. (2008). An investigation of effects of dreams on physiological measures of stress. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document:	No
Keywords:	Sleep / Parasomnias / Hypothalamic-pituitary-adrenal axis / Cortisol / Stress / Endocrinology
An investigation of effects of dreams on physiological measures of stress

Document

New perspectives for the study of lucid dreaming: from brain stimulation to philosophical theories of self-consciousness

2010

BIAL Foundation Archive
- BIAL Grants
  - 2008 Grants
    - 054 - Brain activity during remote information access
      - New perspectives for the study of lucid dreaming: from brain stimulation to philosophical theories of self-consciousness

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2008
Location:	Arquivo PCA - Pastas 1 a
Title:	2008 Grants
Start date:	2009-01

Reference code:	PT/FB/BL-2008-054
Location:	Arquivo PCA - Pasta 3/2008
Title:	054 - Brain activity during remote information access
Duration:	2009-10 - 2011-06
Researcher(s):	Jérôme Daltrozzo, Boris Kotchoubey, Ahmed A. Karim
Institution(s):	Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University, Tübingen (Germany)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report Articles
Language:	eng
Author:	Daltrozzo, J.
Secondary author(s):	Kotchoubey, B., Karim, A. A.
Number of reproductions:	1
Keywords:	Psychophysiology / Out-of-body experience (OBE) / Brain structure and function / Sleep and dreams / Body awareness

Reference code:	PT/FB/BL-2008-054.03
Location:	Arquivo PCA - Pasta 3/2008
Title:	New perspectives for the study of lucid dreaming: from brain stimulation to philosophical theories of self-consciousness
Publication year:	2010
URL:	http://archiv.ub.uni-heidelberg.de/ojs/index.php/IJoDR/article/view/586
Abstract/Results:	ABSTRACT: The neural mechanisms underlying lucid dreaming have recently been investigated using brain imaging techniques such as electroencephalography and functional magnetic resonance imaging, which produce insightful but merely correlative results. We propose that research on the neurophysiology of lucid dreaming, for instance concerning the exact relationship between the dorsolateral prefrontal cortex and metacognitive insight into the fact that one is dreaming, should be complemented by methods allowing direct causal interference with neural functioning during sleep. To achieve this aim, several stimulation methods are proposed, i.e. transcranial magnetic stimulation, transcranial direct current stimulation, and galvanic vestibular stimulation. Given the broad range of cognitive and metacognitive processing in dreams, which support a continuous view of lucid and nonlucid dreaming, we further propose that certain aspects of dream lucidity and its neural mechanisms can be investigated in so-called ordinary, nonlucid dreams. This would allow for phenomenologically more comprehensive and practically more efficient experiments in this field of dream research. Such experiments would also provide a solid ground for understanding self-consciousness in lucid and non-lucid dreams, as well as for integrating dream research into more general neurophilosophical theories of consciousness and the self.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Noreika, V.
Secondary author(s):	Windt, J., Lenggenhager, B., Karim, A. A.
Document type:	Article
Number of reproductions:	1
Reference:	Noreika, V., Windt, J., Lenggenhager, B., & Karim, A. A. (2010). New perspectives for the study of lucid dreaming: from brain stimulation to philosophical theories of self-consciousness. International Journal of Dream Research, 3(1), 36-45. https://doi.org/10.11588/ijodr.2010.1.586
Indexed document:	No
Keywords:	Lucid dreaming / Brain stimulation / Self-consciousness / Sleep
Novo ficheiro

Document

Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
      - Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-154
Location:	Arquivo PCA - Pasta 5/2006
Title:	154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration:	2008-01 - 2009-10
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s):	Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code:	PT/FB/BL-2006-154.01
Location:	Arquivo PCA - Pasta 5/2006
Title:	Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Publication year:	2009
URL:	http://www.bial.com/imagem/Bolsa15406_21022014.pdf
Abstract/Results:	RESULTS: This study relied on nine epilepsy surgery candidates implanted with foramen ovale electrodes. 1.5-3Hz rhythmic slow activity (RSA) was a predominant activity pattern during REM sleep in most patients. This activity was also found to be highly synchronous both intra- and interhemispherically. Positive half-waves of the 1.5–3Hz RSA were identified by a semi-automatic algorithm during REM sleep. High-frequency activity was assessed as root mean square (RMS) for 11 consecutive 20 Hz–wide frequency bands between 20 and 240Hz. Calculating individual spectra revealed a broad but definite peak in the high-frequency band in seven cases (hemispheres). Statistical analysis revealed a clear phase-coupling of high-frequency activity in all patients and for most of the high-frequency bands studied. This phase relation was similar across the high frequency bands within the same patient and hemisphere. This allowed us to use individually defined fixed intervals of 0.1 s to statistically compare RMS values corresponding to the peak and the trough of the triggered RMS curve. Typically the preferred phase occurred before the RSA peak used as trigger. In most cases modulation statistics exhibited a U-shaped curve with highest significance levels in the middle frequency bands (60–80Hz and 80–100Hz). Compared to these bands modulation generally weakened across both decreasing and increasing frequency ranges. Such a phase-coupling between delta and gamma activity is similar to that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding delta rather than theta as the human analogue of RSA in animals.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Sleep / Epilepsy / Rhythmic slow activity
Final report - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

Document

Fine-tuned coupling between human parahippocampal ripples and sleep spindles

2011

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
      - Fine-tuned coupling between human parahippocampal ripples and sleep spindles

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-154
Location:	Arquivo PCA - Pasta 5/2006
Title:	154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration:	2008-01 - 2009-10
Researcher(s):	Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s):	Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Halász, P.
Secondary author(s):	Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code:	PT/FB/BL-2006-154.04
Location:	Arquivo PCA - Pasta 5/2006
Title:	Fine-tuned coupling between human parahippocampal ripples and sleep spindles
Publication year:	2011
URL:	http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2010.07505.x/pdf
Abstract/Results:	ABSTRACT: Sleep-associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led to the concept that ripples originating from hippocampus combine with spindles to provide a fine-tuned temporal frame for a persistent transfer of memory-related information to the neocortex. The present study focused on characterizing the temporal relationship between parahippocampal ripple activity (80-140 Hz) and spindles recorded from frontal, parietal and parahippocampal cortices in 12 epilepsy patients implanted with parahippocampal foramen ovale electrodes. Overall, parietal and parahippocampal spindles showed closer relationships to parahippocampal ripple activity than frontal spindles, with the latter following parietal and parahippocampal spindles at a variable delay of up to 0.5 s. On a timescale of seconds, ripple activity showed a continuous increase before the peak of parietal and parahippocampal spindles, and decreased thereafter. At a fine timescale of milliseconds, parahippocampal ripple activity was tightly phase-locked to the troughs of these spindles. The demonstration of spindle phase-locked ripple activity in humans is consistent with the idea of a temporally fine-tuned hippocampus-to-neocortex transfer of information taking place during SWS.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Clemens, Z.
Secondary author(s):	Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., Born, J.
Document type:	Article
Number of reproductions:	1
Reference:	Clemens, Z., Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., & Born, J. (2011). Fine-tuned coupling between human parahippocampal ripples and sleep spindles. European Journal of Neuroscience, 33(3), 511-520. https://doi.org/10.1111/j.1460-9568.2010.07505.x
2-year Impact Factor:	3.631\|2011
Times cited:	162\|2025-02-10
Indexed document:	Yes
Quartile:	Q2
Keywords:	Epilepsy / Hippocampus / Ripples / Sleep / Spindles
Fine-tuned coupling between human parahippocampal ripples and sleep spindles

Document

Adolescent mothers providing massage to their 0 to 3 month-old infants

2008

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 023 - Massagem ao bebé prematuro em cuidados intensivos neonatais: Efeito no funcionamento psicofisiológico dos bebés e pais
      - Adolescent mothers providing massage to their 0 to 3 month-old infants

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-023
Location:	Arquivo PCA - Pasta 16/2006
Title:	023 - Massagem ao bebé prematuro em cuidados intensivos neonatais: Efeito no funcionamento psicofisiológico dos bebés e pais
Duration:	2007-07 - 2010-11
Researcher(s):	Bárbara Figueiredo, Clara Sofia Domingues Paz Dias, Maria Alice Peixoto Freitas, Maria Agostinha Costa Andrade, Maria José Faria Novais Rebelo, Susana Nunes da Silva, Maria de Lurdes Alves Senra, Maria José Carvalho Ferreira, César Bessa Pinheiro Teixeira, Mariana Pinto Basto Teixeira, Diana Patrícia Pires Pinto, Mariana Bianchi de Aguiar, Ana Guedes, José Pombeiro
Institution(s):	Cipsi, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 3 Articles
Language:	por
Author:	Figueiredo, B.
Secondary author(s):	Dias, C., Freitas, M., Andrade, M., Rebelo, M., Silva, S., Senra, M., Ferreira, M., Teixeira, C., Teixeira, M., Pinto, D., Bianchi Aguiar, M., Guedes, A., Pombeiro, J.
Number of reproductions:	1
Keywords:	Psychophysiology / Affective and social behavior / Parenthood / Conjugality / Biopsychological problems / Mental health / Intervention

Reference code:	PT/FB/BL-2006-023.04
Location:	Arquivo PCA - Pasta 16/2006
Title:	Adolescent mothers providing massage to their 0 to 3 month-old infants
Publication year:	2008
URL:	http://www.isisweb.org/SpringboardWebApp/userfiles/isis/file/ICIS08%20Abstract%20Volume.pdf
Abstract/Results:	ABSTRACT: BACKGROUND: Adolescent mothers and their infants are at risk for poor health and developmental outcomes. Massage is a relatively simple strategy to improve mother’s sensibility to the infant’s cues. AIM: The aim of the study was to analyse how massage can improve infant’s sleeping habits and reduce their teenage mothers’ psychopathological symptoms. METHODS: A sample of 30 adolescent mothers and their infants were recruited at the Júlio Dinis Maternity Hospital (Porto, Portugal) just after delivery. A socio-demographic Questionnaire was completed at the time. Premature infants (gestational age < 37 weeks or weight < 2.500) and infant with chronic illness (impeditive of regular sleep habits), as well as mothers with twins, and mothers that do not know how to read and write in Portuguese were excluded from the study. Two weeks after recruitment, the Children’s Sleep Habit Questionnaire (Owens et al., 2000), the State-Trait Anxiety Inventory (Spielberg et al., 1970) and the Edinburgh Postnatal Depression Scale (Cox et al;) was administrated to the mothers (pre-test). A Massage Instruction Manual and a Massage Booklet were also provided. The massage was taught to an experimental group of 15 mothers. At 3 months postpartum the mothers completed again the Sleep Chronogram, the CSHQ, STAI and EPDS. RESULTS: Infant’s receiving massage by their mothers show better sleep patterns and better sleep habits, and the mothers who provided the massage show less anxiety and less depression at 3 months postpartum. CONCLUSION: Adolescent mothers providing massage to their 0 to 3 months-old infants present less postpartum anxiety and depression and their infants seem to sleep better.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Bianchi Aguiar, M.
Secondary author(s):	Figueiredo, B., Guedes, A., Magarinho, R., Pombeiro, J.
Document type:	Abstract book
Number of reproductions:	1
Reference:	Bianchi Aguiar, M., Figueiredo, B., Guedes, A., Magarinho, R., & Pombeiro, J. (2008). Adolescent mothers providing massage to their 0 to 3 month-old infants. In Abstract book of the XVI Conference on Infant Studies (p. 131). Vancouver, Canada.
Indexed document:	No
Keywords:	Adolescent mothers / Massage / Sleep / Postpartum anxiety / Postpartum depression
Adolescent mothers providing massage to their 0 to 3 month-old infants

Document

Required time for cognitive and motor activities in lucid dreams

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 072 - Required time for cognitive and motor activities in lucid dreams
      - Required time for cognitive and motor activities in lucid dreams

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-072
Location:	Arquivo PCA - Pasta 2/2006
Title:	072 - Required time for cognitive and motor activities in lucid dreams
Duration:	2007-01 - 2009-01
Researcher(s):	Daniel Erlacher, Michael Schredl, Carmen Gebhart
Institution(s):	University of Heidelberg, Institute for Sport and Sports Science, Heidelberg (Germany)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final report
Language:	eng
Author:	Erlacher, D.
Secondary author(s):	Schredl, M., Gebhart, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Altered states of consciousness / Lucid dreaming

Reference code:	PT/FB/BL-2006-072.02
Location:	Arquivo PCA - Pasta 2/2006
Title:	Required time for cognitive and motor activities in lucid dreams
Publication year:	2010
URL:	http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results:	ABSTRACT: OBJECTIVES: The relationship between time in dreams and real time has intrigued scientists for centuries (cf. Schredl, 2000). In a recent study by Erlacher and Schredl (2004) it was shown that the required time to perform a motor task in a lucid dream was significant longer than the required time for the same task in the waking state. In contrast, the time intervals for counting were quite similar in lucid dreams and in wakefulness. In this experiment a simple cognitive task was used to investigate the relationship between the time needed in a lucid dream and the time needed for the same activity performed in the waking state. METHODS: Two experiments were conducted whereas in experiment 1 the participant’s task was to count to 10, 20, and 30 and in experiment 2 to walk 10, 20, and 30 steps in their lucid dreams. The lucid dreamers were instructed to mark the events by LRLR: the onset of lucidity, the beginning of each sequence and the end of the lucid dream task. The LRLR are clearly visible in the EOG recording and the interval between two LRLR can be measured. Sleep was recorded by means of standard procedures (EEG, EOG, EMG) by the standard recording device Trex Longtime EEG recorder (XLTEK). RESULTS: For the first and second experiment the results showed that the absolute duration of counting or walking in the lucid dream takes more time than for counting or walking during wakefulness. The relative timing, however, revealed for both conditions quite similar percentages for the two conditions (lucid dreaming and wakefulness). DISCUSSION: The results showed that in lucid dreams a tendency exists to overestimate durations for simple cognitive and motor tasks, but, that those differences are not visible for the relative timing of the tasks. In general the statistical analysis has to face the problem of testing for equivalence, because the alternative hypothesis predicts a similar result and not a difference (c.f. Wellek, 2003).
Accessibility:	Document does not exist in file
Language:	eng
Author:	Erlacher, D.
Secondary author(s):	Schredl, M., Gebhart, C.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Erlacher, D., Schredl, M., & Gebhart, C. (2010). Required time for cognitive and motor activities in lucid dreams. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 218). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Sleep / Lucid dreaming / Time / Counting / Walking
Required time for cognitive and motor activities in lucid dreams

Document

Final report - Sleep-dependent emotion regulation

2013

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 154 - Sleep-dependent emotion regulation
      - Final report - Sleep-dependent emotion regulation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-154
Location:	Arquivo PCA - Pasta 4/2010
Title:	154 - Sleep-dependent emotion regulation
Duration:	2011-05 - 2013-05
Researcher(s):	Pascal Hot, Yoshiniro Kobayashi, Adeline Paignon
Institution(s):	Laboratoire de Psychologie et Neurocognition (LPNC), Université de Savoie, Chambéry (France)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final report
Language:	eng
Author:	Hot, P.
Secondary author(s):	Kobayashi, Y., Paignon, A.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and dreams / Emotion / Brain structure and function

Reference code:	PT/FB/BL-2010-154.01
Location:	Arquivo PCA - Pasta 4/2010
Title:	Final report - Sleep-dependent emotion regulation
Publication year:	2013
URL:	http://www.bial.com/imagem/Bolsa15410.pdf
Abstract/Results:	RESULTS: GOAL: Recent neuroimaging studies support that emotion regulation could be strengthened by sleep. First, MRI findings (Yoo et al., 2007; Walker et al., 2011) have demonstrated that REM sleep decreases amygdala reactivity to intrinsically emotional stimuli, previously experienced. Second, one study (Pace-Schott et al., 2009) suggests that sleep reduces affective impact of an emotional learning. The main goal of our work is to identify neural activities during sleep as the cause of reduced emotional reactivity for a new emotional learning. METHODS: Two groups, a “sleep” group (13 participants) and a “wake” group (15 participants) have performed the protocol. Both groups watched a set of 15 short neutral and scary movies (4 sec each) ended with the presentation of neutral pictures. Conditioned neutral pictures (previously associated to scary movies) were next presented alone, immediately after the conditioning and after a 12hr delay. Physiological and psychological responses to conditioning pictures were measured. For the sleep group, sleep EEG was recorded during 3 consecutive nights, the last one following the conditioning protocol. RESULTS AND DISCUSSION: Main results showed that emotional responses were reduced in the sleep group compared to the wake group. In the sleep group, significant differences were observed between the control night and the ‘emotional’ night only for the theta band during the REM sleep. By contrast EEG activity during both light and deep sleep appears to be globally unaffected by experimental conditions. This result suggests that theta rhythm is increased during REM-sleep subsequent to emotional learning, sustaining emotional adaptation process.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Hot, P.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Sleep / Emotion / Neuroscience
Final report - Sleep-dependent emotion regulation

Document

Disturbed dreaming and sleep quality: Altered sleep architecture in subjects with frequent nightmares

2012

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
      - Disturbed dreaming and sleep quality: Altered sleep architecture in subjects with frequent nightmares

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-055
Location:	Arquivo PCA - Pasta 11/2010
Title:	055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Duration:	2011-03 - 2014-02
Researcher(s):	Róbert Bódizs, Peter Daniel Simor, Piroska Sándor, Szilvia Csóka, Klára Horváth
Institution(s):	Institute of Behavioural Sciences, Semmelweis University, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final reports 7 Articles ( published or submittedr publication) 5 Conference abstracts
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Sándor, P., Csóka, S., Horváth, K.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Developmental psychology

Reference code:	PT/FB/BL-2010-055.02
Location:	Arquivo PCA - Pasta 10/2010
Title:	Disturbed dreaming and sleep quality: Altered sleep architecture in subjects with frequent nightmares
Publication year:	2012
URL:	http://link.springer.com/article/10.1007%2Fs00406-012-0318-7
Abstract/Results:	ABSTRACT: Nightmares are intense, emotionally negative mental experiences that usually occur during late-night sleep and result in abrupt awakenings. Questionnaire-based studies have shown that nightmares are related to impaired sleep quality; however, the polysomnographic profile of nightmare subjects has been only scarcely investigated. We investigated the sleep architecture of 17 individuals with frequent nightmares and 23 control subjects based on polysomnographic recordings of a second night spent in the laboratory after an adaptation night. Nightmare subjects in comparison with control subjects were characterized by impaired sleep architecture, as reflected by reduced sleep efficiency, increased wakefulness, a reduced amount of slow wave sleep, and increased nocturnal awakenings, especially from Stage 2 sleep. While these differences were independent of the effects of waking psychopathology, nightmare subjects also exhibited longer durations of REM sleep that was mediated by heightened negative affect. Our results support that nightmares are related to altered sleep architecture, showing impaired sleep continuity and emotion-related increase in REM propensity.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Simor, P.
Secondary author(s):	Horváth, K., Gombos, F., Takács, K., Bódizs, R.
Document type:	Article
Number of reproductions:	1
Reference:	Simor, P., Horváth, K., Gombos, F., Takács, K., & Bódizs, R. (2012). Disturbed dreaming and sleep quality: Altered sleep architecture in subjects with frequent nightmares. European Archives of Psychiatry and Clinical Neuroscience, 262(8), 687-696. https://doi.org/10.1007/s00406-012-0318-7
2-year Impact Factor:	3.200\|2012
Times cited:	73\|2025-02-10
Indexed document:	Yes
Quartile:	Q2
Keywords:	Nightmares / Sleep / Dreaming / Electroencephalogram (EEG) / Polysomnography / Sleep quality
Disturbed dreaming and sleep quality: Altered sleep architecture in subjects with frequent nightmares

Document

Fluctuations between sleep and wakefulness: Wake-like features indicated by increased EEG alpha power during different sleep stages in nightmare disorder

2013

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
      - Fluctuations between sleep and wakefulness: Wake-like features indicated by increased EEG alpha power during different sleep stages in nightmare disorder

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-055
Location:	Arquivo PCA - Pasta 11/2010
Title:	055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Duration:	2011-03 - 2014-02
Researcher(s):	Róbert Bódizs, Peter Daniel Simor, Piroska Sándor, Szilvia Csóka, Klára Horváth
Institution(s):	Institute of Behavioural Sciences, Semmelweis University, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final reports 7 Articles ( published or submittedr publication) 5 Conference abstracts
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Sándor, P., Csóka, S., Horváth, K.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Developmental psychology

Reference code:	PT/FB/BL-2010-055.04
Location:	Arquivo PCA - Pasta 10/2010
Title:	Fluctuations between sleep and wakefulness: Wake-like features indicated by increased EEG alpha power during different sleep stages in nightmare disorder
Publication year:	2013
URL:	http://www.sciencedirect.com/science/article/pii/S0301051113001609
Abstract/Results:	ABSTRACT: Although a growing body of research indicates that frequent nightmares are related to impaired sleep regulation, the pathophysiology of nightmare disorder is far from being fully understood. We examined the relative spectral power values for NREM and REM sleep separately in 19 individuals with nightmare disorder and 21 healthy controls, based on polysomnographic recordings of the second nights’ laboratory sleep. Nightmare subjects compared to controls exhibited increased relative high alpha (10–14.5 Hz) and fronto-central increases in high delta (3–4 Hz) power during REM sleep, and a trend of increased fronto-central low alpha (7.75–9 Hz) power in NREM sleep. These differences were independent of the confounding effects of waking emotional distress. High REM alpha and low NREM alpha powers were strongly related in nightmare but not in control subjects. The topographical distribution and spectral components of REM alpha activity suggest that nightmare disordered subjects are characterized by wake-like electroencephalographic features during REM sleep.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Simor, P.
Secondary author(s):	Horváth, K., Ujma, P., Gombos, F., Bódizs, R.
Document type:	Article
Number of reproductions:	1
Reference:	Simor, P., Horváth, K., Ujma, P., Gombos, F., & Bódizs, R. (2013). Fluctuations between sleep and wakefulness: Wake-like features indicated by increased EEG alpha power during different sleep stages in nightmare disorder. Biological Psychology, 94(3), 592-600. https://doi.org/10.1016/j.biopsycho.2013.05.022
2-year Impact Factor:	3.473\|2013
Times cited:	36\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Alpha oscillations / Nightmares / Power spectral analysis / REM parasomnia / Sleep
Fluctuations between sleep and wakefulness: Wake-like features indicated by increased EEG alpha power during different sleep stages in nightmare disorder

Document

Objective and subjective components of the first-night effect in young nightmare sufferers and healthy participants

2013

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
      - Objective and subjective components of the first-night effect in young nightmare sufferers and healthy participants

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-055
Location:	Arquivo PCA - Pasta 11/2010
Title:	055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Duration:	2011-03 - 2014-02
Researcher(s):	Róbert Bódizs, Peter Daniel Simor, Piroska Sándor, Szilvia Csóka, Klára Horváth
Institution(s):	Institute of Behavioural Sciences, Semmelweis University, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final reports 7 Articles ( published or submittedr publication) 5 Conference abstracts
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Sándor, P., Csóka, S., Horváth, K.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Developmental psychology

Reference code:	PT/FB/BL-2010-055.05
Location:	Arquivo PCA - Pasta 10/2010
Title:	Objective and subjective components of the first-night effect in young nightmare sufferers and healthy participants
Publication year:	2013
URL:	http://www.tandfonline.com/doi/full/10.1080/15402002.2013.829062#.UsGhgdGYYq4
Abstract/Results:	ABSTRACT: The first-night effect—marked differences between the first- and the second-night sleep spent in a laboratory—is a widely known phenomenon that accounts for the common practice of excluding the first-night sleep from any polysomnographic analysis. The extent to which the first-night effect is present in a participant, as well as its duration (1 or more nights), might have diagnostic value and should account for different protocols used for distinct patient groups. This study investigated the first-night effect on nightmare sufferers (NM; N = 12) and healthy controls (N = 15) using both objective (2-night-long polysomnography) and subjective (Groningen Sleep Quality Scale for the 2 nights spent in the laboratory and 1 regular night spent at home) methods. Differences were found in both the objective (sleep efficiency, wakefulness after sleep onset, sleep latency, Stage-1 duration, Stage-2 duration, slow-wave sleep duration, and REM duration) and subjective (self-rating) variables between the 2 nights and the 2 groups, with a more pronounced first-night effect in the case of the NM group. Furthermore, subjective sleep quality was strongly related to polysomnographic variables and did not differ among 1 regular night spent at home and the second night spent in the laboratory. The importance of these results is discussed from a diagnostic point of view.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Kis, A.
Secondary author(s):	Szakadát, S., Simor, P., Gombos, F., Horváth, K., Bódizs, R.
Document type:	Article
Number of reproductions:	1
Reference:	Kis, A., Szakadát, S., Simor, P., Gombos, F., Horváth, K., & Bódizs, R. (2013). Objective and subjective components of the first-night effect in young nightmare sufferers and healthy participants. Behavioral Sleep Medicine, 12, 1-12. https://doi.org/10.1080/15402002.2013.829062
2-year Impact Factor:	1.744\|2013
Times cited:	20\|2025-02-10
Indexed document:	Yes
Quartile:	Q3
Keywords:	First-night effect / Polysomnography / Nightmares / Sleep
Objective and subjective components of the first-night effect in young nightmare

Document

Spectral sleep EEG features of nightmare sufferers: evidence for a NREM disorder?

2011

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
      - Spectral sleep EEG features of nightmare sufferers: evidence for a NREM disorder?

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-055
Location:	Arquivo PCA - Pasta 11/2010
Title:	055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Duration:	2011-03 - 2014-02
Researcher(s):	Róbert Bódizs, Peter Daniel Simor, Piroska Sándor, Szilvia Csóka, Klára Horváth
Institution(s):	Institute of Behavioural Sciences, Semmelweis University, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final reports 7 Articles ( published or submittedr publication) 5 Conference abstracts
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Sándor, P., Csóka, S., Horváth, K.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Developmental psychology

Reference code:	PT/FB/BL-2010-055.09
Location:	Arquivo PCA - Pasta 10/2010
Title:	Spectral sleep EEG features of nightmare sufferers: evidence for a NREM disorder?
Publication year:	2011
URL:	http://www.cecog.eu/ducog_2011_abstractbook.pdf
Abstract/Results:	ABSTRACT: Nightmare disorder characterised by recurrent vivid, dysphoric dreams charged with negative emotions is one of the most common sleep problems. While there are two studies about the sleep architecture of nightmare sufferers (NS), as far as we know, the sleep EEG characteristics of them have not been investigated yet. Psychological (Beck Depression and State-Trait Anxiety Inventory) and two-night polysomnographic testing were conducted on 21 university students (10 NS, 11 control) without any prior history of mental or chronic somatic disease. EEG spectra were obtained by using Fast-Fourier Transformation on the second night recordings for REM and NREM separately. We examined the group differences by ANCOVA controlling for the BDI and STAI score. In the nightmare group higher NREM theta (4,25-7,5 Hz) and high sigma (12,75-15 Hz) activities were found mainly at the centroparietal region and the frontal area, respectively. The frontal high sigma activity was correlated significantly with poor sleep assessed by the Groningen Sleep Quality Scale. No significant differences in REM spectra have been observed. The results suggest that NS differ from controls more in NREM than in REM sleep. The covert REM sleep phenomena might explain the higher theta activity in NS.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Horváth, K.
Secondary author(s):	Simor, P., Sándor, P., Vida, R., Lihi, R., Sulyok, Z., Bódizs, R.
Document type:	Abstract book
Number of reproductions:	1
Reference:	Horváth, K., Simor, P., Sándor, P., Vida, R., Lihi, R., Sulyok, Z., & Bódizs, R. (2011). Spectral sleep EEG features of nightmare sufferers: evidence for a NREM disorder? In Central European Cognitive Science Association (CECOG) (Ed.), Abstract book of the 3rd Dubrovnik Conference on Cognitive Science - DuCog III: Implicit processes across the life span (p. 23). Dubrovnik, Croatia.
Indexed document:	No
Keywords:	Nightmares / Sleep / Electroencephalogram (EEG) / Dreaming / Covert REM sleep / Sigma activity / Sleep quality
Spectral sleep EEG features of nightmare sufferers: evidence for a NREM disorder?

Document

Neurotelemedicina

BIAL Foundation Archive
- Documentation and Information Center
  - Neurotelemedicina

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/E
Entity holding:	BIAL Foundation
Title:	Documentation and Information Center
History:	Books that are part of the documentation center

Reference code:	PT/FB/E/039
Title:	Neurotelemedicina
Número de inventário:	M-0040
Local:	Porto
Publisher:	Laboratórios Bial
Date:	2000
Pag., vols.:	104 p.
Illustration:	il.
Dimension/support:	24 cm
Accessibility:	Document exists in archive
Copyright/Reproduction:	By permission
Language:	por
Notes:	Prémio Bial de Medicina Clínica 2000
Edition:	1ª ed.
Collection:	(Bial ; 24)
Author:	Paiva, T.
Secondary author(s):	Araújo, M., Coelho, H., Belo, C., Gonçalves, M., Navarro, T., Cruz, M., Penzel, T., Zulley, J.
Document type:	Book
Keywords:	Telemedicine / Neurology / Sleep

Document

Final report - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity

2014

BIAL Foundation Archive
- BIAL Grants
  - 2010 Grants
    - 055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
      - Final report - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2010
Location:	Arquivo PCA - Pastas 1 a 23
Title:	2010 Grants
Start date:	2011-01

Reference code:	PT/FB/BL-2010-055
Location:	Arquivo PCA - Pasta 11/2010
Title:	055 - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Duration:	2011-03 - 2014-02
Researcher(s):	Róbert Bódizs, Peter Daniel Simor, Piroska Sándor, Szilvia Csóka, Klára Horváth
Institution(s):	Institute of Behavioural Sciences, Semmelweis University, Budapest (Hungary)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress report Final reports 7 Articles ( published or submittedr publication) 5 Conference abstracts
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Sándor, P., Csóka, S., Horváth, K.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Developmental psychology

Reference code:	PT/FB/BL-2010-055.01
Location:	Arquivo PCA - Pasta 10/2010
Title:	Final report - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity
Publication year:	2014
URL:	http://www.bial.com/imagem/Bolsa5510_27022014.pdf
Abstract/Results:	RESULTS: We aimed to characterize sleep and to test the frontal dysfunction hypothesis of nightmares, as well as to bridge the relationship between the ontogeny of frontal-executive and emotion regulation functions with age-related peculiarities of dreams and nightmares. Nightmare sufferers (NS) were characterized by performance decreases in several executive tasks (Emotional Go/NoGo, Emotional Stroop, Verbal Fluency). Alterations in the sleep architecture (decreases: sleep efficiency, slow wave sleep; increases: wakefulness, arousals, REM sleep), microstructure (increases in A2-microarousals of the cyclic alternating pattern), and qEEG (increased REM sleep 10–14 Hz power and synchronization) were paralleled by a more pronounced first-night effect of NS. Children are more accomplished dreamers with dream narratives closer to adult dream reports than authors of previous laboratory findings described. 4–8 years old children were characterized by a positive correlation of dream report length with slow wave sleep and with performance in the Emotional Stroop test. Negative correlation between the developmental level of executive functioning and dream recall frequency was also established. Our results suggest that NS are characterized by impairments in executive tasks involving the suppression of task-irrelevant semantic representations. Moreover, nightmare-related alterations in sleep architecture and microstructure are characterized by wake-like intrusions disturbing the neurocognitive function of sleep, as well as by emotion-related increases in REM propensity. Children’s dreams should be collected by novel methods, involving their parents. Children’s dreams depend on the maturation of emotion regulation and executive functions.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Bódizs, R.
Secondary author(s):	Simor, P., Horváth, K., Sándor, P., Csóka, S.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Nightmares / Sleep / Electroencephalogram (EEG) / Dreaming / Children
Final report - The developmental and psychophysiological emergence of dreams and nightmares: state-dependent and state-independent fronto-cortical disconnectivity

Document

Sleep and Emotional Functions

2014

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
      - Sleep and Emotional Functions

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-225
Location:	Arquivo PCA - Pasta 12/2012
Title:	225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration:	2013-10 - 2016-02
Researcher(s):	Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s):	Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final report Article
Language:	eng
Author:	Schwartz, S.
Secondary author(s):	Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code:	PT/FB/BL-2012-225.02
Location:	Arquivo PCA - Pasta 12/2012
Title:	Sleep and Emotional Functions
Publication year:	2014
URL:	http://link.springer.com/chapter/10.1007%2F7854_2013_271
Abstract/Results:	ABSTRACT: In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Perogamvros, L.
Secondary author(s):	Schwartz, S.
Document type:	Article
Number of reproductions:	1
Reference:	Perogamvros, L., & Schwartz, S. (2014). Sleep and Emotional Functions. Current Topics in Behavioral Neurosciences, 25, 411-431. https://doi.org/10.1007/7854_2013_271
2-year Impact Factor:	N/A
Times cited:	N/A
Indexed document:	Yes
Quartile:	N/A
Keywords:	Sleep / Sleep deprivation / Dreaming / Emotion / Cognition / Reward / Sexual function / Creativity / Memory consolidation / Brain development / Amygdala / Prefrontal cortex / Hippocampus / Ventral tegmental area / Striatum / Nucleus accumbens / Dopamine / Limbic / Mesolimbic
Sleep and Emotional Functions

Document

Sleep and dreaming are for important matters

2013

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
      - Sleep and dreaming are for important matters

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-225
Location:	Arquivo PCA - Pasta 12/2012
Title:	225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration:	2013-10 - 2016-02
Researcher(s):	Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s):	Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final report Article
Language:	eng
Author:	Schwartz, S.
Secondary author(s):	Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code:	PT/FB/BL-2012-225.03
Location:	Arquivo PCA - Pasta 12/2012
Title:	Sleep and dreaming are for important matters
Publication year:	2013
URL:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722492/
Abstract/Results:	ABSTRACT: Recent studies in sleep and dreaming have described an activation of emotional and reward systems, as well as the processing of internal information during these states. Specifically, increased activity in the amygdala and across mesolimbic dopaminergic regions during REM sleep is likely to promote the consolidation of memory traces with high emotional/motivational value. Moreover, coordinated hippocampal-striatal replay during NREM sleep may contribute to the selective strengthening of memories for important events. In this review, we suggest that, via the activation of emotional/motivational circuits, sleep and dreaming may offer a neurobehavioral substrate for the offline reprocessing of emotions, associative learning, and exploratory behaviors, resulting in improved memory organization, waking emotion regulation, social skills, and creativity. Dysregulation of such motivational/emotional processes due to sleep disturbances (e.g., insomnia, sleep deprivation) would predispose to reward-related disorders, such as mood disorders, increased risk-taking and compulsive behaviors, and may have major health implications, especially in vulnerable populations.
Accessibility:	Document exists in file
Language:	eng
Author:	Perogamvros, L.
Secondary author(s):	Dang-Vu, T., Desseilles, M., Schwartz, S.
Document type:	Article
Number of reproductions:	1
Reference:	Perogamvros, L., Dang-Vu, T., Desseilles, M., & Schwartz, S. (2013). Sleep and dreaming are for important matters. Frontiers in Psychology, 4: 474. https://doi.org/10.3389/fpsyg.2013.00474
2-year Impact Factor:	2.843\|2013
Times cited:	50\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Sleep / Dreaming / Emotion / Memory / Learning / Reward system / Creativity
Sleep and dreaming are for important matters

Document

Using whole-brain computational modelling for identifying hubs necessary for transitioning between sleep stages measured with MEG

2014

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 220 - Consciousness disconnects during sleep
      - Using whole-brain computational modelling for identifying hubs necessary for transitioning between sleep stages measured with MEG

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-220
Location:	Arquivo PCA - Pasta 15/2012
Title:	220 - Consciousness disconnects during sleep
Duration:	2013-04 - 2016-05
Researcher(s):	Giovanni Piantoni
Institution(s):	Cortical Physiology Lab, Massachusets General Hospital, Harvard Medical School (USA) and Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final reports 1 article Submitted papers
Language:	eng
Author:	Piantoni, G.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Sleep and dreams

Reference code:	PT/FB/BL-2012-220.02
Location:	Arquivo PCA - Pasta 15/2012
Title:	Using whole-brain computational modelling for identifying hubs necessary for transitioning between sleep stages measured with MEG
Publication year:	2014
URL:	http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=4da09ec6-f098-4bf1-9af3-8457926fe748&cKey=56e8f950-5ebd-4db6-819e-f6589b25cdf9&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Abstract/Results:	ABSTRACT: Sleep in normal adults is characterised by highly consistent state-transitions in the brain over time. Compared to the descent to sleep, which is, at least partly, a voluntary act, the switching between sleep stages appears almost mechanistic. The temporal order and relationship between the brain states of various sleep stages are remarkably constant. Describing the whole-brain activity of individual sleep stages was one of the first merits of electroencephalography (EEG), and more advanced forms of neuroimaging have expanded our understanding of the spatiotemporal unfolding of sleep. Yet, the mechanisms underlying, and brain regions orchestrating the transitions between wakefulness and the various sleep states remain unresolved. Understanding this may lead to important insights into not only the fundamental principles of the human brain function but also the causes of sleep disorders. Viewing the brain as an intricately connected network, in which activity occurs as a result of communication between parts of this network has helped the investigation of spontaneous brain activity. By combining analysis of structural imaging data, such as diffusion tensor imaging (DTI), and functional imaging data, such as functional Magnetic Resonance Imaging and magnetoencephalography (MEG), computational modelling has successfully been applied to describe how spontaneous dynamics can arise from the structural properties of the network. Modelling of whole-brain activity can assist in elucidating the causal links facilitating the transitions between brain states of sleep. In computational terms the aim is to understand the interplay between integration and segregation in the brain and to find the important binding regions that are necessary and sufficient for network transitions between states. In the current study we used MEG to measure whole-brain activity of 11 healthy adults that went through the different phases of sleep. We obtained the spatiotemporal dynamics of brain activity by extracting the slow fluctuating changes in the Hilbert power envelope of frequency filtered and beamformed time-series. A Hidden Markov Model (HMM) makes it possible to resolve non-stationarity of functional networks. Thus each sleep stage was tested as individual transient states of the network. Finally, we applied a whole-brain computational model that allowed us to identify the necessary and sufficient brain regions binding information across the brain and facilitating the transitions between brain states during sleep.
Accessibility:	Document does exist in file
Language:	eng
Author:	Stevner, A.
Secondary author(s):	Piantoni, G., Colclough, G., Woolrich, M., Parsons, C., Cabral, J., Van Someren, E., van der Werf, Y., Deco, G., Kringelbach, M.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Stevner, A., Piantoni, G., Colclough, G., Woolrich, M., Parsons, C., Cabral, J., Van Someren, E., van der Werf, Y., Deco, G., & Kringelbach, M. (2014, November). Using whole-brain computational modelling for identifying hubs necessary for transitioning between sleep stages measured with MEG. Poster presented at the 2014 Society for Neuroscience meeting, Washington, D. C. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=4da09ec6-f098-4bf1-9af3-8457926fe748&cKey=56e8f950-5ebd-4db6-819e-f6589b25cdf9&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Indexed document:	No
Keywords:	Sleep / Network / MEG